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A Previously Healthy 21-Year Old Female Presenting with Baclofen Toxicity 一名先前健康的21岁女性以巴氯芬中毒表现
Pub Date : 2022-05-01 DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a2989
T. Donenfeld, E. Ibeson, I. Nwosu, A. Bernstein, M. Marcelin, Y. Kupfer
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引用次数: 0
An Elusive Case of E-Cigarette, or Vaping, Product Use Associated Lung Injury (EVALI) Lacking Respiratory Symptoms 电子烟或电子烟产品使用相关肺损伤(EVALI)无呼吸道症状的难以捉摸的案例
Pub Date : 2022-05-01 DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a2977
H. Shanmugavel Geetha, S. Shah, D. Markowitz
Introduction: Electronic vaping-associated lung injury (EVALI), attributed to inhalation through E-cigarettes and other devices was first characterized in the US in July 2019. By February 2020, 2807 cases were reported. Patients often present with respiratory, gastrointestinal, and constitutional symptoms. The presence of EVALI without respiratory complaints is under-recognized, only reported three times in the literature thus far. Case: A 22-year-old female student presented with five days of fever, watery, nonmucoid, non-bloody diarrhea, nausea, 3-4 episodes of vomiting, and generalized weakness, without cough, dyspnea, chest or abdominal pain. Social history revealed vaping e-cigarettes containing nicotine and tetrahydrocannabinol for the past 3-4 years with increased use recently due to upcoming exams. She denied smoking traditional cigarettes, marijuana, or illicit drugs. A temperature of 101oF and 98% SaO2 were recorded. Physical examination was notable for bilateral diffuse crackles with a normal abdominal examination. Initial labs demonstrated a WBC of 14,600 without a shift and the remaining labs were within normal limits. Despite the absence of respiratory symptoms, her chest radiograph revealed bilateral multifocal airspace disease. Further investigation with Chest CT showed extensive multifocal bilateral infiltrates and predominantly peripheral ground-glass opacities. COVID-19 PCR was negative three times. Influenza A and B, RSV, mycoplasma, and legionella testing were negative. She was unable to provide sputum for culture. Stool cultures were negative and an abdominal and pelvic CT was normal. She denied any history of dietary intolerances, prior diarrhea, or chronic colitis. Empiric treatment for atypical community-acquired pneumonia with intravenous ceftriaxone and azithromycin was initiated, with little improvement over the subsequent 4 days. Lack of clinical effect with antibiotics prompted a suspicion for EVALI and intravenous methylprednisolone 1mg/kg every 8 hours was initiated. There was a significant improvement of her gastrointestinal and constitutional symptoms within 24 hours. After three days of IV steroids, she was discharged on an enteral taper. A repeat Chest CT scan 2 weeks later demonstrated complete resolution of the previously identified ground-glass opacities. Discussion: The use of E-cigarettes has grown by 900% between 2011 and 2019 among young adults but used by older individuals as well. This has contributed to the burgeoning EVALI epidemic. Although COVID has taken the centre stage while identifying diffuse interstitial lung abnormalities, there must be a high index of suspicion regarding the incidence of EVALI, especially in young patients, considering the varied presentations and the potential absence of respiratory symptoms.
电子烟相关肺损伤(EVALI)是由电子烟和其他设备吸入引起的,于2019年7月在美国首次发现。截至2020年2月,共报告2807例。患者通常表现为呼吸道、胃肠道和体质症状。EVALI无呼吸症状的存在未得到充分认识,迄今为止文献中仅报道了三次。病例:一名22岁女学生,表现为5天发热、水样、非粘液样、无血性腹泻、恶心、3-4次呕吐和全身无力,无咳嗽、呼吸困难、胸痛或腹痛。社会历史显示,在过去的3-4年里,他们吸食含有尼古丁和四氢大麻酚的电子烟,最近由于即将到来的考试,使用量有所增加。她否认吸食传统香烟、大麻或非法毒品。温度为101oF, SaO2含量为98%。体格检查发现双侧弥漫性裂纹,腹部检查正常。最初的实验室显示WBC为14600,无移位,其余实验室在正常范围内。尽管没有呼吸道症状,她的胸片显示双侧多灶性空域疾病。胸部CT进一步检查显示广泛的双侧多灶浸润和周围主要的磨玻璃影。COVID-19 PCR 3次阴性。甲型和乙型流感、呼吸道合胞病毒、支原体和军团菌检测均为阴性。她无法提供痰培养。大便培养阴性,腹部和盆腔CT正常。她否认有任何饮食不耐受史,既往腹泻或慢性结肠炎。开始静脉注射头孢曲松和阿奇霉素治疗非典型社区获得性肺炎,在随后的4天内几乎没有改善。抗生素缺乏临床效果,怀疑EVALI和开始静脉注射甲基强的松龙1mg/kg每8小时。在24小时内,她的胃肠道和体质症状有了明显改善。静脉注射类固醇三天后,她以肠内减量出院。2周后复查胸部CT显示先前发现的毛玻璃样混浊完全消失。讨论:从2011年到2019年,年轻人中电子烟的使用量增长了900%,但老年人也在使用电子烟。这促成了EVALI流行病的迅速发展。尽管在确定弥漫性间质性肺异常时,COVID已经占据了中心位置,但考虑到不同的表现和可能没有呼吸道症状,对EVALI的发病率必须高度怀疑,特别是在年轻患者中。
