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Trace Metals and Safe Consumption of Edible Fungi from Upper-Katanga (DR Congo) 上加丹加省(刚果民主共和国)食用菌的微量金属及安全食用
Pub Date : 2020-06-25 DOI: 10.37532/JFND.2020.9(2).274
Bill Kasongo Wa Ngoy Kashiki, A. Kesel, N. Noret, P. Meerts, J. Degreef, M. Shutcha
Abstract In Upper Katanga region (Democratic Republic of the Congo) Wild Edible Fungi (WEF) are an important source of food and income. This study is the first to present the trace metal content of six edible mushrooms collected from the mining region around Lubumbashi. Samples were taken in places where local people collect fruit bodies for consumption. Inductively Coupled Plasma Spectrometry (ICP-OES,) was used to determine concentrations of ten trace metals (Al, Cr, Cu, Co, Pb, Cd, Fe, Ni, Mn and Zn) in Amanita loosii, Amanita pudica, Cantharellus congolensis, Cantharellus densifolius, Cantharellus platyphyllus, and Cantharellus ruber. Concentrations of Cr, Ni, and Pb are under the EU norm in all six species, but values for Al, Co, Cu, Fe, Mn, and in some cases also for Zn or Cd are above. Significant differences between species were observed for Al, Cd, Co, Cr, Cu, Mn, and Zn. Large variations for Al and Fe concentrations are likely partly explained by soil dust contamination, as these two elements are very abundant in soils. Co, Cu, and Mn are abundant in soil samples of MMG-Kinsevere, Cr is abundant in soil samples of Mikembo. Cd concentrations are highest in Amanita while Al and Co reach the highest concentrations in Cantharellus species. Recommended tolerable, monthly, weekly or daily intake of metals and average metal concentrations in edible fungi were used to calculate the safe weekly consumption (SWC, in kg fresh weight/week) for a 60 kg person. Cd limits the consumption of A. loosii and A. pudica to 0.6 kg-1.2 kg FW/week, Fe limits Cantharellus congolensis and C. platyphyllus to 2.2 kg-2.5 kg FW/week and Al limits C. ruber and C. densifolius to 3.5 kg-3.8 kg FW/week. Recommendations are listed to further reduce the intake of metals through the consumption of wild edible fungi.
在上加丹加地区(刚果民主共和国),野生食用菌(WEF)是食物和收入的重要来源。本研究首次报道了从卢本巴希矿区采集的六种食用菌的微量金属含量。样本取自当地人采集果体供食用的地方。采用电感耦合等离子体光谱法(ICP-OES)测定了白桦伞、梅花伞、刚果油桐、密油桐、白桦油桐和橡胶油桐中Al、Cr、Cu、Co、Pb、Cd、Fe、Ni、Mn、Zn等10种微量金属的含量。在所有六种物种中,Cr、Ni和Pb的浓度都低于欧盟标准,但Al、Co、Cu、Fe、Mn的浓度,在某些情况下,Zn或Cd的浓度也高于欧盟标准。Al, Cd, Co, Cr, Cu, Mn和Zn在物种间存在显著差异。Al和Fe浓度的巨大变化可能部分归因于土壤粉尘污染,因为这两种元素在土壤中非常丰富。MMG-Kinsevere土壤样品中Co、Cu、Mn含量丰富,Mikembo土壤样品中Cr含量丰富。Cd在金刚伞属植物中含量最高,Al和Co在斑蝥属植物中含量最高。采用推荐耐受量、每月、每周或每天的金属摄入量以及食用菌中金属的平均浓度来计算一个60公斤体重的人的安全周摄入量(SWC,以公斤新鲜体重/周为单位)。镉对松茸和长叶松茸的摄取量限制在0.6 kg-1.2 kg FW/周,铁对刚果油桐和白桦油桐的摄取量限制在2.2 kg-2.5 kg FW/周,铝对橡胶油桐和密叶油桐的摄取量限制在3.5 kg-3.8 kg FW/周。建议通过食用野生食用菌进一步减少金属的摄入量。
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引用次数: 0
Antioxidant and Anti-diabetic Properties of Microalgae Spirulina platensis Produced in Turkey 土耳其产微藻螺旋藻的抗氧化和抗糖尿病特性
Pub Date : 2020-04-27 DOI: 10.37532/JFND.2020.9(2).273
Guldas Ziyanok, S-Demirtas, S. Yildiz, E. Yıldız
