Pub Date : 2023-07-25DOI: 10.36647/jpri/03.02.a001
Aasif Manzoor Bhat
Free radicals are the primary cause of the majority of degenerative diseases. The substances that collect free radicals are antioxidants. The main intent of current research was to make an inquiry into the phyto-chemical & in-vitro anti-oxidant profile of fruit husk of Juglans regia extract. The technique used to put to the test the antioxidant abilities of extracts included the DPPH assay, superoxide radical scavenging, ferric thiocyanate (FTC], and hydroxyl radical scavenging assay. Preliminary phytochemical analysis was screened using standard methods. Phytochemical investigation found that it contains carbohydrates, alkaloids, terpenoids, tannins, flavonoids, glycosides and saponins. Methanolic extract of Juglans regia showed better antioxidant capability than ethyl acetate extract. According to the results of this study, Juglans regia fruit husks may be a reliable source of natural antioxidants.
{"title":"Phytochemical Analysis and Antioxidant Activity of Juglans Regia L.","authors":"Aasif Manzoor Bhat","doi":"10.36647/jpri/03.02.a001","DOIUrl":"https://doi.org/10.36647/jpri/03.02.a001","url":null,"abstract":"Free radicals are the primary cause of the majority of degenerative diseases. The substances that collect free radicals are antioxidants. The main intent of current research was to make an inquiry into the phyto-chemical & in-vitro anti-oxidant profile of fruit husk of Juglans regia extract. The technique used to put to the test the antioxidant abilities of extracts included the DPPH assay, superoxide radical scavenging, ferric thiocyanate (FTC], and hydroxyl radical scavenging assay. Preliminary phytochemical analysis was screened using standard methods. Phytochemical investigation found that it contains carbohydrates, alkaloids, terpenoids, tannins, flavonoids, glycosides and saponins. Methanolic extract of Juglans regia showed better antioxidant capability than ethyl acetate extract. According to the results of this study, Juglans regia fruit husks may be a reliable source of natural antioxidants.","PeriodicalId":419985,"journal":{"name":"Journal of Pharmaceutical Research and Innovation","volume":"95 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133111464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-30DOI: 10.36647/jpri/03.01.a002
Monisha Krishnan, L. Narasimman
Catheter use in debilitated patients often precedes a number of nosocomial infections by bacterial strains that show multidrug resistance or total drug resistance, particularly through biofilm formation. Common etiological agents include Staphylococcus aureus (MRSA), Pseudomonas aeruginosa, Escherichia coli, Salmonella spp., Klebsiella spp., Acinetobacter baumannii, and Burkholderia cepacia. As catheters provide exposure to typically sterile environments, fomites and aerosols are able to transfer severe infection to the affected patients, particularly due to their immunocompromised states. The catheters may be coated using a hydrogel layer containing immobilized bacteriophages, yet different approaches may be used, including stratification, serial activation of strata, liquid nanocoatings, diffusible membranes, multi-receptor bacteriophages, and the use of lytic and lysogenic phages should be distinguished. The multifaceted growth requirements of the bacteria additionally allow for factors such as pH and temperature to be utilized in the hydrogel layer through absorptive action once bacterial attachment to the layer occurs. Moreover, nanocoating is aimed at preventing the colonization of numerous bacterial cells, thus inhibiting quorum sensing ability of the bacteria and biofilm formation.
