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Proliferative Epithelial Lesions Associated With End-Stage Renal Disease 终末期肾病相关的增生性上皮病变
IF 0.2 Pub Date : 2015-11-01 DOI: 10.1097/PCR.0000000000000113
E. Turbat-Herrera
Abstract Kidney changes seen in end-stage renal disease, after a period of chronic progressive renal disease, may to give rise to different benign and malignant epithelial proliferative lesions. These epithelial proliferations are many times associated with dialysis, but not necessarily so. Many of these lesions are part and parcel of acquired cystic kidney disease. These may also happen without prior cystic changes. A review of the literature is presented, and the different proliferative lesions discussed. Lesions such as hyperplasia of the Bowman capsule classified as embryonal because of the primitive appearance of the cells, which may or may not form tubular structures, are described. Lesions such as unusual epithelial proliferations within the lining of cysts and endothelial and granular metaplasia noted in patients with hypertension where a hyperplasia of renin-producing cells is seen in the juxtaglomerular apparatus are covered in this article. Patients with end-stage renal disease, especially those on dialysis, can develop acquired cystic kidney disease, and some of the cysts can exhibit atypical epithelial proliferations with multiple layers and pseudopapillary formations. Neoplasms whether benign or malignant are also associated with end-stage kidney disease; these seems to have a predominance of papillary neoplasms, which occur more often than in sporadic tumors. Although these tumors, for the most part, share similar histological appearance with the sporadic ones, these have different molecular imprints.
终末期肾脏病变,经过一段时间的慢性进展性肾脏疾病,可引起不同的良恶性上皮增生性病变。这些上皮细胞增生常常与透析有关,但不一定如此。许多病变是获得性囊性肾病的重要组成部分。这些也可能在没有囊性改变的情况下发生。回顾文献提出,并讨论了不同的增生性病变。由于细胞的原始外观,如鲍曼囊增生被归类为胚胎性病变,可能形成管状结构,也可能不形成管状结构。本文讨论了高血压患者的病变,如囊肿内膜内异常上皮增生、内皮细胞和颗粒化生(肾小球旁器官中肾素生成细胞增生)。终末期肾病患者,尤其是透析患者,可发展为获得性囊性肾病,一些囊肿可表现为非典型上皮增生,具有多层和假乳头状形成。良性或恶性肿瘤也与终末期肾脏疾病有关;这些似乎以乳头状肿瘤为主,它比散发性肿瘤更常发生。尽管这些肿瘤在大多数情况下与散发性肿瘤具有相似的组织学外观,但它们具有不同的分子印迹。
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引用次数: 0
Cystic Renal Diseases: A Primer for Diagnosing and Understanding These Disorders 囊性肾脏疾病:诊断和理解这些疾病的入门
IF 0.2 Pub Date : 2015-11-01 DOI: 10.1097/PCR.0000000000000117
G. Herrera
Abstract There are many types of cystic renal diseases, each with specific clinical and morphologic correlates, genetics, and clinical behavior and prognosis. This article addresses the important facts that are characteristic of each of the cystic conditions in the kidney to provide criteria to allow their accurate diagnosis.
