The purpose of the study was to evaluate the effectiveness of antihypertensive therapy based on the data of daily blood pressure monitoring in patients with hypertension and a history of myocardial infarction, taking into account the A1166C polymorphism of the angiotensin II type 1 receptor gene, based on the results of long-term follow-up. Materials and methods. The study included 36 men with arterial hypertension of the 1st to 3rd degree who had suffered a myocardial infarction. The average age was 57.0 (52.0; 64.0) years, the experience of arterial hypertension – 6.3 (4.0; 15.0) years, the period after a myocardial infarction – 48.0 (12.0; 144.0) months. When determining the A1166C polymorphism of the angiotensin II type 1 receptor gene, patients were divided into 3 groups: group 1 consisted of 18 (50%) patients with the AA genotype, group 2 included 12 (33.3%) patients with the AС genotype, and group 3 – 6 (16.7%) patients with СС genotype of angiotensin II type 1 receptor gene. Daily blood pressure monitoring was carried out at the beginning of the study and after 38 months. Results and discussion. At the beginning of the study, based on the results of daily blood pressure monitoring, it was found that in the group as a whole, the levels of systolic blood pressure and diastolic blood pressure, the pressure load index – the diastolic blood pressure time index corresponded to the target values according to the median, but the pressure load indices for systolic blood pressure exceeded the normal range. Against the background of long-term antihypertensive therapy, a reliable decrease in systolic blood pressure levels was established for all time periods of the day, especially during the daytime. A significant decrease in the values of the pressure load indices was established – the time index of systolic blood pressure at daytime (delta -10.49%, which was -27.9%) and the area index of systolic blood pressure at daytime (delta -34.89 mm Hg x h, which was -32.0%) (p <0.05). When analyzing the effectiveness of long-term antihypertensive therapy depending on the A1166C polymorphism of the angiotensin II type 1 receptor gene, it was established that the highest percentage of achieving the target blood pressure level (66.7%) in combination with the normalization of the circadian blood pressure rhythm was determined in patients with the AA genotype of the AGTR1 gene. Among patients with AC genotype, 33.3% reached the target blood pressure levels, but it was not possible to achieve normalization of blood pressure variability and pathological patterns of the circadian rhythm of blood pressure persisted, which are signs of a prognostically unfavorable course of the disease. Among patients with CC genotype of the AGTR1 gene, against the background of long-term treatment, 33.3% achieved the target level of blood pressure, in general, the group normalized the degree of nocturnal decrease in blood pressure, but only a decrease in the levels of systolic blood
{"title":"Influence of Angiotensin II Type 1 Receptor Gene Polymorphism on the Effectiveness of Antihypertensive Therapy in Patients with Hypertension Disease who Suffered Myocardial Infarction according to the Results of Long-Term Follow-Up","authors":"T. Kolesnyk, O. Fursa","doi":"10.26693/jmbs08.01.122","DOIUrl":"https://doi.org/10.26693/jmbs08.01.122","url":null,"abstract":"The purpose of the study was to evaluate the effectiveness of antihypertensive therapy based on the data of daily blood pressure monitoring in patients with hypertension and a history of myocardial infarction, taking into account the A1166C polymorphism of the angiotensin II type 1 receptor gene, based on the results of long-term follow-up. Materials and methods. The study included 36 men with arterial hypertension of the 1st to 3rd degree who had suffered a myocardial infarction. The average age was 57.0 (52.0; 64.0) years, the experience of arterial hypertension – 6.3 (4.0; 15.0) years, the period after a myocardial infarction – 48.0 (12.0; 144.0) months. When determining the A1166C polymorphism of the angiotensin II type 1 receptor gene, patients were divided into 3 groups: group 1 consisted of 18 (50%) patients with the AA genotype, group 2 included 12 (33.3%) patients with the AС genotype, and group 3 – 6 (16.7%) patients with СС genotype of angiotensin II type 1 receptor gene. Daily blood pressure monitoring was carried out at the beginning of the study and after 38 months. Results and discussion. At the beginning of the study, based on the results of daily blood pressure monitoring, it was found that in the group as a whole, the levels of systolic blood pressure and diastolic blood pressure, the pressure load index – the diastolic blood pressure time index corresponded to the target values according to the median, but the pressure load indices for systolic blood pressure exceeded the normal range. Against the background of long-term antihypertensive therapy, a reliable decrease in systolic blood pressure levels was established for all time periods of the day, especially during the daytime. A significant decrease in the values of the pressure load indices was established – the time index of systolic blood pressure at daytime (delta -10.49%, which was -27.9%) and the area index of systolic blood pressure at daytime (delta -34.89 mm Hg x h, which was -32.0%) (p <0.05). When analyzing the effectiveness of long-term antihypertensive therapy depending on the A1166C polymorphism of the angiotensin II type 1 receptor gene, it was established that the highest percentage of achieving the target blood pressure level (66.7%) in combination with the normalization of the circadian blood pressure rhythm was determined in patients with the AA genotype of the AGTR1 gene. Among patients with AC genotype, 33.3% reached the target blood pressure levels, but it was not possible to achieve normalization of blood pressure variability and pathological patterns of the circadian rhythm of blood pressure persisted, which are signs of a prognostically unfavorable course of the disease. Among patients with CC genotype of the AGTR1 gene, against the background of long-term treatment, 33.3% achieved the target level of blood pressure, in general, the group normalized the degree of nocturnal decrease in blood pressure, but only a decrease in the levels of systolic blood ","PeriodicalId":413454,"journal":{"name":"Ukraïnsʹkij žurnal medicini, bìologìï ta sportu","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124792047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The purpose of the study was to evaluate the effectiveness of the developed physical therapy program on the parameters of sarcopenia in elderly people with total knee arthroplasty in the remote period after surgery. Materials and methods. During the research, 80 elderly people were examined. The control group consisted of 13 men and 15 women who did not undergo total endoprosthetic surgery of the joints of the lower limbs, without signs of sarcopenia. The comparison group consisted of 11 men and 16 women with total knee arthroplasty and diagnosed sarcopenia with low therapeutic (rehabilitation) compliance with the active rehabilitation intervention recommended based on the results of the initial examination. The main group consisted of 9 men, 16 women with total knee arthroplasty and diagnosed sarcopenia with a high level of therapeutic (rehabilitation) alliance regarding the active rehabilitation intervention recommended by the results of the initial examination. For them, a 6-month long physical therapy program was developed and implemented, which included the following elements: therapeutic exercises, functional training, massage of the lower limbs and