{"title":"A Review on Potential Applications of Phage-Based Binding Affinity in Antibacterial Catheter Nanocoatings","authors":"Monisha Krishnan, L. Narasimman","doi":"10.36647/jpri/03.01.a002","DOIUrl":"https://doi.org/10.36647/jpri/03.01.a002","url":null,"abstract":"Catheter use in debilitated patients often precedes a number of nosocomial infections by bacterial strains that show multidrug resistance or total drug resistance, particularly through biofilm formation. Common etiological agents include Staphylococcus aureus (MRSA), Pseudomonas aeruginosa, Escherichia coli, Salmonella spp., Klebsiella spp., Acinetobacter baumannii, and Burkholderia cepacia. As catheters provide exposure to typically sterile environments, fomites and aerosols are able to transfer severe infection to the affected patients, particularly due to their immunocompromised states. The catheters may be coated using a hydrogel layer containing immobilized bacteriophages, yet different approaches may be used, including stratification, serial activation of strata, liquid nanocoatings, diffusible membranes, multi-receptor bacteriophages, and the use of lytic and lysogenic phages should be distinguished. The multifaceted growth requirements of the bacteria additionally allow for factors such as pH and temperature to be utilized in the hydrogel layer through absorptive action once bacterial attachment to the layer occurs. Moreover, nanocoating is aimed at preventing the colonization of numerous bacterial cells, thus inhibiting quorum sensing ability of the bacteria and biofilm formation.","PeriodicalId":419985,"journal":{"name":"Journal of Pharmaceutical Research and Innovation","volume":"98 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128194874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-30DOI: 10.36647/jpri/03.01.a001
P. Sahu, N. Gupta
Writing research reveals that there is no thorough explanatory approach for the examination of selected pharmaceuticals Nebivolol and Hydrochlorothaizide, ALSK and Amlodipine, and ATNL and BCTM by synchronous estimation using Bio pertinent media in RP-HPLC using Bio pertinent media. HPLC, HPTLC and spectrophotometer are scientific methods that may be used to analyse mixtures either alone or in combination with other procedures. As a result, it was decided that a new logical strategy innovation was required for the simultaneous estimation of Nebivolol and Hydrochlorothaizide, ALSK and Amlodipine, ATNL and BCTM in pharmaceutical dosage frames and their estimate in bioapplicable medium. RP-HPLC for synchronous examination of Nebivolol and Hydrochlorothaizide, ALSK and Amlodipine, and ATNL and BCTM is being developed to establish another fundamental, rapid and accurate, prolific and repeatable RP-HPLC technology. By adhering to ICH regulations, the method will be accepted.
{"title":"Method Development and Validation of Anti Diabetic and Antihypertensive Drugs by using- RP HPLC","authors":"P. Sahu, N. Gupta","doi":"10.36647/jpri/03.01.a001","DOIUrl":"https://doi.org/10.36647/jpri/03.01.a001","url":null,"abstract":"Writing research reveals that there is no thorough explanatory approach for the examination of selected pharmaceuticals Nebivolol and Hydrochlorothaizide, ALSK and Amlodipine, and ATNL and BCTM by synchronous estimation using Bio pertinent media in RP-HPLC using Bio pertinent media. HPLC, HPTLC and spectrophotometer are scientific methods that may be used to analyse mixtures either alone or in combination with other procedures. As a result, it was decided that a new logical strategy innovation was required for the simultaneous estimation of Nebivolol and Hydrochlorothaizide, ALSK and Amlodipine, ATNL and BCTM in pharmaceutical dosage frames and their estimate in bioapplicable medium. RP-HPLC for synchronous examination of Nebivolol and Hydrochlorothaizide, ALSK and Amlodipine, and ATNL and BCTM is being developed to establish another fundamental, rapid and accurate, prolific and repeatable RP-HPLC technology. By adhering to ICH regulations, the method will be accepted.","PeriodicalId":419985,"journal":{"name":"Journal of Pharmaceutical Research and Innovation","volume":"81 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134539736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-21DOI: 10.36647/jpri/02.02.a005
Vanita Suthar
Punica Granatum L. is in the family Punicaceae, which has a lot of different species. Pomegranate contains a high concentration of potentially bioactive compounds throughout the fruit, including the kernel, peel, juice and leaves. In traditional medical practise, these plants have been utilised to treat a variety of conditions, including those related to the digestive tract, cardiovascular health, and the endocrine system. The goal of this study was to give an overview of what scientists and traditional healers know about P. Granatum in terms of its phytochemical composition and medicinal uses. This information could be used to make new medicines in the near future. There have been reports that the plant has a wide variety of phytochemical components: these components include polyphenolics, flavonoids, anthocyanosides, alkaloids, and terpenes. In randomised clinical trials, the pharmacological effects of pomegranate have been found to be beneficial for a variety of diseases and conditions. These conditions and diseases include diabetes, cardiovascular disease, problems with the oral mucosa, endocrine disorders, and cancer. Some of the traditional applications of the plants have been backed by scientific research, specifically their use in the diagnosis of cardiovascular and endocrine disorders.
