Pub Date : 2022-08-31DOI: 10.47363/jjcmr/2022(2)138
S. Dixit, Reva Kanash
An awareness study about the Eye safety while breast feeding in small children and infants, as there are always chances of an eye injury to the baby with the hook of mother’s blouse. In India blouse is a traditional top women used to wear mostly.
{"title":"Eye Injuries in Infants and Babies during Breast Feeding","authors":"S. Dixit, Reva Kanash","doi":"10.47363/jjcmr/2022(2)138","DOIUrl":"https://doi.org/10.47363/jjcmr/2022(2)138","url":null,"abstract":"An awareness study about the Eye safety while breast feeding in small children and infants, as there are always chances of an eye injury to the baby with the hook of mother’s blouse. In India blouse is a traditional top women used to wear mostly.","PeriodicalId":415591,"journal":{"name":"Japan Journal of Clinical & Medical Research","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131992280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-30DOI: 10.47363/jjcmr/2022(2)137
Mbah C A
Piper guineense (Uziza in Igbo) is a medicinal plant whose leaves are commonly used as spices.This study is to investigate the effects of the ethanolic leaf extracts of P.guineenseon the histology of the liver, liver biomarker enzymes of paraquat-induced Thirty (30) adult male Wistar rats weighing between 160g – 200g which was randomly assigned to six Groups (A-F) of 5 rats each. The control Group A was not induced with paraquat, while Groups B, D, E and F were induced with 20mg/kg of paraquat. Group C received 200mg/kg of the extract only. After the fourteenth day, groups E and F were withdrawn and treated with 80mg/kg and 100mg/kg of the extract, respectively, for another fourteen days; while Group D was withdrawn without treatment.The results showed that animals in all Groups (P<0.05) except B (-21.67 ± 22.55) and D (-12.21 ± 15.67) had decreased in body weight; severely degenerated hepatic tissue with severe aggregates of intra lobular inflammatory cells, sever intra hepatic haemorrhage and necrotic debris around the haemorrhagic area; These effects were ameliorated in Groups E and F which received the variable doses of the ethanolic leaf extracts of P.guineense. The ethanolic leaf extracts of P.guineense have ameliorative effects on the body weight, serum levels of ALT, AST, ALP, and histologic changes in liver and testes of paraquat-induced Wistar rats.
{"title":"Effects of Ethanolic Leaf Extract of Piper Guineense (Uziza) On The Liver of Paraquat Induced Adult Male Wistar Rats","authors":"Mbah C A","doi":"10.47363/jjcmr/2022(2)137","DOIUrl":"https://doi.org/10.47363/jjcmr/2022(2)137","url":null,"abstract":"Piper guineense (Uziza in Igbo) is a medicinal plant whose leaves are commonly used as spices.This study is to investigate the effects of the ethanolic leaf extracts of P.guineenseon the histology of the liver, liver biomarker enzymes of paraquat-induced Thirty (30) adult male Wistar rats weighing between 160g – 200g which was randomly assigned to six Groups (A-F) of 5 rats each. The control Group A was not induced with paraquat, while Groups B, D, E and F were induced with 20mg/kg of paraquat. Group C received 200mg/kg of the extract only. After the fourteenth day, groups E and F were withdrawn and treated with 80mg/kg and 100mg/kg of the extract, respectively, for another fourteen days; while Group D was withdrawn without treatment.The results showed that animals in all Groups (P<0.05) except B (-21.67 ± 22.55) and D (-12.21 ± 15.67) had decreased in body weight; severely degenerated hepatic tissue with severe aggregates of intra lobular inflammatory cells, sever intra hepatic haemorrhage and necrotic debris around the haemorrhagic area; These effects were ameliorated in Groups E and F which received the variable doses of the ethanolic leaf extracts of P.guineense. The ethanolic leaf extracts of P.guineense have ameliorative effects on the body weight, serum levels of ALT, AST, ALP, and histologic changes in liver and testes of paraquat-induced Wistar rats.","PeriodicalId":415591,"journal":{"name":"Japan Journal of Clinical & Medical Research","volume":"62 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128538686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-30DOI: 10.47363/jjcmr/2022(2)135
D. Maisuradze
Echocardiography is now the most commonly used noninvasive tool for the assessment of cardiac anatomy and function. In addition to commonly established roles such as confirming the diagnosis, etiologic work-up, complication screening, and disease monitoring, echocardiography plays an important clinical role in prognostic assessment.
