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Non-metallic foreign bodies - diagnostic and therapeutic difficulties 非金属异物。诊断和治疗困难
IF 0.6 Q3 Medicine Pub Date : 2023-01-01 DOI: 10.5604/01.3001.0016.3171
Krzysztof Kowalik, A. Gruszczyńska, Karolina Knychalska, Konrad Kaźmierczak, A. Modrzejewski
Introduction: The management of wounds where the presence of a foreign body is possible can be a major problem. This is especially true for bodies that are not visible on x-ray. The most common of these are wood and glass. The size of the foreign body is also important. If even the smallest foreign body is left behind, it can cause permanent local tissue damage or contribute to a systemic infection such as sepsis or permanent local tissue damage. Foreign body recognition in one third of patients does not occur during primary provision. [1]The authors present four patients in whom a foreign body in the form of wood or glass was left in the wound after trauma. The diagnosis and removal of these foreign bodies caused many difficulties. The foreign bodies were not completely removed from the wounds after the injury, leading to an inflammatory process. The authors discuss the management of non-metallic foreign bodies in everyday medical practice.
导言:处理可能存在异物的伤口是一个主要问题。对于在x射线上看不见的物体来说尤其如此。其中最常见的是木头和玻璃。异物的大小也很重要。即使是最小的异物留下,也会造成永久性的局部组织损伤或导致全身感染,如败血症或永久性的局部组织损伤。三分之一的患者在初次分娩时没有发现异物。[1]作者介绍了4例外伤后在伤口中留下木头或玻璃形状的异物的患者。这些异物的诊断和清除造成了许多困难。受伤后,异物没有完全从伤口中清除,导致炎症过程。本文就日常医疗实践中非金属异物的处理进行了探讨。
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引用次数: 0
Predictive Factors for Anastomotic Leak in Colorectal Surgery: A Bi-National Database Study. 结直肠手术吻合口漏的预测因素:一项两国数据库研究。
IF 0.6 Q3 Medicine Pub Date : 2022-12-20 DOI: 10.5604/01.3001.0016.1602
Swetha Prabhakaran, Sowmya Prabhakaran, Wei Mou Lim, Glen Guerra, Alexander G Heriot, Joseph C Kong

IntroductionAnastomotic leak (AL) is a serious complication following colorectal surgery. This study aimed to identify factors associated with the development of AL and analyze its impact on survival.Materials and MethodsAll consecutive adult colorectal cancer resections with curative intent and anastomosis formation were included from a prospectively maintained bi-national database between 2007 and 2020. The primary outcome measure was the rate of AL. The secondary outcome measure was 5-year overall survival (OS).ResultsThere were 7566 eligible patients. The rate of AL was 2.3% and 4.4% in patients with colon and rectal cancer respectively. AL was a significant independent predictor of reduced 5-year OS in patients who underwent curative surgery for rectal cancer (Odds ratio 1.999, p = 0.017). Emergency surgery (p = 0.013), surgery at a public hospital (p < 0.01), and an open surgical approach (p = 0.002) were all significantly associated with a higher risk of AL in patients with colon cancer, with higher rates of AL noted in left colectomies as compared to right hemicolectomies (6.8% vs 1.6%, p < 0.05). In rectal cancer patients, ultra-low anterior resections had the highest risk of AL (4.6%), and associations were found with neoadjuvant chemotherapy (p = 0.011), surgery in a public hospital (p = 0.019), and an open approach (p = 0.035). Anastomosis formation technique (hand-sewn vs stapled) did not impact on rate of AL.DiscussionClinicians should be cognizant of the predictive factors for AL and consider early intervention for patients at risk of this.