囊性肾病有多种类型,每种类型都有特定的临床和形态学相关性、遗传学、临床行为和预后。这篇文章解决了重要的事实,是特点的每一个囊性条件在肾脏提供标准,以允许他们的准确诊断。
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引用次数: 0
Evaluating Donor Kidneys for Transplantation: What to Look for and How to Compile a Meaningful Report 评估供肾移植:寻找什么以及如何编写有意义的报告
IF 0.2 Pub Date : 2015-11-01 DOI: 10.1097/PCR.0000000000000120
G. Herrera
Abstract The severe shortage of kidneys for transplantation has led efforts to expand the kidney donor pool, and to accomplish this goal, kidneys from expanded-criteria donors are being considered today for transplantation. Despite the frequent use of pretransplant biopsies of donor kidneys, no consensus has been reached regarding the prognostic significance of the various pathologic findings. The pathologic evaluation is focused on determining the percentage of globally sclerosed glomeruli; degree of interstitial fibrosis; arteriolar and arterial damage, including degree of vessel wall thickening and the presence/absence of vascular thrombosis; and identifying “significant” glomerular, inflammatory tubulointerstitial or vascular pathology. This information is provided to the transplant surgeon who then makes a determination of whether to transplant or not the deceased- or living-donor kidney in question, if any or a combination of the previously mentioned findings is identified. The present article describes how these donor kidneys should be evaluated morphologically and the impact of the various findings that may be found in deciding whether the kidney should be transplanted and addresses prognostic issues related to transplantation of kidneys exhibiting some of the previously mentioned findings not deemed to be severe enough to prevent transplantation. A review of the different criteria and systems that have been used in the past will be provided to understand how the evaluation process has been viewed by various investigators and the relationship of the various findings to immediate function and prognosis of the grafts. This information is important for surgical pathologists who may be asked to do frozen sections in these kidneys before transplant and/or sign out these specimens in their practices.
用于移植的肾脏严重短缺导致了扩大肾脏供体池的努力,为了实现这一目标,来自扩大标准供体的肾脏正在被考虑用于移植。尽管经常使用供体肾脏的移植前活检,但关于各种病理结果的预后意义尚未达成共识。病理评估的重点是确定全局硬化肾小球的百分比;间质纤维化程度;动脉和动脉损伤,包括血管壁增厚程度和血管血栓形成的存在/不存在;鉴别“显著的”肾小球、炎性小管间质或血管病变。这些信息将提供给移植外科医生,如果发现了上述任何一种或几种发现,移植外科医生将决定是否移植死者或活体供体的肾脏。本文描述了这些供肾应该如何进行形态学评估,以及在决定肾脏是否应该移植时可能发现的各种结果的影响,并讨论了与肾脏移植相关的预后问题,展示了一些先前提到的发现,这些发现并不被认为严重到足以阻止移植。本文将回顾过去使用的不同标准和系统,以了解不同研究者如何看待评估过程,以及各种结果与移植物即时功能和预后的关系。这些信息对外科病理学家很重要,他们可能会被要求在移植前对这些肾脏进行冷冻切片和/或在他们的实践中签出这些标本。
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引用次数: 0
Transplant Kidney With Acute Humoral Rejection Diagnosed by Needle Core Biopsy—A Case Report With Review of Pathological Morphology 肾移植急性体液性排斥反应的针芯活检诊断——附病理形态学回顾1例
IF 0.2 Pub Date : 2015-11-01 DOI: 10.1097/PCR.0000000000000112
J. Aufman
Abstract Needle core biopsy is an important procedure used to evaluate transplanted kidneys. By examining the morphological findings, the pathologist can inform the nephrologist of certain findings that help guide the therapeutic management to prolong the life of the transplant kidney. The request for a kidney biopsy is usually decided as soon as signs and symptoms of renal dysfunction are noticed by the nephrologist, and therefore, most biopsies of the transplanted kidneys usually have some type of morphological pathology, which may be minimal because of the acute awareness of early rejection. This review discusses the history of acute antibody-mediated rejection and the morphological findings seen in humor rejection of the transplanted kidney.
摘要:穿刺活检是评估移植肾的重要方法。通过检查形态学结果,病理学家可以告知肾科医生某些发现,这些发现有助于指导治疗管理,以延长移植肾的生命。肾内科医生一旦发现肾功能不全的体征和症状,通常就会决定是否进行肾活检,因此,大多数移植肾的活检通常有某种形态病理学,由于早期排斥反应的急性意识,这可能是最小的。本文综述了急性抗体介导的排斥反应的历史和移植肾幽默性排斥反应的形态学发现。
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引用次数: 0
What a Nonnephropathologist Must Know About Kidney Rejection 非肾脏病理学家必须知道的关于肾脏排斥反应
IF 0.2 Pub Date : 2015-11-01 DOI: 10.1097/PCR.0000000000000114
J. Aufman
Abstract This article shows the evolving history of the Banff classification for allograft biopsies and gives helpful clues on properly diagnosing each classification. In today’s pathology practice, a general pathologist who does not regularly sign out many transplant kidney cases may be unsure of the details that the nephrologist may need to know for proper patient treatment. This article also discusses the latest Banff classification and the differential diagnoses one may encounter when diagnosing an allograft biopsy.
