Pub Date : 2021-11-01DOI: 10.1136/lupus-2021-lupus21century.30
M. Hocaoğlu, M. Valenzuela-Almada, Jesse Y Dabit, S. Osei-Onomah, B. Chevet, R. Giblon, C. Crowson, A. Duarte-García
{"title":"512 The rising incidence, prevalence and mortality gap of lupus nephritis: a population-based study over four decades","authors":"M. Hocaoğlu, M. Valenzuela-Almada, Jesse Y Dabit, S. Osei-Onomah, B. Chevet, R. Giblon, C. Crowson, A. Duarte-García","doi":"10.1136/lupus-2021-lupus21century.30","DOIUrl":"https://doi.org/10.1136/lupus-2021-lupus21century.30","url":null,"abstract":"","PeriodicalId":427449,"journal":{"name":"500 – Lupus nephritis","volume":"53 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124612605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-01DOI: 10.1136/lupus-2021-lupus21century.27
P. Hoover, M. Peters, Jeffery B. Hodgin, Tony D. Jones, Jon Chen, A. Davidson, N. Hacohen
511 Figure 1 Lupus patients have more unstable gut microbiota than healthy individuals, and a subset of Lupus patients have blooms of Ruminococcus blautia gnavus concordant with disease flares. (A) To compare the overall dynamics of shifts in fecal communities sampled overtime in different subjects, subject variances were computed based on Jensen-Shannon Divergence using the Tw2 statistic. Variances in these three groups were significantly different (Kruskal Wallis ANOVA, p = 0.03). Patients with Lupus nephritis, based on ACR criteria, whereas the patients in the non-renal group were without a history of documented lupus nephritis. Temporal-dependent variance documents instability in the gut microbiota communities of Lupus patients compared to healthy. (B) In 11 SLE patients, a stable low abundance of RG representation was detected. (C) In 5/16 (31%) of SLE patients evaluated overtime, abundance of RG fluctuated greatly overtime. In these cases, RG abundance at much higher levels were present in fecal samples obtained proximal to visits in which disease flares were documented. In all but one excluded of these patients had documented LN. RG relative abundance was evaluated for 16 SLE in 44 samples obtained at different time points, and for CTL subjects in 49 samples obtained at different time points, which ranged from 2-12 samples per donor. Dotted line depicts 1% threshold of 16S rRNA amplicon representing RG abundance. Note that in panel C, for patient S78 the greater range of RG abundance necessitated a different scale. SLEDAI 8 was considered high disease activity. Abstracts A18 Lupus Science & Medicine 2021;8(Suppl 2):A1–A75 coright. on D ecem er 9, 2021 by gest. P rocted by httpupus.bm jcom / Lpus S ci M d: frst pulished as 10.1136/lup1-lupus21century.28 on 4 N ovem er 221. D ow nladed fom
511图1狼疮患者的肠道微生物群比健康个体更不稳定，一部分狼疮患者的蓝褐瘤球菌大量繁殖与疾病爆发一致。(A)为了比较不同受试者粪便群落随时间变化的总体动态，使用Tw2统计量基于Jensen-Shannon Divergence计算受试者方差。三组的方差差异有统计学意义(Kruskal Wallis ANOVA, p = 0.03)。狼疮性肾炎患者，基于ACR标准，而非肾脏组患者无狼疮性肾炎病史。与健康患者相比，时间依赖性方差记录了狼疮患者肠道微生物群群落的不稳定性。(B)在11例SLE患者中，检测到稳定的低丰度RG代表。(C)在5/16(31%)的SLE患者中，RG丰度随时间波动较大。在这些病例中，在记录疾病发作的就诊近端获得的粪便样本中存在高得多的RG丰度。除一例外，所有被排除的患者均有LN。在不同时间点获得的44个样本中，16个SLE受试者的RG相对丰度被评估，在不同时间点获得的49个样本中，CTL受试者的RG相对丰度从每个供者2-12个样本不等。虚线表示RG丰度的16S rRNA扩增子的1%阈值。注意，在C组中，对于患者S78, RG丰度的较大范围需要不同的刻度。SLEDAI 8被认为是高疾病活动性。[摘要]狼疮科学与医学[j]; 2021;8(增刊2):A1-A75。最迟在2021年9月9日。由httpuus赞助。[j] / Lpus S ci M d:首发号10.1136/lup1-lupus21世纪。4n上的28 / 2221。我们从
