Noreen Mirza, Vikramjit S. Purewal, Joanna Pater, Sayed A. Shah, Fajr Mirza, I. Farouji, P. Randhawa
Percutaneous coronary intervention (PCI) is an effective method for coronary revascularization, however, alongside its benefits, it can be accompanied by complications. Catheter induced coronary artery dissection (CICAD) is rare and the consequences can be devastating if left untreated. The incidence has been reported to be as low as 0.1%. Also, propagation of the dissection to the aortic root remains uncommon. The mechanism of dissection is related to mechanical injury to the arterial wall during manipulation with the catheter or wire. It may also occur due to injection of contrast, stenting or balloon dilation. Timely recognition is important in these cases to facilitate optimal patient outcomes which is usually accomplished with stenting. Herein, we report a rare case of a 68-year-old female with multivessel coronary artery disease who presented for routine left heart catheterization and developed catheter induced right coronary artery (RCA) dissection with propagation towards the aortic root which was treated with stenting and watchful waiting.
{"title":"A rare case of right coronary artery dissection during routine left heart catheterization","authors":"Noreen Mirza, Vikramjit S. Purewal, Joanna Pater, Sayed A. Shah, Fajr Mirza, I. Farouji, P. Randhawa","doi":"10.21542/gcsp.2024.24","DOIUrl":"https://doi.org/10.21542/gcsp.2024.24","url":null,"abstract":"\u0000\u0000\u0000Percutaneous coronary intervention (PCI) is an effective method for coronary revascularization, however, alongside its benefits, it can be accompanied by complications. Catheter induced coronary artery dissection (CICAD) is rare and the consequences can be devastating if left untreated. The incidence has been reported to be as low as 0.1%. Also, propagation of the dissection to the aortic root remains uncommon. The mechanism of dissection is related to mechanical injury to the arterial wall during manipulation with the catheter or wire. It may also occur due to injection of contrast, stenting or balloon dilation. Timely recognition is important in these cases to facilitate optimal patient outcomes which is usually accomplished with stenting. Herein, we report a rare case of a 68-year-old female with multivessel coronary artery disease who presented for routine left heart catheterization and developed catheter induced right coronary artery (RCA) dissection with propagation towards the aortic root which was treated with stenting and watchful waiting.\u0000\u0000\u0000","PeriodicalId":416388,"journal":{"name":"Global Cardiology Science and Practice","volume":"128 44","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140977273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kaoutar Kabbadj, Safae El Haddaoui, Nora Taiek, A. J. El Hangouche
Cardiovascular disease is a growing challenge worldwide, and Morocco is no exception. Despite its growing popularity, cardiac rehabilitation is still largely underutilized. In order to improve the provision of cardiac rehabilitation, a study of the knowledge, attitudes, and practices of physiotherapists in Morocco, key players in cardiac rehabilitation, is described. This assessment highlights existing skill gaps and enables the necessary corrective measures to be identified. This cross-sectional study included Moroccan physiotherapists working in different institutions (public and private) in different regions of Morocco. A total of 145 valid questionnaires were collected (33% response rate). The results showed that 72.4% of respondents had a medium level of knowledge of cardiac rehabilitation, 93.8% had a positive attitude, and 73% of physiotherapists said they sometimes practiced cardiac rehabilitation. Subgroup analysis showed that the lower the level of education, the more negative the knowledge and practice of rehabilitation. The results also showed that physiotherapists working in education sector and private clinics had better practice than those working in hospitals.
