Yaehee Cho, Vidal Yook, Young-Hwan Choi, Mi Jin Park, Hyunsoo Kim, H. Jeon
{"title":"Validation of the highly sensitive person scale for suicide screening in high-risk groups: A case-control study","authors":"Yaehee Cho, Vidal Yook, Young-Hwan Choi, Mi Jin Park, Hyunsoo Kim, H. Jeon","doi":"10.23838/pfm.2022.00100","DOIUrl":"https://doi.org/10.23838/pfm.2022.00100","url":null,"abstract":"","PeriodicalId":42462,"journal":{"name":"Precision and Future Medicine","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2022-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49155347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Heejun Lee, S. Cho, Y. Shin, Dongwon Shin, Jae-Hyun Park, Mukyeong Kim, K. Oh, S. Jeon
Purpose: This study investigated the relationship between increased working hours and suicidal ideation among Korean full-time employees by gender.Methods: Participants were employees from 54 companies and local government organizations in Korea, aged 19 to 68, who completed a self-reported questionnaire on sociodemographic factors, daily perceived stress, resilience, depressive symptoms, and suicidal ideation. Of the initial 15,360 respondents, participants who worked less than 40 hours were excluded. The final sample size was 9,326 (5,652 men, 3,674 women). Sociodemographic factors and psychological characteristics of participants with suicidal ideation were analyzed using Student’s t-tests and chi-square tests for continuous and categorical variables, respectively. Hierarchical logistic regression analyses were performed using suicidality as the dependent variable respectively for all participants, for male, and female. Furthermore, we used these results to compare differences between men and women associated with regard to long working hours to better understand how long working hours correlate with suicidal ideation; further, we examined the impact of gender on this relationship.Results: In univariate analyses, suicidal ideation was associated with increased working hours. Hierarchical logistic regression analyses of sociodemographic and psychological factors found no association between long working hours and suicidal ideation for the participants overall. However, they showed significant differences between men and women, such that long working hours were associated with suicidal ideation in men but were non-significant for women.Conclusion: Suicidal ideation is associated with long working hours among Korean male full-time workers, while other factors are more likely to lead to suicidal ideation among female workers. Suicide prevention measures for employees should thus be developed based on gender.
{"title":"Suicidal ideation and long work hours by gender in Korean employees: The Kangbuk Samsung Workplace Mental Health Study: A cross-sectional study","authors":"Heejun Lee, S. Cho, Y. Shin, Dongwon Shin, Jae-Hyun Park, Mukyeong Kim, K. Oh, S. Jeon","doi":"10.23838/pfm.2022.00086","DOIUrl":"https://doi.org/10.23838/pfm.2022.00086","url":null,"abstract":"Purpose: This study investigated the relationship between increased working hours and suicidal ideation among Korean full-time employees by gender.Methods: Participants were employees from 54 companies and local government organizations in Korea, aged 19 to 68, who completed a self-reported questionnaire on sociodemographic factors, daily perceived stress, resilience, depressive symptoms, and suicidal ideation. Of the initial 15,360 respondents, participants who worked less than 40 hours were excluded. The final sample size was 9,326 (5,652 men, 3,674 women). Sociodemographic factors and psychological characteristics of participants with suicidal ideation were analyzed using Student’s t-tests and chi-square tests for continuous and categorical variables, respectively. Hierarchical logistic regression analyses were performed using suicidality as the dependent variable respectively for all participants, for male, and female. Furthermore, we used these results to compare differences between men and women associated with regard to long working hours to better understand how long working hours correlate with suicidal ideation; further, we examined the impact of gender on this relationship.Results: In univariate analyses, suicidal ideation was associated with increased working hours. Hierarchical logistic regression analyses of sociodemographic and psychological factors found no association between long working hours and suicidal ideation for the participants overall. However, they showed significant differences between men and women, such that long working hours were associated with suicidal ideation in men but were non-significant for women.Conclusion: Suicidal ideation is associated with long working hours among Korean male full-time workers, while other factors are more likely to lead to suicidal ideation among female workers. Suicide prevention measures for employees should thus be developed based on gender.","PeriodicalId":42462,"journal":{"name":"Precision and Future Medicine","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47989992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fibromuscular dysplasia (FMD) is a noninflammatory and nonatherosclerotic disease that predominantly affects the renal and internal carotid arteries. However, the cause of this disease remains unclear. Radiological studies are important diagnostic methods, which generally involve luminal features on computed tomographic angiography, magnetic resonance angiography, and digital subtraction angiography. However, the high-resolution magnetic resonance imaging (HR-MRI) features of FMD have not yet been reported. Herein, we report the HR-MRI features of patients with FMD who showed typical involvement of the internal carotid arteries. Although both patients presented a beading appearance typical of medial fibroplasia, HR-MRI nevertheless showed distinct features. HR-MRI revealed concentric wall thickening and circular enhancement with dystrophic calcification in one and wall thickening, but no enhancement in the others. Further studies are required to determine whether these HR-MRI features are related to the type of FMD or patient prognosis.
