Pub Date : 2021-02-18DOI: 10.1007/s11560-021-00490-6
H. Frank, C. Röcken
{"title":"Spezielle Ursache einer Niereninsuffizienz nach Dominolebertransplantation","authors":"H. Frank, C. Röcken","doi":"10.1007/s11560-021-00490-6","DOIUrl":"https://doi.org/10.1007/s11560-021-00490-6","url":null,"abstract":"","PeriodicalId":41844,"journal":{"name":"Nephrologe","volume":"16 1","pages":"299 - 302"},"PeriodicalIF":0.0,"publicationDate":"2021-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11560-021-00490-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47203128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-02-05DOI: 10.1007/s11560-021-00488-0
M. Fleck, C. Buser, H. Hopfer, M. Gregor, A. Fischer
{"title":"Alles hängt zusammen – oder auch nicht?","authors":"M. Fleck, C. Buser, H. Hopfer, M. Gregor, A. Fischer","doi":"10.1007/s11560-021-00488-0","DOIUrl":"https://doi.org/10.1007/s11560-021-00488-0","url":null,"abstract":"","PeriodicalId":41844,"journal":{"name":"Nephrologe","volume":"16 1","pages":"229 - 232"},"PeriodicalIF":0.0,"publicationDate":"2021-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11560-021-00488-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44755395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-22DOI: 10.1007/s11560-020-00481-z
G. S. Braun, Katharina Kittelmann, J. Floege
{"title":"Akute Nierenschädigung bei kardiorenalem Syndrom","authors":"G. S. Braun, Katharina Kittelmann, J. Floege","doi":"10.1007/s11560-020-00481-z","DOIUrl":"https://doi.org/10.1007/s11560-020-00481-z","url":null,"abstract":"","PeriodicalId":41844,"journal":{"name":"Nephrologe","volume":"16 1","pages":"71 - 80"},"PeriodicalIF":0.0,"publicationDate":"2021-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11560-020-00481-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44365299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01Epub Date: 2021-02-18DOI: 10.1007/s11560-021-00491-5
{"title":"Mitteilungen des BDI.","authors":"","doi":"10.1007/s11560-021-00491-5","DOIUrl":"https://doi.org/10.1007/s11560-021-00491-5","url":null,"abstract":"","PeriodicalId":41844,"journal":{"name":"Nephrologe","volume":"16 2","pages":"124-126"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11560-021-00491-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25395753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01Epub Date: 2021-02-03DOI: 10.1007/s11560-021-00487-1
Anja Gäckler, Oliver Witzke
Thrombotic microangiopathy (TMA) is characterized by an endothelium injury-associated formation of platelet clots in arterial and venous microvessels. Concomitant ischemia causes severe organ dysfunction and can be acutely life threatening. The underlying etiology of TMA shows a very heterogeneous disease spectrum. In addition to thrombotic thrombocytopenic purpura, which is characterized by a greatly reduced activity of a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13), infection-associated classical hemolytic uremic syndrome (HUS) and complement-mediated atypical HUS (aHUS), further very rare diseases or secondary forms can be present. The differential diagnostic classification is pivotal as different treatment approaches are necessary. Initiation of novel specific pharmacotherapy methods has greatly improved the prognosis of TMA.
{"title":"[Thrombotic microangiopathy].","authors":"Anja Gäckler, Oliver Witzke","doi":"10.1007/s11560-021-00487-1","DOIUrl":"https://doi.org/10.1007/s11560-021-00487-1","url":null,"abstract":"<p><p>Thrombotic microangiopathy (TMA) is characterized by an endothelium injury-associated formation of platelet clots in arterial and venous microvessels. Concomitant ischemia causes severe organ dysfunction and can be acutely life threatening. The underlying etiology of TMA shows a very heterogeneous disease spectrum. In addition to thrombotic thrombocytopenic purpura, which is characterized by a greatly reduced activity of a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13), infection-associated classical hemolytic uremic syndrome (HUS) and complement-mediated atypical HUS (aHUS), further very rare diseases or secondary forms can be present. The differential diagnostic classification is pivotal as different treatment approaches are necessary. Initiation of novel specific pharmacotherapy methods has greatly improved the prognosis of TMA.</p>","PeriodicalId":41844,"journal":{"name":"Nephrologe","volume":"16 2","pages":"113-123"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11560-021-00487-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25341292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01Epub Date: 2020-12-11DOI: 10.1007/s11560-020-00469-9
K Amann, P Boor, T Wiech
Apart from the pulmonary disease, acute kidney injury is one of the most frequent and most severe organ complications in severe coronavirus disease 2019 (COVID-19). Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) could also be detected in renal tissue. Patients with chronic kidney disease and on dialysis as well as kidney transplantation patients represent a particularly vulnerable population. The increasing number of patients infected with SARS-CoV‑2 has aroused increased interest in the exact pathophysiology and morphology of kidney damage as well as the direct detection of the virus in the kidneys, which in contrast to the lungs is overall more difficult to perform. Meanwhile, data from several large autopsy and kidney biopsy studies are now available. While the detection of SARS-CoV‑2 RNA in tissue leads to consistently reproducible results, the use of electron microscopy for visualization of the virus is critically discussed due to various artefacts. The exact and direct effects of SARS-CoV‑2 on the kidneys are not yet known in detail and are currently the focus of intensive research.
{"title":"[COVID-19 and kidney involvement].","authors":"K Amann, P Boor, T Wiech","doi":"10.1007/s11560-020-00469-9","DOIUrl":"https://doi.org/10.1007/s11560-020-00469-9","url":null,"abstract":"<p><p>Apart from the pulmonary disease, acute kidney injury is one of the most frequent and most severe organ complications in severe coronavirus disease 2019 (COVID-19). Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) could also be detected in renal tissue. Patients with chronic kidney disease and on dialysis as well as kidney transplantation patients represent a particularly vulnerable population. The increasing number of patients infected with SARS-CoV‑2 has aroused increased interest in the exact pathophysiology and morphology of kidney damage as well as the direct detection of the virus in the kidneys, which in contrast to the lungs is overall more difficult to perform. Meanwhile, data from several large autopsy and kidney biopsy studies are now available. While the detection of SARS-CoV‑2 RNA in tissue leads to consistently reproducible results, the use of electron microscopy for visualization of the virus is critically discussed due to various artefacts. The exact and direct effects of SARS-CoV‑2 on the kidneys are not yet known in detail and are currently the focus of intensive research.</p>","PeriodicalId":41844,"journal":{"name":"Nephrologe","volume":"16 1","pages":"14-19"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11560-020-00469-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38731589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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