{"title":"Knowledge, attitudes, and practices of cardiac rehabilitation among physiotherapists in Morocco","authors":"Kaoutar Kabbadj, Safae El Haddaoui, Nora Taiek, A. J. El Hangouche","doi":"10.21542/gcsp.2024.23","DOIUrl":"https://doi.org/10.21542/gcsp.2024.23","url":null,"abstract":"\u0000\u0000\u0000Cardiovascular disease is a growing challenge worldwide, and Morocco is no exception. Despite its growing popularity, cardiac rehabilitation is still largely underutilized. In order to improve the provision of cardiac rehabilitation, a study of the knowledge, attitudes, and practices of physiotherapists in Morocco, key players in cardiac rehabilitation, is described. This assessment highlights existing skill gaps and enables the necessary corrective measures to be identified. This cross-sectional study included Moroccan physiotherapists working in different institutions (public and private) in different regions of Morocco. A total of 145 valid questionnaires were collected (33% response rate). The results showed that 72.4% of respondents had a medium level of knowledge of cardiac rehabilitation, 93.8% had a positive attitude, and 73% of physiotherapists said they sometimes practiced cardiac rehabilitation. Subgroup analysis showed that the lower the level of education, the more negative the knowledge and practice of rehabilitation. The results also showed that physiotherapists working in education sector and private clinics had better practice than those working in hospitals.\u0000\u0000\u0000\u0000 ","PeriodicalId":416388,"journal":{"name":"Global Cardiology Science and Practice","volume":"83 21","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140978635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Desiana Desiana, Z. Muchlisin, Khairi Suhud, Basri A. Gani
Background: One of the factors that contributes to coronary heart disease and stroke is high blood pressure, or hypertension. Hypertension is influenced by race and sex. The objective of this study was to assess the hypertensive population in Aceh by tribal community and to examine the relationship between cholesterol history and hypertension.Methods: This study used incidental sampling as a non-probability sampling method, in which 152 participants were evaluated for the profile of hypertension with a history of cholesterol. Blood pressure was measured using a blood pressure measuring device. HDL, LDL, triglyceride, and total cholesterol levels were measured using LIPID Pro. Data analysis was performed using the Kruskal–Wallis and Mann–Whitney tests with p<0.05.Results: The study population (N=152) consisted of 81 males (53%) and 71 females (47%) across the ethnicities of Aceh (64:42%), Gayo (19:13%), Alas (33:22%), and Aneuk Jamee (36:24%). In the male group, hypertension was associated with total cholesterol (r=0.03; p=0.78), HDL (r=0.20; p=0.07), and LDL (r=0.21; p=0.07) levels, whereas in the female group, hypertension was primarily correlated with LDL levels (r=0.20; p=0.09).Conclusion: In general, hypertension in males and females in the four tribes in Aceh is associated with HDL, LDL, and total cholesterol levels.
{"title":"Tribal differences in hypertension and cholesterol profiles in Aceh, Indonesia","authors":"Desiana Desiana, Z. Muchlisin, Khairi Suhud, Basri A. Gani","doi":"10.21542/gcsp.2024.22","DOIUrl":"https://doi.org/10.21542/gcsp.2024.22","url":null,"abstract":"\u0000\u0000\u0000Background: One of the factors that contributes to coronary heart disease and stroke is high blood pressure, or hypertension. Hypertension is influenced by race and sex. The objective of this study was to assess the hypertensive population in Aceh by tribal community and to examine the relationship between cholesterol history and hypertension.Methods: This study used incidental sampling as a non-probability sampling method, in which 152 participants were evaluated for the profile of hypertension with a history of cholesterol. Blood pressure was measured using a blood pressure measuring device. HDL, LDL, triglyceride, and total cholesterol levels were measured using LIPID Pro. Data analysis was performed using the Kruskal–Wallis and Mann–Whitney tests with p<0.05.Results: The study population (N=152) consisted of 81 males (53%) and 71 females (47%) across the ethnicities of Aceh (64:42%), Gayo (19:13%), Alas (33:22%), and Aneuk Jamee (36:24%). In the male group, hypertension was associated with total cholesterol (r=0.03; p=0.78), HDL (r=0.20; p=0.07), and LDL (r=0.21; p=0.07) levels, whereas in the female group, hypertension was primarily correlated with LDL levels (r=0.20; p=0.09).Conclusion: In general, hypertension in males and females in the four tribes in Aceh is associated with HDL, LDL, and total cholesterol levels.\u0000\u0000\u0000","PeriodicalId":416388,"journal":{"name":"Global Cardiology Science and Practice","volume":" 1279","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140988892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nicholas L Hudock, H. Hughes, Nour Shaheen, Abdelraouf Ramadan, Kinna Parikh, F. Anami̇ka, Rohit Jain
Background: Atrial fibrillation is responsible for over 400,000 hospitalizations in the United States (US) each year. This costs the US health system over 4 billion each year. New smartwatches can constantly monitor pulse, oxygen saturation, and even heart rhythm. The FDA has provided clearance for select smartwatches to detect arrhythmias, including atrial fibrillation. Findings: These devices are not currently widely implemented as diagnostic tools. In this review, we delve into the mechanism of how smartwatches work as healthcare tools and how they capture health data. Additionally, we analyze the reliability of the data collected by smartwatches and the accuracy of their sensors in monitoring health parameters. Moreover, we explore the accessibility of smartwatches as healthcare tools and their potential to promote self- care among individuals. Finally, we assess the outcomes of using smartwatches in healthcare, including the limited studies on the clinical effects and barriers to uptake by the community. Conclusion: Although smartwatches are accurate for the detection of atrial fibrillation, they still face many hurdles, including access to aging populations and trust in the medical community.