{"title":"Correlation Between Transmitral Early and Late Diastolic Velocities Ratio and Ratio of Medial Mitral Annular Early and Late Tissue Doppler Velocities","authors":"D. Maisuradze","doi":"10.47363/jjcmr/2022(2)135","DOIUrl":"https://doi.org/10.47363/jjcmr/2022(2)135","url":null,"abstract":"Echocardiography is now the most commonly used noninvasive tool for the assessment of cardiac anatomy and function. In addition to commonly established roles such as confirming the diagnosis, etiologic work-up, complication screening, and disease monitoring, echocardiography plays an important clinical role in prognostic assessment.","PeriodicalId":415591,"journal":{"name":"Japan Journal of Clinical & Medical Research","volume":"2014 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132752052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-30DOI: 10.47363/jjcmr/2022(2)131
Akash Agnihotri, Saravana Kumar Ramasubbu
In 2021, the US Food and Drug Administration approved 50 novel drugs. Twenty three of the 50 (46%) drugs were categorized as orphan drug, and 9 of the 50 (18%) were approved under accelerated approval. This review includes a summary of the novel drugs approved by the US Food and Drug Administration in 2021
{"title":"A Mini Review on New Drugs Approved in 2021","authors":"Akash Agnihotri, Saravana Kumar Ramasubbu","doi":"10.47363/jjcmr/2022(2)131","DOIUrl":"https://doi.org/10.47363/jjcmr/2022(2)131","url":null,"abstract":"In 2021, the US Food and Drug Administration approved 50 novel drugs. Twenty three of the 50 (46%) drugs were categorized as orphan drug, and 9 of the 50 (18%) were approved under accelerated approval. This review includes a summary of the novel drugs approved by the US Food and Drug Administration in 2021","PeriodicalId":415591,"journal":{"name":"Japan Journal of Clinical & Medical Research","volume":"93 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121379317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-30DOI: 10.47363/jjcmr/2022(2)130
Bamgboye M Afolabi, Titilola M Afolabi
Introduction: Malaria is still both a health and an economic burden to various communities in sub-Saharan Africa. Few studies have been conducted on perception of and behavioral pattern of young care-givers to malaria, especially in the populated communities along the Atlantic Ocean coastline in Nigeria.
{"title":"The Perception and Behavioral Attitude to Malaria of Non-parental Care-givers Living on an Atlantic Ocean Coastal Community in Nigeria: Paper 1","authors":"Bamgboye M Afolabi, Titilola M Afolabi","doi":"10.47363/jjcmr/2022(2)130","DOIUrl":"https://doi.org/10.47363/jjcmr/2022(2)130","url":null,"abstract":"Introduction: Malaria is still both a health and an economic burden to various communities in sub-Saharan Africa. Few studies have been conducted on perception of and behavioral pattern of young care-givers to malaria, especially in the populated communities along the Atlantic Ocean coastline in Nigeria.","PeriodicalId":415591,"journal":{"name":"Japan Journal of Clinical & Medical Research","volume":"160 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127550938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-30DOI: 10.47363/jjcmr/2022(2)129
Frank Y. Shan, Dong-xia Feng
CNS tumors include primary and metastatic neoplasms, which together account for about 1% of human body tumors. The fragile nature of brain and spinal cord parenchyma limits both diagnostic and therapeutic approaches. Fortunately, the recently developed liquid based biopsy (LBB) technique provide highly convenient, fast and less-invasive method to collect and test the potential biomarkers. Biomarkers derived from liquid biopsies can promptly reflect changes on the gene expression profile of tumors. Biomarker derived from tumor cells contain abundant genetic information, which may provide a strong basis for the diagnosis and the individualized treatment of brain tumor patients. CSF can be used as a resource of biomarkers, the sensitivity and specificity of CSF biomarkers of patients with brain tumor is typically higher than those detected in peripheral blood and other sources. This chapter reviews the current different biomarkers in CSF and their significance in brain tumor diagnosis and monitoring.