{"title":"Fibromuscular dysplasia of internal carotid arteries: features on high-resolution magnetic resonance imaging","authors":"D. Lim, O. Bang, Nam Jin Heo, J. Cha, T. Jee","doi":"10.23838/pfm.2022.00107","DOIUrl":"https://doi.org/10.23838/pfm.2022.00107","url":null,"abstract":"Fibromuscular dysplasia (FMD) is a noninflammatory and nonatherosclerotic disease that predominantly affects the renal and internal carotid arteries. However, the cause of this disease remains unclear. Radiological studies are important diagnostic methods, which generally involve luminal features on computed tomographic angiography, magnetic resonance angiography, and digital subtraction angiography. However, the high-resolution magnetic resonance imaging (HR-MRI) features of FMD have not yet been reported. Herein, we report the HR-MRI features of patients with FMD who showed typical involvement of the internal carotid arteries. Although both patients presented a beading appearance typical of medial fibroplasia, HR-MRI nevertheless showed distinct features. HR-MRI revealed concentric wall thickening and circular enhancement with dystrophic calcification in one and wall thickening, but no enhancement in the others. Further studies are required to determine whether these HR-MRI features are related to the type of FMD or patient prognosis.","PeriodicalId":42462,"journal":{"name":"Precision and Future Medicine","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42031896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Methylene blue (MB) is a well-known pharmaceutical ingredient that is thought to have a multi-targeted therapeutic effect as an anti-malarial and neuroprotective agent and has recently been identified as a treatment for coronavirus disease 2019 (COVID-19). In this review, we present an overview of relevant clinical trials, including ongoing trials, on the therapeutic uses of MB. A search for clinical trials on clinicaltrials.gov was performed using the terms "methylene blue" and "methylthionine chloride." This review focuses on clinical trials of MB-based therapies applied to brain diseases, cancer imaging and diagnosis, infectious diseases such as malaria or COVID-19, and cardiovascular diseases. Nanoparticle-based delivery techniques have also been briefly discussed in addition to common delivery methods.
{"title":"Clinical effectiveness and prospects of methylene blue: A systematic review","authors":"Assel Seitkazina, Jin-Kyoung Yang, Sehoon Kim","doi":"10.23838/pfm.2022.00079","DOIUrl":"https://doi.org/10.23838/pfm.2022.00079","url":null,"abstract":"Methylene blue (MB) is a well-known pharmaceutical ingredient that is thought to have a multi-targeted therapeutic effect as an anti-malarial and neuroprotective agent and has recently been identified as a treatment for coronavirus disease 2019 (COVID-19). In this review, we present an overview of relevant clinical trials, including ongoing trials, on the therapeutic uses of MB. A search for clinical trials on clinicaltrials.gov was performed using the terms \"methylene blue\" and \"methylthionine chloride.\" This review focuses on clinical trials of MB-based therapies applied to brain diseases, cancer imaging and diagnosis, infectious diseases such as malaria or COVID-19, and cardiovascular diseases. Nanoparticle-based delivery techniques have also been briefly discussed in addition to common delivery methods.","PeriodicalId":42462,"journal":{"name":"Precision and Future Medicine","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2022-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48582991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chronic rhinosinusitis (CRS) is classified as CRS with nasal polyps (CRSwNP) and CRS without nasal polyps (CRSsNP). CRSwNP is a distinct phenotype with heterogeneous endotypes and complex pathophysiological mechanisms. Inflammation of the sinonasal mucosa that forms NPs causes symptoms such as nasal obstruction, rhinorrhea, and smell loss, and lowers patients’ quality of life. In recent years, researchers have attempted to elucidate the inflammatory endotypes of CRSwNP, and the inflammatory pattern of Asian CRSwNP was found to be different from that of Western CRSwNP. The main en-dotype of CRSwNP is type 2 inflammation, in which interleukin (IL)-4, IL-5, and IL-13 are key cytokines. In contrast, type 1 inflammation (interferon-γ) and type 3 inflammation (IL-17 or IL-22) play essential roles in Asian CRSwNP. Biological agents, which have recently been highlighted for the treatment of CRSwNP, are very effective in suppressing the type 2 inflammatory response and recovering smell loss. However, little information is available on the efficacy of these biologics in Asian patients with CRSwNP. Herein, we reviewed the endotypes of Asian CRSwNP and compared them to those of Western CRSwNP. We identified changes in the inflammatory patterns and summarized the therapeutic options for Asian CRSwNP.
