Pub Date : 2019-01-23DOI: 10.1002/9781119056942.order
P. Cunningham
A 45-year-old female complained of a right breast mass for 1 month. Ultrasound-guided breast biopsy confirmed invasive ductal carcinoma. The patient underwent [18F]FDG PET/CT for tumor staging and was included in a clinical trial of [68 Ga]Ga-FAPI (NCT04499365). Written informed consent was obtained from the patient. In [18F]FDG (a–b) and [68 Ga]Ga-FAPI PET/CT (c–d), the primary lesions (black arrow) of the right breast and the right axillary metastatic lymph nodes (black dotted arrow) showed high radioactivity uptake. No increased uptake of the tracers and abnormal bone mineral density were found in the right ilium and acetabulum (g). However, the abnormally increased uptake was observed in the right ilium and acetabulum with [99mTc] MDP SPECT/CT (e–f). The patient subsequently underwent a needle biopsy of the right iliac lesion, which was pathologically confirmed to be a bone metastasis from breast cancer (h). In this case, underlying the combination of negative FDG PET and CT findings, and positive MDP findings, it is rational to think that the lesion might be an early osteogenic bone metastasis. It has been reported that FDG uptake in osteoblastic bone metastases may not be obvious [1, 2], while MDP uptake is significantly increased. [68 Ga]GaFAPI serves as a promising radiotracer for the assessment of solid tumors [3, 4]. However, this present case is the first study to reveal that [68 Ga]Ga-FAPI might have false negative results in detecting bone metastasis. The reason might be the low expression of FAPI in early bone metastasis. Therefore, the value of [68 Ga]Ga-FAPI in bone metastases requires further investigation.
{"title":"Both","authors":"P. Cunningham","doi":"10.1002/9781119056942.order","DOIUrl":"https://doi.org/10.1002/9781119056942.order","url":null,"abstract":"A 45-year-old female complained of a right breast mass for 1 month. Ultrasound-guided breast biopsy confirmed invasive ductal carcinoma. The patient underwent [18F]FDG PET/CT for tumor staging and was included in a clinical trial of [68 Ga]Ga-FAPI (NCT04499365). Written informed consent was obtained from the patient. In [18F]FDG (a–b) and [68 Ga]Ga-FAPI PET/CT (c–d), the primary lesions (black arrow) of the right breast and the right axillary metastatic lymph nodes (black dotted arrow) showed high radioactivity uptake. No increased uptake of the tracers and abnormal bone mineral density were found in the right ilium and acetabulum (g). However, the abnormally increased uptake was observed in the right ilium and acetabulum with [99mTc] MDP SPECT/CT (e–f). The patient subsequently underwent a needle biopsy of the right iliac lesion, which was pathologically confirmed to be a bone metastasis from breast cancer (h). In this case, underlying the combination of negative FDG PET and CT findings, and positive MDP findings, it is rational to think that the lesion might be an early osteogenic bone metastasis. It has been reported that FDG uptake in osteoblastic bone metastases may not be obvious [1, 2], while MDP uptake is significantly increased. [68 Ga]GaFAPI serves as a promising radiotracer for the assessment of solid tumors [3, 4]. However, this present case is the first study to reveal that [68 Ga]Ga-FAPI might have false negative results in detecting bone metastasis. The reason might be the low expression of FAPI in early bone metastasis. Therefore, the value of [68 Ga]Ga-FAPI in bone metastases requires further investigation.","PeriodicalId":42372,"journal":{"name":"VIRGINIA QUARTERLY REVIEW","volume":"161 1","pages":"78 - 78"},"PeriodicalIF":0.2,"publicationDate":"2019-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86950147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"文学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The advent of digital music has brought with it plenty of tools for discovering new music. From online music blogs to crowd sourced recommendation services, modern music lovers have no shortage of resources for seeking out new tunes and old favorites to listen to wherever they are. However, current music discovery tools do not address a significant aspect of the music discovery process; music is an incredibly social form of art that connects users. The social element of music discovery is so inherent to the process of music discovery that some users only listen to new songs or artists on the suggestion of a trusted friend. Currently, the only tools that users have to facilitate this social music discovery require users to actively participate in this process. Merge seeks to remedy this by automating the process of music discovery and selection based on music preferences of peers as well as environmental factors and listening history.
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Book file PDF easily for everyone and every device. You can download and read online Souvenir file PDF Book only if you are registered here. And also you can download or read online all Book PDF file that related with Souvenir book. Happy reading Souvenir Bookeveryone. Download file Free Book PDF Souvenir at Complete PDF Library. This Book have some digital formats such us :paperbook, ebook, kindle, epub, fb2 and another formats. Here is The Complete PDF Book Library. It's free to register here to get Book file PDF Souvenir.
{"title":"Souvenir","authors":"B. Stroud, Eleni Kalorkoti","doi":"10.1002/pfi.4140400305","DOIUrl":"https://doi.org/10.1002/pfi.4140400305","url":null,"abstract":"Book file PDF easily for everyone and every device. You can download and read online Souvenir file PDF Book only if you are registered here. And also you can download or read online all Book PDF file that related with Souvenir book. Happy reading Souvenir Bookeveryone. Download file Free Book PDF Souvenir at Complete PDF Library. This Book have some digital formats such us :paperbook, ebook, kindle, epub, fb2 and another formats. Here is The Complete PDF Book Library. It's free to register here to get Book file PDF Souvenir.","PeriodicalId":42372,"journal":{"name":"VIRGINIA QUARTERLY REVIEW","volume":"102 1","pages":"106 - 110"},"PeriodicalIF":0.2,"publicationDate":"2019-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76388972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"文学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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