lower back, kinesiological taping of the operated limbs; dietary recommendations; patient education. The effectiveness of the program was evaluated by the dynamics of the grip strength indicators, the Edmonton Frail Scale, and the SarQoL questionnaire. Results and discussion. In elderly patients with knee arthroplasty and sarcopenia, low strength (according to the value of grip strength), subjective physical weakness, difficulties in performing activities of daily living (according to the Edmonton Frail Scale questionnaire), were revealed, which led to a deterioration in the quality of life (according to the SarQoL questionnaire). The developed physical therapy program revealed a statistically significantly better effect on strength indicators, the state of physical weakness and quality of life parameters in comparison with the initial indicators for all studied parameters (р <0.05). Low rehabilitation compliance in elderly patients with knee arthroplasty and sarcopenia, despite being aware of the risks of this polymorbidity, was associated with a lack of improvement over a similar follow-up period. Conclusion. Elderly patients with the consequences of total knee arthroplasty and sarcopenia require the development of physical therapy programs taking into account and correcting the specifics of each condition, the presence of physical status disorders and impaired performance of activities of daily life, which increases the quality of life of this contingent of patients
{"title":"Effectiveness of Correction of Sarcopenia Signs in Elderly People with Knee Arthroplasty","authors":"Kh. V. Petruniv, E. Lapkovskyi","doi":"10.26693/jmbs08.01.214","DOIUrl":"https://doi.org/10.26693/jmbs08.01.214","url":null,"abstract":"The purpose of the study was to evaluate the effectiveness of the developed physical therapy program on the parameters of sarcopenia in elderly people with total knee arthroplasty in the remote period after surgery. Materials and methods. During the research, 80 elderly people were examined. The control group consisted of 13 men and 15 women who did not undergo total endoprosthetic surgery of the joints of the lower limbs, without signs of sarcopenia. The comparison group consisted of 11 men and 16 women with total knee arthroplasty and diagnosed sarcopenia with low therapeutic (rehabilitation) compliance with the active rehabilitation intervention recommended based on the results of the initial examination. The main group consisted of 9 men, 16 women with total knee arthroplasty and diagnosed sarcopenia with a high level of therapeutic (rehabilitation) alliance regarding the active rehabilitation intervention recommended by the results of the initial examination. For them, a 6-month long physical therapy program was developed and implemented, which included the following elements: therapeutic exercises, functional training, massage of the lower limbs and lower back, kinesiological taping of the operated limbs; dietary recommendations; patient education. The effectiveness of the program was evaluated by the dynamics of the grip strength indicators, the Edmonton Frail Scale, and the SarQoL questionnaire. Results and discussion. In elderly patients with knee arthroplasty and sarcopenia, low strength (according to the value of grip strength), subjective physical weakness, difficulties in performing activities of daily living (according to the Edmonton Frail Scale questionnaire), were revealed, which led to a deterioration in the quality of life (according to the SarQoL questionnaire). The developed physical therapy program revealed a statistically significantly better effect on strength indicators, the state of physical weakness and quality of life parameters in comparison with the initial indicators for all studied parameters (р <0.05). Low rehabilitation compliance in elderly patients with knee arthroplasty and sarcopenia, despite being aware of the risks of this polymorbidity, was associated with a lack of improvement over a similar follow-up period. Conclusion. Elderly patients with the consequences of total knee arthroplasty and sarcopenia require the development of physical therapy programs taking into account and correcting the specifics of each condition, the presence of physical status disorders and impaired performance of activities of daily life, which increases the quality of life of this contingent of patients","PeriodicalId":413454,"journal":{"name":"Ukraïnsʹkij žurnal medicini, bìologìï ta sportu","volume":"680 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116108620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The information and communication technologies introduction is a necessary component in education. With the help of these technology methods of active memorization of educational material can be significantly improved. In terms of an intensive information and communication technologies implementation in education, it is necessary to prepare the teaching staff of a higher education institution. Namely, to develop skillfully possessed information culture and competence at the level of a modern student, or maybe even a little better. The article is about the possibilities of improvement of information technologies in the educational process. These are, for example, the use of visual material with the help of interactive posters and mind maps, as well as the latest methods of conducting classes – WebQuests, the use of the scribing technique when presenting the material of a practical lesson or lecture. The purpose of the study was to consider and propose some methods of presenting educational material, first of all, the use of the possibilities of an interactive poster and mind maps, as well as the method of presenting educational material – scribing and the use of WebQuests. Results and discussion. The teaching staff of a higher education institution today faces a difficult task – to win the attention and affection of a modern student. The vast majority of students belong to generation Z (born in 2003), for whom communication on the Internet is a priority. They best perceive information visually (pictures, images, videos). Generation Z are talented, creative, imaginative individuals, leaders by nature, and express their feelings with the help of emoticons and various emojis, statuses in social networks. Distance education has emphasized the role of the teacher by making him or her a guide, adviser and tutor. The teaching staff of the higher education institution in the distance learning mode coordinates the student’s cognitive process and constantly improves the distance courses of the discipline in the Moodle system, increases own original creativity and qualification in accordance with innovations and license conditions. The use of interactive possibilities of distance education should also be used during face-to-face training, it will help students to learn the educational material better. Constant search for new didactic approaches and tools, the use of modern and diverse teaching methods will contribute to the training of specialists who possess not only the knowledge and skills of professional activity, but also think strategically, systematically approach the analysis and solution of real situations. For future doctors, it is a primarily important aspect of clinical thinking. Thus, all the available possibilities of modern presentation of the material will help future specialists in the medical field to develop it. Conclusion. Thanks to the transformation of the educational material in pathological anatomy to the form of an even more visual i
