: BACKGROUND AND AIM: Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive lung disease with a poor prognosis, characterized by advanced fibrosis. The course of the disease varies from patient to patient. The factors that determine the course of the disease are yet to be clarified. Here, we aimed to assess patient characteristics, overall mortality, and mortality-associ-ated factors in our IPF patient cohort. METHODS: Our multicenter, retrospective cohort study reviewed the records of 169 patients diagnosed with IPF who had mild-to-moderate functional impairment and were followed up for at least one year from diagnosis until death between 2009 and 2019. RESULTS: The mean age of the 169 IPF patients was 69.7±8.8 years, and 73.4% were male. The diagnosis was established clinically and radiologically in 152 (89.9%) patients and histopathologically in 17 (10%) patients. A smoking history was found in 72.2% of the patients, with an average smoking quantity of 35.6±14.7 pack-years. Among the patients, 28 (16.6%) did not receive treatment, 87 (51.5%) received pirfenidone, and 54 (31.9%) nintedanib treatment. The median Gender, Age, and Physiology (GAP) score of the patients was 3. The mean forced vital capacity (FVC) was 79.6%±19.7%, the mean diffusing capacity of the lungs for carbon monoxide (DLCO) was 52.8%
{"title":"Factors associated with mortality in cases of idiopathic pulmonary fibrosis with mild to moderate functional impairment","authors":"Aysun Şengül","doi":"10.14744/ejp.2022.1202","DOIUrl":"https://doi.org/10.14744/ejp.2022.1202","url":null,"abstract":": BACKGROUND AND AIM: Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive lung disease with a poor prognosis, characterized by advanced fibrosis. The course of the disease varies from patient to patient. The factors that determine the course of the disease are yet to be clarified. Here, we aimed to assess patient characteristics, overall mortality, and mortality-associ-ated factors in our IPF patient cohort. METHODS: Our multicenter, retrospective cohort study reviewed the records of 169 patients diagnosed with IPF who had mild-to-moderate functional impairment and were followed up for at least one year from diagnosis until death between 2009 and 2019. RESULTS: The mean age of the 169 IPF patients was 69.7±8.8 years, and 73.4% were male. The diagnosis was established clinically and radiologically in 152 (89.9%) patients and histopathologically in 17 (10%) patients. A smoking history was found in 72.2% of the patients, with an average smoking quantity of 35.6±14.7 pack-years. Among the patients, 28 (16.6%) did not receive treatment, 87 (51.5%) received pirfenidone, and 54 (31.9%) nintedanib treatment. The median Gender, Age, and Physiology (GAP) score of the patients was 3. The mean forced vital capacity (FVC) was 79.6%±19.7%, the mean diffusing capacity of the lungs for carbon monoxide (DLCO) was 52.8%","PeriodicalId":42933,"journal":{"name":"Eurasian Journal of Pulmonology","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135709316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
: Pulmonary embolism (PE) is a preventable cause of death associated with high morbidity and mortality rates. Cancer is a significant risk factor for PE. In this case report, we present a patient with PE who was diagnosed with hepatocellular carcinoma (HCC) one month later. The patient had an unresectable tumor in the liver that had invaded both the inferior vena cava and the right atrium. He underwent transarterial chemoembolization (TACE) and sorafenib treatment. After two years, he underwent stereotactic radiosurgery, and he was switched to regorafenib. After five years, he was cured. This case is unique in terms of long survival compared to the literature.