{"title":"Diagnosis of CNS Lesions by CSF","authors":"Frank Y. Shan, Dong-xia Feng","doi":"10.47363/jjcmr/2022(2)129","DOIUrl":"https://doi.org/10.47363/jjcmr/2022(2)129","url":null,"abstract":"CNS tumors include primary and metastatic neoplasms, which together account for about 1% of human body tumors. The fragile nature of brain and spinal cord parenchyma limits both diagnostic and therapeutic approaches. Fortunately, the recently developed liquid based biopsy (LBB) technique provide highly convenient, fast and less-invasive method to collect and test the potential biomarkers. Biomarkers derived from liquid biopsies can promptly reflect changes on the gene expression profile of tumors. Biomarker derived from tumor cells contain abundant genetic information, which may provide a strong basis for the diagnosis and the individualized treatment of brain tumor patients. CSF can be used as a resource of biomarkers, the sensitivity and specificity of CSF biomarkers of patients with brain tumor is typically higher than those detected in peripheral blood and other sources. This chapter reviews the current different biomarkers in CSF and their significance in brain tumor diagnosis and monitoring.","PeriodicalId":415591,"journal":{"name":"Japan Journal of Clinical & Medical Research","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128512308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-30DOI: 10.47363/jjcmr/2022(2)132
Ashraf Marzouk El Tantawi
Rac1 is basis for ATPase, ribosomes repairs, Gactin activities, and regulating fatty Acyl-COA productions (upon OPA1 function) which are main for epidermal growth factor “EGF” synthesis and for both PLCs and IFNs synthesis. Rac1 basically are S6K rich Proline and hydrophobic amino acids that each amino acid especially Proline characterize Rac1 for scpsific functions and activity for regulating specific anti-inflammatory cycles and specific anti-inflammatory growth, that Rac1 has the roles of acting on inflammatory sources for analyzing and producing long fatty chains which will follow the OPA1 oxidative function (which activated by GTPase which promoted by Rac1 active molecules ) for producing fatty Acyl-COAs isoforms which considered as GP-GTP isoforms Gp-GTP gamma, GP-GTP beta, and GP-GTP alpha isoforms where some said that GTPase has been analyzed to give Gp isoforms but GTPase has activated OPA1 enzymes which produced Gp-GTP nuclear isoforms upon effect on long fatty chains, that GP-GTP beta and alpha have the roles of promoting PLCs and IFNs isoforms for anti-inflammatory processes and for anti-inflammatory growth . That The Rho family Rac1-GTPase (Gp isoforms) mediates a variety of signal transduction processes leading to activation of NADPH oxidase, actin cytoskeleton reorganization and anti-inflammatory growth.