{"title":"Experience in Using Information and Communication Technologies in Teaching Pathomorphology","authors":"O. V. Garvasiuk","doi":"10.26693/jmbs08.01.246","DOIUrl":"https://doi.org/10.26693/jmbs08.01.246","url":null,"abstract":"The information and communication technologies introduction is a necessary component in education. With the help of these technology methods of active memorization of educational material can be significantly improved. In terms of an intensive information and communication technologies implementation in education, it is necessary to prepare the teaching staff of a higher education institution. Namely, to develop skillfully possessed information culture and competence at the level of a modern student, or maybe even a little better. The article is about the possibilities of improvement of information technologies in the educational process. These are, for example, the use of visual material with the help of interactive posters and mind maps, as well as the latest methods of conducting classes – WebQuests, the use of the scribing technique when presenting the material of a practical lesson or lecture. The purpose of the study was to consider and propose some methods of presenting educational material, first of all, the use of the possibilities of an interactive poster and mind maps, as well as the method of presenting educational material – scribing and the use of WebQuests. Results and discussion. The teaching staff of a higher education institution today faces a difficult task – to win the attention and affection of a modern student. The vast majority of students belong to generation Z (born in 2003), for whom communication on the Internet is a priority. They best perceive information visually (pictures, images, videos). Generation Z are talented, creative, imaginative individuals, leaders by nature, and express their feelings with the help of emoticons and various emojis, statuses in social networks. Distance education has emphasized the role of the teacher by making him or her a guide, adviser and tutor. The teaching staff of the higher education institution in the distance learning mode coordinates the student’s cognitive process and constantly improves the distance courses of the discipline in the Moodle system, increases own original creativity and qualification in accordance with innovations and license conditions. The use of interactive possibilities of distance education should also be used during face-to-face training, it will help students to learn the educational material better. Constant search for new didactic approaches and tools, the use of modern and diverse teaching methods will contribute to the training of specialists who possess not only the knowledge and skills of professional activity, but also think strategically, systematically approach the analysis and solution of real situations. For future doctors, it is a primarily important aspect of clinical thinking. Thus, all the available possibilities of modern presentation of the material will help future specialists in the medical field to develop it. Conclusion. Thanks to the transformation of the educational material in pathological anatomy to the form of an even more visual i","PeriodicalId":413454,"journal":{"name":"Ukraïnsʹkij žurnal medicini, bìologìï ta sportu","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114354693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The purpose of the study was to consider the main methods of increasing the physical activity of people with disabilities (in wheelchairs) in emergency situations, military conflicts, natural disasters, etc. Materials and methods. The study of physical rehabilitation of people with disabilities (in wheelchairs) was conducted by the author during many years working as a trainer of the Kyiv Regional Center for Physical Culture and Sports for the Disabled “Invasport” and continued during the military actions in the country in 2022–2023 with an emphasis on the problems of rehabilitation of patients in military and emergency conditions. In order to increase the physical activity of people with disabilities (in wheelchairs) in conditions limited by military operations, it is recommended to pay special attention to exercises for the muscles of the neck, joints, and muscles of upper limbs; exercises for the lower limbs and pelvic organs; exercises for back and trunk muscles; balance exercises, breathing exercises, etc. Massage and self-massage procedures will also be useful in such situations. Results and discussion. The effectiveness of rehabilitation and, as a result, the successful outcome of maintaining the physical activity of people with spinal injuries and disabilities largely depends on the early start and correct selection of rehabilitation programs. In addition, the choice of methods and means of physical rehabilitation and physical activity for people with disabilities in the limited military and emergency conditions depends on their general physical and mental condition, the presence of accompanying diseases and complications, as well as on the surrounding circumstances. However, regardless of the difficulties and surrounding circumstances, people with disabilities (in a wheelchair) or with an injury and spine diseases must be engaged in physical therapy and do physical exercises in order not to lose the physical capacity for action, even limited, to be able to adapt to the circumstances and mobilize functional reserves of their bodies. Conclusion. Comprehensive rehabilitation is an integral part of therapy for patients with spinal injuries, people with disabilities (in wheelchairs), etc. Physical exercises not only affect the development of the motor activity of people with disabilities but also increase the body's resistance to adverse environmental factors, activating vegetative systems, stimulating and normalizing functions of body systems. The gradual adaptation of the body to physical exertion leads to adaptation, mobilization and use of the body's functional reserves. Physical training itself is an adaptation process that activates the body's hidden reserves
{"title":"Ensuring Physical Activity of People with Injuries and Diseases of the Musculoskeletal System in Military and Emergency Conditions","authors":"M. A. Saveliev","doi":"10.26693/jmbs08.01.235","DOIUrl":"https://doi.org/10.26693/jmbs08.01.235","url":null,"abstract":"The purpose of the study was to consider the main methods of increasing the physical activity of people with disabilities (in wheelchairs) in emergency situations, military conflicts, natural disasters, etc. Materials and methods. The study of physical rehabilitation of people with disabilities (in wheelchairs) was conducted by the author during many years working as a trainer of the Kyiv Regional Center for Physical Culture and Sports for the Disabled “Invasport” and continued during the military actions in the country in 2022–2023 with an emphasis on the problems of rehabilitation of patients in military and emergency conditions. In order to increase the physical activity of people with disabilities (in wheelchairs) in conditions limited by military operations, it is recommended to pay special attention to exercises for the muscles of the neck, joints, and muscles of upper limbs; exercises for the lower limbs and pelvic organs; exercises for back and trunk muscles; balance exercises, breathing exercises, etc. Massage and self-massage procedures will also be useful in such situations. Results and discussion. The effectiveness of rehabilitation and, as a result, the successful outcome of maintaining the physical activity of people with spinal injuries and disabilities largely depends on the early start and correct selection of rehabilitation programs. In addition, the choice of methods and means of physical rehabilitation and physical activity