{"title":"Pulmonary embolism as the first sign of hepatocellular carcinoma in a patient who was cured after five years","authors":"Dorina Esendağlı","doi":"10.14744/ejp.2023.4007","DOIUrl":"https://doi.org/10.14744/ejp.2023.4007","url":null,"abstract":": Pulmonary embolism (PE) is a preventable cause of death associated with high morbidity and mortality rates. Cancer is a significant risk factor for PE. In this case report, we present a patient with PE who was diagnosed with hepatocellular carcinoma (HCC) one month later. The patient had an unresectable tumor in the liver that had invaded both the inferior vena cava and the right atrium. He underwent transarterial chemoembolization (TACE) and sorafenib treatment. After two years, he underwent stereotactic radiosurgery, and he was switched to regorafenib. After five years, he was cured. This case is unique in terms of long survival compared to the literature.","PeriodicalId":42933,"journal":{"name":"Eurasian Journal of Pulmonology","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67326286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
: Pulmonary ossification is an uncommon, chronic, and progressive lung disease characterized by the presence of mature bone within the lung parenchyma. Diagnosis during life is rare; most cases are detected incidentally during autopsies. Chronic interstitial inflammation typically occurs in the lungs. This often leads to fibrosis in the parenchyma, though it can sometimes be idiopathic. Dendriform pulmonary ossification (DPO) can be classified as either idiopathic or secondary to an existing lung disease. Even though most patients are diagnosed through autopsy series, we present our case diagnosed using a videothoracoscopic wedge resection. A 49-year-old male patient, who has no chronic diseases and has never smoked, worked in aluminum casting for nine years, approxiately a decade ago. He visited the chest diseases clinic with complaints of increasing chest pain and shortness of breath over the past year. Physical examination revealed rales in the bilateral lung bases, but no clubbing. His oxygen saturation was 98%. Reticulonodular patterns were noted in all zones of both hemithoraces on a chest X-ray. The thorax Computed Tomography (CT) showed milimetric punctate calcific diffuse nodular and septal thickenings accompanied by pleuroparenchymal bands in both lungs. The patient, whose pulmonary function test was limited, was started on a therapeutic dose of 32 mg prednol. Gas exchange was reassessed with Diffusing Capacity of the Lung for Carbon Monoxide (DLCO) after two weeks. A diagnostic biportal videotho-racoscopic wedge resection was performed on the patient. Due to the tough nature of the lung tissue, two staples broke during the operation. The patient was discharged on the second post-operative day with a pathology report confirming dendriform pulmonary ossification. The patient’s outpatient follow-up is ongoing. DPO is most often diagnosed from surgical samples or during autopsies. It is a rare lung pathology characterized by the presence of mature bone tissue within the lung parenchyma. The disease frequently arises secondary to an underlying lung condition. Chronic inflammation is believed to play a role in its etiology. As seen in our patient’s case, professions like aluminum casting can also cause chronic lung inflammation, potentially leading to DPO.
{"title":"A very rare pulmonary pathology from symptom to diagnosis: Dendriform pulmonary ossification","authors":"Merve Ekinci Fidan","doi":"10.14744/ejp.2023.1206","DOIUrl":"https://doi.org/10.14744/ejp.2023.1206","url":null,"abstract":": Pulmonary ossification is an uncommon, chronic, and progressive lung disease characterized by the presence of mature bone within the lung parenchyma. Diagnosis during life is rare; most cases are detected incidentally during autopsies. Chronic interstitial inflammation typically occurs in the lungs. This often leads to fibrosis in the parenchyma, though it can sometimes be idiopathic. Dendriform pulmonary ossification (DPO) can be classified as either idiopathic or secondary to an existing lung disease. Even though most patients are diagnosed through autopsy series, we present our case diagnosed using a videothoracoscopic wedge resection. A 49-year-old male patient, who has no chronic diseases and has never smoked, worked in aluminum casting for nine years, approxiately a decade ago. He visited the chest diseases clinic with complaints of increasing chest pain and shortness of breath over the past year. Physical examination revealed rales in the bilateral lung bases, but no clubbing. His oxygen saturation was 98%. Reticulonodular patterns were noted in all zones of both hemithoraces on a chest X-ray. The thorax Computed Tomography (CT) showed milimetric punctate calcific diffuse nodular and septal thickenings accompanied by pleuroparenchymal bands in both lungs. The patient, whose pulmonary function test was limited, was started on a therapeutic dose of 32 mg prednol. Gas exchange was reassessed with Diffusing Capacity of the Lung for Carbon Monoxide (DLCO) after two weeks. A diagnostic biportal videotho-racoscopic wedge resection was performed on the patient. Due to the tough nature of the lung tissue, two staples broke during the operation. The patient was discharged on the second post-operative day with a pathology report confirming dendriform pulmonary ossification. The patient’s outpatient follow-up is ongoing. DPO is most often diagnosed from surgical samples or during autopsies. It is a rare lung pathology characterized by the presence of mature bone tissue within the lung parenchyma. The disease frequently arises secondary to an underlying lung condition. Chronic inflammation is believed to play a role in its etiology. As seen in our patient’s case, professions like aluminum casting can also cause chronic lung inflammation, potentially leading to DPO.","PeriodicalId":42933,"journal":{"name":"Eurasian Journal of Pulmonology","volume":"71 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135709340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