In our research, Spirulina produced in Turkey has a high antioxidant capacity that changes between 1.281 and 7.110 mg GAE/100 g and determined by the three common methods (ABTS, CUPRAC, and DPPH). The major phenolics found in Spirulina were acacetin (53.62%) and pinocembrin (41.28%). The bio-accessibility values of the phenolic compounds in Spirulina were approximately 60%. PUFA’s are the significant antioxidant compounds to prevent lipid peroxidation. S. platensis has been found to reduce blood sugar and oxidative stress due probably to the high amount of omega-6 PUFA. Antioxidant enzyme levels of GSH-Px and SOD were increased 140% and 59% in the healthy rats treated with Spirulina and the diabetics treated with Spirulina. In diabetic rats fed with Spirulina, glucose, triglyceride, total cholesterol levels in blood and malondialdehyde content in body tissues were decreased by 20, 31, 22 and up to 56%, respectively. In-vitro and in-vivo tests have shown that Spirulina has anti-hyperglycaemic, anti-hyperlipidaemia and antioxidative effects on diabetic rats.
在我们的研究中,土耳其生产的螺旋藻具有较高的抗氧化能力,在1.281 ~ 7.110 mg GAE/100 g之间,通过三种常用的方法(ABTS, CUPRAC和DPPH)测定。在螺旋藻中发现的主要酚类物质为双曲素(53.62%)和松皮素(41.28%)。螺旋藻中酚类化合物的生物可及性值约为60%。PUFA是防止脂质过氧化的重要抗氧化化合物。人们发现,可能是由于大量的omega-6 PUFA,白檀具有降低血糖和氧化应激的作用。健康大鼠和糖尿病大鼠体内抗氧化酶GSH-Px和SOD水平分别升高140%和59%。糖尿病大鼠喂食螺旋藻后,血液中葡萄糖、甘油三酯、总胆固醇和身体组织中丙二醛含量分别降低了20%、31%、22%和56%。体外和体内实验表明,螺旋藻对糖尿病大鼠具有抗高血糖、抗高脂血症和抗氧化作用。
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引用次数: 0
Multilevel Analysis of Determinants of Stunting Prevalence Among Children Under Age Five in Ethiopia: Evidence from 2016 Ethiopian Demographic and Health Survey Data 埃塞俄比亚5岁以下儿童发育迟缓患病率决定因素的多水平分析:来自2016年埃塞俄比亚人口与健康调查数据的证据
Pub Date : 2020-04-21 DOI: 10.37532/JFND.2020.9(2).272
Yenefenta Wube Bayileyegn
Background: Stunting is a well established child health indicator of chronic malnutrition related to environmental and socio economic circumstances. In Ethiopia, childhood stunting is the most widely prevalent among children under age five years. Thus, this study aimed to assess and model the determinants of stunting prevalence among children under age five in Ethiopia. Methods: Samples of 8487 children under age five and 640 community clusters were selected from the 2016 Ethiopian Demographic and Health Survey in this study. The survey sample was designed to provide national, urban/rural, and regional representative estimates for key health and demographic indicators. The sample was selected using a two-stage stratified sampling process. The statistical model applied to determine the individual and community level factors associated with childhood stunting in Ethiopia was multilevel logistic regression model. Results: This study revealed that the prevalence of stunting among children under age five years in Ethiopia was around 39.39%. The multilevel binary logistic regression analysis was performed to investigate the variation of predictor variables of the prevalence of stunting among children under age five. Accordingly, it has been identified that ages of the child above 12 months, male gender, children from poor households and no mother education have a significant effect on prevalence of stunting in Ethiopia. It is found that variances related to the random term were statistically significant implying that there is variation in prevalence of stunting across the regional states of Ethiopia. Conclusion: The current study confirmed that prevalence of stunting among children under aged five years in Ethiopia was severe public health problem, where 39.39% of them are stunting. Therefore, governmental and nongovernmental organizations or stakeholders should pay attention to all significant factors mentioned in the analysis of this study.