{"title":"Endotypes of Asian chronic rhinosinusitis with nasal polyps: A narrative review","authors":"Gwanghui Ryu, H. Kim, Y. Jung, S. Hong","doi":"10.23838/pfm.2022.00072","DOIUrl":"https://doi.org/10.23838/pfm.2022.00072","url":null,"abstract":"Chronic rhinosinusitis (CRS) is classified as CRS with nasal polyps (CRSwNP) and CRS without nasal polyps (CRSsNP). CRSwNP is a distinct phenotype with heterogeneous endotypes and complex pathophysiological mechanisms. Inflammation of the sinonasal mucosa that forms NPs causes symptoms such as nasal obstruction, rhinorrhea, and smell loss, and lowers patients’ quality of life. In recent years, researchers have attempted to elucidate the inflammatory endotypes of CRSwNP, and the inflammatory pattern of Asian CRSwNP was found to be different from that of Western CRSwNP. The main en-dotype of CRSwNP is type 2 inflammation, in which interleukin (IL)-4, IL-5, and IL-13 are key cytokines. In contrast, type 1 inflammation (interferon-γ) and type 3 inflammation (IL-17 or IL-22) play essential roles in Asian CRSwNP. Biological agents, which have recently been highlighted for the treatment of CRSwNP, are very effective in suppressing the type 2 inflammatory response and recovering smell loss. However, little information is available on the efficacy of these biologics in Asian patients with CRSwNP. Herein, we reviewed the endotypes of Asian CRSwNP and compared them to those of Western CRSwNP. We identified changes in the inflammatory patterns and summarized the therapeutic options for Asian CRSwNP.","PeriodicalId":42462,"journal":{"name":"Precision and Future Medicine","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2022-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49263503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Characterized by impaired mucociliary clearance with subsequent compromised microbial elimination, chronic rhinosinusitis (CRS) is known as a multifactorial disease process in which bacterial infection or colonization could play a role in the initiation or propagation of the inflammatory response. Various non-systemic, topical therapies have recently emerged as an alternative to conventional oral regimens in managing CRS. A topical sinonasal drug delivery system using a bioabsorbable stent represents one of the most attractive methods among multiple topical delivery options. This review discusses the commercially available topical drug delivery platform (sinus stents) for CRS and its shortcomings. Based on the current drawbacks of sinus stents, this article has also highlighted the future developmental perspectives to create the next generation of a sinus stent, thereby harnessing the full potential of the sinus stent as efficient topical drug delivery for recalcitrant CRS.