: BACKGROUND AND AIM: The neutrophil/lymphocyte ratio (NLR) has been demonstrated to be a prognostic marker in various cancers, including non-small cell lung cancer (NSCLC). Nevertheless, very little is known about this ratio in the specific NSCLC population that includes a targetable epidermal growth factor receptor (EGFR) mutation. METHODS: Histologically or cytologically confirmed stage IIIB or IV NSCLC cases with a targetable EGFR mutation between 2014 and 2018 were retrospectively evaluated. The optimal cut-off value for NLR for prognostic purposes was determined by Receiver Operating Characteristic (ROC) analysis. The patients were divided into two groups according to the determined cut-off value, and the groups were compared in terms of variables, and the effect on overall survival was evaluated. Univariate cox regression analysis included age, gender, the extent of the primary tumor (T), involvement of regional lymph nodes (N), Tumor, Node, and Metastasis (TNM), and cancer treatment, in addition to NLR. RESULTS: The study included 62 patients. In the ROC analysis, Area Under the Curve (AUC): 0.643 (95% Confidence Interval (CI): 0.504−0.783), and the cut-off for NLR was determined as 2.57 considering the highest “Youden’s index”. Accordingly, the specificity was found to be 51.85%, and sensitivity was 74.29%. Survival was 23 (15.824−30.176) months in the NLR>2.57 group, while it was 38 (29.665−46.335) months in the NLR equal to or lower than 2.57 (p=0.218). No statistically significant difference was found between the NLR rate and overall survival (OS). CONCLUSIONS: Although no statistical significance was reached, the high NLR ratio was possibly found to be associated with poor prognosis in cases with EGFR mutant lung cancer, mostly composed of stage 4 cancer.
{"title":"The contribution of neutrophil-lymphocyte ratio on prognosis in patients diagnosed with epidermal growth factor receptor mutant lung adenocarcinoma","authors":"Suna Kavurgacı","doi":"10.14744/ejp.2023.1003","DOIUrl":"https://doi.org/10.14744/ejp.2023.1003","url":null,"abstract":": BACKGROUND AND AIM: The neutrophil/lymphocyte ratio (NLR) has been demonstrated to be a prognostic marker in various cancers, including non-small cell lung cancer (NSCLC). Nevertheless, very little is known about this ratio in the specific NSCLC population that includes a targetable epidermal growth factor receptor (EGFR) mutation. METHODS: Histologically or cytologically confirmed stage IIIB or IV NSCLC cases with a targetable EGFR mutation between 2014 and 2018 were retrospectively evaluated. The optimal cut-off value for NLR for prognostic purposes was determined by Receiver Operating Characteristic (ROC) analysis. The patients were divided into two groups according to the determined cut-off value, and the groups were compared in terms of variables, and the effect on overall survival was evaluated. Univariate cox regression analysis included age, gender, the extent of the primary tumor (T), involvement of regional lymph nodes (N), Tumor, Node, and Metastasis (TNM), and cancer treatment, in addition to NLR. RESULTS: The study included 62 patients. In the ROC analysis, Area Under the Curve (AUC): 0.643 (95% Confidence Interval (CI): 0.504−0.783), and the cut-off for NLR was determined as 2.57 considering the highest “Youden’s index”. Accordingly, the specificity was found to be 51.85%, and sensitivity was 74.29%. Survival was 23 (15.824−30.176) months in the NLR>2.57 group, while it was 38 (29.665−46.335) months in the NLR equal to or lower than 2.57 (p=0.218). No statistically significant difference was found between the NLR rate and overall survival (OS). CONCLUSIONS: Although no statistical significance was reached, the high NLR ratio was possibly found to be associated with poor prognosis in cases with EGFR mutant lung cancer, mostly composed of stage 4 cancer.","PeriodicalId":42933,"journal":{"name":"Eurasian Journal of Pulmonology","volume":"139 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135709321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
: Coronavirus Disease 2019 (COVID-19), a highly infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), has emerged as a global pandemic. The disease has a range of manifestations in terms of severity; it mainly causes respiratory dysfunction but can also lead to damage in multiple organs. Although the majority of COVID-19 patients can fully recover, severe cases may result in post-infectious complications. Pulmonary fibrosis is one of the severe long-term complications reported in COVID-19 that may lead to permanent lung damage or death. The long-term sequelae of COVID-19 raise significant global health concerns related to the pandemic. Currently, there is no proven effective strategy for managing post-COVID-19 pulmonary fibrosis. As its incidence is estimated to increase in the near future, it is important to learn about and stay updated on the progress of this disease. This article explores and discusses the latest clinical evidence on post-COVID-19 pulmonary fibrosis, including the underlying mechanisms, potential risk factors, and appropriate management options.