背景:发育迟缓是与环境和社会经济环境有关的慢性营养不良的一项公认的儿童健康指标。在埃塞俄比亚,儿童发育迟缓在5岁以下儿童中最为普遍。因此,本研究旨在评估和模拟埃塞俄比亚5岁以下儿童发育迟缓患病率的决定因素。方法:选取2016年埃塞俄比亚人口与健康调查中8487名5岁以下儿童和640个社区群为样本。调查样本的目的是提供国家、城市/农村和区域对主要健康和人口指标的代表性估计。样本的选择采用两阶段分层抽样过程。用于确定与埃塞俄比亚儿童发育迟缓相关的个人和社区层面因素的统计模型是多水平logistic回归模型。结果:本研究显示,埃塞俄比亚5岁以下儿童发育迟缓患病率约为39.39%。采用多水平二元logistic回归分析,探讨5岁以下儿童发育迟缓患病率的预测变量变化。因此,已查明,12个月以上儿童的年龄、男性、贫困家庭儿童和未受过母亲教育对埃塞俄比亚发育迟缓的发生率有重大影响。研究发现,与随机项相关的方差在统计上具有显著意义,这意味着埃塞俄比亚区域各州的发育迟缓患病率存在差异。结论:目前的研究证实,埃塞俄比亚五岁以下儿童发育迟缓的患病率是一个严重的公共卫生问题,其中39.39%的儿童发育迟缓。因此,政府和非政府组织或利益相关者应该关注本研究分析中提到的所有重要因素。
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引用次数: 1
Effect of Processing on Phytochemicals and Nutrient Composition of Tiger Nut (Cyperus esculentus L) 加工对虎坚果(Cyperus esculentus L)植物化学成分和营养成分的影响
Pub Date : 2020-04-21 DOI: 10.37532/JFND.2020.9(2).271
Ogunka-Nnoka Cu, Ben-Piakor Te, Mepba Hd, I. Mo
The study investigated the effect of processing on phytochemicals and nutrient composition of tiger nut (Cyperus esclentus L). Tiger nut also is known as Earth-almond was purchased as dried tiger nut tubers, carefully selected to remove dust particles and shared into four sets. The first set was further air-dried (EAAd) for four days and blended using laboratory miller. The second, third and fourth sets were soaked in water for four days to rehydrate. After which the following processing methods were applied; blanching at 80°C for 10 minutes (EAB), soaking in water to ferment for 4 days (EAF) and dehydrated (EAD) by oven drying again after rehydration respectively. The 2nd-4th sets were then oven-dried at a temperature of 60°C for 17 hours before milling into flour. Results of proximate analysis of the processed Earth-almond showed EAF to have the highest concentration of protein (8.37 ± 0.12), carbohydrate (49.01 ± 0.17) and ash (6.20 ± 0.12). The highest lipid (7.55 ± 0.06) and crude fibre (19.50 ± 0.23) was recorded for EAD, while the highest moisture content was recorded for EAB (19.71 ± 0.35). EAF, significantly (p<0.05) improved mineral and amino acid contents; while processing generally reduced the phytochemical content when compared with the air-dried sample (EAAd).
