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Introductory Chapter: The Rationale for a Multimodal Approach to Pain Treatment 导论章:多模式疼痛治疗的基本原理
Pub Date : 2019-10-02 DOI: 10.5772/intechopen.85864
M. Cascella
The symptom pain is a perception affected by complex interconnections of biological, psychological, and social factors. Analgesic monotherapy can often provide pain relief in clinical conditions featuring non-severe pain. In other circumstances, such as those characterized by intractable cancer pain, or concerning acute/ chronic non-cancer neuropathic pain, the intensity and quality of the pain require individualized multidrug approaches, with different analgesics and adjuvants used in combination according to clinical practice guidelines published by international and regional professional associations [1]. Moreover, because pharmacological strategies may not be able to successfully treat all patients with acute or chronic pain, nonpharmacological strategies should be included in the analgesic program, supporting and strengthening drug therapy [2]. Again, especially, chronic pain represents a dynamic experience, profoundly changeable in a spatial-temporal manner; thus, standardized and fixed protocols are not universally applicable for pain therapy. From these premises, the individualized, dynamic, and multicomponent pathway is summarized by the concept of the multimodal approach to pain management and represents a real revolution in this field of medicine. This optimization strategy can allow managing the pain by treating this symptom in its variegated clinical expressions through multiple interventions. According to the concept of multimodal therapy, the objective of pain relief is possible by targeting different sites of the nociceptive pathway [3] and by managing the galaxy of pain-related conditions through pharmacologic and nonpharmacologic modalities [4]. However, several considerations should be addressed in order to better understand its rational application for both acute (e.g., postoperative) and chronic pain management.
疼痛症状是一种受生物、心理和社会因素复杂联系影响的感知。镇痛单一疗法往往可以提供缓解疼痛的临床条件,以非严重的疼痛。在其他情况下,如顽固性癌性疼痛,或急性/慢性非癌性神经性疼痛,疼痛的强度和质量需要个性化的多药治疗方法,根据国际和地区专业协会发布的临床实践指南联合使用不同的镇痛药和佐剂[1]。此外,由于药物策略可能无法成功治疗所有急性或慢性疼痛患者,因此应将非药物策略纳入镇痛方案,支持和加强药物治疗[2]。特别是,慢性疼痛代表了一种动态的体验,在时空上深刻地变化着;因此,标准化和固定的方案并不普遍适用于疼痛治疗。从这些前提出发,个性化的、动态的、多组分的通路被多模态疼痛管理方法的概念所总结,并代表了这一医学领域的真正革命。这种优化策略可以通过多种干预措施来治疗这种临床表现各异的症状,从而控制疼痛。根据多模式治疗的概念,通过靶向伤害感受通路的不同部位[3],以及通过药物和非药物方式管理疼痛相关疾病[4],疼痛缓解的目标是可能的。然而,为了更好地理解其在急性(如术后)和慢性疼痛管理中的合理应用,应该考虑几个问题。
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引用次数: 3
Cancer Pain 癌症疼痛
Pub Date : 2019-10-02 DOI: 10.5772/intechopen.84452
A. Ščiupokas, Liuda Brogiene, D. Skorupskienė
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引用次数: 2
Wireless Neuromodulation: From Bench to Bedside 无线神经调节:从实验室到床边
Pub Date : 2019-04-18 DOI: 10.5772/INTECHOPEN.85501
L. Perryman
Spinal cord stimulation (SCS), as a neuromodulation therapy, has rapidly evolved over the past few decades to become the treatment of choice for many chronic pain syndromes. However, many equipment-related limitations such as the bulk of the equipment, an implantable pulse generator (IPG), the limited therapeutic stimulation frequency utilized, and the potential adverse events have restricted SCS applications. Recently, advanced nanotechnology and minimally invasive surgical techniques have shown promising options to expand the indications due to reduced surgical trauma/hospital time/costs. We describe the basis for nanotechnology neuromodulation and the preliminary experience with wireless SCS in the treatment of chronic pain conditions. The equipment utilizes a miniature stimulator with microelectronics, percutaneously placed at the appropriate stimulation target, with wireless control to provide the desired stimulation, and then moderated by the clinician and the patient. The wireless device reduces the bulk of the SCS equipment to a single electrode (with embedded sensors), using the new improved neuralelectric interface. This wireless neuromodulation (WNM) has been clinically used in several chronic pain conditions, including failed back surgery syndrome, facial pain, chronic regional pain syndrome, and postherpetic neuralgia, with encouraging outcome, without the complications of a traditional SCS resulting from the IPG or its accessories.