{"title":"Pulmonary fibrosis as a sequela of COVID-19 infection: What do we know?","authors":"Sandy Nur Vania Putri","doi":"10.14744/ejp.2023.1004","DOIUrl":"https://doi.org/10.14744/ejp.2023.1004","url":null,"abstract":": Coronavirus Disease 2019 (COVID-19), a highly infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), has emerged as a global pandemic. The disease has a range of manifestations in terms of severity; it mainly causes respiratory dysfunction but can also lead to damage in multiple organs. Although the majority of COVID-19 patients can fully recover, severe cases may result in post-infectious complications. Pulmonary fibrosis is one of the severe long-term complications reported in COVID-19 that may lead to permanent lung damage or death. The long-term sequelae of COVID-19 raise significant global health concerns related to the pandemic. Currently, there is no proven effective strategy for managing post-COVID-19 pulmonary fibrosis. As its incidence is estimated to increase in the near future, it is important to learn about and stay updated on the progress of this disease. This article explores and discusses the latest clinical evidence on post-COVID-19 pulmonary fibrosis, including the underlying mechanisms, potential risk factors, and appropriate management options.","PeriodicalId":42933,"journal":{"name":"Eurasian Journal of Pulmonology","volume":"139 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135710926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
: BACKGROUND AND AIM: Musculoskeletal pain, anxiety, and sleep problems may persist in people after Coronavirus Disease 2019 (COVID-19). The aim of this study was to examine the effects of strengthening and relaxation exercises on musculoskeletal pain, anxiety, and sleep quality in COVID-19 survivors. METHODS: The study was conducted at Gaziosmanpaşa Training and Research Hospital and included outpatients aged between 18 and 65 who were diagnosed with COVID-19 in the last 3 months. Subjects were randomly assigned to either experimental or control groups. The experimental group participated in a home-based strengthening and relaxation exercises program 3 times a week for 8 weeks, while control group participants did not receive any exercise program. McGill Pain Scale Short Form (SF-MPQ), Short-Form 36 (SF-36), Beck Anxiety Scale, and Pittsburgh Sleep Quality Index (PSQI) were conducted on all patients before and after the study. RESULTS: A total of 117 COVID-19 survivors were screened for eligibility, and 76 eligible subjects were randomized into groups. Baseline characteristics and assessment results were similar between the groups (p>0.05). After the study, a significant difference was found in the experimental group in terms of all outcome results (p<0.05). In the control group, there was a statistically significant difference in all assessments except McGill-Current score, SF-36-Physical Role Diffi-culty, SF-36-Social Functioning, and SF-36-Pain sub-dimension scores (p<0.05). The improvement was significantly higher in the experimental group than in the control group except for the SF-36-Emotional Role Difficulty sub-dimension (p<0.05). CONCLUSIONS: In conclusion, strengthening and relaxation exercises had a significantly positive effect on post-COVID-19 musculoskeletal pain, anxiety, and sleep quality.
{"title":"The effect of strengthening and relaxation exercises on musculoskeletal pain, anxiety, and sleep quality in COVID-19 survivors","authors":"B. Keskin","doi":"10.14744/ejp.2023.9003","DOIUrl":"https://doi.org/10.14744/ejp.2023.9003","url":null,"abstract":": BACKGROUND AND AIM: Musculoskeletal pain, anxiety, and sleep problems may persist in people after Coronavirus Disease 2019 (COVID-19). The aim of this study was to examine the effects of strengthening and relaxation exercises on musculoskeletal pain, anxiety, and sleep quality in COVID-19 survivors. METHODS: The study was conducted at Gaziosmanpaşa Training and Research Hospital and included outpatients aged between 18 and 65 who were diagnosed with COVID-19 in the last 3 months. Subjects were randomly assigned to either experimental or control groups. The experimental group participated in a home-based strengthening and relaxation exercises program 3 times a week for 8 weeks, while control group participants did not receive any exercise program. McGill Pain Scale Short Form (SF-MPQ), Short-Form 36 (SF-36), Beck Anxiety Scale, and Pittsburgh Sleep Quality Index (PSQI) were conducted on all patients before and after the study. RESULTS: A total of 117 COVID-19 survivors were screened for eligibility, and 76 eligible subjects were randomized into groups. Baseline characteristics and assessment results were similar between the groups (p>0.05). After the study, a significant difference was found in the experimental group in terms of all outcome results (p<0.05). In the control group, there was a statistically significant difference in all assessments except McGill-Current score, SF-36-Physical Role Diffi-culty, SF-36-Social Functioning, and