{"title":"Therapeutic Effects of Pomegranate (Punica Granatum)","authors":"Vanita Suthar","doi":"10.36647/jpri/02.02.a005","DOIUrl":"https://doi.org/10.36647/jpri/02.02.a005","url":null,"abstract":"Punica Granatum L. is in the family Punicaceae, which has a lot of different species. Pomegranate contains a high concentration of potentially bioactive compounds throughout the fruit, including the kernel, peel, juice and leaves. In traditional medical practise, these plants have been utilised to treat a variety of conditions, including those related to the digestive tract, cardiovascular health, and the endocrine system. The goal of this study was to give an overview of what scientists and traditional healers know about P. Granatum in terms of its phytochemical composition and medicinal uses. This information could be used to make new medicines in the near future. There have been reports that the plant has a wide variety of phytochemical components: these components include polyphenolics, flavonoids, anthocyanosides, alkaloids, and terpenes. In randomised clinical trials, the pharmacological effects of pomegranate have been found to be beneficial for a variety of diseases and conditions. These conditions and diseases include diabetes, cardiovascular disease, problems with the oral mucosa, endocrine disorders, and cancer. Some of the traditional applications of the plants have been backed by scientific research, specifically their use in the diagnosis of cardiovascular and endocrine disorders.","PeriodicalId":419985,"journal":{"name":"Journal of Pharmaceutical Research and Innovation","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115294143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-21DOI: 10.36647/jpri/02.02.a006
Vanita Suthar
Tulsi has a significant amount of therapeutic value. Studies have shown that Tulsi can help people with diabetes by lowering the amount of glucose in their blood. Tulsi is a powerful medicine that can treat severe cases of acute respiratory syndrome. The juice extracted from its leaves is said to be effective in treating coughs, bronchitis, fever, and colds. The ear drop that is utilised is also made from tulsi oil. Tulsi is beneficial in the treatment of malaria. It is highly efficient against conditions such as cholera, indigestion, headaches, hysteria, and insomnia. Every day, millions of people all around the world consume the fresh leaves of the Tulsi plant. Tulsi is particularly useful for supporting the functions of the heart, blood vessels, liver, and lungs, and it can also help manage blood pressure and blood sugar levels. In nearly all of the old ayurvedic writings that have been preserved, OS has been praised highly for the excellent medicinal powers it possesses. It has a taste that is pungent and astringent, and the effect that it has on the body is one that is hot, light and dry. It is said that the seeds of this plant have a chilling effect on the humans who consume them. Tulsi has various different therapeutic characteristics that can be found in its roots, leaves, and seeds. It has been given upon us by Mother Nature a very rich botanical richness, and throughout the United States you can find a wide variety of plant species growing in their natural habitats. Traditional medicine, modern medicine, modern drugs, nutraceuticals, food ingredients, folk medicine, pharmaceuticals and the chemicals that are used to make synthetic drugs all get most of their drugs from plants. Plants used for medical purposes have a significant economic worth in many parts of the world. Tulsi, which is also known as Ocimum sanctum Linn, is a too useful plant that is used in India's traditional medical practises. In the next round of studies, the healing properties of this plant will be looked into, since it has been shown to help with a broad range of oral and systemic conditions