脊髓刺激(SCS)作为一种神经调节疗法,在过去的几十年里迅速发展成为许多慢性疼痛综合征的治疗选择。然而,许多与设备相关的限制,如设备体积大、可植入脉冲发生器(IPG)、使用的治疗刺激频率有限以及潜在的不良事件,限制了SCS的应用。最近,由于减少了手术创伤/住院时间/费用,先进的纳米技术和微创手术技术已经显示出扩大适应症的有希望的选择。我们描述了纳米技术神经调节的基础和无线SCS治疗慢性疼痛的初步经验。该设备利用微电子微型刺激器,经皮放置在适当的刺激目标处,通过无线控制提供所需的刺激,然后由临床医生和患者调节。无线设备使用新的改进的神经电接口,将SCS设备的体积减小到单个电极(带有嵌入式传感器)。这种无线神经调节(WNM)已在临床上用于多种慢性疼痛,包括背部手术失败综合征、面部疼痛、慢性局部疼痛综合征和带状疱疹后神经痛,结果令人鼓舞,没有传统SCS由IPG或其附件引起的并发症。
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引用次数: 0
Features and Clinical Effectiveness of the Regenerative Injection Treatments: Prolotherapy and Platelet-Rich Plasma for Musculoskeletal Pain Management 再生注射治疗:前驱疗法和富血小板血浆治疗肌肉骨骼疼痛的特点和临床疗效
Pub Date : 2019-04-03 DOI: 10.5772/INTECHOPEN.84580
İ. Solmaz, Aydan Örsçelik
Pain is a symptom caused by a disease process and/or tissue injury. With the prolongation of life expectancy in humans, the incidence of degenerative joint diseases and as a result pain has increased. Unfortunately, a method of treatment that stops or reverses progression by affecting the pathogenesis in these diseases has not been developed. Physical therapeutics such as medicine and physical rehabilitation often are prescribed for patients suffering with pain. Recently, in addition to these routine therapies used in pain treatment, many regenerative injection-based therapies, including prolotherapy (PrT) or platelet-rich plasma (PRP) have been widely used. PrT is using for damaged or degenerated connective tissue healing, such as ligaments, tendons, and cartilage. The combination of local inflammatory effect, stimulation of local growth factor release, and down regulation of neuropathic inflammation can be defined as the mechanism. As a result of these, joint instability and ligament laxity reduce and pain decrease. PRP is the cellular component of the plasma. Although PRP is used for the same reasons as PrT, it can be used in acute cases unlike PrT. This chapter is intended to understand the use of regenerative injection therapies (PrT and PRP) better in the treatment of pain.