吻合口漏(AL)是结直肠手术后的严重并发症。本研究旨在确定与AL发展相关的因素,并分析其对生存的影响。材料和方法纳入2007年至2020年期间前瞻性维护的双国数据库中所有具有治疗目的和吻合形成的连续成人结直肠癌切除术。主要结局指标是AL的发生率。次要结局指标是5年总生存期(OS)。结果入选患者7566例。结肠癌和直肠癌患者AL的发生率分别为2.3%和4.4%。AL是直肠癌根治性手术患者5年OS降低的重要独立预测因子(优势比1.999,p = 0.017)。急诊手术(p = 0.013)、公立医院手术(p <0.01)和开放手术入路(p = 0.002)均与结肠癌患者AL风险升高显著相关,左侧结肠切除术的AL发生率高于右侧半结肠切除术(6.8% vs 1.6%, p <0.05)。在直肠癌患者中,超低前切除术发生AL的风险最高(4.6%),与新辅助化疗(p = 0.011)、公立医院手术(p = 0.019)和开放入路(p = 0.035)相关。吻合口形成技术(手工缝合或钉接)对AL的发生率没有影响。讨论临床医生应认识到AL的预测因素,并考虑对有此风险的患者进行早期干预。
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引用次数: 0
Soft tissue reconstruction of thumb: Classification of defects and standardization of treatment. 拇指软组织重建:缺损分类及规范化治疗。
IF 0.6 Q3 Medicine Pub Date : 2022-12-20 DOI: 10.5604/01.3001.0016.1601
Mansoor Khan, Waqas Hayat, Nasir Khan, Hidayat Ullah, Qazi Ali, Rashid Khan

Objective: The aim of this article is to share our experience of thumb defects based on the defect irrespective of the etiology of the defect and to work towards standardizing the treatment for thumb defects.

Methodology: This study was conducted at the Burns and plastic surgery center at Hayatabad Medical complex from 2018 to 2021. Thumb defects were divided into small (< 3 cm), medium (4-8cm) and large defects (> 9cm). Post-operatively, patients were evaluated for complications. The type of flaps were stratified for size and site of the soft tissue defects to generate a standardized algorithm for thumb soft tissue reconstruction.

Results: After scrutinizing the data, 35 patients qualified for the study, including 71.4% (25) males and 28.6% (10) females. The mean age was 31.17+15.8SD. Right thumb was affected in majority of the study population (57.1%). Majority of the study population was affected by machine injury and post-traumatic contractures, affecting 25.7% (n=9) and 22.9% (n=8) respectively. First web-space and injuries distal to IPJ of thumb were the most common areas affected, accounting for 28.6% (n=10) each. First dorsal metacarpal artery flap was the most common flap followed by retrograde posterior interosseous artery flap, observed in 11 (31.4%) and 6 (17.1%) cases. The most common complication observed in the study population was flap congestion (n=2, 5.7%) with a complete flap loss in 1 patient (2.9%) cases. Based on the cross tabulation of flaps against the size and location of defects, an algorithm was developed to help standardize reconstruction of thumb defects.

Conclusion: Thumb reconstruction is critical in restoring hand function of the patient. The structured approach towards these defects make their assessment and reconstruction easy especially for novice surgeons. This algorithm can further be extended to include defects of the hand irrespective of etiology. Most of these defects can be covered with local easy to do flaps without the need for a microvascular reconstruction.

目的:本文的目的是分享我们的经验,以缺陷为基础,不考虑缺陷的病因,并朝着规范拇指缺陷的治疗工作。方法:本研究于2018年至2021年在Hayatabad医疗中心的烧伤和整形外科中心进行。拇指缺损分为细小的(<3厘米),中等(4-8cm)和大缺陷(>9厘米)。术后对患者进行并发症评估。根据软组织缺损的大小和部位对皮瓣类型进行分层,生成拇指软组织重建的标准化算法。结果:经资料审查,35例患者符合研究条件,其中男性25例,占71.4%,女性10例,占28.6%。平均年龄31.17+15.8SD。大多数研究人群(57.1%)的右拇指受到影响。大多数研究人群受到机械损伤和创伤后挛缩的影响,分别影响25.7% (n=9)和22.9% (n=8)。第一蹼间隙和拇指指间关节远端损伤是最常见的部位,各占28.6% (n=10)。第一掌背动脉瓣是最常见的皮瓣,其次是逆行后骨间动脉瓣,分别有11例(31.4%)和6例(17.1%)。在研究人群中观察到的最常见并发症是皮瓣充血(n=2, 5.7%), 1例(2.9%)患者皮瓣完全丧失。基于皮瓣与缺损大小和位置的交叉表,开发了一种有助于规范拇指缺损重建的算法。结论:拇指重建是恢复患者手部功能的关键。针对这些缺陷的结构化方法使其评估和重建容易,特别是对于新手外科医生。该算法可以进一步扩展到包括手部的缺陷,而不考虑病因。大多数这些缺陷可以用局部容易做的皮瓣覆盖,而不需要微血管重建。
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引用次数: 1
Silver Nanoparticle-Based Dressings for Various Wounds: Benefits and Adverse Effects. 基于银纳米颗粒的各种伤口敷料:益处和副作用。
IF 0.6 Q3 Medicine Pub Date : 2022-11-28 DOI: 10.5604/01.3001.0016.1101
Korapin Phatanodom, Chayanin Angthong