for people with disabilities in the limited military and emergency conditions depends on their general physical and mental condition, the presence of accompanying diseases and complications, as well as on the surrounding circumstances. However, regardless of the difficulties and surrounding circumstances, people with disabilities (in a wheelchair) or with an injury and spine diseases must be engaged in physical therapy and do physical exercises in order not to lose the physical capacity for action, even limited, to be able to adapt to the circumstances and mobilize functional reserves of their bodies. Conclusion. Comprehensive rehabilitation is an integral part of therapy for patients with spinal injuries, people with disabilities (in wheelchairs), etc. Physical exercises not only affect the development of the motor activity of people with disabilities but also increase the body's resistance to adverse environmental factors, activating vegetative systems, stimulating and normalizing functions of body systems. The gradual adaptation of the body to physical exertion leads to adaptation, mobilization and use of the body's functional reserves. Physical training itself is an adaptation process that activates the body's hidden reserves","PeriodicalId":413454,"journal":{"name":"Ukraïnsʹkij žurnal medicini, bìologìï ta sportu","volume":"104 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116137530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The purpose of the work was to study the micropermeability between portions of restorative materials under different surface preparation in laboratory conditions. Materials and methods. The study used 50 samples of cylindrical restorative materials with a diameter of 5.0 mm and a height of 4.0 mm, divided into five groups 10 samples each. The samples of group 1 consisted of two portions of photocomposite without preliminary preparation. The samples of group 2 were produced from two portions, between which the V generation adhesive system was applied. In the samples of group 3, the vertical surface of the first portion of the photocomposite was moistened, adhesive preparation was performed, and the second portion was added. In the samples of group 4, the vertical surface of the portion was polished and similar measures were taken. Group 5 samples consisted of glass ionomer cement and photocomposite. The surfaces of the samples, except for the border, were isolated, the samples were immersed for a day in the dye, sprayed and the depth of its penetration was estimated through the border on vertical cuts in points and by a computer program in millimeters. Results and discussion. Micropermeability in the samples of group 1 was 1.3 ± 0.15 points and was significantly (p<0.05) the lowest among all groups except group 2. The indicator in the samples of group 2 was 1.7 ± 0.15 points with an unreliable (p>0.05) difference from the given indicator, in the samples of group 3 – 1.9 ± 0.18 points with a significant (p<0.05) difference, the last two indicators had an unreliable difference (p>0.05) between them. Significantly (p<0.05) the highest micropermeability was in the samples of group 4 – 4.1 ± 0.18 points. In samples of group 5, the indicator was equal to 2.6 ± 0.16 points (p<0.05). According to the computer analysis of the image in the samples of group 1, the dye deepened by 0.55 ± 0.15 mm, which is reliably (p<0.05) the lowest indicator. In the samples of group 2, it was 1.20 ± 0.18 mm, in the samples of group 3 – 1.31 ± 0.12 mm (the difference was not significant, p>0.05). The indicator was significantly (p<0.05) higher in the samples of group 5 – 2.13 ± 0.16 mm, in the samples of group 4 it was 3.65 ± 0.19 mm and was significantly (p<0.05) the highest, exaggerating by 6.6 times the indicator of the samples of group 1. A significantly high indicator of micropermeability was found in the samples consisting of glass ionomer cement and photocomposite, and this should be a certain warning, however, in clinical conditions, when using an open “sandwich technique”, as a rule, photocomposite material overlaps a certain area of glass ionomer cement without marking a clear border between materials. Nevertheless, it is necessary to pay special attention to the formation of this border during the direct restoration of teeth with damage to their contact and occlusal surfaces in the “sandwich technique” and to ensure the tightest adhesion of the photocomposite to t
本研究的目的是在实验室条件下研究不同表面处理下修复材料各部分之间的微渗透性。材料和方法。本研究使用直径5.0 mm，高度4.0 mm的圆柱形修复材料样本50个，分为5组，每组10个样本。第1组样品由两部分光复合材料组成，未进行预处理。第2组的样品分为两部分，两部分之间使用V代胶粘剂系统。在第3组样品中，对第一部分光复合材料的垂直表面进行润湿，进行粘合剂制备，并添加第二部分。在第4组样品中，对部分的垂直表面进行抛光处理，并采取类似措施。第5组样品由玻璃离子水门合剂和光复合材料组成。样品的表面，除了边界，被隔离，样品在染料中浸泡一天，喷洒，其渗透的深度是通过边界的垂直切割点和以毫米为单位的计算机程序估计的。结果和讨论。第1组样品微渗透率为1.3±0.15点，与给定指标差异有统计学意义(p0.05);第3组样品微渗透率为1.9±0.18点，与给定指标差异有统计学意义(p0.05)。显著(p0.05)。5组样品的该指标显著(p<0.05)高于2.13±0.16 mm, 4组样品的该指标为3.65±0.19 mm，显著(p<0.05)最高，是1组样品的6.6倍。在由玻璃离子水门合剂和光复合材料组成的样品中发现了明显高的微渗透性指标，这应该是一个一定的警告，然而，在临床条件下，当使用开放式“三明治技术”时，通常，光复合材料与玻璃离子水门合剂的一定区域重叠，而没有在材料之间标记明确的边界。然而，在“三明治技术”中直接修复牙齿接触面和咬合面受损的牙齿时，有必要特别注意该边界的形成，并在视觉控制有限的情况下确保光复合材料与玻璃离聚体的最紧密粘附。结论。根据两种估计，在没有任何表面制备的情况下，在光复合材料的部分之间建立了最低微渗透率指标。在将光复合材料应用于材料抛光表面的情况下，发现微渗透率最高
{"title":"Laboratory Study of Micropermeability between Dental Restorative Materials","authors":"O. Udod, M. V. Kibishauri","doi":"10.26693/jmbs08.01.183","DOIUrl":"https://doi.org/10.26693/jmbs08.01.183","url":null,"abstract":"The purpose of the work was to study the micropermeability between portions of restorative materials under different surface preparation in laboratory conditions. Materials and methods. The study used 50 samples of cylindrical restorative materials with a diameter of 5.0 mm and a height of 4.0 mm, divided into five groups 10 samples each. The samples of group 1 consisted of two portions of photocomposite without preliminary preparation. The samples of group 2 were produced from two portions, between which the V generation adhesive system was applied. In the samples of group 3, the vertical surface of the first portion of the photocomposite was moistened, adhesive preparation was performed, and the second portion was added. In the samples of group 4, the vertical surface of the portion was polished and similar measures were taken. Group 5 samples consisted of glass ionomer cement and photocomposite. The surfaces of the samples, except for the border, were isolated, the samples were immersed for a day in the dye, sprayed and the depth of its penetration was estimated through the border on vertical cuts in points and by a computer program in millimeters. Results and discussion. Micropermeability in the samples of group 1 was 1.3 ± 0.15 points and was significantly (p<0.05) the lowest among all groups except group 2. The indicator in the samples of group 2 was 1.7 ± 0.15 points with an unreliable (p>0.05) difference from the given indicator, in the samples of group 3 – 1.9 ± 0.18 points with a significant (p<0.05) difference, the last two indicators had an unreliable difference (p>0.05) between them. Significantly (p<0.05) the highest micropermeability was in the samples of group 4 – 4.1 ± 0.18 points. In samples of group 5, the indicator was equal to 2.6 ± 0.16 points (p<0.05). According to the computer analysis of the image in the samples of group 1, the dye deepened by 0.55 ± 0.15 mm, which is reliably (p<0.05) the lowest indicator. In the samples of group 2, it was 1.20 ± 0.18 mm, in the samples of group 3 – 1.31 ± 0.12 mm (the difference was not significant, p>0.05). The indicator was significantly (p<0.05) higher in the samples of group 5 – 2.13 ± 0.16 mm, in the samples of group 4 it was 3.65 ± 0.19 mm and was significantly (p<0.05) the highest, exaggerating by 6.6 times