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Diagnostic Evaluation of Foreign Body Aspiration in Children 儿童异物吸入的诊断评价
IF 0.3 Q4 PEDIATRICS Pub Date : 2021-03-01 DOI: 10.4274/jpr.galenos.2020.10692
A. Erdem, B. Etensel, M. Yazıcı, Sezen Karaca Özkısacık
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引用次数: 1
Review of Tuberous Sclerosis Complex: A Single Center Experience 结节性硬化综合征的单中心经验综述
IF 0.3 Q4 PEDIATRICS Pub Date : 2021-03-01 DOI: 10.4274/JPR.GALENOS.2020.47750
A. Tosun, Beste Kıpçak Yüzbaşı, A. Akyol
Introduction Tuberous sclerosis complex (TSC) is an autosomal dominant inherited genetic disease in which multiple organ involvement is characterized by common hamartomas in many organs especially including the brain, skin, heart, eye, kidney, lung and liver. TSC is due to programmed hyperplasia of ectodermal and mesodermal cells, which is characterized by epilepsy, adenoma sebaceum and mental retardation. It has a variable age of onset and variable clinical severity. About 2/3 of these cases are formed via spontaneous mutation. Due to mutations in the TSC1 (9q34) and TSC2 (16p13.3) genes respectively, the functions of the hamartin and tuberin proteins encoded by these genes are impaired. The mammalian target of hamartin-tuberin proteins is to
结节性硬化综合征(TSC)是一种常染色体显性遗传性疾病,其多器官受累的特征是多器官常见的错构瘤,尤其是大脑、皮肤、心脏、眼睛、肾脏、肺和肝脏。TSC是由于外胚层和中胚层细胞的程序性增生,其特征是癫痫、皮脂腺腺瘤和智力迟钝。它的发病年龄和临床严重程度各不相同。这些病例中约有2/3是通过自发突变形成的。由于TSC1(9q34)和TSC2(16p13.3)基因分别发生突变,这些基因编码的hamartin和tuber蛋白的功能受损。hamartin-tuberin蛋白的哺乳动物靶点是
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引用次数: 1
Clinical Characteristics and Neurological Findings of Pediatric Patients with Acute Carbon Monoxide Intoxication 小儿急性一氧化碳中毒的临床特点和神经学表现
IF 0.3 Q4 PEDIATRICS Pub Date : 2021-03-01 DOI: 10.4274/JPR.GALENOS.2020.17894
Ülkühan Öztoprak, E. Aksoy, Özlem Yayıcı Köken, Ayşegül Danış, Ayşe Seçil Ekşioğlu, N. Tuygun, D. Yüksel
Results: A total of 326 children (166 girls, 160 boys; age range 1 to 17.8 years) with CO poisoning were identified. Their ages ranged from 1 to 17.8 years, with a mean of 8.3±4.8 years. Improperly vented coal or wood stoves were the most common (80.7%) cause of intoxication. The most common presenting symptoms were nausea/vomiting and headache. Seizure was seen in 32 patients (9.8%). Two patients died and the mortality was 0.6%. All patients received normobaric oxygen therapy until their carboxyhemoglobin (COHb) levels were decreased below 2% and their symptoms resolved. One hundred of the 326 patients (30.7%) also were treated with hyperbaric oxygen (HBO) therapy as indicated by the signs and symptoms or COHb levels. Brain imaging was performed in 19 patients (thirteen magnetic resonance imaging and six computerized tomography), and was normal in 15. Acute brain stem demyelination related to water pipe smoking developed in one patient. All patients showed complete recovery without neurological sequelae except one who had mild right hemiparesis at discharge.