{"title":"Rac1 Rich Proline are OPA1 Flux Influencer for PLCs and IFNs Synthesis where Immune and Toxicity Due Deficiency in Synthetase and in Proline Synthesis","authors":"Ashraf Marzouk El Tantawi","doi":"10.47363/jjcmr/2022(2)132","DOIUrl":"https://doi.org/10.47363/jjcmr/2022(2)132","url":null,"abstract":"Rac1 is basis for ATPase, ribosomes repairs, Gactin activities, and regulating fatty Acyl-COA productions (upon OPA1 function) which are main for epidermal growth factor “EGF” synthesis and for both PLCs and IFNs synthesis. Rac1 basically are S6K rich Proline and hydrophobic amino acids that each amino acid especially Proline characterize Rac1 for scpsific functions and activity for regulating specific anti-inflammatory cycles and specific anti-inflammatory growth, that Rac1 has the roles of acting on inflammatory sources for analyzing and producing long fatty chains which will follow the OPA1 oxidative function (which activated by GTPase which promoted by Rac1 active molecules ) for producing fatty Acyl-COAs isoforms which considered as GP-GTP isoforms Gp-GTP gamma, GP-GTP beta, and GP-GTP alpha isoforms where some said that GTPase has been analyzed to give Gp isoforms but GTPase has activated OPA1 enzymes which produced Gp-GTP nuclear isoforms upon effect on long fatty chains, that GP-GTP beta and alpha have the roles of promoting PLCs and IFNs isoforms for anti-inflammatory processes and for anti-inflammatory growth . That The Rho family Rac1-GTPase (Gp isoforms) mediates a variety of signal transduction processes leading to activation of NADPH oxidase, actin cytoskeleton reorganization and anti-inflammatory growth.","PeriodicalId":415591,"journal":{"name":"Japan Journal of Clinical & Medical Research","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130326119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-02-28DOI: 10.47363/jjcmr/2022(2)126
Mahmoud Al-Masaeed
Aim and Significance: The review examines the impact of Australian government policies on healthcare quality delivery to the minority communities of the aboriginal and Torres Strait Islander community within Australia. The focus is on the value and impacts of the policies, denoting their success and limitation areas. This is informed by the need to ensure equity for all in accessing healthcare services as a global healthcare provision sustainability goal. Methods: This review was based on a search of the existing secondary data that is publicly available. The analysis searched the Australian government website for its official healthcare policy publications and supporting peer reviews from the Google scholar, PubMed, Scopus, and Medline databases, respectively. The findings were analysed through the PRISMA model, and inclusion and exclusion criteria were applied to ensure findings relevance and alignment with the review aim. Findings and Conclusion: The review analysis established that the Australian government has enacted healthcare policies targeting the aboriginal and Torres Strait Islander community within Australia. Key areas of focus in enhancing healthcare quality for this target healthcare population were (i) improving healthcare access and (ii) enhancing healthcare affordability through cost reduction.
{"title":"Examining the Role of Government Policies in Improving Healthcare Quality to the Aboriginal and Torres Strait Islander Communities in Australia: Rapid Review","authors":"Mahmoud Al-Masaeed","doi":"10.47363/jjcmr/2022(2)126","DOIUrl":"https://doi.org/10.47363/jjcmr/2022(2)126","url":null,"abstract":"Aim and Significance: The review examines the impact of Australian government policies on healthcare quality delivery to the minority communities of the aboriginal and Torres Strait Islander community within Australia. The focus is on the value and impacts of the policies, denoting their success and limitation areas. This is informed by the need to ensure equity for all in accessing healthcare services as a global healthcare provision sustainability goal. Methods: This review was based on a search of the existing secondary data that is publicly available. The analysis searched the Australian government website for its official healthcare policy publications and supporting peer reviews from the Google scholar, PubMed, Scopus, and Medline databases, respectively. The findings were analysed through the PRISMA model, and inclusion and exclusion criteria were applied to ensure findings relevance and alignment with the review aim. Findings and Conclusion: The review analysis established that the Australian government has enacted healthcare policies targeting the aboriginal and Torres Strait Islander community within Australia. Key areas of focus in enhancing healthcare quality for this target healthcare population were (i) improving healthcare access and (ii) enhancing healthcare affordability through cost reduction.","PeriodicalId":415591,"journal":{"name":"Japan Journal of Clinical & Medical Research","volume":"12 18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125640122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-14DOI: 10.21203/RS.3.RS-532104/V1
S. Buyukberber, I. Mumcuoglu, B. Ozbay, A. Aypak, B. Dinç
Comamonas testosteroni is a Gram- negative, aerobic, motile, non-spore-forming bacillus. It has not been recognized as a component of the endogenous human microflora. Due to its ability to survive in liquid environments, it can survive for a long time in a hospital environment and cause opportunistic infections. Although rare, C. testosteroni has been reported as a cause of cellulitis, peritonitis, endocarditis, meningitis, endophthalmitis, tenosynovitis, pneumonia and bacteremia. Here, we present a case of a 4-year-old girl who was operated on for persistent cloaca with C. testosteroni isolated in her urine culture. Identification studies were performed by MALDI-TOF MS (bioMerieux, France) mass spectrophotometer method. Antibiotic susceptibility tests were performed with the automatic device VITEK-2 Compact (bioMérieux, France). Microorganism was found susceptible to ceftazidime and ciprofloxacin; intermediate susceptible to meropenem and piperacillin / tazobactam and resistant to gentamicin, amikacin, imipenem and trimethoprim-sulfamethoxazole. With this case report, C. testosteroni was reported as the first cause of urinary tract infection in our country and the third in the world.