{"title":"Wearable health monitoring: wave of the future or waste of time?","authors":"Nicholas L Hudock, H. Hughes, Nour Shaheen, Abdelraouf Ramadan, Kinna Parikh, F. Anami̇ka, Rohit Jain","doi":"10.21542/gcsp.2024.21","DOIUrl":"https://doi.org/10.21542/gcsp.2024.21","url":null,"abstract":"\u0000\u0000\u0000Background: Atrial fibrillation is responsible for over 400,000 hospitalizations in the United States (US) each year. This costs the US health system over 4 billion each year. New smartwatches can constantly monitor pulse, oxygen saturation, and even heart rhythm. The FDA has provided clearance for select smartwatches to detect arrhythmias, including atrial fibrillation.\u0000Findings: These devices are not currently widely implemented as diagnostic tools. In this review, we delve into the mechanism of how smartwatches work as healthcare tools and how they capture health data. Additionally, we analyze the reliability of the data collected by smartwatches and the accuracy of their sensors in monitoring health parameters. Moreover, we explore the accessibility of smartwatches as healthcare tools and their potential to promote self- care among individuals. Finally, we assess the outcomes of using smartwatches in healthcare, including the limited studies on the clinical effects and barriers to uptake by the community.\u0000Conclusion: Although smartwatches are accurate for the detection of atrial fibrillation, they still face many hurdles, including access to aging populations and trust in the medical community.\u0000\u0000\u0000","PeriodicalId":416388,"journal":{"name":"Global Cardiology Science and Practice","volume":"42 17","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140663044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
We report a case of Budd-Chiari syndrome (BCS) in a 44-year-old man with inferior vena cava (IVC) thrombosis and nephrotic syndrome. This case was complicated by right atrial clot and pulmonary emboli. Endothelial injury of the IVC was the likely mechanism, following a kick from a donkey. Abdominal ultrasonography revealed a large thrombosis located in a segment of IVC near its orifice in the right atrium. Transthoracic echocardiography (TTE) revealed IVC thrombosis that extended to the right atrium; however, pulmonary emboli (PE) were not documented in TTE. Intraoperative exploration revealed multiple clots in the main and left pulmonary artery branches. The patient recovered well after open-heart surgery with resection of the right atrium, IVC, and pulmonary artery emboli. BCS should be routinely considered for patients with nephrotic syndrome.
{"title":"Budd-Chiari syndrome following abdominal trauma","authors":"R. Faraji, F. Sabzi","doi":"10.21542/gcsp.2024.19","DOIUrl":"https://doi.org/10.21542/gcsp.2024.19","url":null,"abstract":"\u0000We report a case of Budd-Chiari syndrome (BCS) in a 44-year-old man with inferior vena cava (IVC) thrombosis and nephrotic syndrome. This case was complicated by right atrial clot and pulmonary emboli. Endothelial injury of the IVC was the likely mechanism, following a kick from a donkey. Abdominal ultrasonography revealed a large thrombosis located in a segment of IVC near its orifice in the right atrium. Transthoracic echocardiography (TTE) revealed IVC thrombosis that extended to the right atrium; however, pulmonary emboli (PE) were not documented in TTE. Intraoperative exploration revealed multiple clots in the main and left pulmonary artery branches. The patient recovered well after open-heart surgery with resection of the right atrium, IVC, and pulmonary artery emboli. BCS should be routinely considered for patients with nephrotic syndrome.\u0000","PeriodicalId":416388,"journal":{"name":"Global Cardiology Science and Practice","volume":"57 49","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140362646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chest pain represents a symptom of significant clinical concern due to the potential for lethal etiologies. Accordingly, it is critical to ascertain the presence of stable angina through various diagnostic tests to inform subsequent therapeutic strategies. Stable angina, while potentially progressing to more severe conditions if left untreated, suffers from a paucity of research regarding its management compared to other more fatal causes of chest pain. Recent advancements in radiological imaging necessitate a re-evaluation of the array and functionality of diagnostic tests, with particular emphasis on prioritizing non-invasive methods such as electrocardiography and echocardiography. This study undertakes a comprehensive review of the literature pertaining to various diagnostic tests for stable angina. We conclude that the management of a patient presenting with chest pain encompasses a continuum of care, beginning with a detailed patient history to estimate pre-test probability and culminating in computed tomography coronary angiography. This continuum is highly individualized, taking into account patient-specific variables, disease burden, and test indications. In an era of rapid research advancement, our findings delineate the optimal sequence of initial diagnostic tests, emphasizing the role of current non- invasive imaging modalities as outlined in standard clinical guidelines.