疼痛是由疾病过程和/或组织损伤引起的症状。随着人类预期寿命的延长,退行性关节疾病的发病率以及由此引起的疼痛也在增加。不幸的是,目前还没有一种通过影响这些疾病的发病机制来阻止或逆转疾病进展的治疗方法。物理治疗,如药物和物理康复,经常被开给患有疼痛的病人。近年来,除了这些常规治疗疼痛的方法外,许多基于再生注射的治疗方法,包括前驱疗法(PrT)或富血小板血浆疗法(PRP)已被广泛应用。PrT用于损伤或退化的结缔组织愈合,如韧带、肌腱和软骨。可将其机制定义为局部炎症作用、刺激局部生长因子释放、下调神经性炎症共同作用。因此,关节不稳定和韧带松弛减少,疼痛减轻。PRP是血浆的细胞成分。虽然PRP的使用原因与PrT相同,但与PrT不同,它可以用于急性病例。本章旨在更好地了解再生注射疗法(PrT和PRP)在治疗疼痛中的应用。
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引用次数: 8
Food-Derived Opioids: Production and the Effects of Opioids on Human Health 食物来源的阿片类药物:阿片类药物的生产和对人类健康的影响
Pub Date : 2019-03-25 DOI: 10.5772/INTECHOPEN.84195
Sevda Arısoy, Işık Çoban, Özlem Üstün‐Aytekin
Traditional opioids have been used for the people who suffer from cancer, burns, surgery, HIV/AIDS, and other serious illness pains for years. However, numerous side effects like dizziness, apnea, physical dependence, tolerance, addiction, nau-sea, and vomiting push the researchers to look forward to the new opioid options. The opioid peptides which derived from foods provide significant advantages as the safe and natural alternative. The researchers reported that it is also promising a new functional food and nutraceutical. In this chapter, the type of food-derived opioids, their origins, possible receptors, their amino acid sequences, opioid effects, production techniques, and health benefits are reviewed.
多年来,传统的阿片类药物一直用于患有癌症、烧伤、手术、艾滋病毒/艾滋病和其他严重疾病疼痛的人。然而,许多副作用,如头晕、呼吸暂停、身体依赖、耐受性、成瘾、恶心和呕吐,促使研究人员期待新的阿片类药物选择。从食品中提取的类阿片肽作为安全、天然的替代品,具有显著的优势。研究人员报告说,它还有望成为一种新的功能性食品和营养保健品。在本章中,综述了食物来源的阿片样物质的类型、来源、可能的受体、氨基酸序列、阿片样物质的作用、生产技术和健康益处。
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引用次数: 5
Breakthrough Cancer Pain 突破性癌症疼痛
Pub Date : 2019-03-11 DOI: 10.5772/INTECHOPEN.84581
Xuehai Yan
Breakthrough cancer pain has attracted more and more attentions recently because it has become the biggest obstacle to control cancer pain. Pain can occur at any stage of cancer. Despite the aggressive treatment, some patients still experience high-intensity pain in the short term, which is commonly referred to as breakthrough pain. Typical breakthrough pain has clinical features such as rapid onset and short duration, and it has uncontrollable and unpredictable characteristics, which impact the overall life quality of patients and the therapeutic effect of cancer pain. It has always been a puzzle and difficult in clinical treatment of breakthrough cancer pain. This paper aims to provide a more detailed review of the definition, assessment tools, classification and characteristics, epidemiology, and mechanism and treatment of breakthrough cancer pain, in order to facilitate the future development of this work in clinical treatment.
突破性癌痛已成为控制癌痛的最大障碍,近年来受到越来越多的关注。疼痛可以发生在癌症的任何阶段。尽管进行了积极的治疗,一些患者仍然会在短期内经历高强度的疼痛,这通常被称为突破性疼痛。典型的突发性疼痛具有起病快、持续时间短等临床特点,具有不可控、不可预测的特点,影响患者的整体生活质量和癌痛的治疗效果。突破性癌痛一直是临床治疗中的一个难题和难点。本文旨在对突破性癌性疼痛的定义、评估工具、分类与特征、流行病学、机制与治疗等方面进行较为详细的综述,以促进该工作在临床治疗中的进一步发展。
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引用次数: 0
Management of Odontogenic and Nonodontogenic Oral Pain 牙源性和非牙源性口腔疼痛的处理
Pub Date : 2019-03-01 DOI: 10.5772/INTECHOPEN.83837
Sameer Shaikh
Pain in the orofacial region is by far the commonest reason for patients to seek treatment. Tooth and intraoral structures are often the main sources of orofacial pain. Odontogenic pain, also commonly known as tooth pain, originates from dental structures, pulpal or periodontal. Nonodontogenic oral pain can originate from intraoral structures such as gingiva and buccal mucosa. Arriving at a correct and definitive diagnosis is of paramount importance to institute an appropriate treatment. Obtaining a detailed history from the patient including the location, duration, frequency, periodicity, character, and quality of pain assists in differentiating odontogenic from nonodontogenic causes. Wide varieties of pharmacological agents, along with invasive and noninvasive procedures, are available to manage odontogenic and nonodontogenic pain. While managing orofacial pain, clinical and pharmacological judgment should encompass a systematic and objective assessment in compliance with the strongest evidence available. In this chapter, there will be a discussion of various choices and options available to manage a few of the orofacial pain complaints.