{"title":"The next generation of sinus stents for chronic rhinosinusitis: A systematic review","authors":"D. Lim, D. Cho","doi":"10.23838/pfm.2022.00065","DOIUrl":"https://doi.org/10.23838/pfm.2022.00065","url":null,"abstract":"Characterized by impaired mucociliary clearance with subsequent compromised microbial elimination, chronic rhinosinusitis (CRS) is known as a multifactorial disease process in which bacterial infection or colonization could play a role in the initiation or propagation of the inflammatory response. Various non-systemic, topical therapies have recently emerged as an alternative to conventional oral regimens in managing CRS. A topical sinonasal drug delivery system using a bioabsorbable stent represents one of the most attractive methods among multiple topical delivery options. This review discusses the commercially available topical drug delivery platform (sinus stents) for CRS and its shortcomings. Based on the current drawbacks of sinus stents, this article has also highlighted the future developmental perspectives to create the next generation of a sinus stent, thereby harnessing the full potential of the sinus stent as efficient topical drug delivery for recalcitrant CRS.","PeriodicalId":42462,"journal":{"name":"Precision and Future Medicine","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2022-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48601731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Systemic vasculopathy associated with an RNF213 p.Arg4810Lys variant in moyamoya disease: A review","authors":"Duk-Kyung Kim, S. Jang, Sung‐A Chang, T. Park","doi":"10.23838/pfm.2022.00009","DOIUrl":"https://doi.org/10.23838/pfm.2022.00009","url":null,"abstract":"Moyamoya\u0007disease\u0007(MMD)\u0007is\u0007a\u0007steno-occlusive\u0007disease\u0007of\u0007the\u0007distal\u0007cerebral\u0007arteries.\u0007 Ring\u0007finger\u0007protein\u0007213\u0007(RNF213)\u0007p.Arg4810Lys\u0007is\u0007a\u0007susceptibility\u0007gene\u0007of\u0007MMD\u0007for\u0007which\u0007 related\u0007vasculopathies\u0007are\u0007not\u0007well\u0007characterized.\u0007Heterozygous\u0007patients\u0007were\u0007mostly\u0007 asymptomatic\u0007or\u0007exhibited\u0007isolated\u0007MMD.\u0007Homozygous\u0007patients\u0007showed\u0007a\u0007very\u0007unique\u0007 pattern\u0007of\u0007diffuse\u0007narrowing\u0007of\u0007the\u0007entire\u0007aorta\u0007along\u0007with\u0007stenosis\u0007of\u0007the\u0007splanchnic,\u0007 renal,\u0007coronary,\u0007iliofemoral,\u0007and/or\u0007peripheral\u0007pulmonary\u0007arteries,\u0007regardless\u0007of\u0007pres-ence\u0007or\u0007absence\u0007of\u0007MMD.\u0007RNF213\u0007p.Arg4810Lys\u0007is\u0007associated\u0007with\u0007high\u0007penetrance\u0007of\u0007 systemic\u0007vasculopathy\u0007in\u0007homozygous\u0007patients\u0007and\u0007low\u0007penetrance\u0007of\u0007intracranial\u0007ste-nosis,\u0007i.e.,\u0007MMD,\u0007in\u0007heterozygous\u0007patients,\u0007which\u0007suggests\u0007a\u0007gene-dosage\u0007effect.","PeriodicalId":42462,"journal":{"name":"Precision and Future Medicine","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2022-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47411996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The Bonghan system (BHS) was discovered in the 1950s by Dr. Bong Han Kim in North Korea. His first report, published in 1962, revealed the identity of ‘acupuncture meridian’ as a vascular system. Kim published five reports, containing completely new facts on BHS: its distribution throughout the entire body, even in blood and lymphatic vessels and self-renovating function via a new cell cycle, demonstrating its fundamental nature in life. In about 1966, Kim’s research abruptly ceased but in about 2000, it was revived by Dr. Kwang-Sup Soh in South Korea, who later gave it another name, primo vascular system (PVS). Soh and other PVS scientists also uncovered new BHS/PVS facts: e.g., its roles in stem cell productions and in cancer metastasis. The review provides a glimpse of BHS/PVS science, which is so worthy of furthering. It includes: BHS and acupuncture meridian; BHS subtypes; sanal (산알)-cell cycle for cell-renovation and blood cell productions; sanals and stem cells; and cancer associated-PVS. The bases of BHS/PVS sciences are now laid out in front of us and it is up to us to combine our efforts together to further this important science. The review invites scientists in all fields to active debates to move forward and implement BHS/PVS sciences in healthcare.
