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Third Edition of the HSI Journal: Volume 2 Issue 1, 2021 Publication.最新文献

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Multilevel analysis of risk factors associated with severe underweight among children under 5 years: evidence from the 2014 Ghana Demographic and Health Survey 5岁以下儿童严重体重不足相关风险因素的多层次分析:来自2014年加纳人口与健康调查的证据
Pub Date : 2021-06-29 DOI: 10.46829/hsijournal.2021.6.2.1.166-172
J. Aheto, D. O. Alangea
Background: Undernutrition among children <5yr. is a global public health problem, especially in developing countries like Ghana. Undernutrition increases the risk of child morbidity and mortality. There is paucity of data on household-level effects on severe underweight and associated factors. Objective: The study investigated the risk factors associated with severe underweight among children < 5yr.in Ghana and examined unobserved differences across households based on the 2014 Ghana Demographic and Health surveys (GDHS) data. Methods: Data from a population-based cross-sectional study was obtained from the 2014 Ghana Demographic and Health Survey. Data on 2720 children nested within 1972 households was extracted for analysis. Our regression analysis used data on 2716 children with complete data on the outcome and risk factors. Children with weight-for-age Z-score below -3 standard deviations were classified as severely underweight based on the 2006 WHO child growth standards. We applied random intercept multilevel logistic regression to examine whether severe underweight status in children differ across households while simultaneously identifying potential risk factors.Results: A total of 2720 children had valid weight-for-age z-score and 53 (1.95%) of them were identified as severely underweight. In the univariate model, child level variables such as multiple birth [odds ratio (OR), 4.03;95%confidence interval (CI): 1.85-8.76]and child born average (OR, 2.17;95%CI: 1.09-4.32) or small (OR, 4.08; 95%CI: 2.01-8.28) in size at birth are associated with increased odds of severe underweight. Maternal/household level variables such as increase in number of children below 5 yr. (OR, 1.61; 95%CI: 1.28-2.04), poorest households (OR, 4.85; 95%CI: 1.14-20.59) and increase in number of births in last 5 yr. (OR, 1.80, 95%CI: 1.24-2.60) were associated with increased odds of severe underweight. Increase in maternal years of education (OR, 0.89; 95%CI: 0.83-0.95) was associated with reduced odds of severe underweight. In the multilevel logistic model, only type of birth (OR, 1.61;95%CI: 1.28-2.04), size of child (average: OR, 2.12;95%CI: 1.04-4.33; small: OR, 3.87;95%CI: 1.80-8.33) at birth, and maternal education (OR, 0.92;95%CI: 0.84-1.00) were independently associated with severe underweight. There were no significant residual household-level variations in severe underweight status.Conclusion:Our findings suggest that improving maternal education, socioeconomic conditions of families, and family planning are critical in addressing severe underweight
