Pub Date : 2022-05-04DOI: 10.19080/crdoj.2022.15.555919
Jessica L Turton
Background: The aim of this study was to explore the clinical application of reduced-carbohydrate (RC) diets for type 1 diabetes (T1D) management at a community-based diabetes centre. Methods: To be included in this retrospective case series, adults with T1D must have attended at least two appointments with a Credentialled Diabetes Educator and Accredited Practising Dietitian (CDE/APD) for advice regarding: (a) advanced carbohydrate counting, (b) carbohydrate reduction, and/or (b) low-carbohydrate diet support. Data regarding specific dietary recommendations and clinical outcomes was extracted from patient records stored at the center. A semi-structured interview with the CDE/APD was conducted to collect additional information about the design and delivery of the RC diets. Thematic analysis was used to identify core components of the RC diets, and descriptive statistics were used to assess pre-post changes in clinical T1D outcomes. Results: 26 adults with T1D were eligible and included (77% female). The RC diets represented a patient-led approach involving adjustments to energy and macronutrient intakes, glucose self-monitoring, and insulin management. 22/26 participants attended the center seeking low-carbohydrate diet support, and the average carbohydrate prescription was 63g/day (22-253g/day) which translated to a 37% reduction from baseline. HbA1c reduced from 9.0% (75mmol/mol) to 7.0% (53mmol/mol) (-5.7 to -0.1%), with an average follow-up of 55weeks (n=8). Estimated A1c reduced from 7.1% (54mmol/mol) to 6.3% (45mmol/mol) (-2.9 to+0.6%) over 21 weeks (n=19). Mean total daily insulin reduced from 44 to 31 U/day (-46 to+6 U/day), with an average follow-up of 17 weeks (n=15). Conclusions: This study provides real-world insights into the clinical application of RC diets in the management of adults with T1D at a community-based diabetes centre. Prospective clinical trials are needed to conclusively determine the effects of RC diets on clinical T1D outcomes.
{"title":"Clinical Application of Reduced-Carbohydrate Diets for Type 1 Diabetes Management: A Retrospective Case Series","authors":"Jessica L Turton","doi":"10.19080/crdoj.2022.15.555919","DOIUrl":"https://doi.org/10.19080/crdoj.2022.15.555919","url":null,"abstract":"Background: The aim of this study was to explore the clinical application of reduced-carbohydrate (RC) diets for type 1 diabetes (T1D) management at a community-based diabetes centre. Methods: To be included in this retrospective case series, adults with T1D must have attended at least two appointments with a Credentialled Diabetes Educator and Accredited Practising Dietitian (CDE/APD) for advice regarding: (a) advanced carbohydrate counting, (b) carbohydrate reduction, and/or (b) low-carbohydrate diet support. Data regarding specific dietary recommendations and clinical outcomes was extracted from patient records stored at the center. A semi-structured interview with the CDE/APD was conducted to collect additional information about the design and delivery of the RC diets. Thematic analysis was used to identify core components of the RC diets, and descriptive statistics were used to assess pre-post changes in clinical T1D outcomes. Results: 26 adults with T1D were eligible and included (77% female). The RC diets represented a patient-led approach involving adjustments to energy and macronutrient intakes, glucose self-monitoring, and insulin management. 22/26 participants attended the center seeking low-carbohydrate diet support, and the average carbohydrate prescription was 63g/day (22-253g/day) which translated to a 37% reduction from baseline. HbA1c reduced from 9.0% (75mmol/mol) to 7.0% (53mmol/mol) (-5.7 to -0.1%), with an average follow-up of 55weeks (n=8). Estimated A1c reduced from 7.1% (54mmol/mol) to 6.3% (45mmol/mol) (-2.9 to+0.6%) over 21 weeks (n=19). Mean total daily insulin reduced from 44 to 31 U/day (-46 to+6 U/day), with an average follow-up of 17 weeks (n=15). Conclusions: This study provides real-world insights into the clinical application of RC diets in the management of adults with T1D at a community-based diabetes centre. Prospective clinical trials are needed to conclusively determine the effects of RC diets on clinical T1D outcomes.","PeriodicalId":411114,"journal":{"name":"Current Research in Diabetes & Obesity Journal","volume":"84 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117260681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-25DOI: 10.19080/crdoj.2022.15.555918