Bonghan系统（BHS）是由Bong Han Kim博士于20世纪50年代在朝鲜发现的。他的第一份报告发表于1962年，揭示了“经络”作为血管系统的身份。金发表了五份报告，其中包含了关于BHS的全新事实：它分布在全身，甚至在血液和淋巴管中，并通过新的细胞周期发挥自我修复功能，展示了它在生命中的基本性质。1966年左右，金的研究突然停止，但在2000年左右，韩国的Kwang Sup Soh博士重新启动了这项研究，他后来给它起了另一个名字，原始血管系统（PVS）。Soh和其他PVS科学家也发现了新的BHS/PVS事实：例如，它在干细胞生产和癌症转移中的作用。该综述提供了BHS/PVS科学的一瞥，这是非常值得进一步发展的。它包括：BHS和针灸经络；行李处理系统亚型；疗养院(산알)-用于细胞更新和血细胞产生的细胞周期；疗养院和干细胞；以及癌症相关PVS。BHS/PVS科学的基础现在摆在我们面前，我们应该共同努力，推动这一重要科学的发展。该综述邀请所有领域的科学家进行积极的辩论，以推进并在医疗保健中实施BHS/PVS科学。
{"title":"Bonghan (primo vascular) system, elucidated by Bong Han Kim: Kim’s findings, later verifications, new findings, and prospective: A review","authors":"K. A. Kang","doi":"10.23838/pfm.2022.00030","DOIUrl":"https://doi.org/10.23838/pfm.2022.00030","url":null,"abstract":"The Bonghan system (BHS) was discovered in the 1950s by Dr. Bong Han Kim in North Korea. His first report, published in 1962, revealed the identity of ‘acupuncture meridian’ as a vascular system. Kim published five reports, containing completely new facts on BHS: its distribution throughout the entire body, even in blood and lymphatic vessels and self-renovating function via a new cell cycle, demonstrating its fundamental nature in life. In about 1966, Kim’s research abruptly ceased but in about 2000, it was revived by Dr. Kwang-Sup Soh in South Korea, who later gave it another name, primo vascular system (PVS). Soh and other PVS scientists also uncovered new BHS/PVS facts: e.g., its roles in stem cell productions and in cancer metastasis. The review provides a glimpse of BHS/PVS science, which is so worthy of furthering. It includes: BHS and acupuncture meridian; BHS subtypes; sanal (산알)-cell cycle for cell-renovation and blood cell productions; sanals and stem cells; and cancer associated-PVS. The bases of BHS/PVS sciences are now laid out in front of us and it is up to us to combine our efforts together to further this important science. The review invites scientists in all fields to active debates to move forward and implement BHS/PVS sciences in healthcare.","PeriodicalId":42462,"journal":{"name":"Precision and Future Medicine","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44948372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The discovery of novel autoantibodies in neurological disorders contributes to a better understanding of its pathogenesis, improves the accuracy of diagnosis, and leads to new treatment strategies. Advances in techniques for the screening and detection of autoantibodies have enabled the discovery of new antibodies in the central nervous system (CNS) and neuromuscular diseases. Cell-based assays using live or fixed cells overexpressing target antigens are widely used for autoantibody-based diagnosis in clinical practice. Common pathogenic autoantibodies are unknown in most patients with multiple sclerosis (MS) and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). Novel pathogenic autoantibodies to aquaporin-4 and myelin oligodendrocyte glycoprotein (MOG) have been identified in neuromyelitis optica spectrum disorder and MOG antibody-associated disease, respectively. These diseases have clinical similarities to MS, but with the discovery of pathogenic autoantibodies, they are now recognized as distinct disease entities. Antibodies to paranodal membrane proteins such as neurofascin-155, contactin‑1, contactin‑associated protein‑1 in CIDP and muscle-specific kinase and low-density lipoprotein receptor–related protein 4 in myasthenia gravis were added to the profiles of autoantibodies in neurological disorders. Despite the relatively low frequency of seropositivity, autoantibody detection is currently essential for the clinical diagnosis of CNS and neuromuscular autoimmune disorders, and differential approaches to seropositive patients will contribute to more personalized medicine. We reviewed recent discoveries of autoantibodies and their clinical implications in CNS and neuromuscular disorders.