研究了加工对虎坚果(Cyperus esclentus L)植物化学物质和营养成分的影响。虎坚果也被称为土杏仁,是作为干燥的虎坚果块茎购买的,经过精心挑选去除灰尘颗粒,分成四份。第一组进一步风干(EAAd) 4天,并使用实验室研磨机混合。第二组,第三组和第四组在水中浸泡四天以补充水分。之后采用以下处理方法;80℃焯水10分钟(EAB),浸泡发酵4天(EAF),复水后再烘箱干燥脱水(EAD)。然后将第2 -4组在60°C的温度下烘干17小时,然后磨成面粉。结果表明,加工后的土杏仁蛋白(8.37±0.12)、碳水化合物(49.01±0.17)和灰分(6.20±0.12)含量最高。EAD的脂肪含量最高(7.55±0.06),粗纤维含量最高(19.50±0.23),EAB的水分含量最高(19.71±0.35)。EAF显著(p<0.05)提高了饲粮中矿物质和氨基酸含量;而与风干样品(EAAd)相比,处理通常降低了植物化学成分的含量。
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引用次数: 0
Dehydration and Cognition 脱水与认知
Pub Date : 2020-03-16 DOI: 10.37532/JFND.2020.9(1).268
S. Frank, T. Burkhalter
Dehydration is a common issue that many people will face at some point during their lifetime. Dehydration can cause an abundance of health problems, both physically and mentally. However, many people are unaware that a lack of hydration can impair their cognitive ability, which can be especially harmful to individuals enrolled in a university. College students are often overwhelmed by the chaos of homework and other obligations, causing them to spend little time reflecting on their health and well-being. Individuals may forget to eat or drink water on a daily basis, which can have negative consequences for both physical and mental health. Specifically, dehydration can cause a significant decline in a student’s academic performance.
脱水是许多人一生中都会面临的一个常见问题。脱水会导致身体和精神上的各种健康问题。然而,许多人都没有意识到,缺乏水分会损害他们的认知能力,这对大学新生来说尤其有害。大学生经常被作业和其他义务的混乱所淹没,导致他们很少花时间思考自己的健康和幸福。个人可能会忘记每天吃饭或喝水,这可能对身心健康产生负面影响。具体来说,脱水会导致学生学习成绩显著下降。
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引用次数: 1
The Relationship between Physical Activity, Diet, Fatty Acid Composition and Obesity, in Tunisian Population 突尼斯人群体力活动、饮食、脂肪酸组成与肥胖的关系
Pub Date : 2020-03-03 DOI: 10.37532/JFND.2020.9(1).269
W. Khamlaoui, S. Mehri, R. Chaaba, S. Hammami, M. Hammami
Aim: To study the situation of obesity in the Tunisian population by identifying the factors of contributing to obesity and exploring its impact on both genders. Methods: This is a descriptive retrospective study. We studied 401 randomly selected Tunisian subjects. Participants were characterized as obese if their BMI was ≥ 30 kg/m2. Results: A total of 401 patients aged 30-62 years were included in this study with a mean age of 48.94 ± 9.57 years. About 60.8% of patients are men and 39.2% are women. One hundred fifty three of patients were overweight and 61.8% were obese. Regarding diet, the majority of men consumed high amounts of fried potato, biscuits and sweets, Fruits and vegetables, sandwiches and Soft drinks and processed juices. Most of patients were physically inactive (63.9% of male and 59.2% of female practiced light physical activity). The majority of patients was farmers, employers and retires (36.4%, 30.2 and 18% respectively). Two hundred and sixteen of patients had high school level (53.3% of men and 54.8% of women). The major complication was dyslipidemia (58.1%), digestive diseases (11%) and immune disorders (9.5%).  Regarding treatments, most participants did not use treatment (43.1%: 27.9% males and 15.2% females).  Bariatricsurgery was more prevalent in male patients than females (8% vs. 7%). Plasma from female participants had significantly higher content of linoleic acid, γ-linolenic, Dihomo-γ-linolenic, docosatetraenoic, eicosapentaenoic, clupanodonic, docosahexaenoic acids than males. Conclusion: Obesity rates across Tunisia are alarming. The present study serves to highlight the need for better-quality surveillance data and effective public health interventions to curb rising obesity rates.