{"title":"509 The localization of novel macrophage subsets in class III and IV lupus nephritis kidney sections","authors":"P. Hoover, M. Peters, Jeffery B. Hodgin, Tony D. Jones, Jon Chen, A. Davidson, N. Hacohen","doi":"10.1136/lupus-2021-lupus21century.27","DOIUrl":"https://doi.org/10.1136/lupus-2021-lupus21century.27","url":null,"abstract":"511 Figure 1 Lupus patients have more unstable gut microbiota than healthy individuals, and a subset of Lupus patients have blooms of Ruminococcus blautia gnavus concordant with disease flares. (A) To compare the overall dynamics of shifts in fecal communities sampled overtime in different subjects, subject variances were computed based on Jensen-Shannon Divergence using the Tw2 statistic. Variances in these three groups were significantly different (Kruskal Wallis ANOVA, p = 0.03). Patients with Lupus nephritis, based on ACR criteria, whereas the patients in the non-renal group were without a history of documented lupus nephritis. Temporal-dependent variance documents instability in the gut microbiota communities of Lupus patients compared to healthy. (B) In 11 SLE patients, a stable low abundance of RG representation was detected. (C) In 5/16 (31%) of SLE patients evaluated overtime, abundance of RG fluctuated greatly overtime. In these cases, RG abundance at much higher levels were present in fecal samples obtained proximal to visits in which disease flares were documented. In all but one excluded of these patients had documented LN. RG relative abundance was evaluated for 16 SLE in 44 samples obtained at different time points, and for CTL subjects in 49 samples obtained at different time points, which ranged from 2-12 samples per donor. Dotted line depicts 1% threshold of 16S rRNA amplicon representing RG abundance. Note that in panel C, for patient S78 the greater range of RG abundance necessitated a different scale. SLEDAI 8 was considered high disease activity. Abstracts A18 Lupus Science & Medicine 2021;8(Suppl 2):A1–A75 coright. on D ecem er 9, 2021 by gest. P rocted by httpupus.bm jcom / Lpus S ci M d: frst pulished as 10.1136/lup1-lupus21century.28 on 4 N ovem er 221. D ow nladed fom","PeriodicalId":427449,"journal":{"name":"500 – Lupus nephritis","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116067476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-01DOI: 10.1136/lupus-2021-lupus21century.19
Marie-Hélene Normand, S. Lan, S. Juillard, Julie Turgeon, Annie Karakeussian-Rimbaud, Francis Migneault, É. Boilard, G. Bollée, M. Hébert, M. Dieudé
503 Figure 1 Abstracts Lupus Science & Medicine 2021;8(Suppl 2):A1–A75 A13 coright. on D ecem er 8, 2021 by gest. P rocted by httpupus.bm jcom / Lpus S ci M d: frst pulished as 10.1136/lup1-lupus21century.20 on 4 N ovem er 221. D ow nladed fom
狼疮科学与医学2021;8(增刊2):A1-A75 A13 right。最迟在2021年8月8日。由httpuus赞助。[j] / Lpus S ci M d:首发号10.1136/lup1-lupus21世纪。4号楼20号楼221号楼。我们从
{"title":"501 Anti-LG3 antibodies contribute to microvascular loss and fibrosis in lupus nephritis","authors":"Marie-Hélene Normand, S. Lan, S. Juillard, Julie Turgeon, Annie Karakeussian-Rimbaud, Francis Migneault, É. Boilard, G. Bollée, M. Hébert, M. Dieudé","doi":"10.1136/lupus-2021-lupus21century.19","DOIUrl":"https://doi.org/10.1136/lupus-2021-lupus21century.19","url":null,"abstract":"503 Figure 1 Abstracts Lupus Science & Medicine 2021;8(Suppl 2):A1–A75 A13 coright. on D ecem er 8, 2021 by gest. P rocted by httpupus.bm jcom / Lpus S ci M d: frst pulished as 10.1136/lup1-lupus21century.20 on 4 N ovem er 221. D ow nladed fom","PeriodicalId":427449,"journal":{"name":"500 – Lupus nephritis","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114404665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-01DOI: 10.1136/lupus-2021-lupus21century.25
M. Olferiev, D. Greenman, Jeffrey Zhang-Sun, David Fernandez, K. Kirou, M. Crow