{"title":"Benefit of Tulsi for General and Dental Medicine","authors":"Vanita Suthar","doi":"10.36647/jpri/02.02.a006","DOIUrl":"https://doi.org/10.36647/jpri/02.02.a006","url":null,"abstract":"Tulsi has a significant amount of therapeutic value. Studies have shown that Tulsi can help people with diabetes by lowering the amount of glucose in their blood. Tulsi is a powerful medicine that can treat severe cases of acute respiratory syndrome. The juice extracted from its leaves is said to be effective in treating coughs, bronchitis, fever, and colds. The ear drop that is utilised is also made from tulsi oil. Tulsi is beneficial in the treatment of malaria. It is highly efficient against conditions such as cholera, indigestion, headaches, hysteria, and insomnia. Every day, millions of people all around the world consume the fresh leaves of the Tulsi plant. Tulsi is particularly useful for supporting the functions of the heart, blood vessels, liver, and lungs, and it can also help manage blood pressure and blood sugar levels. In nearly all of the old ayurvedic writings that have been preserved, OS has been praised highly for the excellent medicinal powers it possesses. It has a taste that is pungent and astringent, and the effect that it has on the body is one that is hot, light and dry. It is said that the seeds of this plant have a chilling effect on the humans who consume them. Tulsi has various different therapeutic characteristics that can be found in its roots, leaves, and seeds. It has been given upon us by Mother Nature a very rich botanical richness, and throughout the United States you can find a wide variety of plant species growing in their natural habitats. Traditional medicine, modern medicine, modern drugs, nutraceuticals, food ingredients, folk medicine, pharmaceuticals and the chemicals that are used to make synthetic drugs all get most of their drugs from plants. Plants used for medical purposes have a significant economic worth in many parts of the world. Tulsi, which is also known as Ocimum sanctum Linn, is a too useful plant that is used in India's traditional medical practises. In the next round of studies, the healing properties of this plant will be looked into, since it has been shown to help with a broad range of oral and systemic conditions","PeriodicalId":419985,"journal":{"name":"Journal of Pharmaceutical Research and Innovation","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127754857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-12DOI: 10.36647/jpri/02.01.a002
Upendra Kumar, Hifza Jamal, Prashansa Kapoor, Samyak Jain, S. Khan, Abhinay Mishra, Pawan Rao, Dr. Gaurav Rajauria, D. J. Patel
Background: Diabetic complications are becoming common community problems. The outcomes of diabetic complications are increased hospitalization, increased direct patient costs, and mortality. In Dessie, the prevalence of diabetic complications is not well studied so far. Aim: This study aims to assess the prevalence of diabetic complications and associated factors among adult diabetic patients in north India. Method & Materials: A cross-sectional study was conducted from Jan to March 2020, in the general medicine department. All diabetic patients who visited the clinic during the study period were included. Data was collected using an interview-guided-administered questionnaire. the presence of complications and the type of medications the patient was on were identified through a review of patient records. Results: Eighty-one (81) diabetic patients who came to the follow-up clinic during the 3 months of data collection were included in the study. The majority of the patients (57.4%) were males. The median age of the patients was 45 (±17.677) and they were known diabetic patients for a mean duration of 5.00 (±5.70) years. Complications were strongly associated with the occurrence of diabetic complications but self-reported adherence, attitude, and knowledge level of patients. Conclusion: The prevalence of complications among diabetic patients in Dessie Referral Hospital was high. Targeted counseling and health information provided to the patients by the clinical staff will help reduce avoidable morbidity and mortality in the patients. Keyword : — Diabetes, Complication, Ketoacidosis, Hypoglycemia, Prevalence
{"title":"Diabetic Complications among Adult Diabetic Patients","authors":"Upendra Kumar, Hifza Jamal, Prashansa Kapoor, Samyak Jain, S. Khan, Abhinay Mishra, Pawan Rao, Dr. Gaurav Rajauria, D. J. Patel","doi":"10.36647/jpri/02.01.a002","DOIUrl":"https://doi.org/10.36647/jpri/02.01.a002","url":null,"abstract":"Background: Diabetic complications are becoming common community problems. The outcomes of diabetic complications are increased hospitalization, increased direct patient costs, and mortality. In Dessie, the prevalence of diabetic complications is not well studied so far. Aim: This study aims to assess the prevalence of diabetic complications and associated factors