目的:通过确定导致肥胖的因素并探讨其对两性的影响,研究突尼斯人口的肥胖状况。方法:采用描述性回顾性研究。我们研究了401名随机选择的突尼斯人。如果参与者的BMI≥30 kg/m2,则被认为是肥胖。结果:共纳入401例患者,年龄30 ~ 62岁,平均年龄48.94±9.57岁。男性占60.8%,女性占39.2%。153例患者超重,61.8%为肥胖。在饮食方面,大多数男性食用大量油炸土豆、饼干和糖果、水果和蔬菜、三明治、软饮料和加工果汁。大多数患者缺乏体育活动(63.9%的男性和59.2%的女性进行轻度体育活动)。以农民、雇主和退休人员居多(分别为36.4%、30.2%和18%)。216例患者具有高中学历(男性53.3%,女性54.8%)。主要并发症为血脂异常(58.1%)、消化系统疾病(11%)和免疫系统疾病(9.5%)。在治疗方面,大多数参与者没有使用治疗(43.1%:男性27.9%,女性15.2%)。减肥手术在男性患者中比女性患者更普遍(8%对7%)。女性受试者血浆中亚油酸、γ-亚麻酸、二homo-γ-亚麻酸、二十二碳四烯酸、二十碳五烯酸、二十二碳六烯酸、二十二碳六烯酸的含量显著高于男性。结论:突尼斯全国的肥胖率令人担忧。本研究旨在强调需要更优质的监测数据和有效的公共卫生干预措施来遏制不断上升的肥胖率。
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引用次数: 0
Cancer Therapeutic and Preventive Effects of Dried Seaweed (Porphyra yezoensis) Extract by Gut Immunity Activation 干紫菜(Porphyra yezoensis)提取物对肠道免疫激活的治疗和预防癌症作用
Pub Date : 2020-03-03 DOI: 10.37532/JFND.2020.9(1).270
H. Ichihara, Masaki Okumura, T. Doi, Tatsuro Inano, K. Goto, Y. Matsumoto
The application of active ingredients in biomass in pharmaceutical products is eagerly anticipated, such as the use of dried seaweed (nori, Porphyra yezoensis) currently discarded as biomass. In this study, we used mice subcutaneously transplanted with malignant melanoma and lymphoma cells as models to examine the cancer-preventive and therapeutic effects of dried seaweed extract mediated by the immuno-stimulatory effects of components of the extract. The 15-day oral administration of seaweed extract resulted in lower tumor (melanoma) weight in the model mice. Time-dependent increases in IgA and IgG levels were observed in the serum of melanoma model mice following oral administration of seaweed extract. We observed an increase in IgA levels in a solution of the supernatant from homogenized ileal tissue from the melanoma model mice following the administration of seaweed extract. Furthermore, immunostaining revealed multiple IgA-positive cells in the ileal tissue sections of the melanoma model mice that were orally administered seaweed extract. In addition, when the model mice were orally administered seaweed extract for 7 days, the size of the subcutaneous lymphoma tumors tended to decrease, suggesting the therapeutic effect of the extract. When the mice were administered seaweed extract as a pre-treatment for 7 days before lymphoma tumor transplantation, significant shrinkage of the tumor was observed in the seaweed extract-treated mice compared with the control mice, which suggested the preventive effect of seaweed extract.