结果:共326例儿童(女孩166例,男孩160例;年龄介乎1至17.8岁),均为一氧化碳中毒。年龄1 ~ 17.8岁,平均8.3±4.8岁。通风不当的煤炉或柴炉是最常见的中毒原因(80.7%)。最常见的症状是恶心/呕吐和头痛。发作32例(9.8%)。死亡2例,死亡率0.6%。所有患者均接受常压氧治疗,直至其碳氧血红蛋白(COHb)水平降至2%以下且症状缓解。根据症状和体征或COHb水平,326例患者中有100例(30.7%)也接受了高压氧(HBO)治疗。19例患者进行了脑显像(13例磁共振成像,6例计算机断层扫描),15例正常。1例急性脑干脱髓鞘与水烟吸烟有关。除1例出院时出现轻度右半瘫外,所有患者均完全康复,无神经系统后遗症。
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引用次数: 0
Neonatal Outcomes of Immigrant and Turkish Preterm Infants Treated in a Level-3 Neonatal Intensive Care Unit: A Retrospective Study 移民和土耳其早产儿在三级新生儿重症监护病房治疗的新生儿结局:一项回顾性研究
IF 0.3 Q4 PEDIATRICS Pub Date : 2021-03-01 DOI: 10.4274/JPR.GALENOS.2020.90377
Nuriye Tarakçı, F. H. Yılmaz, H. Altunhan
Ad dress for Cor res pon den ce Nuriye Tarakçı MD, Necmettin Erbakan University, Meram Faculty of Medicine, Department of Neonatology, Konya, Turkey Phone: +90 532 739 09 34 E-mail: nuriyetarakci@hotmail.com ORCID: orcid.org/0000-0003-2444-4725 Re cei ved: 10.01.2020 Ac cep ted: 18.06.2020 Introduction The number of refugees who leave their home country due to civil wars in Middle Eastern countries has been increasing gradually over the years. In parallel with low socioeconomic status, unhealthy living conditions and an increased birth rate among these immigrants, health issues are also increasing. There have been many studies that investigated the perinatal status of the global immigrant population, and their findings revealed that having an immigrant status is related to insufficient antenatal care, perinatal mortality, prematurity, low birth weight (BW) and congenital anomalies (1-4). In addition to individual/patientassociated factors in host and immigrant populations, inequality and variability in healthcare access are factors that contribute to the poor perinatal outcomes of the immigrant population.
广告服装为Cor res pon den ce Nuriye tarakmd, Necmettin Erbakan大学,Meram医学院,新生儿科,科尼亚,土耳其电话:+90 532 739 09 34 E-mail: nuriyetarakci@hotmail.com ORCID: orcid.org/0000-0003-2444-4725接收:10.01.2020 Ac接收:18.06.2020引言由于中东国家的内战而离开祖国的难民人数近年来逐渐增加。在这些移民中,除了社会经济地位低、生活条件不健康和出生率增加之外,健康问题也在增加。有许多研究调查了全球移民人口的围产期状况,他们的研究结果表明,拥有移民身份与产前护理不足、围产期死亡率、早产、低出生体重(BW)和先天性异常有关(1-4)。除了东道国和移民人口中的个人/患者相关因素外,医疗保健机会的不平等和可变性也是导致移民人口围产期结局不佳的因素。
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引用次数: 0
Relationship Among Obesity Awareness, Emotional Eating, and Obesity in Middle School Children 中学生肥胖意识、情绪性饮食与肥胖的关系
IF 0.3 Q4 PEDIATRICS Pub Date : 2021-03-01 DOI: 10.4274/JPR.GALENOS.2020.14471
Gülçin Özalp Gerçeker, Murat Bektaş
The ratio of childhood obesity has doubled in the last 30 years (4). The ratio of obese children and adolescents in the US was 16.9% (5). According to the investigation report on monitoring the growth of school children (6-10-year-old age group) project in Turkey by the General Directorate of Basic Health Services of the Turkish Ministry of Health (6) 8.5% of children were obese and the ratios of overweight children in cities and rural areas were 16.3% and 11.9%, respectively. There is a global increase in the prevalence of obesity and being overweight in children and adolescents. Researchers have the important task to investigate the causes of obesity such as sedentarism, emotional eating, parents, and children’s awareness about obesity. Demir and Bektas (7) reported that eating behaviors and parental feeding styles affect the occurrence of obesity in childhood. Parents may influence their children’s eating behaviors and result in high levels of disinhibited emotional eating in early adolescents (8). There are only a small number of studies that investigate the relationship between emotional eating and obesity in children (9,10).