睾酮单胞菌是一种革兰氏阴性，需氧，运动，不形成孢子的芽孢杆菌。它还没有被认为是内源性人类微生物群的一个组成部分。由于它在液体环境中生存的能力，它可以在医院环境中存活很长时间并引起机会性感染。尽管罕见，睾酮C.已被报道为蜂窝织炎、腹膜炎、心内膜炎、脑膜炎、眼内炎、腱鞘炎、肺炎和菌血症的病因。在这里，我们提出一个4岁的女孩谁是手术的持久性泄殖腔与C.睾酮分离在她的尿液培养。鉴定采用MALDI-TOF MS (bioMerieux, France)质谱法。使用自动装置VITEK-2 Compact (biomacrieux，法国)进行抗生素敏感性试验。微生物对头孢他啶和环丙沙星敏感;对美罗培南和哌拉西林/他唑巴坦中间敏感，对庆大霉素、阿米卡星、亚胺培南和甲氧苄啶-磺胺甲恶唑耐药。此例报告表明，睾酮睾固酮睾固酮已成为我国泌尿系感染的第一大病因，世界泌尿系感染的第三大病因。
{"title":"A Rare Pathogen Comamonas Testosteroni: A Case Report And Review of The Literature","authors":"S. Buyukberber, I. Mumcuoglu, B. Ozbay, A. Aypak, B. Dinç","doi":"10.21203/RS.3.RS-532104/V1","DOIUrl":"https://doi.org/10.21203/RS.3.RS-532104/V1","url":null,"abstract":"\u0000 Comamonas testosteroni is a Gram- negative, aerobic, motile, non-spore-forming bacillus. It has not been recognized as a component of the endogenous human microflora. Due to its ability to survive in liquid environments, it can survive for a long time in a hospital environment and cause opportunistic infections. Although rare, C. testosteroni has been reported as a cause of cellulitis, peritonitis, endocarditis, meningitis, endophthalmitis, tenosynovitis, pneumonia and bacteremia. Here, we present a case of a 4-year-old girl who was operated on for persistent cloaca with C. testosteroni isolated in her urine culture. Identification studies were performed by MALDI-TOF MS (bioMerieux, France) mass spectrophotometer method. Antibiotic susceptibility tests were performed with the automatic device VITEK-2 Compact (bioMérieux, France). Microorganism was found susceptible to ceftazidime and ciprofloxacin; intermediate susceptible to meropenem and piperacillin / tazobactam and resistant to gentamicin, amikacin, imipenem and trimethoprim-sulfamethoxazole. With this case report, C. testosteroni was reported as the first cause of urinary tract infection in our country and the third in the world.","PeriodicalId":415591,"journal":{"name":"Japan Journal of Clinical & Medical Research","volume":"280 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127717788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：