到目前为止,患者寻求治疗的最常见原因是口面部疼痛。牙齿和口腔内结构通常是口腔面部疼痛的主要来源。牙源性疼痛,又称牙痛,起源于牙齿结构、牙髓或牙周。非牙源性口腔疼痛可起源于口腔内结构,如牙龈和颊粘膜。获得正确和明确的诊断对于制定适当的治疗方案至关重要。从患者那里获得详细的病史,包括疼痛的位置、持续时间、频率、周期性、特征和质量,有助于区分牙源性和非牙源性原因。各种各样的药物,以及侵入性和非侵入性手术,可用于治疗牙源性和非牙源性疼痛。在处理口面部疼痛时,临床和药理学判断应包括系统和客观的评估,并遵循最有力的证据。在本章中,将讨论各种选择和可用于管理一些口腔面部疼痛主诉的选项。
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引用次数: 1
myoActivation: A Structured Process for Chronic Pain Resolution 肌激活:慢性疼痛解决的结构化过程
Pub Date : 2019-02-25 DOI: 10.5772/INTECHOPEN.84377
G. Lauder, N. West, Greg Siren
Chronic pain is a significant burden in all societies. The myofascial origins of chronic pain are often unrecognized but play a major role in chronic pain generation. Myofascial release has been shown to be effective and can augment the limited number of therapeutic tools available to manage chronic pain. However, there is no standardized approach that allows for comparative analysis of this technique. myoActivation ® is a unique therapeutic system, which targets active myofascial trigger points, fascia in tension, and scars in patients with chronic pain. Targets for intervention are determined through obtaining a history of lifetime trauma and a structured, reproducible posture, and movement assessment. Catenated cycles of movement tests, palpation, and needling are used to achieve the goal of pain resolution through restoration of soft tissue integrity. This chapter describes the distinctive features of myoActivation from the important key elements of the patient’s clinical history, through to the aftercare instructions. Relevant evidence for each component will be presented. Case studies will be used to illustrate some important concepts and the effectiveness of myoActivation . This chapter is relevant to all clinicians that manage people living with chronic pain.
慢性疼痛是所有社会的重大负担。慢性疼痛的肌筋膜起源往往不被认识,但在慢性疼痛的产生中起着重要作用。肌筋膜释放已被证明是有效的,可以增加有限的治疗工具,可用于管理慢性疼痛。然而,没有标准化的方法可以对这种技术进行比较分析。myoActivation®是一种独特的治疗系统,针对慢性疼痛患者的活跃肌筋膜触发点,筋膜紧张和疤痕。通过获得终生创伤史和结构化的、可重复的姿势和运动评估来确定干预目标。运动测试、触诊和针刺的连续循环被用来通过恢复软组织完整性来达到疼痛缓解的目的。本章描述了肌激活的独特特征,从患者的临床病史的重要关键因素,到后续护理说明。将介绍每个组成部分的相关证据。案例研究将用来说明一些重要的概念和肌激活的有效性。本章与所有管理慢性疼痛患者的临床医生相关。
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引用次数: 4
The Use of Neurotoxins for Palliative Treatment of Chronic Joint Pain 神经毒素在慢性关节痛的姑息治疗中的应用
Pub Date : 2019-02-20 DOI: 10.5772/INTECHOPEN.84593
H. Krug
Osteoarthritis is a significant public health problem and is rapidly increasing in prevalence with the aging population. Pain is the most disabling consequence of osteoarthritis. Treatment for pain is inadequate and needs to be addressed with new therapeutic modalities. Chronic pain is often the result of peripheral and central pain sensitization which reduces the pain threshold and increases the perceived pain response to noxious and even non-noxious stimuli. Neurotoxins can reduce this sensitization by various mechanisms and are a fertile area of research for the treatment of chronic pain. Botulinum toxins, vanilloids, and conotoxin have all been studied for the treatment of chronic pain. Botulinum toxins and vanilloids have the greatest potential as analgesics for chronic joint pain thus far. Monoclonal antibodies directed against nerve growth factor have also been developed for the treatment of chronic joint pain due to osteoarthritis. These antibodies are not technically neurotoxins but have significant analgesic potential. However, they may have undesirable side effects and are still being evaluated as possible therapies for chronic osteoarthritis pain.