{"title":"Role of non-invasive coronary imaging in stable angina","authors":"Zahra Adnan, Binay Panjiyar, Areeba Mehmood, Alekhya Nanisetty","doi":"10.21542/gcsp.2024.18","DOIUrl":"https://doi.org/10.21542/gcsp.2024.18","url":null,"abstract":"\u0000\u0000\u0000Chest pain represents a symptom of significant clinical concern due to the potential for lethal etiologies. Accordingly, it is critical to ascertain the presence of stable angina through various diagnostic tests to inform subsequent therapeutic strategies. Stable angina, while potentially progressing to more severe conditions if left untreated, suffers from a paucity of research regarding its management compared to other more fatal causes of chest pain. Recent advancements in radiological imaging necessitate a re-evaluation of the array and functionality of diagnostic tests, with particular emphasis on prioritizing non-invasive methods such as electrocardiography and echocardiography. This study undertakes a comprehensive review of the literature pertaining to various diagnostic tests for stable angina. We conclude that the management of a patient presenting with chest pain encompasses a continuum of care, beginning with a detailed patient history to estimate pre-test probability and culminating in computed tomography coronary angiography. This continuum is highly individualized, taking into account patient-specific variables, disease burden, and test indications. In an era of rapid research advancement, our findings delineate the optimal sequence of initial diagnostic tests, emphasizing the role of current non- invasive imaging modalities as outlined in standard clinical guidelines.\u0000\u0000\u0000","PeriodicalId":416388,"journal":{"name":"Global Cardiology Science and Practice","volume":" 552","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140092531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hadi Farhat, Celine J Kassab, Yehya Tlaiss, S. D. Gutlapalli, Vijay Durga Pradeep Ganipineni, Jananthan Paramsothy, Sarah Tedesco, Tharunjan Kailayanathan, Razan Abdulaal, Philip Otterbeck
Hydroxychloroquine (HCQ), which was initially used as an antimalarial drug, is now being used to treat other illnesses, especially rheumatic autoimmune disorders such as systemic lupus erythematosus, primary Sjögren's syndrome, and rheumatoid arthritis, because it is safe, effective, and cost efficient. This drug has shown high efficacy and has become the first-line treatment for many of these diseases. Although HCQ has many therapeutic effects, it has unfortunately shown some complications, especially with its long-term use. One of these side effects is arrhythmia through prolongation of the QT interval. This narrative literature review focuses on the effects of HCQ on the QT interval in patients with rheumatologic diseases who have been prescribed this drug. In particular, we will focus on the increased risk of arrhythmia when HCQ is administered with other drugs, such as azithromycin and many others, along with drug-drug interactions. In addition, we investigated the safety of this drug in pregnant women.