人们热切期待生物质中活性成分在医药产品中的应用,例如使用目前废弃的干海藻(海苔,紫菜)作为生物质。在本研究中,我们以小鼠皮下移植恶性黑色素瘤和淋巴瘤细胞为模型,研究了干海藻提取物通过其成分的免疫刺激作用介导的癌症预防和治疗作用。口服海藻提取物15天可降低模型小鼠的肿瘤(黑色素瘤)重量。口服海藻提取物后,黑色素瘤模型小鼠血清中IgA和IgG水平呈时间依赖性升高。我们观察到,在施用海藻提取物后,黑色素瘤模型小鼠匀浆回肠组织的上清液中IgA水平增加。此外,免疫染色显示口服海藻提取物的黑色素瘤模型小鼠的回肠组织切片中有多个iga阳性细胞。另外,模型小鼠口服海藻提取物7 d后,皮下淋巴瘤肿瘤有缩小的趋势,说明海藻提取物具有一定的治疗作用。在淋巴瘤肿瘤移植前7天给予海藻提取物作为预处理,与对照组相比,海藻提取物处理的小鼠肿瘤明显缩小,说明海藻提取物具有预防作用。
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引用次数: 0
Comparative Effects of Garlic, Yogurt, Beniseed Liquor and Fresh Orange Juice on Induced Type-1 Diabetes Mellitus in Rabbits using Streptozotocin 大蒜、酸奶、茴香酒和鲜橙汁对链脲佐菌素诱导家兔1型糖尿病的影响比较
Pub Date : 2019-11-26 DOI: 10.37532/jfnd.2019.8(3).267
Omoya Fo, M. Ao
Streptozotocin (STZ) was used to induce type-1 diabetes mellitus in animal models (twenty-one rabbits) at 60 mg/kg birth weight with two weekly booster doses to cause chronic diabetes in New Zealand White rabbits. They were given single intravenous dose of STZ in 1mL citrate buffer having a pH 4.6 and the booster dose given after 7 days and 14 days respectively. The blood glucose level was monitored along with the clinical signs including changes in behavior and weight loss. Treatment commenced immediately after the third booster when the rise in blood sugar was observed (4 hours later). They were treated with glucovance (a drug), fresh garlic extract, yogurt, beniseed liquor and orange juice for a period of 12 weeks (3 months) with the effect of the treatments checked on the glucose level of their blood, full blood count analysis using Mindray BC3300 auto-hematology analyzer and histopathology analysis of their pancreas. The results showed that the glucose level of the rabbits was within 70.02 ± 1.0 mg/dl at p ≤ 0.05 before they were induced. The level rose to 187.33 ± 0.9 mg/dl after the 3rd booster dose of streptozotocin was given to the rabbits. Gross morphology of selected organs showed that the inducement caused discoloration of the kidneys, oedema of the pancreas and significant increase in weight of the heart at p ≤ 0.05. There were no significant differences at p ≤ 0.05 between Packed Cell Volume (PCV) of the control group and the group induced and treated with diabetes drug; while there were significant differences in the fibrinogen values for the experimental groups. The induced type 1 diabetes mellitus caused an increase in the basophils, monocytes, and neutrophils while it caused significant decrease in the percentage of lymphocytes. Histopathologically, the inducement caused poor formation of the islet of Langerhans cells and dot necrotized cells. There is profuse hemorrhage from highly vascularized pancreatic acini surrounded by parenchyma fat cells. The group induced and treated with garlic extract showed some good features that not only depict a good and fast recovery from diabetes but showed some other health benefits of garlic. They are presence of well-formed pancreatic acini and cell infiltrations with well-spaced interstitial cells of the pancreas that shows active cell division of the pancreatic ducts and acini. There is splay and intrafaradization of the cracked pancreatic ducts. The presence of artifacts is seen at the anterior portion of the plate with well-formed interlobular and intralobular ducts. The effect of garlic extract as a good antidiabetic agent has been well established in this research. The curative strength of other foods such as yogurt and fruit extract has been proven in the findings of this research. Therefore, garlic has the most outstanding positive effect on diabetes and is recommended for people who are diabetic to feed on it or use it as food supplement.