A. Oleaga
{"title":"Observational Study on the Effectiveness of Treatment with the GLP1-Receptor Agonist Dulaglutide in Patients with Type 2 Diabetes Mellitus: Real-Life Study in Spain","authors":"A. Oleaga","doi":"10.19080/crdoj.2022.15.555918","DOIUrl":"https://doi.org/10.19080/crdoj.2022.15.555918","url":null,"abstract":"","PeriodicalId":411114,"journal":{"name":"Current Research in Diabetes & Obesity Journal","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115825329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-29DOI: 10.19080/crdoj.2022.15.555917
Yo Tsuchiya
{"title":"The Effects of Dietary Fibers on Improvement of Glucose Metabolism","authors":"Yo Tsuchiya","doi":"10.19080/crdoj.2022.15.555917","DOIUrl":"https://doi.org/10.19080/crdoj.2022.15.555917","url":null,"abstract":"","PeriodicalId":411114,"journal":{"name":"Current Research in Diabetes & Obesity Journal","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114430217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-23DOI: 10.19080/crdoj.2022.15.555916
M. Soltanizadeh
{"title":"The Effectiveness of Mindfulness-Based Cognitive Therapy (MBCT) on Sexual Self-Esteem in Obese Women","authors":"M. Soltanizadeh","doi":"10.19080/crdoj.2022.15.555916","DOIUrl":"https://doi.org/10.19080/crdoj.2022.15.555916","url":null,"abstract":"","PeriodicalId":411114,"journal":{"name":"Current Research in Diabetes & Obesity Journal","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122709585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-02-21DOI: 10.19080/crdoj.2022.15.555914
T. Forst
{"title":"Evaluation of Non-Alcoholic Fatty Liver Disease (NAFLD) in Obese Adult Volunteers According to Increasing Insulin Resistance and Loss of Glucose Control","authors":"T. Forst","doi":"10.19080/crdoj.2022.15.555914","DOIUrl":"https://doi.org/10.19080/crdoj.2022.15.555914","url":null,"abstract":"","PeriodicalId":411114,"journal":{"name":"Current Research in Diabetes & Obesity Journal","volume":"182 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124563611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-02-09DOI: 10.19080/crdoj.2022.15.555913
Komal V Umbarkar
{"title":"Investigation of Effect of Polyherbal Mixtures on Cafeteria Diet Induced Obesity in Wistar rats","authors":"Komal V Umbarkar","doi":"10.19080/crdoj.2022.15.555913","DOIUrl":"https://doi.org/10.19080/crdoj.2022.15.555913","url":null,"abstract":"","PeriodicalId":411114,"journal":{"name":"Current Research in Diabetes & Obesity Journal","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132295987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-02-08DOI: 10.19080/crdoj.2022.15.555912
{"title":"Characterization of Gut Microbiota in Lean and Overweight Children with Type 1 Diabetes Compared to Matched Healthy Control Subjects","authors":"","doi":"10.19080/crdoj.2022.15.555912","DOIUrl":"https://doi.org/10.19080/crdoj.2022.15.555912","url":null,"abstract":"","PeriodicalId":411114,"journal":{"name":"Current Research in Diabetes & Obesity Journal","volume":"125 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128431247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-31DOI: 10.19080/crdoj.2022.15.555911
L. Zaabar
{"title":"Specific Immunohistochemical Profile of Poorly Differentiated Thyroid Carcinoma in a Diabetic Patient: One Case Report","authors":"L. Zaabar","doi":"10.19080/crdoj.2022.15.555911","DOIUrl":"https://doi.org/10.19080/crdoj.2022.15.555911","url":null,"abstract":"","PeriodicalId":411114,"journal":{"name":"Current Research in Diabetes & Obesity Journal","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125440090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-07DOI: 10.19080/crdoj.2021.15.555909
R. Bist
Neuropathy is one among the known disorders corresponding diabetes. The biochemical mechanisms of this devastating neurodegenerative disorder of diabetic neuropathy (DN) have not yet clearly understood. DN is loss of function nerves beginning distally in the lower extremities that is also characterized by pain and substantial morbidity. It leads to distressing and expensive clinical complications such as foot ulceration, leg amputation, and neuropathic pain. Despite countless promising therapeutic research efforts, effective drugs are still lacking for the treatment of DN. Therefore, current review emphasizes on complications and therapeutic strategies which could be effective in DN. Various search engines like Google Scholar, PubMed, SpringerLink, Medline and Science direct were used for