背景:5岁以下儿童营养不良。是一个全球性的公共卫生问题,特别是在加纳这样的发展中国家。营养不良增加了儿童发病和死亡的风险。关于严重体重不足及其相关因素的家庭层面影响的数据不足。目的:探讨5岁以下儿童严重体重不足的相关危险因素。并根据2014年加纳人口与健康调查(GDHS)数据检查了未观察到的家庭差异。方法:基于人群的横断面研究数据来自2014年加纳人口与健康调查。提取了1972个家庭中2720名儿童的数据进行分析。我们的回归分析使用了2716名儿童的数据,这些数据具有完整的结果和危险因素数据。根据2006年世卫组织儿童生长标准,年龄体重z分数低于-3个标准差的儿童被归类为严重体重不足。我们采用随机截距多水平逻辑回归来检验不同家庭儿童的严重体重不足状况是否存在差异,同时确定潜在的危险因素。结果:2720名儿童有有效年龄体重z-score,其中53名(1.95%)被诊断为严重体重不足。在单变量模型中,儿童水平变量,如多胎[优势比(OR), 4.03;95%可信区间(CI): 1.85-8.76]和儿童出生平均(OR, 2.17;95%CI: 1.09-4.32)或小胎(OR, 4.08;95%可信区间:2.01-8.28)与严重体重不足的几率增加有关。母亲/家庭水平的变量,如5岁以下儿童数量的增加(OR, 1.61;95%CI: 1.28-2.04),最贫困家庭(OR, 4.85;95%CI: 1.14-20.59)和最近5年内出生数的增加(OR, 1.80, 95%CI: 1.24-2.60)与严重体重不足的几率增加相关。母亲受教育年限增加(OR, 0.89;95%CI: 0.83-0.95)与严重体重不足的几率降低相关。在多层logistic模型中,只有出生类型(OR, 1.61;95%CI: 1.28-2.04)、孩子的大小(平均OR, 2.12;95%CI: 1.04-4.33;小:OR, 3.87;95%CI: 1.80-8.33)和母亲受教育程度(OR, 0.92;95%CI: 0.84-1.00)与严重体重不足独立相关。在严重体重不足状态中,没有显著的剩余家庭水平差异。结论:我们的研究结果表明,改善母亲教育、家庭社会经济条件和计划生育是解决严重体重不足的关键
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引用次数: 1
Factors associated with birth injuries in neonates admitted to the neonatal intensive care unit: a retrospective study in a Ghanaian tertiary care setting 新生儿重症监护病房新生儿出生损伤相关因素:在加纳三级医疗机构的回顾性研究
Pub Date : 2021-06-29 DOI: 10.46829/hsijournal.2020.12.1.2.196-201
A. Abdul-Mumin, K. A. Bimpong, A. Buunaaim, Ernest K Cheyuo, K. Osman
Background: A birth injury is structural damage or functional deterioration of the neonate’s body due to a traumatic incident at birth. The prevalence and the type of birth injury vary from place to place. There is paucity of data on the prevalence of birth injuries in Ghana.Objective: The study aimed to determine the prevalence and factors associated with birth injury in neonates admitted in a tertiary institution in Northern Ghana. Methods: This was a quantitative retrospective study carried out on neonates admitted to the neonatal intensive care unit (NICU) of the Tamale Teaching Hospital between January 2018 through December 2019.Results: Out of 5590 neonates admitted to the NICU, 205 were noted to have various forms of birth injury corresponding to a prevalence of 3.66%(37 per 1000 neonates admitted to our unit). Majority were male (n=123/205, 60.0%), most deliveries occurred in the study hospital(n=143/205, 69.75%), and spontaneous vaginal delivery accounted for 70.73% (n=145/205). Extracranial injuries (n=146/221, 66.06%) were the most common form of birth injury. Next was musculoskeletal injuries (n=41/221, 18.55%) with humeral fractures (n=15/221, 6.78%) being the most frequent in this category. Among the neonates with birth injuries there were 23 deaths recorded (11.22%) all but one of whom had associated birth asphyxia. Birth injuries were significantly associated with place of delivery(p=0.029). Out-born babies were more likely to have extracranial injuries (adjusted odds ratio,5.10; 95% CI: 1.53-16.94;p=0.008).Conclusion: Extracranial injuries were the most common in this study. Place of delivery was significantly associated with birth injuries. Building the capacity of health care professionals is essential to reduce incidence of birth injuries. Some of these injuries can be avoided if high risk pregnancies are referred early to institutions that have the resources and skill to deliver such babies.