采用链脲佐菌素(STZ)以60 mg/kg出生体重诱导1型糖尿病动物模型(21只兔),每周2次加强剂量诱导新西兰白兔慢性糖尿病。分别于第7天和第14天静脉注射pH为4.6的1mL柠檬酸缓冲液中的STZ单次静脉注射。监测血糖水平和临床症状,包括行为改变和体重减轻。当观察到血糖升高时(4小时后),在第三次强化治疗后立即开始治疗。他们接受葡萄糖(一种药物)、新鲜大蒜提取物、酸奶、茴香酒和橙汁治疗12周(3个月),检查治疗对他们血液中的葡萄糖水平的影响,使用迈瑞BC3300自动血液分析仪进行全血细胞计数分析,并对他们的胰腺进行组织病理学分析。结果表明:诱导前家兔血糖水平在70.02±1.0 mg/dl, p≤0.05;经第3次链脲佐菌素加强剂量后,家兔血清中该水平上升至187.33±0.9 mg/dl。所选脏器大体形态显示,诱导引起肾脏变色、胰腺水肿、心脏重量显著增加(p≤0.05)。对照组与糖尿病药物诱导和治疗组的细胞堆积体积(PCV)差异无统计学意义(p≤0.05);而实验组间纤维蛋白原值差异有统计学意义。诱导的1型糖尿病引起嗜碱性粒细胞、单核细胞和中性粒细胞增加,而淋巴细胞百分比明显下降。组织病理学上,诱导导致朗格汉斯细胞的胰岛形成不良和斑点坏死细胞。血管化程度高的胰腺腺泡被实质脂肪细胞包围,可见大量出血。用大蒜提取物诱导和处理的组显示出一些良好的特征,不仅描绘了糖尿病的良好和快速恢复,而且显示了大蒜的一些其他健康益处。可见形态良好的胰腺腺泡和间隙良好的胰腺间质细胞浸润,显示胰腺导管和腺泡细胞分裂活跃。破裂的胰管呈张开状和血管内化。在钢板前部可见假影,可见形成良好的小叶间和小叶内导管。大蒜提取物作为一种良好的抗糖尿病药物的作用已经在本研究中得到了很好的证实。其他食物如酸奶和水果提取物的疗效也在这项研究中得到了证实。因此,大蒜对糖尿病的积极作用最为突出,建议糖尿病患者食用大蒜或将其作为食物补充。
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引用次数: 3
Lactose-free Yogurts do not Show any Benefits for Lactose-Intolerant Subjects, Compared with Lactose- Containing Yogurts 与含乳糖酸奶相比,无乳糖酸奶对乳糖不耐症患者没有任何益处
Pub Date : 2019-07-31 DOI: 10.37532/jfnd.2019.8(3).262
Martin Gottel, Brittany Ghio, Daniel Márquez, Benjamín Peche, Franco Peña, Felipe Saavedra, Nicolas Palma, Constanza Cárcamo
Nowadays, there is constant increase of commercial lactose-free yogurts for lactose-intolerant individuals. However, the real interest of these yogurts is unclear considering that several clinical trials have shown that the living bacteria present in the yogurt improved lactose tolerance in hypolactasic subjects, due to their s-galactosidase activity that remains functional in the small intestine of these individuals. The aim of this study was to determine whether the intake of lactose-free yogurt (LFY) is beneficial for hypolactasic lactose-intolerant subjects compared with that of traditional, lactose-containing yogurt (LCY). Twenty-two subjects with auto-reported digestive symptoms after milk consumption carried out a hydrogen breath test (HBT) with 25g lactose to confirm their hypolactasic status. Fourteen subjects (63.6%) who exhibit a positive HBT accompanied by digestive symptoms were finally incorporated to the study. In two independent days, they have to ingest, in a double-blind and randomized form, 250g of LFY or LCY. These products brought 0.5g and 19.8g of lactose, respectively and both exhibited total counts of lactic acid bacteria higher than 107 CFU/g. Changes in breath H2 excretion and digestive symptoms were registered during 180 min. When the volunteers carried out the HBT with LFY and LCY, no differences were detected in H2 excretion or the intensity of digestive symptoms (individual or total). Accordingly, our results suggest than the intake of LFY that are more expensive than LCY, does not bring any supplementary detectable benefits for the lactose intolerant subjects.