{"title":"Hydroxychloroquine and the associated risk of arrhythmias","authors":"Hadi Farhat, Celine J Kassab, Yehya Tlaiss, S. D. Gutlapalli, Vijay Durga Pradeep Ganipineni, Jananthan Paramsothy, Sarah Tedesco, Tharunjan Kailayanathan, Razan Abdulaal, Philip Otterbeck","doi":"10.21542/gcsp.2024.17","DOIUrl":"https://doi.org/10.21542/gcsp.2024.17","url":null,"abstract":"\u0000\u0000\u0000Hydroxychloroquine (HCQ), which was initially used as an antimalarial drug, is now being used to treat other illnesses, especially rheumatic autoimmune disorders such as systemic lupus erythematosus, primary Sjögren's syndrome, and rheumatoid arthritis, because it is safe, effective, and cost efficient. This drug has shown high efficacy and has become the first-line treatment for many of these diseases. Although HCQ has many therapeutic effects, it has unfortunately shown some complications, especially with its long-term use. One of these side effects is arrhythmia through prolongation of the QT interval. This narrative literature review focuses on the effects of HCQ on the QT interval in patients with rheumatologic diseases who have been prescribed this drug. In particular, we will focus on the increased risk of arrhythmia when HCQ is administered with other drugs, such as azithromycin and many others, along with drug-drug interactions. In addition, we investigated the safety of this drug in pregnant women.\u0000\u0000\u0000","PeriodicalId":416388,"journal":{"name":"Global Cardiology Science and Practice","volume":"277 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140427680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Central venous catheter (CVC) placement is frequently essential for the management of critically ill patients. This report describes a case involving the surgical retrieval of an embolized fragment of a CVC, originally intended for dialysis, following an unsuccessful removal attempt by a nurse due to catheter malfunction. The decision to remove and replace the malfunctioning catheter was made by the patient's physician. However, during the removal process, both the retaining suture and the catheter were inadvertently severed. This report also discusses the complications and management strategies associated with the embolization of a central line.
{"title":"Traumatic fracture of central venous catheter","authors":"F. Sabzi, R. Faraji, A. Bozorgomid","doi":"10.21542/gcsp.2024.16","DOIUrl":"https://doi.org/10.21542/gcsp.2024.16","url":null,"abstract":"Central venous catheter (CVC) placement is frequently essential for the management of critically ill patients. This report describes a case involving the surgical retrieval of an embolized fragment of a CVC, originally intended for dialysis, following an unsuccessful removal attempt by a nurse due to catheter malfunction. The decision to remove and replace the malfunctioning catheter was made by the patient's physician. However, during the removal process, both the retaining suture and the catheter were inadvertently severed. This report also discusses the complications and management strategies associated with the embolization of a central line.","PeriodicalId":416388,"journal":{"name":"Global Cardiology Science and Practice","volume":"80 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140423965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
B. G. de Liyis, Made Dhiyo Wiweka Aryaweda, Luh Oliva Saraswati Suastika
The efficacy of drug-coated balloons (DCB) versus drug-eluting stents (DES) for coronary artery disease (CAD) remains inconclusive. Despite paclitaxel's common use in both DES and DCB, there is a lack of meta-analyses comparing paclitaxel-eluting stents (PES) and paclitaxel-coated balloons (PCB). This meta-analysis aims to evaluate and compare DES and DCB outcomes using paclitaxel. A Systematic literature search in Medline and Cochrane databases yielded six randomized controlled trials with 951 patients (1:1 ratio). Primary endpoints were mortality, target lesion vascularization (TLV), myocardial infarction (MI), target vessel revascularization (TVR), and major adverse cardiovascular events (MACEs). Secondary endpoints included in-device binary stenosis, in-segment binary stenosis, late luminal loss (LLL), post minimal lumen diameter (MLD), and post diameter stenosis. Within the study populations, the incidence of previous MI was significantly lower in the PES group compared to the PCB group (26.70% vs. 39.22%, OR:0.56, 95%CI:0.41–0.76, p=0.0002). The meta-analysis results showed that mortality (OR:1.57, 95%CI:0.67-3.66, p=0.29), TLV (OR:0.74, 95%CI:0.37-1.48, p=0.39), MI (OR:1.76, 95%CI:0.79-3.88, p=0.16), TVR (OR:0.76, 95%CI:0.51-1.12, p=0.16), and MACEs (OR:1.11, 95%CI:0.48-2.58, p=0.81) did not exhibit significant differences between PES and PCB group in CAD. Furthermore, in stent or in balloon binary stenosis (OR:0.80, 95%CI:0.34-1.87, p=0.60), in segment binary stenosis (OR:1.16, 95%CI:0.48-2.80, p=0.74), LLL (MD:0.03, 95%CI:-0.11 to 0.17, p=0.65), post MLD (MD:0.04, 95%CI:-0.23 to 0.30, p=0.77), and post diameter stenosis (MD:-5.48, 95%CI:-13.88 to 2.92, p=0.20) were similar in both groups. Our comprehensive analysis concludes that both PES and PCB manifest comparable effectiveness and safety in the management of CAD.