儿童肥胖率在过去30年中翻了一番(4)。美国肥胖儿童和青少年的比例为16.9%(5)。根据土耳其卫生部基本卫生服务总局关于监测土耳其学龄儿童(6-10岁年龄组)成长项目的调查报告(6)8.5%的儿童肥胖,城市和农村地区超重儿童的比例分别为16.3%和11.9%。儿童和青少年肥胖和超重的患病率在全球范围内呈上升趋势。研究人员的重要任务是调查肥胖的原因,如久坐症、情绪性饮食、父母和儿童对肥胖的认识。Demir和Bektas(7)报告称,饮食行为和父母的喂养方式会影响儿童肥胖的发生。父母可能会影响孩子的饮食行为,并导致青少年早期高水平的去抑制情绪饮食(8)。只有少数研究调查了儿童情绪性饮食与肥胖之间的关系(9,10)。
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引用次数: 0
A Novel Molecular Indicator for Inhibitor Development in Haemophilia A 血友病A抑制剂发展的新分子指标
IF 0.3 Q4 PEDIATRICS Pub Date : 2021-02-22 DOI: 10.4274/JPR.GALENOS.2020.59354
Esra Işık, H. Mehdiyeva, Bilçağ Akgün, T. Köse, K. Kavaklı, F. Özkınay, T. Atik
Aim: Previous studies have reported inhibitor development (ID) risk in those patients who have hemophilia A (HA) with missense mutations to be 3-10%. We investigated the association between ID risk and various features of missense mutations; including the impact directly related to amino acid group change. Materials and Methods: Missense mutations in the F8 gene, clinical findings of the patients including severity of HA, and ID status were obtained from the F8 gene variant database (http://www.factorviii-db.org/). Twenty amino acids were then classified into groups according to their side chains. All information regarding each specific mutation, as well as any impact of the mutation on the amino acid group change, was recorded. Additionally, localization (at which domain) of any changed amino acid in the F8 protein was noted. Combined Annotation Dependent Depletion (CADD), Rare Exome Variant Ensemble Learner (REVEL), Mendelian Clinically Applicable Pathogenicity and Deleterious Annotation using Neural Networks scores were applied to identify a significant cut-off value indicative of ID. Results: Three variations were identified that could be considered as useful in the prediction of ID in mild HA. The first being that among mild HA patients, 7.9% (n=70/883) with mutations causing no amino acid group changes showed ID. This rate, however, was only 2.9% in patients with mutations leading to amino acid group changes. Secondly; in patients with mutations causing no amino acid group changes affecting A2, A3 and C2 domains, ID risk was found to be higher than in patients with mutations leading to amino acid group changes. Thirdly; an association between ID and CADD and REVEL scores was observed. Conclusion: In mild HA patients, the characteristics of missense mutations in terms of amino acid group changes, and CADD and REVEL scores could be of considerable utility in the prediction of ID risk.
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引用次数: 0
The Prevalence of Sports-related Dental Injuries and the Rate of Awareness of Mouthguard Use among Child Athletes 儿童运动员运动性口腔损伤的患病率和对使用护具的知晓率
IF 0.3 Q4 PEDIATRICS Pub Date : 2020-07-08 DOI: 10.4274/jpr.galenos.2020.92678
F. Mojarad, M. Farhadian, S. Torkaman
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引用次数: 4
The Effect of a Nurse Education Program on Infiltration and Extravasation in Pediatric Patients at a University Hospital 某大学医院护士教育计划对儿科患者浸润和外渗的影响
IF 0.3 Q4 PEDIATRICS Pub Date : 2020-07-08 DOI: 10.4274/jpr.galenos.2020.98470
Ayşe Kahraman, Gülçin Özalp Gerçeker, Figen Yardımcı, Elif Bilsin, Ş. Binay Yaz, Hamide Nur Çevik Özdemir, Atiye Karakul, Dilek Zengin, Seda Ardahan Sevgili, Merve Gümüş, Selma Akpınar, D. Başbakkal
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引用次数: 4
Evaluation of Six Patients with Chromosome 18 Structural Anomalies and Novel Findings 18号染色体结构异常6例分析及新发现
IF 0.3 Q4 PEDIATRICS Pub Date : 2020-07-08 DOI: 10.4274/jpr.galenos.2019.38278
Esra Işık, Bilçağ Akgün, T. Atik, F. Özkınay, Ö. Çoğulu
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引用次数: 0
Early Neonatal Outcomes in Premature Rupture of Membranes Beyond Twenty-eight Weeks of Gestation in a Tertiary Care Hospital of Coastal Karnataka 在沿海卡纳塔克邦的三级护理医院,胎膜早破超过28周的早期新生儿结局
IF 0.3 Q4 PEDIATRICS Pub Date : 2020-07-08 DOI: 10.4274/jpr.galenos.2019.75010
S. Shanbhag, R. Alva
1,000 live births. A million of these are due to neonatal infections. Neonatal sepsis is encountered in 1-10 per 1,000 live births in developed countries and is believed to be three times higher in developing countries (1). Premature rupture of membranes (PROM) is responsible for 5.2% of neonatal infections (2). ABS TRACT Aim: Premature rupture of membranes (PROM) is a significant risk factor for various adverse neonatal outcomes such as prematurity, respiratory distress, birth asphyxia and early onset neonatal sepsis. Due to the public health relevance of this topic and its higher burden on health care services, this study was carried out to the identify risk factors and predictors of neonatal outcomes among babies born to mothers with PROM.
1000个活产儿。其中100万人是由于新生儿感染。在发达国家,每1000名活产婴儿中有1-10例新生儿败血症,而在发展中国家,这一比例据信高出三倍(1)。胎膜早破(PROM)是5.2%的新生儿感染的原因(2)。ABS TRACT目的:胎膜早破(PROM)是各种不良新生儿结局的重要危险因素,如早产、呼吸窘迫、出生窒息和早发型新生儿败血症。由于该主题的公共卫生相关性及其对卫生保健服务的更高负担,本研究旨在确定早PROM母亲所生婴儿的新生儿结局的危险因素和预测因素。
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引用次数: 3
期刊
Journal of Pediatric Research
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