背景:出生损伤是由于出生时的创伤事件导致的新生儿身体的结构损伤或功能恶化。产伤的发生率和类型因地而异。关于加纳出生伤害发生率的数据缺乏。目的:本研究旨在确定加纳北部一所高等教育机构新生儿出生损伤的患病率和相关因素。方法:对2018年1月至2019年12月在Tamale教学医院新生儿重症监护病房(NICU)住院的新生儿进行定量回顾性研究。结果:在入住NICU的5590名新生儿中,205名被注意到有各种形式的出生损伤,患病率为3.66%(每1000名新生儿中有37名)。男性居多(n=123/205, 60.0%),分娩主要发生在研究医院(n=143/205, 69.75%),阴道自然分娩占70.73% (n=145/205)。颅外损伤(n=146/221, 66.06%)是最常见的出生损伤形式。其次是肌肉骨骼损伤(n=41/221, 18.55%),其中肱骨骨折(n=15/221, 6.78%)最为常见。在出生损伤的新生儿中,有23例死亡(11.22%),除1例外,其余均伴有出生窒息。分娩损伤与分娩地点显著相关(p=0.029)。外生婴儿更容易发生颅外损伤(校正优势比为5.10;95% CI: 1.53-16.94;p=0.008)。结论:颅外损伤在本研究中最为常见。分娩地点与分娩损伤显著相关。建立保健专业人员的能力对于减少出生伤害的发生率至关重要。如果高风险妊娠及早转介到有资源和技能接生此类婴儿的机构,其中一些伤害是可以避免的。
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引用次数: 2
Uretero-vesical anastomotic stricture: a case report and review of management 输尿管膀胱吻合口狭窄1例及治疗回顾
Pub Date : 2021-06-29 DOI: 10.46829/hsijournal.2021.6.2.1.210-214
M. Kyei, R. Djagbletey, G. Klufio, J. Mensah, B. Toboh
Uretero-vesical anastomosis is the connection of the ureter to the urinary bladder at a new site to achieve unimpeded flow of urine from the ureters into the urinary bladder. A rare complication of this procedure is the development of stricture at the anastomotic site. This report is on a 62-yr. old female with one year history of left flank pain and a prior left uretero-vesical anastomosis done 14 years earlier. She had been managed for recurrent urinary tract infections, but the left flank pain was persistent. Abdominal and pelvic CT scan with intravenous urogram helped establish the diagnosis of uretero-vesical anastomotic stricture. This was successfully managed with endoscopic dilatation after retrograde placement of guide wire under fluoroscopy followed by serial dilation. In a patient presenting with flank pains after a previous uretero-vesical anastomosis, stricture at the anastomotic site is an important differential diagnosis. Endoscopic management is the preferred initial management which produces successful outcomes
输尿管-膀胱吻合术是将输尿管与膀胱连接在一个新的位置,使尿液从输尿管畅通无阻地流入膀胱。这种手术的罕见并发症是吻合口狭窄的发展。这份报告是关于62年的。老年女性,左侧腰痛1年,左侧输尿管膀胱吻合术14年。她曾因复发性尿路感染接受治疗,但左侧疼痛持续存在。腹部和骨盆CT扫描与静脉尿路造影有助于确定输尿管-膀胱吻合口狭窄的诊断。在透视下逆行放置导丝并连续扩张后,通过内镜扩张成功地处理了这一问题。输尿管膀胱吻合术后腹痛的病人,吻合口狭窄是一个重要的鉴别诊断。内镜管理是首选的初始管理,产生成功的结果
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引用次数: 0
Commentary on a case report of Dopa-responsive dystonia or Segawa disease in Ghana 加纳多巴反应性肌张力障碍或Segawa病1例报告评论
Pub Date : 2021-06-29 DOI: 10.46829/hsijournal.2021.6.2.1.153-154
Dr. Yamoah Kwame Mathew Kyei
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引用次数: 0
Awareness and Knowledge of Final Year Health Science Students on Occupational Therapy in a Public University in Ghana. 加纳一所公立大学最后一年健康科学专业学生对职业治疗的认识和知识。
Pub Date : 2021-06-29 DOI: 10.46829/hsijournal.2021.6.2.1.89-195
Eric Nkansah Opoku, Peter Ndaa
Background: Occupational therapists play a major role in the healthcare team in the provision of holistic care to patients. Successful healthcare depends on collaboration and understanding among health professionals and recognition of each health professional’s role in a team. Objective: The study aimed to determine the awareness and knowledge of final-year health sciences students of the University of Ghana on occupational therapy(OT).Methods: A cross-sectional study was employed by means of a questionnaire with final year students in the Medicine, Nursing and Allied Health Professional programmes (physiotherapy, dietetics, radiography, and medical laboratory sciences) of the University of Ghana. Participants were randomly selected and requested to complete a questionnaire. Data was analysed using IBM SPSS Statistics, Version 23.0.Results: The results showed anoverall OT awareness of 94.66% (n = 195/206). About 35.0% (n = 69/206)of participant learned about OT as a health profession through other means rather than their academic curriculum. Collectively, participants demonstrated an average actual knowledge on OT services of 14.43 ± 3.17. The results also showed that, the importance participants accorded OT profession in the healthcare team did not depend on their knowledge on OT scope of practice (rs=0.162, p>0.05).Conclusion: Actions should be channelled towards enabling health science students to learn about OT and other health professions through their university curriculum. Furthermore, OT students should endeavour to sensitise fellow health science students on the unique roles and responsibilities of the OT profession in the healthcare team