本文展示了同种异体移植活检Banff分类的演变历史,并为正确诊断每种分类提供了有用的线索。在今天的病理实践中,一个普通的病理学家如果不定期登记许多移植肾病例,可能不确定肾脏科医生可能需要知道适当的病人治疗的细节。本文还讨论了最新的Banff分类和诊断同种异体移植活检时可能遇到的鉴别诊断。
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引用次数: 0
Conventional and Papillary Renal Cell Carcinomas and Focal Segmental Glomerulosclerosis in a Nephrectomy 肾切除术中的常规、乳头状肾细胞癌和局灶节段性肾小球硬化
IF 0.2 Pub Date : 2015-11-01 DOI: 10.1097/PCR.0000000000000121
Firas Al-Delfi, G. Herrera
This is a case report of a 63-year-old morbidly obese (body mass index, 46.5 kg/m2) African American woman with a medical history of recurrent urinary tract infections, diverticulosis/diverticulitis, duodenitis, colovesical fistula, gout, hypertension, degenerative joint disease, carpal tunnel syndrome, a 20-pack-year history of tobacco use, and bilateral axillary hidradenitis suppurativa. After multiple episodes of gross hematuria and suprapubic discomfort, a computed tomographic scan showed a solid mass in the lower pole of the right kidney. The patient underwent right open radical nephrectomy in May 2010 without major complications. A conventional (clear cell) renal cell carcinoma and a small papillary renal cell carcinoma were found upon histopathologic examination of the kidney. Examination of the nonneoplastic renal parenchyma revealed changes indicative of focal segmental glomerulosclerosis, as well as mild arterial nephrosclerosis. No tumor metastases were detected at 5 years after nephrectomy. Her serum creatinine and estimated glomerular filtration rate gradually deteriorated in the 5 years after nephrectomy. The gradual, less steep renal function deterioration of this patient emphasizes the importance of reporting nonneoplastic renal lesions/diseases in nephrectomies for kidney and renal pelvis tumors. She developed edema, progressive proteinuria reaching 6.5 g/d, and serum creatinine level of 4.2 mg/dL (baseline serum creatinine at time of nephrectomy was 0.7 mg/dL). The early diagnosis helped medically manage and delay the progression of the medical renal disorder. An easy algorithmic approach for nonneoplastic renal parenchymal tissue should be adopted by general/surgical pathologists when evaluating surgical nephrectomies.
本文报告一例63岁的病态肥胖(体重指数46.5 kg/m2)非裔美国女性,既往有反复尿路感染、憩室病/憩室炎、十二指肠炎、膀胱瘘、痛风、高血压、退行性关节疾病、腕管综合征、20年吸烟史和双侧腋窝化脓性汗腺炎病史。在多次出现肉眼血尿和耻骨上不适后,计算机断层扫描显示右肾下极有一个实性肿块。患者于2010年5月行右侧开放性根治性肾切除术,无重大并发症。肾组织病理学检查发现常规(透明细胞)肾细胞癌和小乳头状肾细胞癌。非肿瘤性肾实质检查显示局灶节段性肾小球硬化的改变,以及轻度动脉性肾硬化。肾切除术后5年未发现肿瘤转移。她的血清肌酐和肾小球滤过率在肾切除术后5年内逐渐恶化。该患者肾功能逐渐恶化,且恶化程度较轻,因此在肾和肾盂肿瘤的肾切除术中报告非肿瘤性肾脏病变/疾病的重要性。她出现水肿,进行性蛋白尿达到6.5 g/d,血清肌酐水平为4.2 mg/dL(肾切除术时基线血清肌酐为0.7 mg/dL)。早期诊断有助于医学管理和延缓医学肾病的进展。一般/外科病理学家在评估手术肾切除术时应采用一种简单的非肿瘤性肾实质组织算法方法。
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引用次数: 1
Poorly Differentiated (“Insular”) Thyroid Carcinoma on Fine-Needle Aspiration 细针穿刺显示低分化甲状腺癌
IF 0.2 Pub Date : 2015-09-01 DOI: 10.1097/PCR.0000000000000105
J. Hipp, Syed Z. Ali, C. VandenBussche
