Pub Date : 2017-09-14DOI: 10.19080/gjn.2017.02.555600
Sougata Ghosh
Nanomedicines are emerging outcomes of nanobiotechnology which have promising pharmaceutical applications. Although there are various physical and chemical methods for synthesis of nanoparticles, most of them involve hazardous and toxic chemicals. Thus, there is a continuously growing need for investigation of novel routes to synthesize nanoparticles with enhanced biocompatibility and reduced toxicity. Medicinal plants are rich source of diverse photochemical responsible for simultaneous reduction and stabilization of nanoparticles. Herein, we report for the first time, the synthesis of platinum nanoparticles (PtNPs) and palladium nanoparticles (PdNPs) using Barleria prionitis extract (BPLE). PtNPs and PdNPs were characterized using UV-visible spectroscopy. High resolution transmission electron microscopy (HRTEM) revealed that the PtNPs were between 1 to 2 nm while PdNPs were between 5 to 7 nm. Further energy dispersive spectroscopy (EDS) and dynamic light scattering (DLS) confirmed the elemental composition and hydrodynamic size, respectively. Fourier transformed infrared spectra (FTIR) confirmed the involvement of diverse photochemical in reduction and stabilization of the nanoparticles. Both PtNPs and PdNPs were tested for anticancer activity against human breast adenocarcinoma (MCF-7) cell lines which showed reduced viability up to 60.08 ± 2.4 % and 57.22 ± 1.68 %, respectively. Further, flow cytometric studies and confocal microscopy using dual staining method with annexin V-FITC and propidium iodide indicated apoptosis induction as the plausible mechanism exhibiting externalization of phosphatidylserine and loss of cell membrane integrity. This is the first report on PtNPs and PdNPs synthesized by BPLE as promising anticancer agents.
{"title":"Novel Anticancer Platinum and Palladium Nanoparticles from Barleria prionitis","authors":"Sougata Ghosh","doi":"10.19080/gjn.2017.02.555600","DOIUrl":"https://doi.org/10.19080/gjn.2017.02.555600","url":null,"abstract":"Nanomedicines are emerging outcomes of nanobiotechnology which have promising pharmaceutical applications. Although there are various physical and chemical methods for synthesis of nanoparticles, most of them involve hazardous and toxic chemicals. Thus, there is a continuously growing need for investigation of novel routes to synthesize nanoparticles with enhanced biocompatibility and reduced toxicity. Medicinal plants are rich source of diverse photochemical responsible for simultaneous reduction and stabilization of nanoparticles. Herein, we report for the first time, the synthesis of platinum nanoparticles (PtNPs) and palladium nanoparticles (PdNPs) using Barleria prionitis extract (BPLE). PtNPs and PdNPs were characterized using UV-visible spectroscopy. High resolution transmission electron microscopy (HRTEM) revealed that the PtNPs were between 1 to 2 nm while PdNPs were between 5 to 7 nm. Further energy dispersive spectroscopy (EDS) and dynamic light scattering (DLS) confirmed the elemental composition and hydrodynamic size, respectively. Fourier transformed infrared spectra (FTIR) confirmed the involvement of diverse photochemical in reduction and stabilization of the nanoparticles. Both PtNPs and PdNPs were tested for anticancer activity against human breast adenocarcinoma (MCF-7) cell lines which showed reduced viability up to 60.08 ± 2.4 % and 57.22 ± 1.68 %, respectively. Further, flow cytometric studies and confocal microscopy using dual staining method with annexin V-FITC and propidium iodide indicated apoptosis induction as the plausible mechanism exhibiting externalization of phosphatidylserine and loss of cell membrane integrity. This is the first report on PtNPs and PdNPs synthesized by BPLE as promising anticancer agents.","PeriodicalId":427673,"journal":{"name":"Global Journal of Nanomedicine","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126398607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-08-31DOI: 10.19080/gjn.2017.02.555599
Fei Sun, Deyang Chen
Ferroelectric materials, one of the current research focus with a number of fascinating properties such as ferroelectricity, piezoelectricity, pyroelectricity and dielectricity, has extensive application value in biomedical systems. Here we review the biomedical applications of ferroelectric materials, including ferroelectric ceramics, ferroelectric thin films, and ferroelectric polymers. Some unresolved problems are summarized and the future directions of applications in biomedicine are prospected as well.