骨关节炎是一个重要的公共卫生问题,随着人口老龄化,患病率迅速增加。疼痛是骨关节炎最严重的致残后果。对疼痛的治疗是不够的,需要用新的治疗方式来解决。慢性疼痛通常是外周和中枢性疼痛敏化的结果,它降低了疼痛阈值,增加了对有害甚至非有害刺激的感知疼痛反应。神经毒素可以通过各种机制降低这种致敏性,是慢性疼痛治疗研究的一个丰富领域。肉毒杆菌毒素、香草素和螺毒素都被研究用于治疗慢性疼痛。到目前为止,肉毒杆菌毒素和香草素类药物作为慢性关节疼痛的止痛药潜力最大。针对神经生长因子的单克隆抗体也被开发用于治疗骨关节炎引起的慢性关节疼痛。这些抗体在技术上不是神经毒素,但具有显著的镇痛潜力。然而,它们可能有不良的副作用,仍在评估作为慢性骨关节炎疼痛的可能治疗方法。
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引用次数: 0
The Utility of Patient-Controlled Analgesia for Managing Acute Pain in the Emergency Department 病人自控镇痛在急诊科治疗急性疼痛中的应用
Pub Date : 2019-01-11 DOI: 10.5772/INTECHOPEN.83427
M. Bender, L. Papa
There is a growing expectation of physicians to treat acute pain more aggressively in the emergency department (ED). This has contributed to an increase in opiate prescribing practices that has resulted in a crisis of medication abuse and misuse. The resultant backlash against physicians has created a void within the realm of acute pain management, as physicians search for a means to treat their patients in a way that is both empathetic and responsible. In an effort to combat this growing epidemic, alternative means of pain control are being explored. Patient-controlled analgesia devices (PCADs) have been used extensively in multiple fields of medicine and have demonstrated significant clinical utility for treating pain postoperatively; however there is a dearth of evidence to support their use within the acute care setting. Due to this lack of evidence, PCADs have not been widely implemented in the ED. Recent studies have shown that the use of PCADs may improve objective pain scores and increase both patient and nurse satisfaction while reducing the likelihood of developing chronic pain. The economic feasibility of this undertaking remains unclear; however there is strong evidence for the clinical utility of this modality to treat acute pain in this population.
越来越多的医生期望在急诊科(ED)更积极地治疗急性疼痛。这促成了阿片类药物处方做法的增加,导致了药物滥用和误用的危机。由此产生的对医生的强烈反对在急性疼痛管理领域造成了空白,因为医生正在寻找一种既感同身受又负责任的治疗方法。为了与这种日益流行的疾病作斗争,人们正在探索控制疼痛的其他方法。患者自控镇痛装置(pcad)已广泛应用于多个医学领域,并已证明了显著的临床应用,用于治疗术后疼痛;然而,缺乏证据支持它们在急性护理环境中的使用。由于缺乏证据,pcad尚未在急诊科广泛应用。最近的研究表明,使用pcad可以提高客观疼痛评分,提高患者和护士的满意度,同时降低发生慢性疼痛的可能性。这项工作的经济可行性尚不清楚;然而,有强有力的证据表明,这种方式的临床效用治疗急性疼痛在这一人群。
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引用次数: 0
期刊
From Conventional to Innovative Approaches for Pain Treatment
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