Background: Silver nanoparticles (AgNP) are a novel therapeutic approach to wound dressings because of their antibacterial properties. Silver has been used throughout history for many purposes. However, evidence-based information about the benefits of AgNP-based wound dressings and potential adverse effects is still required. This study is to comprehensively review the benefits and complications of AgNP-based wound dressings for different wound types and address the knowledge gaps.

Material and methods: We collected and reviewed the relevant literature from available sources.

Results: AgNP-based dressings have antimicrobial activity and promote healing with only minor complications, making them suitable for several types of wounds. However, we could not identify any reports on AgNP-based wound dressings for common acute traumatic wounds, such as lacerations and abrasions; this includes comparative studies of AgNP-based and conventional wound dressings for such wound types.

Conclusions: AgNP-based dressings benefit traumatic, cavity, dental, and burn wounds with only minor complications. However, further studies are needed to discern their benefits for specific traumatic wound types.

背景:银纳米颗粒(AgNP)由于其抗菌特性而成为一种新的伤口敷料治疗方法。纵观历史,银被用于许多用途。然而,基于agnp的伤口敷料的益处和潜在的不良反应的证据信息仍然是必需的。本研究旨在全面回顾基于agnp的伤口敷料对不同类型伤口的益处和并发症,并解决知识空白。材料和方法:我们收集并回顾了相关文献。结果:agnp类敷料具有抗菌活性,促进伤口愈合,并发症少,适用于多种类型的伤口。然而,我们没有发现任何基于agnp的伤口敷料用于常见急性创伤伤口(如撕裂和擦伤)的报道;这包括针对此类伤口类型的agnp和传统伤口敷料的比较研究。结论:agnp基敷料对创伤、口腔、口腔和烧伤创面有益,且并发症较少。然而,需要进一步的研究来确定它们对特定创伤类型的益处。
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引用次数: 0
Management of flexor tendon injuries in the digits: an update. 指屈肌腱损伤的处理:最新进展。
IF 0.6 Q3 Medicine Pub Date : 2022-11-28 DOI: 10.5604/01.3001.0016.1103
Andrzej Żyluk, Bernard Piotuch

Currently used techniques of flexor tendon repair and methods of postoperative rehabilitation differ significantly from those used still 10-15 years ago. Techniques of the repair evolved from 2-strand sutures (the Kessler suture) in the direction of much stronger 4-strand and 6-strand sutures (the Adelaide and Savage sutures), what reduced the risk of failure of the repair and made possible more intensive rehabilitation. Also rehabilitation regimes changed on more comfortable for patients than older protocols and allowed to achieve better functional outcomes of the treatment. This study presents updated trends in management of flexor tendon injuries in the digits, with regard to operative technique and postoperative rehabilitation protocols.

目前使用的屈肌腱修复技术和术后康复方法与10-15年前使用的有很大不同。修复技术从2股缝合(Kessler缝合)向更强的4股和6股缝合(Adelaide和Savage缝合)方向发展,这降低了修复失败的风险,并使更密集的康复成为可能。同时,康复疗法对病人来说比以前的疗法更舒适,并且可以达到更好的功能治疗效果。本研究介绍了手指屈肌腱损伤管理的最新趋势,涉及手术技术和术后康复方案。
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引用次数: 0
Role of bariatric surgery on psychological and social outcomes of patients: A systematic review. 减肥手术对患者心理和社会结果的作用:一项系统综述。
IF 0.6 Q3 Medicine Pub Date : 2022-11-28 DOI: 10.5604/01.3001.0016.1104
Azzam Al-Kadi, Lamees Al-Sulaim