Abstract Poorly differentiated thyroid carcinoma (PDTC) is a distinct entity of thyroid follicular origin (without follicular or papillary differentiation), with high-grade features and an aggressive clinical behavior intermediate between that of well-differentiated and undifferentiated thyroid carcinoma. It accounts for 4% to 7% of thyroid malignancies. Poorly differentiated thyroid carcinoma often presents at an advanced stage and tends to metastasize to regional lymph nodes, lungs, and bones. A variety of histological patterns exists for PDTC and the corresponding cytomorphological features are also varied and depend on the growth pattern of the individual neoplasm. We report the cytomorphology of PDTC sampled by fine-needle aspiration and review previously reported cases in the literature. While PDTC do not possess specific cytomorphological features that would allow for a definitive diagnosis on fine-needle aspiration, the presence of certain features may suggest the possibility of this rare neoplasm. In particular, cells with overlapping bland nuclei found both in groups and individually are common features. Lesions are often cellular and lack colloid, providing the sense of a neoplasm. It may be difficult to exclude the more common possibility of a papillary thyroid carcinoma or follicular neoplasm; however, familiarity with this uncommon entity allows one to include it in the differential diagnosis.
低分化甲状腺癌(PDTC)是一种起源于甲状腺滤泡(无滤泡或乳头状分化)的独特肿瘤,具有高级别特征,临床表现介于高分化和未分化甲状腺癌之间。它占甲状腺恶性肿瘤的4%至7%。低分化甲状腺癌通常出现在晚期,并倾向于转移到局部淋巴结、肺和骨骼。PDTC存在多种组织学模式,相应的细胞形态学特征也各不相同,并取决于单个肿瘤的生长模式。我们报告了通过细针穿刺取样的PDTC的细胞形态学,并回顾了文献中先前报道的病例。虽然PDTC没有特定的细胞形态学特征,无法对细针穿刺进行明确诊断,但某些特征的存在可能提示这种罕见肿瘤的可能性。特别是,在群体和个体中发现的具有重叠的淡核的细胞是共同的特征。病变通常是细胞性的,缺乏胶质,给人肿瘤的感觉。很难排除更常见的甲状腺乳头状癌或滤泡性肿瘤的可能性;然而,熟悉这种不常见的实体允许一个包括它在鉴别诊断。
{"title":"Poorly Differentiated (“Insular”) Thyroid Carcinoma on Fine-Needle Aspiration","authors":"J. Hipp, Syed Z. Ali, C. VandenBussche","doi":"10.1097/PCR.0000000000000105","DOIUrl":"https://doi.org/10.1097/PCR.0000000000000105","url":null,"abstract":"Abstract Poorly differentiated thyroid carcinoma (PDTC) is a distinct entity of thyroid follicular origin (without follicular or papillary differentiation), with high-grade features and an aggressive clinical behavior intermediate between that of well-differentiated and undifferentiated thyroid carcinoma. It accounts for 4% to 7% of thyroid malignancies. Poorly differentiated thyroid carcinoma often presents at an advanced stage and tends to metastasize to regional lymph nodes, lungs, and bones. A variety of histological patterns exists for PDTC and the corresponding cytomorphological features are also varied and depend on the growth pattern of the individual neoplasm. We report the cytomorphology of PDTC sampled by fine-needle aspiration and review previously reported cases in the literature. While PDTC do not possess specific cytomorphological features that would allow for a definitive diagnosis on fine-needle aspiration, the presence of certain features may suggest the possibility of this rare neoplasm. In particular, cells with overlapping bland nuclei found both in groups and individually are common features. Lesions are often cellular and lack colloid, providing the sense of a neoplasm. It may be difficult to exclude the more common possibility of a papillary thyroid carcinoma or follicular neoplasm; however, familiarity with this uncommon entity allows one to include it in the differential diagnosis.","PeriodicalId":43475,"journal":{"name":"AJSP-Reviews and Reports","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2015-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/PCR.0000000000000105","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61757540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Anaplastic Thyroid Carcinoma, a Cytologic Perspective: Case Report and Review of Anaplastic Thyroid Carcinoma 甲状腺间变性癌的细胞学观点:甲状腺间变性癌病例报告及综述