背景:职业治疗师在医疗团队中扮演着重要的角色,为患者提供全面的护理。成功的医疗保健取决于卫生专业人员之间的协作和理解,以及对每个卫生专业人员在团队中的作用的认可。目的:本研究旨在了解加纳大学健康科学专业大四学生对职业治疗(OT)的认知和知识。方法:采用横断面研究,对加纳大学医学、护理和联合卫生专业(物理治疗、营养学、放射学和医学实验室科学)的最后一年级学生进行问卷调查。参与者被随机选择并被要求完成一份调查问卷。数据分析使用IBM SPSS Statistics, Version 23.0。结果:患者的整体OT意识为94.66% (n = 195/206)。约35.0% (n = 69/206)的参与者通过其他途径而不是通过学术课程了解OT作为健康专业。总体而言,参与者对OT服务的平均实际知识为14.43±3.17。结果还显示,被试对医疗团队中OT专业的重视程度与他们对OT执业范围的了解程度无关(rs=0.162, p>0.05)。结论:应采取行动,使卫生科学专业的学生通过大学课程了解OT和其他卫生专业。此外,OT专业的学生应该努力让其他健康科学专业的学生认识到OT专业在医疗团队中的独特角色和责任
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引用次数: 0
Utilization of health facility delivery services in the Jomoro District of the Western Region of Ghana 加纳西部地区乔莫罗县卫生设施提供服务的利用情况
Pub Date : 2021-06-29 DOI: 10.46829/hsijournal.2021.6.2.1.173-180
S. Nyarko, Anthony Kusi, Kwabena Opoku Mensah
Background: In the year 2000, member states of the United Nations pledged to work towards a three-quarters reduction in the 1990 maternal mortality ratio by 2015 in line with Millenium. Development Goal 5, but this could not be achieved. This pledge became imperative given the high maternal mortality being recorded, especially among developing countries. The high maternal deaths in developing countries have been attributed partly to the lack of access to skilled birth attendants during delivery.Objective: This study aimed to investigate factors that influence the utilization of health facility delivery services among pregnant women in the Jomoro District of the Western Region of Ghana.Methods: The study used data from a cross-sectional survey among women aged 18 - 49 yr. living in the Jomoro District of Ghana and had given birth between 2012 and 2016 (n = 374). The study participants were randomly selected from women who attended child welfare clinics on clinic days with their babies in eighteen communities. The study used a structured questionnaire to solicit for information about the women’s demographic and socio-economic characteristics, community characteristics and health systems factors likely to influence their decision to seek skilled delivery care as well as their experiences relating to their last delivery. Bivariate analyses were performed between the primary dependent variable and background characteristics of the respondents. Factors influencing the choice of place of delivery were estimated by multiple logistic regression analysis. Data analysis was performed using STATA Statistical Software, Release 14.Results: About 61.0% (n= 228/374) of the women had their last delivery at a health facility while the remaining 38.8% (n= 145/374) delivered at home without skilled assistance. In multivariate analysis, women aged 25 – 29 yr. were less likely to have a skilled delivery (aOR, 0.40; 95% CI: 0.17 - 0.93). Also, professional women had 4.77 odds of having skilled delivery (aOR, 4.77; 95% CI: 1.53 - 14.93). Distance to the nearest health facility also had a statistically significant association with skilled delivery. Women living at 10 – 19 km to a health facility were less likely to have a skilled delivery (aOR, 0.56; 95% CI: 0.32 - 0.97). In addition, the presence of a midwife at a health facility increased the odds of skilled delivery among women (aOR, 4.59; 95% CI: 2.47 - 8.55).Conclusion: Interventions aimed at increasing the uptake of delivery care services to achieve the SDG’s target on maternal mortality must consider improving the socio-economic wellbeing of women in addition to removing the physical and health system barriers impeding access and utilisation of delivery care services.
