{"title":"Les thérapies géniques des hémoglobinopathies : une nouvelle ère, mais à quel prix ?","authors":"","doi":"10.1684/hma.2022.1753","DOIUrl":"https://doi.org/10.1684/hma.2022.1753","url":null,"abstract":"","PeriodicalId":42476,"journal":{"name":"Hematologie","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46225364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
• La leucemie myelomonocytaire chronique (LMMC) appartient au groupe des syndromes myeloproliferatifs/ myelodysplasiques identite par l'OMS il y a pres de 10 ans. Entite bien definie, elle n'eot pourtant que rarement etudiee isolement dans les essais therapeutiques, ou elle eot habituellement associee aux myelodysplasies. Les elements physiopathologiques dont on diapooe actuellement indiquent cependant qu'il s'agit d'une maladie bien distincte dont les mecanismes moleculaires, si l'on en croit le modele voisin de la j leucemie myelomonocytaire juvenile, impliquent les voies de signalisation de type Ras. Des alterations de la structure chromatinienne semblent egalement en cause. Les agents demethylants ont recemment demontre une certaine efficacite dans la LMMC. Cet article s'efforce de synthetiser les donnees dont nouo disposons actuellement dans cette maladie.
{"title":"Leucémie myélomonocytaire chronique","authors":"É. Solary","doi":"10.1684/hma.2022.1752","DOIUrl":"https://doi.org/10.1684/hma.2022.1752","url":null,"abstract":"• La leucemie myelomonocytaire chronique (LMMC) appartient au groupe des syndromes myeloproliferatifs/ myelodysplasiques identite par l'OMS il y a pres de 10 ans. Entite bien definie, elle n'eot pourtant que rarement etudiee isolement dans les essais therapeutiques, ou elle eot habituellement associee aux myelodysplasies. Les elements physiopathologiques dont on diapooe actuellement indiquent cependant qu'il s'agit d'une maladie bien distincte dont les mecanismes moleculaires, si l'on en croit le modele voisin de la j leucemie myelomonocytaire juvenile, impliquent les voies de signalisation de type Ras. Des alterations de la structure chromatinienne semblent egalement en cause. Les agents demethylants ont recemment demontre une certaine efficacite dans la LMMC. Cet article s'efforce de synthetiser les donnees dont nouo disposons actuellement dans cette maladie.","PeriodicalId":42476,"journal":{"name":"Hematologie","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46387221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Traitement en 2022 de la leucémie à tricholeucocytes et de sa forme variante","authors":"","doi":"10.1684/hma.2022.1751","DOIUrl":"https://doi.org/10.1684/hma.2022.1751","url":null,"abstract":"","PeriodicalId":42476,"journal":{"name":"Hematologie","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67567088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clinical and molecular diagnosis of hereditary and idiopathic erythrocytosis","authors":"B. Gardie, Nada Maaziz, F. Girodon","doi":"10.1684/hma.2022.1715","DOIUrl":"https://doi.org/10.1684/hma.2022.1715","url":null,"abstract":"","PeriodicalId":42476,"journal":{"name":"Hematologie","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44092651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Use of thalidomide analogues in the treatment of haematological malignancies","authors":"A. Willaume, Aline Renneville","doi":"10.1684/hma.2022.1718","DOIUrl":"https://doi.org/10.1684/hma.2022.1718","url":null,"abstract":"","PeriodicalId":42476,"journal":{"name":"Hematologie","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41688083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"From Jean Bernard to the present day: what place for ethical reflection in haematology?","authors":"C. Bommier, Laura Simon","doi":"10.1684/hma.2022.1717","DOIUrl":"https://doi.org/10.1684/hma.2022.1717","url":null,"abstract":"","PeriodicalId":42476,"journal":{"name":"Hematologie","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47597513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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