among adult diabetic patients in north India. Method & Materials: A cross-sectional study was conducted from Jan to March 2020, in the general medicine department. All diabetic patients who visited the clinic during the study period were included. Data was collected using an interview-guided-administered questionnaire. the presence of complications and the type of medications the patient was on were identified through a review of patient records. Results: Eighty-one (81) diabetic patients who came to the follow-up clinic during the 3 months of data collection were included in the study. The majority of the patients (57.4%) were males. The median age of the patients was 45 (±17.677) and they were known diabetic patients for a mean duration of 5.00 (±5.70) years. Complications were strongly associated with the occurrence of diabetic complications but self-reported adherence, attitude, and knowledge level of patients. Conclusion: The prevalence of complications among diabetic patients in Dessie Referral Hospital was high. Targeted counseling and health information provided to the patients by the clinical staff will help reduce avoidable morbidity and mortality in the patients. Keyword : — Diabetes, Complication, Ketoacidosis, Hypoglycemia, Prevalence","PeriodicalId":419985,"journal":{"name":"Journal of Pharmaceutical Research and Innovation","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116331628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-12DOI: 10.36647/jpri/02.02.a004
Prashant Chakravarty, Dr. Azimkhan Pathan
Commonly, this legal instrument, which serves as the foundation for the current global drug enforcement structure centred by the UN System, is misunderstood as merely a convention to integrate all previous international security agreements. This is a fallacious position that provides no historical background for contemporary discussions concerning the modification of a similar international agreement system. From a historic and international relations approach, this essay recreates the development of the Convention. A criticism of fundamental pre-1961 agreements is preceded by a comprehensive evaluation of the government records of a United Nations gathering for adopted families of the a Single Symposium on Narcotic Drugs as well as an examination of a status of the treaty as a "solitary" conference in light of successive treaties. The Single Conference on Controlled Substances constitutes a substantial departure from of the locus of control of earlier international conventions; a shift to a more prohibitive perspective that, in terms of international interactions, could be regarded as a transitional government as opposed to the a mere formalisation of earlier instruments. In this way, the essay stresses the eradication of drug use, which has been deeply ingrained in the cultural, economic, and religious traditions of numerous non-Western societies for millennia. In addition, despite being frequently disregarded, this Agreement has failed to perform its stated function as the "only" international instrument for drug control. As a result of the additional treaties signed in later years and the shifting socioeconomic and political settings, the control system contains substantial inconsistencies. Even if a shift of prescriptive focus has happened, this paper suggests that a single panel discussion of Controlled Drugs should be revived in order to correct past mistakes and contradictions within the government, especially with relation to scheduling and conventional narcotic use. Keywords : — Narcotic Drugs, Psychotropic Substances policy, traditional drug.
{"title":"Revisiting The National Narcotic Drugs and Psychotropic Substances policy of India: A Critical Evaluation","authors":"Prashant Chakravarty, Dr. Azimkhan Pathan","doi":"10.36647/jpri/02.02.a004","DOIUrl":"https://doi.org/10.36647/jpri/02.02.a004","url":null,"abstract":"Commonly, this legal instrument, which serves as the foundation for the current global drug enforcement structure centred by the UN System, is misunderstood as merely a convention to integrate all previous international security agreements. This is a fallacious position that provides no historical background for contemporary discussions concerning the modification of a similar international agreement system. From a historic and international relations approach, this essay recreates the development of the