背景:2000年,联合国会员国承诺根据《千年目标》,努力到2015年将1990年的产妇死亡率降低四分之三。发展目标5,但这无法实现。鉴于产妇死亡率很高,特别是在发展中国家,这一承诺变得十分必要。发展中国家产妇死亡率高的部分原因是在分娩期间缺乏熟练的助产人员。目的:本研究旨在调查影响加纳西部地区Jomoro县孕妇利用卫生设施提供服务的因素。方法:该研究使用了一项横断面调查的数据,调查对象是居住在加纳Jomoro区,年龄在18 - 49岁之间,在2012年至2016年期间分娩的妇女(n = 374)。研究参与者是从18个社区的妇女中随机挑选出来的,她们在门诊日带着孩子去了儿童福利诊所。该研究使用了一份结构化问卷,征求有关妇女的人口和社会经济特征、社区特征和卫生系统因素的信息,这些因素可能影响她们寻求熟练分娩护理的决定,以及她们与上次分娩有关的经历。在主要因变量和受访者的背景特征之间进行双变量分析。采用多元logistic回归分析估计影响配送地点选择的因素。数据分析采用STATA统计软件第14版。结果:约61.0% (n= 228/374)的妇女最后一次分娩是在卫生机构进行的,其余38.8% (n= 145/374)在家中分娩,没有专业人员协助。在多变量分析中,25 - 29岁的女性不太可能有熟练的分娩(aOR, 0.40;95% ci: 0.17 - 0.93)。此外,职业女性熟练分娩的几率为4.77 (aOR, 4.77;95% ci: 1.53 - 14.93)。距离最近的卫生设施也与熟练分娩有统计上的显著关联。居住在距离医疗机构10 - 19公里的妇女获得熟练分娩的可能性较小(aOR, 0.56;95% ci: 0.32 - 0.97)。此外,在医疗机构有助产士的情况下,妇女熟练分娩的几率会增加(aOR, 4.59;95% ci: 2.47 - 8.55)。结论:旨在提高分娩护理服务使用率以实现可持续发展目标关于孕产妇死亡率的具体目标的干预措施,除了消除阻碍获得和利用分娩护理服务的物理和卫生系统障碍外,还必须考虑改善妇女的社会经济福祉。
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引用次数: 0
Intracranial stents in the management of wide-neck intracranial aneurysms 颅内支架在宽颈颅内动脉瘤治疗中的应用
Pub Date : 2021-06-29 DOI: 10.46829/hsijournal.2021.6.2.1.205-209
B. Sarkodie, B. B. Jimah, D. Anim, E. Brakohiapa, B. Botwe
Intracranial aneurysms are bulges in vessels that are prone to rupture with attendant morbidity and mortality. Early detection and treatment can avoid rupture and its associated consequences. Endovascular treatment of aneurysms with wide neck can be challenging due to potential coil migration or protrusion. The use of intracranial stents and balloons can help overcome some of these management challenges. We present 3 cases of endovascular treatment of wide-neck intracranial aneurysms. The first patient presented with a wide-neck left middle cerebral artery aneurysm that was successfully treated with stent-assisted coiling with complete obliteration of the aneurysmal sac. The second patient presented with a large, cavernous internal carotid artery aneurysm that was successfully treated with a flow diverter stent with complete obliteration of the aneurysm while the third case presented with a wide-neck left posterior communicating artery aneurysm and was also successfully treated with stent-assisted coiling. Even though endovascular treatment of wide-neck intracranial aneurysms is technically challenging, the evolution of new treatment techniques such as the use of stents and stent-assisted coiling make these treatments safe.