IF 0.2 Pub Date : 2015-09-01 DOI: 10.1097/PCR.0000000000000107
L. Goicochea, Paul N. Staats
Abstract Anaplastic, or undifferentiated, thyroid carcinoma (ATC) is a highly aggressive disease with less than 1-year survival in nearly all patients with this disease. Because of its aggressive nature, ATC is frequently unresectable. Rapid and accurate pretreatment diagnosis is required to attempt local-regional control. Fine-needle aspiration (FNA) and core-needle biopsy (CNB) are the most widely used initial means of obtaining a tissue diagnosis of this entity, and these specimens are often the only tissue procured before definitive therapy. Although the literature on cytologic diagnosis of ATC is limited, the performance characteristics of FNA appear to be good, with high sensitivity and specificity. However, diagnosis can be challenging because of the variable appearance of aspirated cells of ATC and a broad differential diagnosis that includes medullary carcinoma, poorly differentiated thyroid carcinoma, lymphoma, primary thyroid sarcoma, and metastatic tumors. The use of a limited panel of immunohistochemical stains is often helpful in distinguishing these entities. Although ATC arises in many cases from a well-differentiated thyroid carcinoma, the limited nature of an FNA or CNB specimen usually precludes identification of an associated lower-grade lesion. Herein, we report a case of ATC diagnosed on FNA and CNB and review the diagnosis of ATC from a cytopathology perspective.
间变性或未分化甲状腺癌(ATC)是一种高度侵袭性疾病,几乎所有患者的生存期都不到1年。由于其侵袭性,ATC通常无法切除。为了尝试局部区域控制,需要快速准确的预处理诊断。细针穿刺(FNA)和芯针活检(CNB)是获得该实体组织诊断的最广泛使用的初始手段,这些标本通常是在确定治疗之前获得的唯一组织。虽然关于ATC细胞学诊断的文献有限,但FNA的表现特点较好,具有较高的敏感性和特异性。然而,由于ATC的吸出细胞的不同外观和广泛的鉴别诊断,包括髓样癌、低分化甲状腺癌、淋巴瘤、原发性甲状腺肉瘤和转移性肿瘤,诊断可能具有挑战性。使用有限的免疫组织化学染色通常有助于区分这些实体。虽然ATC在许多病例中起源于分化良好的甲状腺癌,但FNA或CNB标本的有限性通常排除了相关低级别病变的识别。在此,我们报告一例经FNA和CNB诊断的ATC,并从细胞病理学角度回顾ATC的诊断。
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引用次数: 1
Image-Guided Fine-Needle Aspiration of Secondary Pancreatic Neoplasms: A Case Series and Review of the Literature 影像引导下细针穿刺治疗继发性胰腺肿瘤:病例系列及文献回顾
IF 0.2 Pub Date : 2015-07-01 DOI: 10.1097/PCR.0000000000000096
W. Foo, K. Youens, P. Jowell, S. Bean
Background Endoscopic ultrasound–guided fine-needle aspiration (FNA) has become a well-established diagnostic method for evaluation of focal lesions in the pancreas. While the majority of malignant lesions evaluated are primary pancreatic adenocarcinomas, rarely, metastatic lesions to the pancreas are discovered, altering treatment and prognosis for patients. In this retrospective case series study, we describe the 22-year experience with cytologic diagnosis of secondary pancreatic neoplasms in a tertiary medical center. Methods A search of the electronic pathology database at Duke University Medical Center was performed to identify all patients who had image-guided FNA biopsy of the pancreas diagnosed with secondary neoplasms from 1990 to 2012. Clinical information including sex, age, prior history of malignancy, imaging features of pancreatic mass(es), cytology diagnosis, treatment, and survival was collected. Descriptive statistics were performed. Results Fifty-three patients had a secondary malignancy