We aim to systematically review the psychological and social outcomes of patients post-bariatric surgery. The comprehensive search using keywords yielded 1224 records utilizing search engines PubMed and Scopus. After a careful analysis, 90 articles were found to be eligible for complete screening that collectively reported the use of 11 different BS procedures reported among 22 countries. This review is unique in that we collectively presented the result of various psychological and social outcome parameters (depression and anxiety, self-confidence, self-esteem, marital relationship, and personality traits) after BS. Regardless of the BS procedures performed, most studies over months to years presented a positive outcome of the parameters considered, while few presented contrasting unsatisfactory results. Thus, the surgery was not a cessation factor for these results to be permanent and thus suggested psychological interventions and long-term monitoring for assessing the psychological effects after BS. Additionally, the patient's endurance to check weight and eating habits after surgery is ultimately necessary.

我们的目的是系统地回顾减肥手术后患者的心理和社会结果。利用PubMed和Scopus搜索引擎对关键词进行综合搜索,得到1224条记录。经过仔细分析,发现有90篇文章有资格进行全面筛选,这些文章共同报告了22个国家报告的11种不同BS程序的使用情况。这篇综述的独特之处在于,我们共同呈现了BS后各种心理和社会结果参数(抑郁和焦虑、自信、自尊、婚姻关系和人格特征)的结果。无论采用何种BS程序,大多数数月至数年的研究都显示了所考虑的参数的积极结果,而少数研究显示了相反的不满意结果。因此,手术并不是使这些结果具有永久性的停止因素,因此建议对BS后的心理影响进行心理干预和长期监测。此外,术后患者的耐力检查体重和饮食习惯是最终必要的。
{"title":"Role of bariatric surgery on psychological and social outcomes of patients: A systematic review.","authors":"Azzam Al-Kadi,&nbsp;Lamees Al-Sulaim","doi":"10.5604/01.3001.0016.1104","DOIUrl":"https://doi.org/10.5604/01.3001.0016.1104","url":null,"abstract":"<p><p>We aim to systematically review the psychological and social outcomes of patients post-bariatric surgery. The comprehensive search using keywords yielded 1224 records utilizing search engines PubMed and Scopus. After a careful analysis, 90 articles were found to be eligible for complete screening that collectively reported the use of 11 different BS procedures reported among 22 countries. This review is unique in that we collectively presented the result of various psychological and social outcome parameters (depression and anxiety, self-confidence, self-esteem, marital relationship, and personality traits) after BS. Regardless of the BS procedures performed, most studies over months to years presented a positive outcome of the parameters considered, while few presented contrasting unsatisfactory results. Thus, the surgery was not a cessation factor for these results to be permanent and thus suggested psychological interventions and long-term monitoring for assessing the psychological effects after BS. Additionally, the patient&apos;s endurance to check weight and eating habits after surgery is ultimately necessary.</p>","PeriodicalId":43422,"journal":{"name":"Polish Journal of Surgery","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2022-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9327226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Liver biopsies in children indications, techniques, results and complications. A single-centre study. 儿童肝活检的指征、技术、结果和并发症。单中心研究。
IF 0.6 Q3 Medicine Pub Date : 2022-11-18 DOI: 10.5604/01.3001.0016.0960
Patrycja Sosnowska-Sienkiewicz, Cezary Miedziarek, Dajana Danielewicz, Przemysław Mańkowski

Introduction: Liver biopsy is a safe and helpful diagnostic tool for many liver disorders. It can be performed using various techniques. Regardless of the technique, the liver biopsy is considered to be a safe procedure.

Aim of the study: We aimed to analyze the indications, techniques, results, and complications of liver biopsies in the paediatric age group.

Material and methods: We retrospectively obtained the data from the medical history records of 63 paediatric patients who underwent the liver biopsy. The data were analyzed statistically.

Results: The most often performed type of biopsy was core needle biopsy (tru-cut), followed by core needle aspiration biopsy, fine-needle aspiration biopsy, open biopsy, and laparoscopic biopsy. Complications in the form of hematoma occurred only in 2 cases. The most common indications for the procedure were viral hepatitis monitoring/diagnosis, focal lesions, and autoimmune hepatitis. The histopathological results were predominantly hepatitis (viral and non-viral) and neoplasm.