颅内动脉瘤是血管内的凸起,容易破裂,并伴有发病率和死亡率。早期发现和治疗可避免破裂及其相关后果。宽颈动脉瘤的血管内治疗可能具有挑战性,因为潜在的线圈迁移或突出。颅内支架和气囊的使用可以帮助克服这些管理上的挑战。我们报告3例宽颈颅内动脉瘤的血管内治疗。第一位患者出现宽颈左大脑中动脉动脉瘤,通过支架辅助卷绕和完全闭塞动脉瘤囊成功治疗。第二例患者出现了一个巨大的海绵状颈内动脉瘤,并成功地用血流分流支架治疗了动脉瘤,而第三例患者出现了一个宽颈左后交通动脉瘤,也成功地用支架辅助卷曲治疗了动脉瘤。尽管宽颈颅内动脉瘤的血管内治疗在技术上具有挑战性,但新治疗技术的发展,如支架和支架辅助盘绕的使用,使这些治疗变得安全。
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引用次数: 0
Intractable bleeding: the role of embolization in a resource-limited country 难治性出血:在资源有限的国家栓塞的作用
Pub Date : 2021-06-29 DOI: 10.46829/hsijournal.2021.6.2.1.215-219
Transarterial catheter embolization is novel in Ghana, even though it has been practiced over three decades in certain parts of the world. The procedure is safer with the advent of new catheter techniques and embolic agents which place interventional radiology at the forefront of the treatment of bleeding due to myriad of indications. It is fast, safe, and minimally invasive relative to open surgery, especially when other conventional minimally invasive procedures such as endoscopic banding and sclerotherapy fail. This paper presents two cases involving pre-and post-embolization digital subtraction angiogram (DSA) of gastroduodenal artery and bilateral iliac arteries. Findings of DSA of the gastroduodenal artery and bilateral iliac arteries showed florid extravasation and extensive neovascularity. Post embolization DSA showed absent extravasation and near total devascularization. The inclusion of embolization to the management protocols of upper gastrointestinal bleeding and intractable haematuria is recommended
经动脉导管栓塞术在加纳是新颖的,尽管它在世界某些地区已经实施了30多年。随着新的导管技术和栓塞剂的出现,由于无数的适应症,介入放射学处于出血治疗的前沿,该过程更加安全。相对于开放手术,它是快速、安全、微创的,特别是当其他传统的微创手术,如内窥镜绑扎和硬化治疗失败时。本文报告两例胃十二指肠动脉和双侧髂动脉的数字减影血管造影(DSA)。胃十二指肠动脉和双侧髂动脉的DSA显示丰富的外渗和广泛的新生血管。栓塞后DSA显示无外渗和几乎完全断流。建议将栓塞纳入上消化道出血和顽固性血尿的治疗方案
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引用次数: 0
Dominant correlates of depressive disorders and effects on quality of life among older adults in low- and middle-income countries: Further analysis of WHO study on Global Ageing and Adult Health 低收入和中等收入国家老年人抑郁症的主要相关因素及其对生活质量的影响:对世卫组织全球老龄化和成人健康研究的进一步分析
Pub Date : 2021-06-29 DOI: 10.46829/hsijournal.2021.6.2.1.155-165
D. Duah, Amuasi Susan A, Gabriel Incoom, Yawson Alfred E, E. Asampong, J. Tetteh, S. Bosomprah
Background: Poor quality of life (QoL) disrupts social functioning, fulfilment of basic needs, and is associated with depressive disorder (DD).Objective: We answered the question of whether there is a common risk factor for DD across six low- and middle-income countries (LMICs) and determined whether this risk factor can be ranked consistently as the most important predictor of DD in all six LMICs. We estimated the effect of DD on QoL for each