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引用次数: 0
Supplement-Induced Thyrotoxicosis Presenting as New Onset Tachycardia 补充剂诱导的甲状腺毒症表现为新发心动过速
Pub Date : 2022-05-01 DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a2990
B. Ascherman, J. Schwartz, Z. Khan, M. Bachan
INTRODUCTION: Dietary and herbal supplements can contain clinically significant amounts of exogenous thyroid stimulants and hormones, including T3 and T4, thus placing consumers at increased risk of thyrotoxicosis and other metabolic-related adverse effects. We present a case of thyrotoxicosis in a young man with no history of thyroid disease, who was found to be consuming an extensive variety of supplements. DESCRIPTION: A 31 year old man with hypertension presented with 1 week of intermittent palpitations. He was in his usual state of health until 1 week prior to admission, when he noticed intermittent, self-resolving episodes of tachycardia as high as the 160s on his smart watch, associated with palpitations, dyspnea, low grade fevers, and intermittent dry cough. He came to the ED for persistence of symptoms. In the ED: T 98.8 F, HR 129, BP 152/77, RR 18, SpO2 98% on RA. CBC, BMP, UA, UTox, blood alcohol content, troponin and COVID tests were unremarkable. TSH was < .007 [0.358-3.740 ulU/mL], with a free thyroxine of 0.54 [0.70-1.48 ng/dL];other thyroid studies later returned with TSI < 0.10 [0.00-0.55 IU/L], free T3 32.50 [1.80-4.60 pg/mL], and an unremarkable thyroid ultrasound. CXR showed no acute infiltrates. EKG revealed sinus tachycardia, no Wolff-Parkinson-White syndrome, and no Brugada waveforms. He was given 2L NS, ceftriaxone 1g IV, aspirin 81mg PO, and tylenol 650mg PO, and admitted to the telemetry unit. Exam revealed an anxious appearing man with tachycardia. On ROS, patient admitted to drinking 6-8 cups of coffee daily, and to taking at least a dozen different supplements. He was started on propranolol 30 mg every 6 hours with improvement in his heart rate, and was counseled to stop the supplements and wean his caffeine intake. He was discharged the following day with plan for endocrinology and primary care follow-up. DISCUSSION: Thyrotoxicosis in this young patient with no history of thyroid disease posed a diagnostic quandary. This prompted further investigation into a more detailed social history, which revealed the extensive variety of supplements he was taking, consistent with thyrotoxicosis factitia. In patients presenting with newonset tachycardia, our case highlights the importance of collecting a thorough social history and maintaining early suspicion for thyroid disease and thyrotoxicosis.
简介:膳食和草药补充剂可能含有临床显著量的外源性甲状腺兴奋剂和激素,包括T3和T4,从而使消费者面临甲状腺毒症和其他代谢相关不良反应的风险增加。我们提出一个甲状腺毒症的情况下,在一个年轻的男子没有甲状腺疾病的历史,谁被发现是消费广泛的各种补充剂。描述:一名31岁的高血压患者出现了1周的间歇性心悸。入院前1周,患者健康状况正常,智能手表显示间歇性、自解性心动过速高达160分,伴有心悸、呼吸困难、低烧和间歇性干咳。他因为症状持续而来急诊室。在ED: T 98.8 F, HR 129, BP 152/77, RR 18, SpO2 98%的RA。CBC、BMP、UA、UTox、血液酒精含量、肌钙蛋白和COVID检测均无显著差异。TSH < 0.008 [0.358-3.740 ulU/mL],游离甲状腺素为0.54 [0.70-1.48 ng/dL];后来其他甲状腺检查显示TSI < 0.10 [0.00-0.55 IU/L],游离T3 32.50 [1.80-4.60 pg/mL],甲状腺超声检查不明显。CXR未见急性浸润。心电图显示窦性心动过速,无Wolff-Parkinson-White综合征,无Brugada波形。患者给予ns2l,头孢曲松1g IV,阿司匹林81mg PO,泰诺650mg PO,并入住遥测病房。检查发现一名心急如火的男子,伴有心动过速。在ROS方面,患者承认每天喝6-8杯咖啡,并服用至少12种不同的补充剂。他开始每6小时服用30毫克心得安,心率有所改善,医生建议他停止服用补充剂,并戒掉咖啡因的摄入。患者于第二天出院,并计划进行内分泌科和初级保健随访。讨论:甲状腺毒症在这个年轻的患者没有甲状腺疾病的历史提出了诊断困境。这促使进一步调查更详细的社会历史,揭示了他正在服用各种各样的补充剂,符合功能性甲状腺毒症。在新发心动过速的患者中,我们的病例强调了收集完整的社会病史和保持对甲状腺疾病和甲状腺毒症的早期怀疑的重要性。
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引用次数: 0
Supraventricular Arrhythmias Induced by Aconite Poisoning 附子中毒致室上性心律失常
Pub Date : 2022-05-01 DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a2987
M. Riego, P. Kim, J. Salonia
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引用次数: 0