of the pancreas from 11 primary sites diagnosed on FNA. The most common primary site was hematopoietic (36%), followed by renal (19%), melanocytic (11%), pulmonary (11%), ovarian (6%), breast (4%), esophageal (4%), and soft tissue (4%). Colorectal (2%), prostatic (2%), and nasopharyngeal (2%) metastases were also identified. No specific imaging features reliably differentiated secondary lesions from primary lesions. The majority of patients (75%) had a prior history of malignancy. Of those without a prior history of malignancy, greater than 90% had a secondary malignancy of hematopoietic origin. Conclusions Cytologic diagnosis of secondary pancreatic neoplasms is rare. The most common secondary neoplasm of the pancreas was of hematopoietic origin. Imaging characteristics of secondary neoplasms are variable and nonspecific.
超声引导下的内镜下细针穿刺(FNA)已成为评估胰腺局灶性病变的一种成熟的诊断方法。虽然评估的大多数恶性病变是原发性胰腺腺癌,但很少发现胰腺转移性病变,从而改变了患者的治疗和预后。在这个回顾性的病例系列研究中,我们描述了22年来在三级医疗中心对继发性胰腺肿瘤的细胞学诊断的经验。方法检索美国杜克大学医学中心电子病理数据库,对1990年至2012年诊断为继发性肿瘤的所有胰腺图像引导FNA活检患者进行检索。收集临床信息,包括性别、年龄、既往恶性病史、胰腺肿块影像学特征、细胞学诊断、治疗和生存。进行描述性统计。结果53例患者经FNA诊断为11个原发部位的胰腺继发恶性肿瘤。最常见的原发部位是造血(36%),其次是肾脏(19%)、黑素细胞(11%)、肺部(11%)、卵巢(6%)、乳房(4%)、食管(4%)和软组织(4%)。结直肠(2%)、前列腺(2%)和鼻咽(2%)转移也被发现。没有特定的影像学特征可靠地区分继发性病变和原发性病变。大多数患者(75%)既往有恶性肿瘤病史。在没有恶性肿瘤病史的患者中,超过90%的患者有造血源性继发性恶性肿瘤。结论继发性胰腺肿瘤的细胞学诊断是罕见的。胰脏最常见的继发性肿瘤为造血源性肿瘤。继发性肿瘤的影像学特征是可变的和非特异性的。
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引用次数: 0
Small Cell Carcinoma of the Pancreas: Primary or Metastatic? 胰腺小细胞癌:原发性还是转移性?
IF 0.2 Pub Date : 2015-07-01 DOI: 10.1097/PCR.0000000000000098
F. Mukhtar, J. Levesque, Shantel Hébert‐Magee, A. Nunez, I. Eltoum
Background Primary small cell carcinoma (SCC) of the pancreas is rare, approximately 35 cases reported in the literature. The aim of this study was to review a large center experience with SCC and determine whether the tumor was primary or metastatic. Methods In this retrospective correlation study, we reviewed electronic medical records and cytology and histology reports of all endoscopic ultrasonography–guided fine-needle aspiration of the pancreas between 2000 and 2010 to identify cases diagnosed as SCC of the pancreas. We determined if lesions were primary or metastatic based on patient history, imaging, and pathologic findings. Metastasis was considered when the patient concurrently or previously had a mass elsewhere as well as immunohistochemical stains supporting the tumor origin. Results Two thousand four hundred forty-five pancreatic fine-needle aspirations were identified during the study period (2000–2010). One hundred thirty-four of 2445 cases were endocrine neoplasms, with 8 patients (6%) identified as SCC (poorly differentiated endocrine carcinoma). Five patients had primary lung carcinoma, and 1 patient had primary cervical SCC, whereas a primary lesion could not be identified in the other 2. The prevalence of SCC was 1.5% of all endocrine neoplasms. Cytologic features and endocrine markers were diagnostic of SCC in all patients. All but 1 patient died, survival ranging from 5 to 32 months (median, 11 months) after the diagnosis. Conclusions Pancreatic SCC is rare and carries a grave prognosis. Most pancreatic SCCs are metastatic; therefore, search for the primary tumor is required, particularly given recent reports of good response of primary SCC to surgical resection.