SF-36-Pain sub-dimension scores (p<0.05). The improvement was significantly higher in the experimental group than in the control group except for the SF-36-Emotional Role Difficulty sub-dimension (p<0.05). CONCLUSIONS: In conclusion, strengthening and relaxation exercises had a significantly positive effect on post-COVID-19 musculoskeletal pain, anxiety, and sleep quality.","PeriodicalId":42933,"journal":{"name":"Eurasian Journal of Pulmonology","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67326399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effects of one-leg exercises in rehabilitation of chronic obstructive pulmonary disease: A systematic review","authors":"Ömer Hekim","doi":"10.14744/ejp.2023.3003","DOIUrl":"https://doi.org/10.14744/ejp.2023.3003","url":null,"abstract":"","PeriodicalId":42933,"journal":{"name":"Eurasian Journal of Pulmonology","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67326186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
: BACKGROUND AND AIM: Coronavirus Disease 2019 (COVID-19) can affect multliple systems simultaneously, particularly the respiratory system. New inflammatory markers have been used to identify high-risk patients and accelerate the decision-making process for admission to intensive care. One of these markers is the Systemic Inflammatory Index (SII), which is a prognostic index associated with peripheral blood parameters such as neutrophils, platelets, and lymphocytes. This study aimed to determine the effect of SII and other inflammatory markers in assessing the need for intensive care. METHODS: The study included patients over the age of 18 who were admitted to the hospital and hospitalized with COVID-19 pneumonia. They were divided into two groups: those with and without direct admission to intensive care. Demographic, clinical, and laboratory results were obtained retrospectively from the hospital data system. RESULTS: A total of 335 patients were included in the study. SII, C-reactive protein (CRP), ferritin, and D-dimer values were significantly higher (p<0.05) in the group with direct Intensive Care Unit (ICU) hospitalization. In the multivariate reduced model, a significant independent (p<0.05) efficacy of age, SII, CRP, ferritin and D-dimer values was observed in differentiating patients who required direct ICU hospitalization from those who did not. An SII cutoff value of 127 was found to be significant (area under the curve 0.786) in distinguishing between the two groups. CONCLUSIONS: COVID-19 leads to alterations in peripheral blood parameters. Clinical symptoms and disease severity may be associated with the levels of inflammatory cells. These parameters should also be examined to determine the need for intensive care and enable prompt treatment initiation.
{"title":"The role of the systemic inflammatory index in determining the need for intensive care in COVID-19 pneumonia","authors":"Burcu Akkok","doi":"10.14744/ejp.2023.1207","DOIUrl":"https://doi.org/10.14744/ejp.2023.1207","url":null,"abstract":": BACKGROUND AND AIM: Coronavirus Disease 2019 (COVID-19) can affect multliple systems simultaneously, particularly the respiratory system. New inflammatory markers have been used to identify high-risk patients and accelerate the decision-making process for admission to intensive care. One of these markers is the Systemic Inflammatory Index (SII), which is a prognostic index associated with peripheral blood parameters such as neutrophils, platelets, and lymphocytes. This study aimed to determine the effect of SII and other inflammatory markers in assessing the need for intensive care. METHODS: The study included patients over the age of 18 who were admitted to the hospital and hospitalized with COVID-19 pneumonia. They were divided into two groups: those with and without direct admission to intensive care. Demographic, clinical, and laboratory results were obtained retrospectively from the hospital data system. RESULTS: A total of 335 patients were included in the study. SII, C-reactive protein (CRP), ferritin, and D-dimer values were significantly higher (p<0.05) in the group with direct Intensive Care Unit (ICU) hospitalization. In the multivariate reduced model, a significant independent (p<0.05) efficacy of age, SII, CRP, ferritin and D-dimer values was observed in differentiating patients who required direct ICU hospitalization from those who did not. An SII cutoff value of 127 was found to be significant (area under the curve 0.786) in distinguishing between the two groups. CONCLUSIONS: COVID-19 leads to alterations in peripheral blood parameters. Clinical symptoms and disease severity may be associated with the levels of inflammatory cells. These parameters should also be examined to determine the need for intensive care and enable prompt treatment initiation.","PeriodicalId":42933,"journal":{"name":"Eurasian Journal of Pulmonology","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135710734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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