{"title":"Autoantibodies in central nervous system and neuromuscular autoimmune disorders: A narrative review","authors":"Mi-Young Jeon, J. Seok, K. Fujihara, B. Kim","doi":"10.23838/pfm.2021.00198","DOIUrl":"https://doi.org/10.23838/pfm.2021.00198","url":null,"abstract":"The discovery of novel autoantibodies in neurological disorders contributes to a better understanding of its pathogenesis, improves the accuracy of diagnosis, and leads to new treatment strategies. Advances in techniques for the screening and detection of autoantibodies have enabled the discovery of new antibodies in the central nervous system (CNS) and neuromuscular diseases. Cell-based assays using live or fixed cells overexpressing target antigens are widely used for autoantibody-based diagnosis in clinical practice. Common pathogenic autoantibodies are unknown in most patients with multiple sclerosis (MS) and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). Novel pathogenic autoantibodies to aquaporin-4 and myelin oligodendrocyte glycoprotein (MOG) have been identified in neuromyelitis optica spectrum disorder and MOG antibody-associated disease, respectively. These diseases have clinical similarities to MS, but with the discovery of pathogenic autoantibodies, they are now recognized as distinct disease entities. Antibodies to paranodal membrane proteins such as neurofascin-155, contactin‑1, contactin‑associated protein‑1 in CIDP and muscle-specific kinase and low-density lipoprotein receptor–related protein 4 in myasthenia gravis were added to the profiles of autoantibodies in neurological disorders. Despite the relatively low frequency of seropositivity, autoantibody detection is currently essential for the clinical diagnosis of CNS and neuromuscular autoimmune disorders, and differential approaches to seropositive patients will contribute to more personalized medicine. We reviewed recent discoveries of autoantibodies and their clinical implications in CNS and neuromuscular disorders.","PeriodicalId":42462,"journal":{"name":"Precision and Future Medicine","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44794483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Y. S. Cho, Eunkyu Lee, Hokyung Jin, D. Oh, Han-Sin Jeong
Purpose: Despite the promising palliative effects of radiation treatment, few reports have studied the role of palliative tumor surgery (PTS) in patients with unresectable head and neck cancer (HNC). Thus, we aimed to present the outcomes of PTS in HNC, and suggest a possible surgical indication for PTS.Methods: We retrospectively reviewed the medical records of 18 patients who underwent PTS for HNC between 2002 and 2017. PTS was defined as surgical debulking of tumor or surgery of loco-regionaltumors in patients with distant metastasis. As functional outcomes, we evaluated changes in pain, diet, respiration, and wound care before and after PTS.Results: Squamous cell carcinoma was the common cancer type (72.2%), followed by salivary gland cancers and others. The median overall survival time was 17 months (95% confidence interval, 7.3 to 26.7). PTS significantly reduced the pain score (P= 0.013), and improved cancer-related wounds (P=0.003 in wound infection). Oral swallowing and respiration status did not change after PTS. The recurrenttumor atthe operation bed was clinically detected at post-operative 1 to 2 months with intact skin (without wound problems). Of note, further chemotherapy or other additional cancer treatments was possible in 66.7% of patients with PTS (P=0.002).Conclusion: PTS could provide a meaningful benefitto selected patients with incurable HNC, in terms of pain control and cancer wound management. Thus, PTS is a considerable option for selected HNC patients, based on the accurate evaluation oftumor extent along with multi-disciplinary consultation as well as patient counseling.
{"title":"Palliative tumor surgery for incurable head and neck cancer: indications and outcomes: A retrospective case review","authors":"Y. S. Cho, Eunkyu Lee, Hokyung Jin, D. Oh, Han-Sin Jeong","doi":"10.23838/pfm.2022.00037","DOIUrl":"https://doi.org/10.23838/pfm.2022.00037","url":null,"abstract":"Purpose: Despite the promising palliative effects of radiation treatment, few reports have studied the role of palliative tumor surgery (PTS) in patients with unresectable head and neck cancer (HNC). Thus, we aimed to present the outcomes of PTS in HNC, and suggest a possible surgical indication for PTS.Methods: We retrospectively reviewed the medical records of 18 patients who underwent PTS for HNC between 2002 and 2017. PTS was defined as surgical debulking of tumor or surgery of loco-regionaltumors in patients with distant metastasis. As functional outcomes, we evaluated changes in pain, diet, respiration, and wound care before and after PTS.Results: Squamous cell carcinoma was the common cancer type (72.2%), followed by salivary gland cancers and others. The median overall survival time was 17 months (95% confidence interval, 7.3 to 26.7). PTS significantly reduced the pain score (P= 0.013), and improved cancer-related wounds (P=0.003 in wound infection). Oral swallowing and respiration status did not change after PTS. The recurrenttumor atthe operation bed was clinically detected at post-operative 1 to 2 months with intact skin (without wound problems). Of note, further chemotherapy or other additional cancer treatments was possible in 66.7% of patients with PTS (P=0.002).Conclusion: PTS could provide a meaningful benefitto selected patients with incurable HNC, in terms of pain control and cancer wound management. Thus, PTS is a considerable option for selected HNC patients, based on the accurate evaluation oftumor extent along with multi-disciplinary consultation as well as patient counseling.","PeriodicalId":42462,"journal":{"name":"Precision and Future Medicine","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48209893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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