{"title":"507 RNAseq gene expression confirms the importance of GWAS associated risk genes in lupus nephritis","authors":"M. Olferiev, D. Greenman, Jeffrey Zhang-Sun, David Fernandez, K. Kirou, M. Crow","doi":"10.1136/lupus-2021-lupus21century.25","DOIUrl":"https://doi.org/10.1136/lupus-2021-lupus21century.25","url":null,"abstract":"","PeriodicalId":427449,"journal":{"name":"500 – Lupus nephritis","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125427550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-01DOI: 10.1136/lupus-2021-lupus21century.28
Fatima Alduraibi, Huma Fatima, J. Hamilton, W. Chatham, H. Hsu, J. Mountz
{"title":"510 B-cell interferon-β correlates with lupus nephritis in systemic lupus erythematosus","authors":"Fatima Alduraibi, Huma Fatima, J. Hamilton, W. Chatham, H. Hsu, J. Mountz","doi":"10.1136/lupus-2021-lupus21century.28","DOIUrl":"https://doi.org/10.1136/lupus-2021-lupus21century.28","url":null,"abstract":"","PeriodicalId":427449,"journal":{"name":"500 – Lupus nephritis","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125134856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-01DOI: 10.1136/lupus-2021-lupus21century.32
A. Saxena, P. Mina-Osorio, C. Mela, V. Birardi, S. Randhawa
{"title":"514 Voclosporin for lupus nephritis: interim analysis of the AURORA 2 extension study","authors":"A. Saxena, P. Mina-Osorio, C. Mela, V. Birardi, S. Randhawa","doi":"10.1136/lupus-2021-lupus21century.32","DOIUrl":"https://doi.org/10.1136/lupus-2021-lupus21century.32","url":null,"abstract":"","PeriodicalId":427449,"journal":{"name":"500 – Lupus nephritis","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129995568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-01DOI: 10.1136/lupus-2021-lupus21century.29
Doua F. Azzouz, Ze Chen, P. Izmirly, D. Fenyo, J. Buyon, A. Alekseyenko, G. Silverman
{"title":"511 Disease flares in lupus are concordant with Ruminococcus Blautia Gnavus blooms arising within unstable gut microbiota communities","authors":"Doua F. Azzouz, Ze Chen, P. Izmirly, D. Fenyo, J. Buyon, A. Alekseyenko, G. Silverman","doi":"10.1136/lupus-2021-lupus21century.29","DOIUrl":"https://doi.org/10.1136/lupus-2021-lupus21century.29","url":null,"abstract":"","PeriodicalId":427449,"journal":{"name":"500 – Lupus nephritis","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134579144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-01DOI: 10.1136/lupus-2021-lupus21century.26
J. Thurman, B. Renner, N. Serkova, D. Ljubanović, L. Kulik, Felix Poppelaars, V. Michael Holers
{"title":"508 C3D-imaging in lupus nephritis","authors":"J. Thurman, B. Renner, N. Serkova, D. Ljubanović, L. Kulik, Felix Poppelaars, V. Michael Holers","doi":"10.1136/lupus-2021-lupus21century.26","DOIUrl":"https://doi.org/10.1136/lupus-2021-lupus21century.26","url":null,"abstract":"","PeriodicalId":427449,"journal":{"name":"500 – Lupus nephritis","volume":"67 12","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132364268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-01DOI: 10.1136/lupus-2021-lupus21century.23
Minjung Kim, Anthony D Marinov, M. Shlomchik, J. Tilstra
{"title":"505 Parenchymal INFγ response regulates murine lupus nephritis","authors":"Minjung Kim, Anthony D Marinov, M. Shlomchik, J. Tilstra","doi":"10.1136/lupus-2021-lupus21century.23","DOIUrl":"https://doi.org/10.1136/lupus-2021-lupus21century.23","url":null,"abstract":"","PeriodicalId":427449,"journal":{"name":"500 – Lupus nephritis","volume":"69 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133782776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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