accessing different articles of world-wide journals to harness the information of previous work done with our relevance. Databases like PDB and NCBI were used to understand molecular information of proteins and DNA in DN. In present review, we discussed causes, mechanisms that lead to promotion of DN and possible therapies of DN. The information provided in this review provide research gap to investigators to understand molecular mechanisms underlying DN and to attempt natural substances as possible effective therapy. Current review discusses significant research gaps for making an attempt to investigate a successful natural product and its molecular target for DN. We also accentuate the use of natural product instead of a synthetic drug for treatment of DN. Diabetes Mellitus; IDF: International Diabetes Federation; PKC: Protein Kinase C; AGEs: Advanced Glycation End Products; GSK: Glycogen Synthase Kinase; DSP: Distal Symmetric Polyneuropathy; DSPN: Distal symmetric polyneuropathy; EDIC: Epidemiology of Diabetes Interventions and Complications; DCCT: Diabetes Control and Complications Trial; AND: Autonomic Diabetic Neuropathy; CAN: Cardiac Autonomic Neuropathy; ED: Erectile Dysfunction; ROS: Reactive Oxygen Species; ER: Endoplasmic Reticulum; DPN: Diabetic Peripheral Neuropathy; SDH: Sorbitol Dehydrogenase; NO: Nitric Oxide; ARI: Aldose Reductase
{"title":"Molecular Basis of Neurodegeneration and Therapies in Diabetic Neuropathy","authors":"R. Bist","doi":"10.19080/crdoj.2021.15.555909","DOIUrl":"https://doi.org/10.19080/crdoj.2021.15.555909","url":null,"abstract":"Neuropathy is one among the known disorders corresponding diabetes. The biochemical mechanisms of this devastating neurodegenerative disorder of diabetic neuropathy (DN) have not yet clearly understood. DN is loss of function nerves beginning distally in the lower extremities that is also characterized by pain and substantial morbidity. It leads to distressing and expensive clinical complications such as foot ulceration, leg amputation, and neuropathic pain. Despite countless promising therapeutic research efforts, effective drugs are still lacking for the treatment of DN. Therefore, current review emphasizes on complications and therapeutic strategies which could be effective in DN. Various search engines like Google Scholar, PubMed, SpringerLink, Medline and Science direct were used for accessing different articles of world-wide journals to harness the information of previous work done with our relevance. Databases like PDB and NCBI were used to understand molecular information of proteins and DNA in DN. In present review, we discussed causes, mechanisms that lead to promotion of DN and possible therapies of DN. The information provided in this review provide research gap to investigators to understand molecular mechanisms underlying DN and to attempt natural substances as possible effective therapy. Current review discusses significant research gaps for making an attempt to investigate a successful natural product and its molecular target for DN. We also accentuate the use of natural product instead of a synthetic drug for treatment of DN. Diabetes Mellitus; IDF: International Diabetes Federation; PKC: Protein Kinase C; AGEs: Advanced Glycation End Products; GSK: Glycogen Synthase Kinase; DSP: Distal Symmetric Polyneuropathy; DSPN: Distal symmetric polyneuropathy; EDIC: Epidemiology of Diabetes Interventions and Complications; DCCT: Diabetes Control and Complications Trial; AND: Autonomic Diabetic Neuropathy; CAN: Cardiac Autonomic Neuropathy; ED: Erectile Dysfunction; ROS: Reactive Oxygen Species; ER: Endoplasmic Reticulum; DPN: Diabetic Peripheral Neuropathy; SDH: Sorbitol Dehydrogenase; NO: Nitric Oxide; ARI: Aldose Reductase","PeriodicalId":411114,"journal":{"name":"Current Research in Diabetes & Obesity Journal","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122873234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-17DOI: 10.19080/crdoj.2021.15.555908
Sanchez Ramiro A
{"title":"Different Effects of Canagliflozin and Perindopril in the Improvement of Arterial Stiffness in Type 2 Diabetic Patients","authors":"Sanchez Ramiro A","doi":"10.19080/crdoj.2021.15.555908","DOIUrl":"https://doi.org/10.19080/crdoj.2021.15.555908","url":null,"abstract":"","PeriodicalId":411114,"journal":{"name":"Current Research in Diabetes & Obesity Journal","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131121382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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