{"title":"Paclitaxel-eluting stents versus paclitaxel-coated balloons in coronary artery disease: a meta-analysis of randomized controlled trials","authors":"B. G. de Liyis, Made Dhiyo Wiweka Aryaweda, Luh Oliva Saraswati Suastika","doi":"10.21542/gcsp.2024.12","DOIUrl":"https://doi.org/10.21542/gcsp.2024.12","url":null,"abstract":"The efficacy of drug-coated balloons (DCB) versus drug-eluting stents (DES) for coronary artery disease (CAD) remains inconclusive. Despite paclitaxel's common use in both DES and DCB, there is a lack of meta-analyses comparing paclitaxel-eluting stents (PES) and paclitaxel-coated balloons (PCB). This meta-analysis aims to evaluate and compare DES and DCB outcomes using paclitaxel. A Systematic literature search in Medline and Cochrane databases yielded six randomized controlled trials with 951 patients (1:1 ratio). Primary endpoints were mortality, target lesion vascularization (TLV), myocardial infarction (MI), target vessel revascularization (TVR), and major adverse cardiovascular events (MACEs). Secondary endpoints included in-device binary stenosis, in-segment binary stenosis, late luminal loss (LLL), post minimal lumen diameter (MLD), and post diameter stenosis. Within the study populations, the incidence of previous MI was significantly lower in the PES group compared to the PCB group (26.70% vs. 39.22%, OR:0.56, 95%CI:0.41–0.76, p=0.0002). The meta-analysis results showed that mortality (OR:1.57, 95%CI:0.67-3.66, p=0.29), TLV (OR:0.74, 95%CI:0.37-1.48, p=0.39), MI (OR:1.76, 95%CI:0.79-3.88, p=0.16), TVR (OR:0.76, 95%CI:0.51-1.12, p=0.16), and MACEs (OR:1.11, 95%CI:0.48-2.58, p=0.81) did not exhibit significant differences between PES and PCB group in CAD. Furthermore, in stent or in balloon binary stenosis (OR:0.80, 95%CI:0.34-1.87, p=0.60), in segment binary stenosis (OR:1.16, 95%CI:0.48-2.80, p=0.74), LLL (MD:0.03, 95%CI:-0.11 to 0.17, p=0.65), post MLD (MD:0.04, 95%CI:-0.23 to 0.30, p=0.77), and post diameter stenosis (MD:-5.48, 95%CI:-13.88 to 2.92, p=0.20) were similar in both groups. Our comprehensive analysis concludes that both PES and PCB manifest comparable effectiveness and safety in the management of CAD.","PeriodicalId":416388,"journal":{"name":"Global Cardiology Science and Practice","volume":"31 123","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140432845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Angad Bedi, Muhammad Sabri, Prerana Sevella, Hussam Al Hennawi, Gregory Pirolli
Right ventricular thrombus is a rare finding found in 4% of people diagnosed with pulmonary embolism. Although right ventricular thrombi are usually associated with atrial fibrillation, deep venous vein thrombi, or intracardiac procedures, isolated right ventricular thrombi are rare. Right ventricular thrombus has also been reported in patients with right ventricular infarction, as hypokinesis of the right ventricle causes blood stasis and promotes thrombosis as per Virchow’s triad. However, we present a case of isolated RV thrombus in a patient without evidence of deep vein thrombosis or right ventricular hypokinesis who presented with dyspnea on exertion.
{"title":"Diagnostic and therapeutic challenge: A case of right ventricular thrombus","authors":"Angad Bedi, Muhammad Sabri, Prerana Sevella, Hussam Al Hennawi, Gregory Pirolli","doi":"10.21542/gcsp.2024.13","DOIUrl":"https://doi.org/10.21542/gcsp.2024.13","url":null,"abstract":"\u0000\u0000\u0000Right ventricular thrombus is a rare finding found in 4% of people diagnosed with pulmonary embolism. Although right ventricular thrombi are usually associated with atrial fibrillation, deep venous vein thrombi, or intracardiac procedures, isolated right ventricular thrombi are rare. Right ventricular thrombus has also been reported in patients with right ventricular infarction, as hypokinesis of the right ventricle causes blood stasis and promotes thrombosis as per Virchow’s triad. However, we present a case of isolated RV thrombus in a patient without evidence of deep vein thrombosis or right ventricular hypokinesis who presented with dyspnea on exertion.\u0000\u0000\u0000","PeriodicalId":416388,"journal":{"name":"Global Cardiology Science and Practice","volume":"40 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140433254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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