{"title":"Ferroelectrics for Biomedical Applications","authors":"Fei Sun, Deyang Chen","doi":"10.19080/gjn.2017.02.555599","DOIUrl":"https://doi.org/10.19080/gjn.2017.02.555599","url":null,"abstract":"Ferroelectric materials, one of the current research focus with a number of fascinating properties such as ferroelectricity, piezoelectricity, pyroelectricity and dielectricity, has extensive application value in biomedical systems. Here we review the biomedical applications of ferroelectric materials, including ferroelectric ceramics, ferroelectric thin films, and ferroelectric polymers. Some unresolved problems are summarized and the future directions of applications in biomedicine are prospected as well.","PeriodicalId":427673,"journal":{"name":"Global Journal of Nanomedicine","volume":"89 2-3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123574859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-08-23DOI: 10.19080/gjn.2017.02.555598
R. Paul
Diamond-like carbon (DLC) is considered as a versatile coating material that finds a variety of mechanical and biomedical applications, including endoprosthesis and dental implants [1]. It provides mechanical robustness and cell-compatibility at the same time. Therefore, DLC has been extensively researched for achieving high hardness, low friction, high wear resistance to make it more sustainable [2]. Furthermore, DLC coatings are antithrombogenic and noncytotoxic. Consequently, they are being critically explored for various in-vivo and in-vitro biomedical applications ranging from orthopaedic applications to cardiovascular as well as neural interfacing agent. As such, DLC coatings has been certified as biocompatible in both in vitro and in vivo studies due to their strong C-C bonding environment [3,4].
{"title":"Diamond-Like-Carbon Coatings for Advanced Biomedical Applications","authors":"R. Paul","doi":"10.19080/gjn.2017.02.555598","DOIUrl":"https://doi.org/10.19080/gjn.2017.02.555598","url":null,"abstract":"Diamond-like carbon (DLC) is considered as a versatile coating material that finds a variety of mechanical and biomedical applications, including endoprosthesis and dental implants [1]. It provides mechanical robustness and cell-compatibility at the same time. Therefore, DLC has been extensively researched for achieving high hardness, low friction, high wear resistance to make it more sustainable [2]. Furthermore, DLC coatings are antithrombogenic and noncytotoxic. Consequently, they are being critically explored for various in-vivo and in-vitro biomedical applications ranging from orthopaedic applications to cardiovascular as well as neural interfacing agent. As such, DLC coatings has been certified as biocompatible in both in vitro and in vivo studies due to their strong C-C bonding environment [3,4].","PeriodicalId":427673,"journal":{"name":"Global Journal of Nanomedicine","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127562866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-08-04DOI: 10.19080/gjn.2017.02.555596
M. Nojima
Imaging mass spectrometric technologies are innovating biological or medical scientific reorganizations using secondary ion mass spectrometry (SIMS) or matrix-assisted laser desorption ionization (MALDI) imaging [1]. This article briefly introduces“ an imaging mass spectrogram” by new principle double rotating electric fields (REFs) type mass spectrometer [2,3]. The imaging mass spectrogram indicates not spatial mass distributions but mass constitutions. Different masses draw annular ring patterns with respect to their existences and intensities on the same field of in the same time. The imaging mass spectrogram can be obtained by specific features of REFs type mass spectrometer; separates mass weight by filtering in high speed double REFs and draws annular ring patterns with direct continuous beam, simultaneously. The imaging mass spectrograms are mostly controlled by frequencies and intensities of REFs. The relationship with a specific frequency: f and a weight of single charged mass: m can be described by following equation [4]. 2 1 acc eV f L m =
成像质谱技术是利用二次离子质谱(SIMS)或基质辅助激光解吸电离(MALDI)成像进行生物或医学科学重组的创新技术[1]。本文简要介绍了新原理双旋转电场(REFs)型质谱仪的“成像质谱”[2,3]。成像质谱图显示的不是空间质量分布，而是质量构成。不同质量在同一场或同一时间内的存在度和强度绘制出环形图案。利用REFs型质谱仪的特定特性，可获得成像质谱图;在高速双REFs中通过滤波分离质量重量，同时用直接连续光束绘制环形图案。成像质谱图主要由REFs的频率和强度控制。特定频率f与单电荷质量质量m的关系可以用下式[4]来描述。2 1 acc eV f L m =
{"title":"Imaging Mass Spectrogram using Rotating Electric Fields Mass Spectrometer","authors":"M. Nojima","doi":"10.19080/gjn.2017.02.555596","DOIUrl":"https://doi.org/10.19080/gjn.2017.02.555596","url":null,"abstract":"Imaging mass spectrometric technologies are innovating biological or medical scientific reorganizations using secondary ion mass spectrometry (SIMS) or matrix-assisted laser desorption ionization (MALDI) imaging [1]. This article briefly introduces“ an imaging mass spectrogram” by new principle double rotating electric fields (REFs) type mass spectrometer [2,3]. The imaging mass spectrogram indicates not spatial mass distributions but mass constitutions. Different masses draw annular ring patterns with respect to their existences and intensities on the same field of in the same time. The imaging mass spectrogram can be obtained by specific features of REFs type mass spectrometer; separates mass weight by filtering in high speed double REFs and draws annular ring patterns with direct continuous beam, simultaneously. The imaging mass spectrograms are mostly controlled by frequencies and intensities of REFs. The relationship with a specific frequency: f and a weight of single charged mass: m can be described by following equation [4]. 2 1 acc eV f L m =","PeriodicalId":427673,"journal":{"name":"Global Journal of Nanomedicine","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116959646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-08-03DOI: 10.19080/gjn.2017.02.555595