Convention. A criticism of fundamental pre-1961 agreements is preceded by a comprehensive evaluation of the government records of a United Nations gathering for adopted families of the a Single Symposium on Narcotic Drugs as well as an examination of a status of the treaty as a \"solitary\" conference in light of successive treaties. The Single Conference on Controlled Substances constitutes a substantial departure from of the locus of control of earlier international conventions; a shift to a more prohibitive perspective that, in terms of international interactions, could be regarded as a transitional government as opposed to the a mere formalisation of earlier instruments. In this way, the essay stresses the eradication of drug use, which has been deeply ingrained in the cultural, economic, and religious traditions of numerous non-Western societies for millennia. In addition, despite being frequently disregarded, this Agreement has failed to perform its stated function as the \"only\" international instrument for drug control. As a result of the additional treaties signed in later years and the shifting socioeconomic and political settings, the control system contains substantial inconsistencies. Even if a shift of prescriptive focus has happened, this paper suggests that a single panel discussion of Controlled Drugs should be revived in order to correct past mistakes and contradictions within the government, especially with relation to scheduling and conventional narcotic use. Keywords : — Narcotic Drugs, Psychotropic Substances policy, traditional drug.","PeriodicalId":419985,"journal":{"name":"Journal of Pharmaceutical Research and Innovation","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123391071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-12DOI: 10.36647/jpri/02.02.a002
Aasif Manzoor Bhat, R. Qureshi, M. Yaseen
Antioxidant plays a major role in protecting our body from disease by reducing the oxidative damage to cellular component caused by Reactive Oxygen Species. The antioxidant activity of plant extracts was determined by different in vitro methods such as the DPPH free radical scavenging assay, SOS activity,hydroxyl radical scavenging and ferric thiocynate activity. Decreased absorbance of the reaction mixture indicates stronger scavenging activity. DPPH radical scavenging activity of Betula utilis ethyl acetate and methanolic extract exhibited percent inhibition 72% and its IC50 value was found to be 30.16 μg/ml and 83.86% and its IC50 value was found to be 27.62 μg/ml respectively. Ascorbic acid was used as a reference compound which exhibited percent inhibition 91.81% and showed IC50 value of 25.82 μg/ml. The Betula utilis ethyl acetate extract displayed SOS activity which exhibited percent inhibition of 72.49% and showed IC50 value of 44.47μg/ml. Similarly, SOS scavenger activity of Betula utilis methanol extract exhibited percent inhibition 81.49% and its IC50 value was found to be 20μg/ml. For SOS activity, Ascorbic acid was used as a reference compound which exhibited percent inhibition 86.72% and showed IC50 value of 12.01μg/ml. Hydroxyl radical scavenging activity of Betula utilis ethyl acetate and methanol extract exhibited percent inhibition 76.93 and 81.62% and its IC50 value was found to be 48.003 and 27.14μg/ml. Similarly, ferric thiocynate activity Betula utilis ethyl acetate and methanol extract exhibited percent inhibition 74.68 and 81.27% and its IC50 value was found to be 40.112 and 23.79μg/ml.The Betula utilis could be valuable natural source of antioxidants that could be further applied for the development of useful pharmaceutical products. Keyword : — Methanolic extract, Ferric thiocynate activity, Betula utilis, Ascorbic acid
{"title":"Phytochemical Investigation and Antioxidant Activity of Methanolic Extract of Betula Utilis Bark","authors":"Aasif Manzoor Bhat, R. Qureshi, M. Yaseen","doi":"10.36647/jpri/02.02.a002","DOIUrl":"https://doi.org/10.36647/jpri/02.02.a002","url":null,"abstract":"Antioxidant plays a major role in protecting our body from disease by reducing the oxidative damage to cellular component caused by Reactive Oxygen Species. The antioxidant activity of plant extracts was determined by different in vitro methods such as the DPPH free radical scavenging assay, SOS activity,hydroxyl radical scavenging and ferric thiocynate activity. Decreased absorbance of the reaction mixture