背景:原发性胰腺小细胞癌(SCC)是罕见的,文献报道的病例约为35例。本研究的目的是回顾一个大型中心的SCC经验,并确定肿瘤是原发的还是转移的。方法在本回顾性相关性研究中,我们回顾了2000年至2010年间所有超声内镜引导下的胰腺细针穿刺的电子病历、细胞学和组织学报告,以确定诊断为胰腺SCC的病例。我们根据患者病史、影像学和病理结果确定病变是原发性还是转移性。当患者同时或以前在其他地方有肿块以及免疫组织化学染色支持肿瘤起源时,考虑转移。结果2000-2010年共发现2445例胰腺细针穿刺。2445例中134例为内分泌肿瘤,其中8例(6%)为内分泌低分化癌(SCC)。5例患者为原发性肺癌,1例患者为原发性宫颈鳞状细胞癌,而另外2例患者未发现原发性病变。SCC的患病率占所有内分泌肿瘤的1.5%。所有患者的细胞学特征和内分泌标志物均可诊断SCC。除1例患者外,其余患者均死亡,诊断后生存期为5至32个月(中位11个月)。结论胰腺鳞状细胞癌罕见,预后严重。大多数胰腺SCCs是转移性的;因此,寻找原发肿瘤是必要的,特别是考虑到最近报道的原发性SCC对手术切除的良好反应。
{"title":"Small Cell Carcinoma of the Pancreas: Primary or Metastatic?","authors":"F. Mukhtar, J. Levesque, Shantel Hébert‐Magee, A. Nunez, I. Eltoum","doi":"10.1097/PCR.0000000000000098","DOIUrl":"https://doi.org/10.1097/PCR.0000000000000098","url":null,"abstract":"Background Primary small cell carcinoma (SCC) of the pancreas is rare, approximately 35 cases reported in the literature. The aim of this study was to review a large center experience with SCC and determine whether the tumor was primary or metastatic. Methods In this retrospective correlation study, we reviewed electronic medical records and cytology and histology reports of all endoscopic ultrasonography–guided fine-needle aspiration of the pancreas between 2000 and 2010 to identify cases diagnosed as SCC of the pancreas. We determined if lesions were primary or metastatic based on patient history, imaging, and pathologic findings. Metastasis was considered when the patient concurrently or previously had a mass elsewhere as well as immunohistochemical stains supporting the tumor origin. Results Two thousand four hundred forty-five pancreatic fine-needle aspirations were identified during the study period (2000–2010). One hundred thirty-four of 2445 cases were endocrine neoplasms, with 8 patients (6%) identified as SCC (poorly differentiated endocrine carcinoma). Five patients had primary lung carcinoma, and 1 patient had primary cervical SCC, whereas a primary lesion could not be identified in the other 2. The prevalence of SCC was 1.5% of all endocrine neoplasms. Cytologic features and endocrine markers were diagnostic of SCC in all patients. All but 1 patient died, survival ranging from 5 to 32 months (median, 11 months) after the diagnosis. Conclusions Pancreatic SCC is rare and carries a grave prognosis. Most pancreatic SCCs are metastatic; therefore, search for the primary tumor is required, particularly given recent reports of good response of primary SCC to surgical resection.","PeriodicalId":43475,"journal":{"name":"AJSP-Reviews and Reports","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2015-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/PCR.0000000000000098","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61757426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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