Conclusions: Liver biopsy is a safe procedure regardless of the technique used to obtain a tissue sample. Therefore, it should not be avoided when it is indicated.

肝活检是一种安全、有用的诊断工具,用于许多肝脏疾病。它可以使用各种技术来执行。无论采用何种技术,肝活检都被认为是安全的。研究目的:我们旨在分析儿科年龄组肝活检的适应症、技术、结果和并发症。材料和方法:我们回顾性地收集了63例接受肝活检的儿科患者的病史记录。对数据进行统计学分析。结果:最常进行的活检类型是核心针活检(真切),其次是核心针穿刺活检、细针穿刺活检、开放式活检和腹腔镜活检。仅2例出现血肿并发症。该手术最常见的适应症是病毒性肝炎监测/诊断、局灶性病变和自身免疫性肝炎。组织病理学结果主要是肝炎(病毒性和非病毒性)和肿瘤。结论:无论采用何种技术获取组织样本,肝活检都是一种安全的手术。因此,当它是指不应该避免。
{"title":"Liver biopsies in children indications, techniques, results and complications. A single-centre study.","authors":"Patrycja Sosnowska-Sienkiewicz,&nbsp;Cezary Miedziarek,&nbsp;Dajana Danielewicz,&nbsp;Przemysław Mańkowski","doi":"10.5604/01.3001.0016.0960","DOIUrl":"https://doi.org/10.5604/01.3001.0016.0960","url":null,"abstract":"<p><strong>Introduction: </strong>Liver biopsy is a safe and helpful diagnostic tool for many liver disorders. It can be performed using various techniques. Regardless of the technique, the liver biopsy is considered to be a safe procedure.</p><p><strong>Aim of the study: </strong>We aimed to analyze the indications, techniques, results, and complications of liver biopsies in the paediatric age group.</p><p><strong>Material and methods: </strong>We retrospectively obtained the data from the medical history records of 63 paediatric patients who underwent the liver biopsy. The data were analyzed statistically.</p><p><strong>Results: </strong>The most often performed type of biopsy was core needle biopsy (tru-cut), followed by core needle aspiration biopsy, fine-needle aspiration biopsy, open biopsy, and laparoscopic biopsy. Complications in the form of hematoma occurred only in 2 cases. The most common indications for the procedure were viral hepatitis monitoring/diagnosis, focal lesions, and autoimmune hepatitis. The histopathological results were predominantly hepatitis (viral and non-viral) and neoplasm.</p><p><strong>Conclusions: </strong>Liver biopsy is a safe procedure regardless of the technique used to obtain a tissue sample. Therefore, it should not be avoided when it is indicated.</p>","PeriodicalId":43422,"journal":{"name":"Polish Journal of Surgery","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2022-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10763572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tension-Free Hiatal Hernia Repair Using Ligamentum Teres in Paraoesophageal Hernia Treatment. 应用圆韧带修补无张力裂孔疝治疗食管旁疝。
IF 0.6 Q3 Medicine Pub Date : 2022-11-18 DOI: 10.5604/01.3001.0016.0958
Oliwia Grząsiak, Adam Durczyński, Piotr Hogendorf, Alicja Majos, Janusz Strzelczyk

AbstractIntroductionType II and III (paraoesophageal and mixed) hiatal hernia treatment remains a technically difficult procedure carrying a risk of complications and recurrence as high as 40%. Using synthetic meshes entails possible serious complications; efficacy of biologic materials remains unclear and requires further research.AimThe aim of the article was to present the centres experience of type II and III large hiatal hernia treatment using the ligamentum teres and to draw attention to potential benefits of conducted procedures.Material and MethodsThe study enrolled 6 patients: 3 women and 3 men aged 37-58 with radiologically and endoscopically confirmed large paraoesophageal hernias. The patients underwent Nissen fundoplication and hiatal hernia repair using the ligamentum teres. The patients were followed up for six months with subsequent radiological and endoscopic assessment.ResultsDuring the six-month follow-up no clinical or radiological characteristics of hiatal hernia recurrence were observed in the patients. Two patients reported symptoms of dysphagia; mortality was 0%.ConclusionsHiatal hernia repair using the vascularized ligamentum teres may constitute an effective and safe method of large hiatal hernia repair.