the indicator of the samples of group 1. A significantly high indicator of micropermeability was found in the samples consisting of glass ionomer cement and photocomposite, and this should be a certain warning, however, in clinical conditions, when using an open “sandwich technique”, as a rule, photocomposite material overlaps a certain area of glass ionomer cement without marking a clear border between materials. Nevertheless, it is necessary to pay special attention to the formation of this border during the direct restoration of teeth with damage to their contact and occlusal surfaces in the “sandwich technique” and to ensure the tightest adhesion of the photocomposite to t","PeriodicalId":413454,"journal":{"name":"Ukraïnsʹkij žurnal medicini, bìologìï ta sportu","volume":"505 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115887505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The purpose of the study was to assess the metabolic status, namely carbohydrate and lipid metabolism, in patients with coronary heart disease and obesity with different genotypes of the leptin receptor gene (Arg223Glu). Materials and methods. The study included 220 patients with coronary heart disease and obesity. The comparison group consisted of 113 patients with coronary heart disease with normal body weight. The control group included 35 healthy individuals. Additionally, patients with coronary heart disease and obesity were divided into subgroups depending on the genotype of the leptin receptor gene (Arg223Glu): the first subgroup included carriers of the A/A genotype (n=57), the second – G/A genotype (n=90), the third – G/G genotype (n=73). Results and discussion. The analysis of carbohydrate metabolism depending on the genotypes of the leptin receptor gene (Arg223Gln) in patients with coronary heart disease and obesity showed that carriers of the G/G genotype have more pronounced disorders of carbohydrate metabolism in the form of hyperinsulinemia and decreased tissue sensitivity to insulin while carriers of the genotypes G/A and A/A have greater resistance to glucose-metabolic disorders. Body mass index in carriers of G/G genotype had the highest value, which is 19.19% and 19.53% more than in carriers of genotypes G/A and A/A. Thus, the G/G genotype in patients with coronary heart disease and obesity was associated with body mass index. The impaired lipid metabolism in patients with coronary heart disease in combination with obesity was defined as hypertriglyceridemia, which is associated with the G/G genotype of the leptin receptor gene polymorphism (Arg223Gln). The results obtained in our work indicate the involvement of the polymorphic locus of the leptin receptor gene (Arg223Gln) in the formation of disorders of carbohydrate and lipid metabolism, which corresponds to the literature. It has been suggested that structural changes in the leptin receptor gene are associated not only with the development of obesity but also with the development of type 2 diabetes mellitus. Conclusion. The features of the combined course of coronary heart disease and obesity were identified: hyperinsulinemia and insulin resistance are associated with the G allele and G/G genotype of the polymorphic locus Arg223Gln leptin receptor gene (r=0.76, p<0.05); the rearrangement of the lipid spectrum due to hypertriglyceridemia is influenced by the homogeny of the G allele of the polymorphic locus of the Arg223Gln gene of the leptin receptor gene (r=0.73, p<0.05)
{"title":"Metabolic Status in Patients with Ischemic Heart Disease and Obesity with Different Genotypes of Leptin Receptor Gene (Arg223Glu)","authors":"O. Kadykova, K. Borovyk, N. Ryndina","doi":"10.26693/jmbs08.01.107","DOIUrl":"https://doi.org/10.26693/jmbs08.01.107","url":null,"abstract":"The purpose of the study was to assess the metabolic status, namely carbohydrate and lipid metabolism, in patients with coronary heart disease and obesity with different genotypes of the leptin receptor gene (Arg223Glu). Materials and methods. The study included 220 patients with coronary heart disease and obesity. The comparison group consisted of 113 patients with coronary heart disease with normal body weight. The control group included 35 healthy individuals. Additionally, patients with coronary heart disease and obesity were divided into subgroups depending on the genotype of the leptin receptor gene (Arg223Glu): the first subgroup included carriers of the A/A genotype (n=57), the second – G/A genotype (n=90), the third – G/G genotype (n=73). Results and discussion. The analysis of carbohydrate metabolism depending on the genotypes of the leptin receptor gene (Arg223Gln) in patients with coronary heart disease and obesity showed that carriers of the G/G genotype have more pronounced disorders of carbohydrate metabolism in the form of hyperinsulinemia and decreased tissue sensitivity to insulin while carriers of the genotypes G/A and A/A have greater resistance to glucose-metabolic disorders. Body mass index in carriers of G/G genotype had the highest value, which is 19.19% and 19.53% more than in carriers of genotypes G/A and A/A. Thus, the G/G genotype in patients with coronary heart disease and obesity was associated with body mass index. The impaired lipid metabolism in patients with coronary heart disease in combination with obesity was defined as hypertriglyceridemia, which is associated with the G/G genotype of the leptin receptor gene polymorphism (Arg223Gln). The results obtained in our work indicate the involvement of the polymorphic locus of the leptin receptor gene (Arg223Gln) in the formation of disorders of carbohydrate and lipid metabolism, which corresponds to the literature. It has been suggested that structural changes in the leptin receptor gene are associated not only with the development of obesity but also with the development of type 2 diabetes mellitus. Conclusion. The features of the combined course of coronary heart disease and obesity were identified: hyperinsulinemia and insulin resistance are associated with the G allele and G/G genotype of the polymorphic locus Arg223Gln leptin receptor gene (r=0.76, p<0.05); the rearrangement of the lipid spectrum due to hypertriglyceridemia is influenced by the homogeny of the G allele of the polymorphic locus of the Arg223Gln gene of the leptin receptor gene (r=0.73, p<0.05)","PeriodicalId":413454,"journal":{"name":"Ukraïnsʹkij žurnal medicini, bìologìï ta sportu","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115936083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The purpose of the study was to determine the dynamics of anthropometric and functional indicators of the physical condition of first-year cadets over three years (from 2019 to 2021). Materials and methods. 