indicates stronger scavenging activity. DPPH radical scavenging activity of Betula utilis ethyl acetate and methanolic extract exhibited percent inhibition 72% and its IC50 value was found to be 30.16 μg/ml and 83.86% and its IC50 value was found to be 27.62 μg/ml respectively. Ascorbic acid was used as a reference compound which exhibited percent inhibition 91.81% and showed IC50 value of 25.82 μg/ml. The Betula utilis ethyl acetate extract displayed SOS activity which exhibited percent inhibition of 72.49% and showed IC50 value of 44.47μg/ml. Similarly, SOS scavenger activity of Betula utilis methanol extract exhibited percent inhibition 81.49% and its IC50 value was found to be 20μg/ml. For SOS activity, Ascorbic acid was used as a reference compound which exhibited percent inhibition 86.72% and showed IC50 value of 12.01μg/ml. Hydroxyl radical scavenging activity of Betula utilis ethyl acetate and methanol extract exhibited percent inhibition 76.93 and 81.62% and its IC50 value was found to be 48.003 and 27.14μg/ml. Similarly, ferric thiocynate activity Betula utilis ethyl acetate and methanol extract exhibited percent inhibition 74.68 and 81.27% and its IC50 value was found to be 40.112 and 23.79μg/ml.The Betula utilis could be valuable natural source of antioxidants that could be further applied for the development of useful pharmaceutical products. Keyword : — Methanolic extract, Ferric thiocynate activity, Betula utilis, Ascorbic acid","PeriodicalId":419985,"journal":{"name":"Journal of Pharmaceutical Research and Innovation","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122013183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-12DOI: 10.36647/jpri/02.01.a003
Tejas P. Chandankhede
Introduction: Chronic pancreatitis is an inflammatory disease characterized by progressive destruction of the anatomy and function of the pancreas. The cells are replaced by tissue fibrosis with repeat attacks of pancreatitis. Chronic pancreatitis is an old inflammatory disease that Causes scarring of the pancreas and irreversible changes. Chronic pancreatitis causes abdominal pain and in some cases diabetes and large, bulky fatty stools. Clinical Findings: Abdominal pain, loss of appetite , vomiting , Fever .Diagnostic Evaluation : Bilirubin total : conjugated – 0.14, , blood test : RBS glucose -180, monocyte -0.2% , Granulocytes -00% , HCT -37. Ultrasonography: Pancreatic cholangiopancreatography Therapeutic Intervention : Tab .Pantaprazole 40 mg orally x OD , Tab . Lipcerna 1 tab 1,000 orally with orally TDS, Tab. Antoxipan 1 tab orally x OD , Tab .Omee 20 mg orally x OD , Syr .Aristozyme 200 ml orally x OD , Tab .Paracetamol 650 mg orally x BD . Outcome : After treatment , the patient show improvement My patient was admitted in medicine ward No -28, with AVBRH with a known case of chronic pancreatitis and he has the chief complaint of fever and pain in the abdomen . After appropriate treatment his condition are improved. Keyword : — Calculus; Diabetes; Epidemiology; India; Islets of Langerhans; Manihot; Pancreas, Exocrine; Pancreatitis, Alcoholism; Pancreatitis, Chronic; Frequency.
慢性胰腺炎是一种以胰腺解剖结构和功能的进行性破坏为特征的炎症性疾病。这些细胞被胰腺炎反复发作的组织纤维化所取代。慢性胰腺炎是一种古老的炎症性疾病，可导致胰腺瘢痕形成和不可逆的变化。慢性胰腺炎会引起腹痛，在某些情况下还会引起糖尿病和大量的脂肪性大便。临床表现:腹痛，食欲不振，呕吐，发热。诊断评价:总胆红素:共轭- 0.14，，血检:RBS葡萄糖-180，单核细胞-0.2%，粒细胞-00%，HCT -37。治疗干预:泮他拉唑40mg口服x OD，Lipcerna 1片口服1000次，口服TDS，安托西班1片口服x OD，欧米尼片口服20 mg x OD，阿里斯托酵素片口服200 ml x OD，扑热息痛片口服650 mg x BD。结果:经治疗，患者病情好转。患者入住内科-28病房，AVBRH合并已知慢性胰腺炎病例，主诉为发热、腹部疼痛。经过适当的治疗，他的病情有所好转。关键词:微积分;糖尿病;流行病学;印度;朗格汉斯群岛;木薯;胰腺外分泌;胰腺炎,酗酒;慢性胰腺炎;频率。
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Pub Date : 2022-07-12DOI: 10.36647/jpri/02.02.a003
V. R
Dry powder inhalation method has been convincing method for treating respiratory diseases as it directly delivers the drugs to the lungs in the form of fine powder. The novel coronavirus causes respiratory infection mainly targeting the ACE-2 receptors in the lower respiratory tract. Repurposing drugs like Remdesivir, Ivermectin, Favipiravir for treatment of covid-19 can be prepared as powders for inhalation. Covid-19 pandemic has increased the application of dry powder inhalation therapy of antiviral drugs. This review presents account on pulmonary drug delivery of repurposing drugs for treatment of Covid-19. Index Terms : — Dry powder inhalers, Novel Coronavirus, Repurposing drugs.
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