country and meta-analyzed the results to generate a pooled effect estimate of DD on QoL in the six LMICs.Methods: We used data from the WHO Study on Global Ageing and Adult Health (SAGE). This study involved a total of 35,164 older adults aged ≥ 50 yr. in six LMICs: China, 13,408; Ghana, 4,305; India, 7,108; Mexico, 2,309; Russian Federation, 3,763; and South Africa, 3,842. We conducted an extensive literature review to select the list of 58 potential risk factors associated with DD. We used double selection Least Absolute Shrinkage and Selection Operator Poisson regression model to identify country-specific risk factors associated with DD. Weighted dominance analysis (WDA) was performed to determine the most important risk factor of DD. To estimate the effect of DD on QoL, we used inverse probability weighting Poisson regression adjustment for each country, and meta-analysis techniques for a pooled estimate of the overall effect.Results: The risk factors for DD were generally country specific. However, asthma was the most common and the most important predictor of DD across all six SAGE countries. In Ghana, the prevalence of DD among older adults who have been diagnosed with asthma or have experienced symptoms of asthma in the 12 months preceding the survey was 14 times that among those without asthma or asymptomatic of asthma [Adjusted Prevalence Ratio (aPR), 14.46, 95% confidence interval (CI): 10.47 - 19.97; p < 0.001]. Similarly, it was 14 times in South Africa (aPR, 14.6; 95% CI: 8.18 - 26.14; p < 0.00) but in Mexico, it was 4 times (aPR, 4.39; 95% CI: 3.00 - 6.42; p < 0.001) and in China (aPR, 5.99; 95% CI: 4.32 - 8.31; p < 0.001) and Russia (aPR, 5.90; 95% CI: 3.9 - 9.0; p < 0.001), it was 6 times. In India, it was 5 times (aPR=5.1; 95% CI: 4.3 - 6.0; p < 0.001. Generally, there was evidence of 8% increase in poor QoL due to the presence of DD (Pooled estimate, 0.08; 95% CI: 6.0 – 12; p < 0.001). Specifically, in China, there was evidence of 12% increase in poor QoL that could be attributed to DD (prevalence difference (PD), 0.12; 95% CI: 0.07 - 0.18; p < 0.001). In India (PD, 0.08; 95% CI: 0.04 - 0.13; p < 0.01) and Russian Federation (PD, 0.08; 95% CI: 0.01 - 0.15; p < 0.01), there was evidence of 8% increase in poor QoL. Although, there was some increase in poor QoL in Mexico, Ghana, and South Africa due to DD, the increase was not statistically significant.Conclusion: Although different factors could explain the prevalence of DD among older adults in the six LMICs, it was evident that as