152 cadets from Ivan Kozhedub Air Force National University were involved in the experiment. The age of participants was from 17 to 22 years. All cadets were informed about the experiment and gave their consent. Anthropometric (measurement of anthropometric data) and medical-biological (rhythm inversion, electromanometry) methods of investigation were used to determine the assessment of the cadets’ physical condition. A highly informative method – the assessment of O. Pirogova index was used for analysis of the cadets’ physical condition. Pirogova physical condition index is a complex indicator based on the heart rate, systolic and diastolic blood pressure, age, body weight, and body height. Statistical analysis of the results was carried out using the EXCEL tables. The data was analyzed using Student’s test, p less than 0.05 was considered the level of significance. Results and discussion. The results of the study showed that the mean values of the anthropometric and functional indicators of the first-year cadets have not been changed statistically significant over three years. The exception is the difference in the average value of systolic blood pressure of control group 1 and control group 3 representatives, which is statistically reliable (p <0.05). Current anthropometric indicators of cadets obtained during the experiment confirmed the data available in the scientific and methodological literature about the anthropometric indicators of candidates for training in higher military educational institutions of Ukraine. The Pirogova physical condition index calculating showed the following average values of the Pirogova physical condition index: control group 1 – 0.704 points, control group 2 – 0.688 points, control group 3 – 0.671 points. However, the results of the study show a statistically significant deterioration of the Pirogova physical condition index of the 2021 recruitment cadets by 4.7% compared to the representatives of 2019. The comparative analysis of the first-year cadets' physical condition assessments demonstrates a gradual, significant decrease in the number of “high” physical condition ratings: 12% among control group 1 cadets (2019 year of recruitment); 9% among control group 2 representatives (2020 year of recruitment) and only 3% among control group 3 cadets (2021 year of recruitment). However, over three years, the percentage of representatives with physical condition assessment rating “Lower than average” has increased significantly: 1% among cadets of control group 1 (2019 year of recruitment); 7% among cadets of control group 2 (2020 year of recruitment); 7% among representatives of control group 3 (2021 year of recruitment). Conclusion. Over the last 3 years, there has been a deterioration of the general physical con
{"title":"Analysis of Physical Condition of First-Year Military Higher Education Institution Cadets","authors":"Yevhen Kurishko, M. Korchahin","doi":"10.26693/jmbs08.01.305","DOIUrl":"https://doi.org/10.26693/jmbs08.01.305","url":null,"abstract":"The purpose of the study was to determine the dynamics of anthropometric and functional indicators of the physical condition of first-year cadets over three years (from 2019 to 2021). Materials and methods. 152 cadets from Ivan Kozhedub Air Force National University were involved in the experiment. The age of participants was from 17 to 22 years. All cadets were informed about the experiment and gave their consent. Anthropometric (measurement of anthropometric data) and medical-biological (rhythm inversion, electromanometry) methods of investigation were used to determine the assessment of the cadets’ physical condition. A highly informative method – the assessment of O. Pirogova index was used for analysis of the cadets’ physical condition. Pirogova physical condition index is a complex indicator based on the heart rate, systolic and diastolic blood pressure, age, body weight, and body height. Statistical analysis of the results was carried out using the EXCEL tables. The data was analyzed using Student’s test, p less than 0.05 was considered the level of significance. Results and discussion. The results of the study showed that the mean values of the anthropometric and functional indicators of the first-year cadets have not been changed statistically significant over three years. The exception is the difference in the average value of systolic blood pressure of control group 1 and control group 3 representatives, which is statistically reliable (p <0.05). Current anthropometric indicators of cadets obtained during the experiment confirmed the data available in the scientific and methodological literature about the anthropometric indicators of candidates for training in higher military educational institutions of Ukraine. The Pirogova physical condition index calculating showed the following average values of the Pirogova physical condition index: control group 1 – 0.704 points, control group 2 – 0.688 points, control group 3 – 0.671 points. However, the results of the study show a statistically significant deterioration of the Pirogova physical condition index of the 2021 recruitment cadets by 4.7% compared to the representatives of 2019. The comparative analysis of the first-year cadets' physical condition assessments demonstrates a gradual, significant decrease in the number of “high” physical condition ratings: 12% among control group 1 cadets (2019 year of recruitment); 9% among control group 2 representatives (2020 year of recruitment) and only 3% among control group 3 cadets (2021 year of recruitment). However, over three years, the percentage of representatives with physical condition assessment rating “Lower than average” has increased significantly: 1% among cadets of control group 1 (2019 year of recruitment); 7% among cadets of control group 2 (2020 year of recruitment); 7% among representatives of control group 3 (2021 year of recruitment). Conclusion. Over the last 3 years, there has been a deterioration of the general physical con","PeriodicalId":413454,"journal":{"name":"Ukraïnsʹkij žurnal medicini, bìologìï ta sportu","volume":"180 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115974716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The purpose of the study was to determine a number of clinical cases of dental implantation with insuficient height of the alveolar ridge based on data of consumption of the dental implants of various designs in dental healthcare institutions during 10 years. Materials and methods. The research was performed on the provided information on the sales of dental implants produced by the DENTIUM corporation, “SuperLine” and “SuperLine NEW” (Korea) from the official supplier in Ukraine (“Stamil” group of companies) for the period 2013–2022. Results and discussion. Quality and sufficient volume of bone tissue around the dental implant is an important condition to achieve an optimal level of osseointegration. In cases of a shortage of available bone an additional option in the choice of treatment tactics is the installation of short dental implants. Compared with dental implants of standard and extended length the short implants showed a higher frequency of rejection and early disintegration. The length of the dental implant body is a critical factor in the long-term successful functioning of implants which is ambiguously evaluated and described in the professional literature. The analysis in the subgroups of the use of short implants showed that in the vast majority of cases, dental implants with a length of 8.00 mm were used – in the volume of ten-year implementation, their specific weight was 24.92%. Accordingly, it can be assumed that the volume of application of such structures is identical to the specific gravity of cases of minimal deficit in the height of the bone tissue of the alveolar crest of the jaws – 2.00 mm. The use of descriptive statistics methods made it possible to calculate the average percentage of such clinical cases – 23.92 ± 5.71 mm (M=25.37 mm). In calculations per decade the specific weight of cases of the alveolar ridge height deficiency of the jaws (lack of available bone tissue) was 30.03%. The average value was 28.80 ± 6.74% (M=30.95%), the minimum – 19.11% and the maximum – 38.08%. There were only 1.42% cases of “compensation” of the short implant length by increasing its diameter (upto 6.00 and 7.00 mm) in the overall structure of the performed operations. The usage of average annual number of short dental implants of increased diameter (from 6.00 mm) was 0.67 ± 0.28% (M=0.56%). The analysis of dynamics of the usage of short dental implants (7.00 mm and 8.00 mm) over ten years period revealed unevenness. For implants with a length of 8.00 mm frequency varied between 15.00–30.00%. The usage of shorter structures (length 7.00 mm) did not have such critical changes – minor deviations near 5.00%. Conclusion. The obtained results allowed to determine indirectly the prevalence of the alveolar ridge height deficiency in patients of “implantation cohort” in Ukraine during the last 10 years