II型和III型(食管旁疝和混合型)裂孔疝的治疗仍然是一个技术上困难的手术,其并发症和复发率高达40%。使用合成网可能会导致严重的并发症;生物材料的功效尚不清楚,需要进一步研究。目的本文的目的是介绍使用圆韧带治疗II型和III型大裂孔疝的中心经验,并提请注意进行手术的潜在益处。材料与方法本研究纳入了6例经放射学和内镜检查证实的食管旁疝患者,其中女性3例,男性3例,年龄37-58岁。患者行尼森底复盖术及圆韧带修补裂孔疝。随访6个月,进行放射学和内窥镜检查。结果随访6个月,无裂孔疝复发的临床及影像学特征。2例患者报告有吞咽困难症状;死亡率为0%。结论血管化圆韧带修补裂孔疝是一种安全有效的修补裂孔疝的方法。
{"title":"Tension-Free Hiatal Hernia Repair Using Ligamentum Teres in Paraoesophageal Hernia Treatment.","authors":"Oliwia Grząsiak,&nbsp;Adam Durczyński,&nbsp;Piotr Hogendorf,&nbsp;Alicja Majos,&nbsp;Janusz Strzelczyk","doi":"10.5604/01.3001.0016.0958","DOIUrl":"https://doi.org/10.5604/01.3001.0016.0958","url":null,"abstract":"<p><p>AbstractIntroductionType II and III (paraoesophageal and mixed) hiatal hernia treatment remains a technically difficult procedure carrying a risk of complications and recurrence as high as 40%. Using synthetic meshes entails possible serious complications; efficacy of biologic materials remains unclear and requires further research.AimThe aim of the article was to present the centres experience of type II and III large hiatal hernia treatment using the ligamentum teres and to draw attention to potential benefits of conducted procedures.Material and MethodsThe study enrolled 6 patients: 3 women and 3 men aged 37-58 with radiologically and endoscopically confirmed large paraoesophageal hernias. The patients underwent Nissen fundoplication and hiatal hernia repair using the ligamentum teres. The patients were followed up for six months with subsequent radiological and endoscopic assessment.ResultsDuring the six-month follow-up no clinical or radiological characteristics of hiatal hernia recurrence were observed in the patients. Two patients reported symptoms of dysphagia; mortality was 0%.ConclusionsHiatal hernia repair using the vascularized ligamentum teres may constitute an effective and safe method of large hiatal hernia repair.</p>","PeriodicalId":43422,"journal":{"name":"Polish Journal of Surgery","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2022-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9327225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Do haematological parameters such as HALP and Lymphocyte to C-reactive protein ratio predict tumor response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer? 血液学参数如HALP和淋巴细胞与c反应蛋白的比值能预测局部晚期直肠癌对新辅助放化疗的肿瘤反应吗?
IF 0.6 Q3 Medicine Pub Date : 2022-11-18 DOI: 10.5604/01.3001.0016.0959
Mevlüt Yordanagil, Hüseyin Bakir, Gülhan Güler Avci, Murat Yildirim, Namik Ozkan, Okan Ismail

AbstractAim:Inflammatory markers are effective in determining the prognosis of malignant diseases. The aim of this study is to investigate the relationship of HALP and LCR with tumor response after neoadjuvant chemoradiotherapy and their effects on prognosis in patients with locally advanced rectal cancer.

Methods: 88 patients who received nCRT with the diagnosis of LARC were included in the study. First, all patients were divided into 2 groups: patients with pathological and clinical complete response (pCR+cCR) group 1 and patients with non-complete response group 2. The 82 patients who underwent surgery were divided into two groups according to the TRG Dworak: good response and poor response groups. Inflammation markers such as HALP and LCR were obtained using biochemical parameters.

Results: HALP and LCR were higher in the complete response group than in the none-complete response group (p<0.05). When TRG 3-4 (good response group) and TRG 0-1-2 (poor response group) were compared, HALP and LCR were higher in the good response group (p<0.05). The cut-off point for the HALP value was 30.17, the sensitivity was 88.2%, and the specificity was 43.7%. The cut-off point for the LCR value was 0.402, the sensitivity was 88.2%, and the specificity was 63.4%. It was found that HALP and LCR calculated prior to neoadjuvant CRT could not predict overall survival.