如今,针对乳糖不耐症患者的商业无乳糖酸奶不断增加。然而,这些酸奶的真正意义尚不清楚,因为一些临床试验已经表明,酸奶中存在的活细菌可以改善低乳酸受试者的乳糖耐受性,因为它们的s-半乳糖苷酶活性在这些个体的小肠中保持功能。本研究的目的是确定与传统的含乳糖酸奶(LCY)相比,摄入无乳糖酸奶(LFY)是否对低乳酸性乳糖不耐症患者有益。对22名自行报告在牛奶消费后出现消化症状的受试者进行了含25g乳糖的氢呼气试验(HBT),以确认其低乳酸状态。14名HBT阳性并伴有消化症状的受试者(63.6%)最终被纳入研究。在独立的两天内,他们必须以双盲和随机的方式摄入250克LFY或LCY。这些产品的乳糖含量分别为0.5g和19.8g,乳酸菌总数均高于107 CFU/g。在180分钟内记录呼吸H2排泄和消化症状的变化。当志愿者与LFY和LCY一起进行HBT时,H2排泄和消化症状的强度(个体或总体)没有差异。因此,我们的研究结果表明,摄入比LCY更昂贵的LFY并没有给乳糖不耐症患者带来任何可检测到的补充益处。
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引用次数: 1
Unhealthy Diet in Children with Cancer: A Case-Reference Study 癌症儿童不健康饮食:一项病例参考研究
Pub Date : 2019-06-21 DOI: 10.4172/2324-9323.1000260
A. Passariello
AbstractObjective: To explore the dietary intake of a children’s cohort with cancer incomparison with an age-matched cohort of healthy children. MethodsWe enrolled children with a confirmed diagnosis of cancer (solid tumors, brain and blood malignancies) aged 1-18 years and agematched children as controls. A 3-days standardized food record was collected by a dietician blinded to the diagnosis. Differences of consumptions of nutrients were compared by parametric andnon-parametric tests, as appropriate. A multivariate discriminant analysis was used to identify the most effective nutrients to discriminate between the patients and controls.Results The diet of patients with solid tumors differed from that of the controls: they consumed a lower level of monounsaturated fats, a higher level of potential renal acid load and had a lower intake of vitamin E and B6. Children with blood malignancies showed greater differences with controls: they consumed lower quantities of calories, proteins, carbohydrates, monounsaturated fats, fibers and higher quantities of potential renal acid load and cholesterol. A multivariate analysis  iscriminated blood malignancy patients by controls, with 90% efficiency, by a lower intake of vitamin E, B6, saturated fats, starch and a higher intake of sodium andvitamin A. Conclusions This extensive analysis of nutrients showed imbalances from recommended dietary intake in children affected by cancer, with significantly less protective nutrients.
摘要:目的:探讨儿童癌症患者的膳食摄入量,并与同龄健康儿童进行比较。方法我们招募1-18岁确诊癌症(实体瘤、脑和血液恶性肿瘤)的儿童和年龄匹配的儿童作为对照。一名对诊断不知情的营养师收集了3天的标准化饮食记录。在适当的情况下,通过参数和非参数测试比较营养素消耗的差异。采用多变量判别分析来确定最有效的营养成分,以区分患者和对照组。结果实体瘤患者的饮食与对照组不同:他们消耗的单不饱和脂肪水平较低,潜在的肾酸负荷水平较高,维生素E和B6的摄入量较低。患有血液恶性肿瘤的儿童与对照组的差异更大:他们摄入的卡路里、蛋白质、碳水化合物、单不饱和脂肪、纤维的量更少,而潜在的肾酸负荷和胆固醇的量更高。一项多变量分析通过降低维生素E、B6、饱和脂肪、淀粉的摄入量,以及增加钠和维生素A的摄入量,将血液恶性肿瘤患者与对照组区分开来,其效率为90%。结论:这一广泛的营养分析表明,受癌症影响的儿童的推荐饮食摄入量不平衡,保护性营养显著减少。
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Journal of Food and Nutritional Disorders
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