{"title":"Retrospective Assessment of Available Bone Deficiency among Ukrainian Patients according to the Usage of Dental Implants of Different Sizes","authors":"S. Tsuperyak, Yu. O. Mochalov","doi":"10.26693/jmbs08.01.195","DOIUrl":"https://doi.org/10.26693/jmbs08.01.195","url":null,"abstract":"The purpose of the study was to determine a number of clinical cases of dental implantation with insuficient height of the alveolar ridge based on data of consumption of the dental implants of various designs in dental healthcare institutions during 10 years. Materials and methods. The research was performed on the provided information on the sales of dental implants produced by the DENTIUM corporation, “SuperLine” and “SuperLine NEW” (Korea) from the official supplier in Ukraine (“Stamil” group of companies) for the period 2013–2022. Results and discussion. Quality and sufficient volume of bone tissue around the dental implant is an important condition to achieve an optimal level of osseointegration. In cases of a shortage of available bone an additional option in the choice of treatment tactics is the installation of short dental implants. Compared with dental implants of standard and extended length the short implants showed a higher frequency of rejection and early disintegration. The length of the dental implant body is a critical factor in the long-term successful functioning of implants which is ambiguously evaluated and described in the professional literature. The analysis in the subgroups of the use of short implants showed that in the vast majority of cases, dental implants with a length of 8.00 mm were used – in the volume of ten-year implementation, their specific weight was 24.92%. Accordingly, it can be assumed that the volume of application of such structures is identical to the specific gravity of cases of minimal deficit in the height of the bone tissue of the alveolar crest of the jaws – 2.00 mm. The use of descriptive statistics methods made it possible to calculate the average percentage of such clinical cases – 23.92 ± 5.71 mm (M=25.37 mm). In calculations per decade the specific weight of cases of the alveolar ridge height deficiency of the jaws (lack of available bone tissue) was 30.03%. The average value was 28.80 ± 6.74% (M=30.95%), the minimum – 19.11% and the maximum – 38.08%. There were only 1.42% cases of “compensation” of the short implant length by increasing its diameter (upto 6.00 and 7.00 mm) in the overall structure of the performed operations. The usage of average annual number of short dental implants of increased diameter (from 6.00 mm) was 0.67 ± 0.28% (M=0.56%). The analysis of dynamics of the usage of short dental implants (7.00 mm and 8.00 mm) over ten years period revealed unevenness. For implants with a length of 8.00 mm frequency varied between 15.00–30.00%. The usage of shorter structures (length 7.00 mm) did not have such critical changes – minor deviations near 5.00%. Conclusion. The obtained results allowed to determine indirectly the prevalence of the alveolar ridge height deficiency in patients of “implantation cohort” in Ukraine during the last 10 years","PeriodicalId":413454,"journal":{"name":"Ukraïnsʹkij žurnal medicini, bìologìï ta sportu","volume":"53 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114478673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The purpose of the study was to determine national tendencies of mortality in Ukraine and the Kharkiv region. Materials and methods. Data from official sources of statistical information of Ukraine were used and systematic analysis and generalization of the obtained data was performed and tendencies of mortality in Ukraine were calculated. Results and discussion. According to the dynamics of mortality rates of the population of Ukraine in 2010–2019, there was a decrease in almost all nosological forms of disease. For some groups of diseases there was a tendency of increasing mortality per 100 thousand population with tendencies for the general population +3.0% and +3.9%, for men +3.4% and +1.1% and women +2.2% and 8.3%. Obtained results on the overall dynamics of declining tendencies in mortality due to major diseases in recent years and their growth due to some nosologies and structural characteristics of the main causes of mortality are in complete agreement with other studies. The study noted an increase in tendencies of mortality of population of Ukraine in 2010–2019 (per 100 thousand population) in several disease groups: neoplasms (tendency +3.0%: males +3.4 %, females +2.2%) and diseases of digestive system (respectively +3.9%: +1.1% and +8.3%). The Kharkiv region leads among other regions in 2019 in such classes: overall – 3rd place (40,611 cases), diseases of the circulatory system – 2nd (28,079), coronary heart disease – 2nd (21,154), diseases of the digestive system – 2nd (1,624), external causes of death – 2nd (2,225), neoplasms – 3rd (5,714), cerebrovascular disease – 4th (5,009), diseases of the respiratory system – 4th (810), diseases of the genitourinary system – 4th (196) and congenital malformations, deformities and chromosomal abnormalities – 4th (69). Significant increase in tendencies found in the Kharkiv region during 2018–2019 both in absolute counts and per 100 thousand: complications of pregnancy, childbirth and postpartum period (+300.0 and +293.8%), certain conditions that occur in the perinatal period (+14.3 and +24.3%), other causes (+13.8 and +14.5%) and urolithiasis (+12.0 and +12.9%) with defined structural characteristics of mortality in diseases of the circulatory system (69.09%), neoplasms (14.04%) and accidents and trauma (5.26%). Conclusion. The obtained results of the general dynamics of decreasing mortality tendencies due to major diseases and their growth due to some nosologies and structural characteristics of the main causes of mortality in Ukraine completely coincide with the data of other studies
{"title":"National Mortality Tendencies of Population in Ukraine and the Kharkiv Region","authors":"M. Mishchenko","doi":"10.26693/jmbs08.01.151","DOIUrl":"https://doi.org/10.26693/jmbs08.01.151","url":null,"abstract":"The purpose of the study was to determine national tendencies of mortality in Ukraine and the Kharkiv region. Materials and methods. Data from official sources of statistical information of Ukraine were used and systematic analysis and generalization of the obtained data was performed and tendencies of mortality in Ukraine were calculated. Results and discussion. According to the dynamics of mortality rates of the population of Ukraine in 2010–2019, there was a decrease in almost all nosological forms of disease. For some groups of diseases there was a tendency of increasing mortality per 100 thousand population with tendencies for the general population +3.0% and +3.9%, for men +3.4% and +1.1% and women +2.2% and 8.3%. Obtained results on the overall dynamics of declining tendencies in mortality due to major diseases in recent years and their growth due to some nosologies and structural characteristics of the main causes of mortality are in complete agreement with other studies. The study noted an increase in tendencies of mortality of population of Ukraine in 2010–2019 (per 100 thousand population) in several disease groups: neoplasms (tendency +3.0%: males +3.4 %, females +2.2%) and diseases of digestive system (respectively +3.9%: +1.1% and +8.3%). The Kharkiv region leads among other regions in 2019 in such classes: overall – 3rd place (40,611 cases), diseases of the circulatory system – 2nd (28,079), coronary heart disease – 2nd (21,154), diseases of the digestive system – 2nd (1,624), external causes of death – 2nd (2,225), neoplasms – 3rd (5,714), cerebrovascular disease – 4th (5,009), diseases of the respiratory system – 4th (810), diseases of the genitourinary system – 4th (196) and congenital malformations, deformities and chromosomal abnormalities – 4th (69). Significant increase in tendencies found in the Kharkiv region during 2018–2019 both in absolute counts and per 100 thousand: complications of pregnancy, childbirth and postpartum period (+300.0 and +293.8%), certain conditions that occur in the perinatal period (+14.3 and +24.3%), other causes (+13.8 and +14.5%) and urolithiasis (+12.0 and +12.9%) with defined structural characteristics of mortality in diseases of the circulatory system (69.09%), neoplasms (14.04%) and accidents and trauma (5.26%). Conclusion. The obtained results of the general dynamics of decreasing mortality tendencies due to major diseases and their growth due to some nosologies and structural characteristics of the main causes of mortality in Ukraine completely coincide with the data of other studies","PeriodicalId":413454,"journal":{"name":"Ukraïnsʹkij žurnal medicini, bìologìï ta sportu","volume":"82 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117268021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Підставі Клінічних, Особливостей Дебюту, У Пацієнтів, Полтавської Області
The purpose of the study was to demonstrate the importance of studying variants of the debut of multiple sclerosis, to reveal the dependence of the rate of progression on the clinical picture of the debut of multiple sclerosis by examining patients and retrospective analysis of clinical data. Materials and methods. The study analyzed 60 cases of relapsing-remitting and secondary-progressive multiple sclerosis in patients who were undergoing inpatient treatment in the neurological department of the communal enterprise “M. V. Sklifosovskyi Poltava Regional Clinical Hospital of the Poltava Regional Council” from 2019 to 2021. Complaints, anamnestic data, results of a complex clinical and neurological examination of patients with multiple sclerosis at the onset and throughout the course of the disease were studied. The diagnosis was established according to Mac-Donald criteria. The severity of clinical manifestations was assessed using the Extended Disability Scale. Results and discussion. The rate of disease progression was assessed retrospectively. The ratio of the number of the Extended Disability Scale points at this moment to the duration of the disease in years was studied. In the group of patients with a monosymptomatic debut, the rate of progression was: 0.64 in women, 1.2 in men. In patients with an acute polysymptomatic onset, the values of the rate of progression were 0.7 and 2.1, respectively. As a result of the retrospective analysis, several options for the onset of multiple sclerosis were identified: monosymptomatic, polysymptomatic, patients with a radiologically isolated syndrome, and patients with a characteristic clinical picture, but without pathological changes on magnetic resonance imaging. One of the most frequent clinical manifestations of the debut in patients in the Poltava region was sensitive disorders. It is worth noting that special attention should be paid to the study of vibration sensitivity. When collecting anamnestic data, it is necessary to clarify the presence of Lhermitte syndrome. The rate of progression of multiple sclerosis was found to be higher in male patients with polysymptomatic onset and motor disturbances, between the first symptoms (patient complaints) and the diagnosis of multiple sclerosis from 3 months to several years. Conclusion. The presented research results can be useful for neurologists, general practitioners, radiologists and doctors of other specialties for early diagnosis, prescribing pathogenetic treatment of multiple sclerosis and predicting its course. Prospects for further research are related to the monitoring of clinical observations of multiple sclerosis with the aim of improving diagnostic, therapeutic and rehabilitation measures
{"title":"Prediction of the Course of Multiple Sclerosis Based on the Clinical Features of the Debut in Patients of the Poltava Region","authors":"Підставі Клінічних, Особливостей Дебюту, У Пацієнтів, Полтавської Області","doi":"10.26693/jmbs08.01.146","DOIUrl":"https://doi.org/10.26693/jmbs08.01.146","url":null,"abstract":"The purpose of the study was to demonstrate the importance of studying variants of the debut of multiple sclerosis, to reveal the dependence of the rate of progression on the clinical picture of the debut of multiple sclerosis by examining patients and retrospective analysis of clinical data. Materials and methods. The study analyzed 60 cases of relapsing-remitting and secondary-progressive multiple sclerosis in patients who were undergoing inpatient treatment in the neurological department of the communal enterprise “M. V. Sklifosovskyi Poltava Regional Clinical Hospital of the Poltava Regional Council” from 2019 to 2021. Complaints, anamnestic data, results of a complex clinical and neurological examination of patients with multiple sclerosis at the onset and throughout the course of the disease were studied. The diagnosis was established according to Mac-Donald criteria. The severity of clinical manifestations was assessed using the Extended Disability Scale. Results and discussion. The rate of disease progression was assessed retrospectively. The ratio of the number of the Extended Disability Scale points at this moment to the duration of the disease in years was studied. In the group of patients with a monosymptomatic debut, the rate of progression was: 0.64 in women, 1.2 in men. In patients with an acute polysymptomatic onset, the values of the rate of progression were 0.7 and 2.1, respectively. As a result of the retrospective analysis, several options for the onset of multiple sclerosis were identified: monosymptomatic, polysymptomatic, patients with a radiologically isolated syndrome, and patients with a characteristic clinical picture, but without pathological changes on magnetic resonance imaging. One of the most frequent clinical manifestations of the debut in patients in the Poltava region was sensitive disorders. It is worth noting that special attention should be paid to the study of vibration sensitivity. When collecting anamnestic data, it is necessary to clarify the presence of Lhermitte syndrome. The rate of progression of multiple sclerosis was found to be higher in male patients with polysymptomatic onset and motor disturbances, between the first symptoms (patient complaints) and the diagnosis of multiple sclerosis from 3 months to several years. Conclusion. The presented research results can be useful for neurologists, general practitioners, radiologists and doctors of other specialties for early diagnosis, prescribing pathogenetic treatment of multiple sclerosis and predicting its course. Prospects for further research are related to the monitoring of clinical observations of multiple sclerosis with the aim of improving diagnostic, therapeutic and rehabilitation measures","PeriodicalId":413454,"journal":{"name":"Ukraïnsʹkij žurnal medicini, bìologìï ta sportu","volume":"92 1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116253882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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