Conclusions: We believe that inflammatory markers such as HALP and LCR can effectively identify rectal cancer patients who respond best to nCRT.

摘要:炎症标志物是判断恶性疾病预后的有效指标。本研究旨在探讨局部晚期直肠癌患者新辅助放化疗后HALP和LCR与肿瘤反应的关系及其对预后的影响。方法:88例诊断为LARC的患者接受了nCRT治疗。首先将所有患者分为病理和临床完全缓解(pCR+cCR)组1和非完全缓解组2。将82例手术患者根据TRG dwork分为两组:反应良好组和反应不良组。采用生化参数测定炎症标志物HALP、LCR。结果:完全缓解组的HALP和LCR高于非完全缓解组(p < 0.05)。比较TRG 3-4(好反应组)和TRG 0-1-2(差反应组),好反应组的HALP和LCR更高(p < 0.05)。HALP值的临界值为30.17,敏感性为88.2%,特异性为43.7%。LCR值的分界点为0.402,敏感性为88.2%,特异性为63.4%。发现在新辅助CRT前计算的HALP和LCR不能预测总生存期。结论:我们认为炎症标志物如HALP和LCR可以有效识别对nCRT反应最好的直肠癌患者。
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引用次数: 0
Modified Frailty Index and Brief Geriatric Assessment does not predict prolonged hospitalization in elderly patients undergoing appendectomy due to Acute Appendicitis. 修正虚弱指数和简要老年评估不能预测急性阑尾炎行阑尾切除术的老年患者住院时间延长。
IF 0.6 Q3 Medicine Pub Date : 2022-10-24 DOI: 10.5604/01.3001.0016.0663
Katarzyna Kołodziejska, Piotr Tylec, Jakub Droś, Artur Kacprzyk, Wojciech Kula, Maciej Matyja, Michał Pędziwiatr, Mateusz Rubinkiewicz

Introduction: Epidemiology and the outcomes of acute appendicitis in elderly people are very different from the younger patients. Aim of this study was to investigate the significance of frailty syndrome in the course of acute appendicitis.

Methods: All patients over 65 years old who underwent laparoscopic appendectomy between 2013 and 2021 in 2nd Department of General Surgery were included in the study. In our assessment Modified Frailty Index and Brief Geriatric Assessment were performed.

Results: In the analyzed period 106 appendectomies were performed in patients over 65 years old. Postoperative complications occurred in 13 patients (12.3%). Prolonged hospitalization (over 3 days) was observed in 48 patients (45.3%). Multivariate analysis showed that every ASA class (OR=2.406; 95% CI 1.089-5.316; p=0.030) and postoperative complication (OR=5.692; 95% CI 1.077-30.073; p=0.041) are risk factors for prolonged hospitalization. Our study identified diabetes (OR=5.956; 95% CI 1.391-25.510; p=0.016) as a risk factor for postoperative complications.

Conclusions: According to our study Modified Frailty Index and Brief Geriatric Assessment does not correlate with prolonged hospitalization or higher risk for postoperative complication after appendectomy in elderly people.

老年人急性阑尾炎的流行病学和预后与年轻患者有很大不同。本研究旨在探讨衰弱综合征在急性阑尾炎病程中的意义。方法:所有2013 - 2021年在普通外科第二科行腹腔镜阑尾切除术的65岁以上患者纳入研究。在我们的评估中,采用了修正的虚弱指数和简要的老年评估。结果:本组65岁以上患者共行阑尾切除术106例。术后并发症13例(12.3%)。48例(45.3%)患者住院时间延长(超过3天)。多因素分析显示,每一类ASA (OR=2.406;95% ci 1.089-5.316;p=0.030)和术后并发症(OR=5.692;95% ci 1.077-30.073;P =0.041)是延长住院时间的危险因素。我们的研究确定了糖尿病(OR=5.956;95% ci 1.391-25.510;P =0.016)为术后并发症的危险因素。结论:根据我们的研究,修改后的虚弱指数和简要老年评估与老年人阑尾切除术后住院时间延长或术后并发症风险增加无关。
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引用次数: 0
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Polish Journal of Surgery
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