A Case of Progressive Massive Fibrosis 进行性块状纤维化1例
Pub Date : 2022-05-01 DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a2985
M. Thakur, S. Kavish, S. Sharma, P. Zhou
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引用次数: 0
Over-the-Counter Pre-Workout Supplement Involvement in Methemoglobinemia and Sulfhemoglobinemia 非处方运动前补充参与高铁血红蛋白血症和硫血红蛋白血症
Pub Date : 2022-05-01 DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a2988
N. Haghshenas, B. Taylor, F. Fuentes, A. Loschner, E. R. Rubio
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引用次数: 0
I'm so Not Fancy: A Case of Hypersensitivity Pneumonitis in Pigeon Fancier's Lung 我一点也不花哨:鸽友肺过敏性肺炎一例
Pub Date : 2022-05-01 DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a2982
A. Haag, C. Ledgerwood, M. Young, J. Esposito,
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引用次数: 0
Acute Interstitial Pneumonia and Acute Respiratory Distress Syndrome (ARDS) from a Forgotten Plant 被遗忘植物引起的急性间质性肺炎和急性呼吸窘迫综合征
Pub Date : 2022-05-01 DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a2986
T. McCann, C. Hayner, N. Patel
Introduction: Conium maculatum, poison hemlock, is native to Europe, North Africa and Western Asia. Over the last 50 years, it has become more prevalent as an invasive species in the United States. Notorious for its role in Socrates' suicide in 399 BC and frequently referenced by Shakespeare, the plant has a rich history of toxicity in man. We present a case of an accidental hemlock exposure leading to acute interstitial pneumonia and acute respiratory distress syndrome. Case Presentation: A 58 year old male presented with acute dyspnea and cough with hemoptysis the morning after clearing wooded brush in his backyard. Other symptoms included tachycardia, diaphoresis, nausea, and diarrhea. His condition rapidly progressed to acute respiratory failure with imaging suggestive of ARDS. Thorough investigation for infectious and inflammatory etiology was unremarkable. Open lung biopsy was consistent with diffuse alveolar damage. Further history from the wife revealed the presence of significant amounts of poison hemlock identified in photos from the yard. Initial treatment included prednisone with prolonged taper with eventual transition to mycophenolate mofetil. After a prolonged hospital course, he was discharged with tracheostomy and continued ventilatory support. Discussion: Hemlock produces piperidine alkaloids akin to nicotine including coniine and γ-coniceine. These inhibit the nicotinic acetylcholine receptors of the central nervous system causing an array of symptoms that without intervention lead to respiratory depression and death. Diagnosis is based on history. Treatment is supportive, in many instances requiring mechanical ventilation. Conclusions: Even in the Covid era, ARDS differential diagnosis is dependent on thorough history taking, including obscure environmental exposures.
简介:毒铁杉,原产于欧洲、北非和西亚。在过去的50年里,它作为一种入侵物种在美国变得更加普遍。这种植物因在公元前399年苏格拉底自杀事件中扮演的角色而臭名昭著,并经常被莎士比亚引用,它对人类的毒性有着丰富的历史。我们提出一个意外的铁杉暴露导致急性间质性肺炎和急性呼吸窘迫综合征的情况。病例介绍:一名58岁男性,在清理后院灌木后的早晨出现急性呼吸困难和咳嗽并咯血。其他症状包括心动过速、出汗、恶心和腹泻。病情迅速发展为急性呼吸衰竭,影像学提示急性呼吸窘迫综合征。对感染和炎症病因的深入调查无显著差异。开放性肺活检符合弥漫性肺泡损伤。他妻子的进一步记录显示在院子里的照片中发现了大量毒铁杉。最初的治疗包括泼尼松,逐渐减少,最终过渡到霉酚酸酯。经过长时间的住院治疗后,他在气管切开术和继续呼吸支持下出院。讨论:铁杉产生类似于尼古丁的胡椒碱生物碱,包括康宁和γ-康宁。这些药物抑制中枢神经系统的烟碱乙酰胆碱受体,引起一系列症状,如果不进行干预,可导致呼吸抑制和死亡。诊断基于病史。治疗是支持性的,在许多情况下需要机械通气。结论:即使在Covid时代,ARDS的鉴别诊断也依赖于彻底的病史记录,包括不明确的环境暴露。
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引用次数: 0
A Case of the Forgotten Crack Pipe 被遗忘的裂缝管案例
Pub Date : 2022-05-01 DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a2980
E. Amaechi, M. Gujral
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引用次数: 0
A Case of Vaping Associated Pneumomediastinum 电子烟相关纵隔气肿1例
Pub Date : 2022-05-01 DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a2976
M. Siddiqui, N. Hristakos, L. Sesemann, A. Shah
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引用次数: 0
期刊
B48. OCCUPATIONAL AND EXPOSURE-RELATED CASE REPORTS
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