背景:生活质量差(QoL)会破坏社会功能、基本需求的满足,并与抑郁症(DD)相关。目的:我们回答了在六个低收入和中等收入国家(LMICs)中是否存在DD的共同风险因素的问题,并确定该风险因素是否可以一致地列为所有六个LMICs中DD的最重要预测因素。我们估计了DD对每个国家生活质量的影响,并对结果进行了荟萃分析,以产生6个低收入国家中DD对生活质量的综合影响估计。方法:我们使用来自世卫组织全球老龄化与成人健康研究(SAGE)的数据。该研究共涉及6个低收入国家的35164名年龄≥50岁的老年人:中国,13408人;加纳,4305;印度,7108;墨西哥,2309;俄罗斯联邦,3 763人;南非3842人。我们进行了广泛的文献回顾,选择了58个与DD相关的潜在危险因素。我们使用双选择最小绝对收缩和选择算子泊松回归模型来确定与DD相关的国家特定风险因素。加权优势分析(WDA)来确定DD最重要的风险因素。为了估计DD对生活质量的影响,我们使用逆概率加权泊松回归调整每个国家。以及综合评估整体效果的荟萃分析技术。结果:DD的危险因素普遍存在国家特异性。然而,在所有六个SAGE国家中,哮喘是最常见和最重要的DD预测因子。在加纳,在调查前12个月内被诊断为哮喘或有哮喘症状的老年人中,DD的患病率是无哮喘或无哮喘症状老年人的14倍[调整患病率比(aPR), 14.46, 95%可信区间(CI): 10.47 - 19.97;P < 0.001]。同样,南非是14倍(aPR, 14.6;95% ci: 8.18 - 26.14;p < 0.00),墨西哥为4倍(aPR, 4.39;95% ci: 3.00 - 6.42;p < 0.001)和中国(aPR, 5.99;95% ci: 4.32 - 8.31;p < 0.001)和俄罗斯(aPR, 5.90;95% ci: 3.9 - 9.0;P < 0.001),为6倍。在印度,是5倍(aPR=5.1;95% ci: 4.3 - 6.0;P < 0.001。一般来说,有证据表明,由于DD的存在,不良生活质量增加了8%(汇总估计,0.08;95% ci: 6.0 - 12;P < 0.001)。具体而言,在中国,有证据表明,12%的不良生活质量增加可归因于DD(患病率差异(PD), 0.12;95% ci: 0.07 - 0.18;P < 0.001)。在印度(PD, 0.08;95% ci: 0.04 - 0.13;p < 0.01)和俄罗斯联邦(PD, 0.08;95% ci: 0.01 - 0.15;p < 0.01),不良生活质量增加8%。尽管在墨西哥、加纳和南非,由于DD,生活质量较差的人有所增加,但这种增加在统计上并不显著。结论:虽然不同的因素可以解释6个低收入中国家老年人DD的患病率,但显然哮喘患者在这一人群中具有更高的DD风险。临床评估和潜在的诊断和治疗存在哮喘的老年人DD可能会提高他们的生活质量
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引用次数: 2
Dopa-responsive dystonia or Segawa disease in Ghana: a case report 加纳多巴反应性肌张力障碍或Segawa病1例报告
Pub Date : 2021-06-29 DOI: 10.46829/hsijournal.2021.6.2.1.202-204
E. Badoe
Dystonias are rare in childhood and consist of variably sustained twisting deformation of a limb or parts of a trunk. Dystonias can be considered primary because of a genetic disorder or secondary due to a central nervous system injury like cerebral palsy or medications. The rare dopa-responsive dystonia is often mistaken for cerebral palsy, stroke, localized limb trauma or conversion disorder. The aim of this report is to increase the awareness of a rare but eminently treatable type of dystonia known as dopa–responsive dystonia or Segawa disease. In this report a young girl with dystonia who was severely disabled and could not attend school was misdiagnosed as cerebral palsy for two years. After treatment with low dose L-dopa within 48 hours, a dramatic and sustained response with restoration of foot dystonia and mobility was observed. Recognition of L-dopa dystonia facilitates proper treatment and significant improvement in quality of life
肌张力障碍在儿童时期很少见,主要表现为肢体或躯干部分的持续扭曲变形。肌张力障碍可以被认为是由遗传疾病引起的原发性疾病,也可以被认为是由中枢神经系统损伤如脑瘫或药物引起的继发性疾病。罕见的多巴反应性肌张力障碍常被误认为脑瘫、中风、局部肢体创伤或转换障碍。本报告的目的是提高对一种罕见但可显著治疗的肌张力障碍类型的认识,即多巴反应性肌张力障碍或Segawa病。在这个报告中,一个患有肌张力障碍的年轻女孩严重残疾,不能上学,被误诊为脑瘫长达两年。在48小时内接受低剂量左旋多巴治疗后,观察到足肌张力障碍和活动能力恢复的显著和持续的反应。识别左旋多巴肌张力障碍有助于适当的治疗和显著改善生活质量
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引用次数: 0
期刊
Third Edition of the HSI Journal: Volume 2 Issue 1, 2021 Publication.
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