M. P
{"title":"Nanoparticle-Assisted Herbal Synergism an Effective Therapeutic Approach for the Targeted Treatment of Breast Cancer: A Novel Prospective","authors":"M. P","doi":"10.19080/gjn.2017.02.555595","DOIUrl":"https://doi.org/10.19080/gjn.2017.02.555595","url":null,"abstract":"","PeriodicalId":427673,"journal":{"name":"Global Journal of Nanomedicine","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127022819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-08-02DOI: 10.19080/gjn.2017.02.555594
Mewa Singh
{"title":"Nanotechnology to Beat Generic and Patent Cliff Ophthalmic Project","authors":"Mewa Singh","doi":"10.19080/gjn.2017.02.555594","DOIUrl":"https://doi.org/10.19080/gjn.2017.02.555594","url":null,"abstract":"","PeriodicalId":427673,"journal":{"name":"Global Journal of Nanomedicine","volume":"288 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127554880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-07-26DOI: 10.19080/gjn.2017.02.555593
Mozafari Mr
Nanoscale lipidic carrier systems have crucial role in drug delivery, drug targeting, diagnostics and nanotherapy. These systems include liposome, nanoliposome, archaeosome, vesicular gels and more recently introduced tocosome. They can accommodate water-soluble material in their aqueous compartment(s) and, if required simultaneously, lipid-soluble substances in their lipid phases. There are already a number of approved liposomal and nanoliposomal products on the market for Human use. However, in order to improve the quality, shelf-life and safety of these products, it is necessary to pay particular attention to the choice of manufacturing method and especially selection of solvents and co-solvents. This entry will focus on the importance of preparation methods and solvents in the manufacture of lipidic nanocarriers.
{"title":"Nanoscale Lipidic Carrier Systems: Importance of Preparation Method and Solvents","authors":"Mozafari Mr","doi":"10.19080/gjn.2017.02.555593","DOIUrl":"https://doi.org/10.19080/gjn.2017.02.555593","url":null,"abstract":"Nanoscale lipidic carrier systems have crucial role in drug delivery, drug targeting, diagnostics and nanotherapy. These systems include liposome, nanoliposome, archaeosome, vesicular gels and more recently introduced tocosome. They can accommodate water-soluble material in their aqueous compartment(s) and, if required simultaneously, lipid-soluble substances in their lipid phases. There are already a number of approved liposomal and nanoliposomal products on the market for Human use. However, in order to improve the quality, shelf-life and safety of these products, it is necessary to pay particular attention to the choice of manufacturing method and especially selection of solvents and co-solvents. This entry will focus on the importance of preparation methods and solvents in the manufacture of lipidic nanocarriers.","PeriodicalId":427673,"journal":{"name":"Global Journal of Nanomedicine","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125527488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-07-26DOI: 10.19080/gjn.2017.02.555592
Ou Cr
{"title":"Al Doping Effect on the Growth Rate Enhancement and Magnetic Properties of ZnO Nanorods Synthesized By Hydrothermal Method","authors":"Ou Cr","doi":"10.19080/gjn.2017.02.555592","DOIUrl":"https://doi.org/10.19080/gjn.2017.02.555592","url":null,"abstract":"","PeriodicalId":427673,"journal":{"name":"Global Journal of Nanomedicine","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114784352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-07-25DOI: 10.19080/gjn.2017.02.555591
R. Bhatia
The element carbon is ubiquitous and is intimately connected with life on earth. Its allotropes, graphite and diamond are well known. Graphite conducts both heat and electricity but diamondone of the hardest materials known is non-conducting. In recent years, other allotropic forms of carbon have been discovered. These include fullerenes, carbon nanotubes and graphene, which play an important role in the field of nanotechnology.
{"title":"Biomedical Applications of Functionalized Carbon Nanotubes","authors":"R. Bhatia","doi":"10.19080/gjn.2017.02.555591","DOIUrl":"https://doi.org/10.19080/gjn.2017.02.555591","url":null,"abstract":"The element carbon is ubiquitous and is intimately connected with life on earth. Its allotropes, graphite and diamond are well known. Graphite conducts both heat and electricity but diamondone of the hardest materials known is non-conducting. In recent years, other allotropic forms of carbon have been discovered. These include fullerenes, carbon nanotubes and graphene, which play an important role in the field of nanotechnology.","PeriodicalId":427673,"journal":{"name":"Global Journal of Nanomedicine","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124484583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-07-07DOI: 10.19080/gjn.2017.02.555590
Mohit Rawat
{"title":"Green Synthesis of Silver Nanoparticles via Various Plant Extracts for Anti-Cancer Applications","authors":"Mohit Rawat","doi":"10.19080/gjn.2017.02.555590","DOIUrl":"https://doi.org/10.19080/gjn.2017.02.555590","url":null,"abstract":"","PeriodicalId":427673,"journal":{"name":"Global Journal of Nanomedicine","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129982211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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