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Need for evidence synthesis for quality control of healthcare decision-making 医疗决策质量控制需要证据综述
IF 3.9 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2023-12-23 DOI: 10.3126/nje.v13i3.61004
B. Sathian, E. V. Van Teijlingen, Israel Junior Borges Do Nascimento, M. Khatib, Indrajit Banerjee, P. Simkhada, Russell Kabir, Hanadi Al Hamad
Systematic reviews that are out-of-date delay policymaking, create controversy, and can erode trust in research. To avoid this issue, it is preferable to keep summaries of the study evidence. Living evidence is a synthesis approach that provides up-to-date rigorous research evidence summaries to decision-makers. This strategy is particularly useful in rapidly expanding research domains, uncertain existing evidence, and new research that may impact policy or practice, ensuring that physicians have access to the most recent evidence. Addressing global challenges – ranging from public health crises to climate change or political instability - requires evidence-based judgements. An obsolete, biased, or selective information poses risks of poor decisions and resource misallocation. The relatively nascent practice of living evidence proves invaluable in maintaining continuous interest and team engagement. The concept of living evidence has been particularly relevant during the COVID-19 pandemic due to the rapidly evolving nature of the virus, the urgent need for timely information, and the continuous emergence of new research findings. Although the COVID-19 pandemic accelerated the adoption of evidence systems, researchers and funders of research should rigorously test the living-evidence model across diverse domains to further advance and optimize its methodology.
过时的系统综述会延误政策制定,引起争议,并可能削弱对研究的信任。为避免这一问题,最好保留研究证据摘要。活证据是一种综合方法,可为决策者提供最新的严格研究证据摘要。这一策略对于快速扩展的研究领域、不确定的现有证据以及可能影响政策或实践的新研究尤为有用,可确保医生获得最新证据。应对全球挑战--从公共卫生危机到气候变化或政治不稳定--需要基于证据的判断。过时、有偏见或选择性的信息会带来决策失误和资源分配不当的风险。事实证明,相对新兴的 "活证据 "实践在保持持续关注和团队参与方面非常有价值。在 COVID-19 大流行期间,"活证据 "的概念尤为重要,因为病毒的性质迅速演变,迫切需要及时的信息,而且新的研究成果不断涌现。尽管 COVID-19 大流行加速了证据系统的采用,但研究人员和研究资助者应在不同领域严格测试活证据模式,以进一步推进和优化其方法。
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引用次数: 0
Strengthening Healthcare through Academic and Industry Partnership Research. 通过学术和行业合作研究加强医疗保健。
IF 3.9 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2023-08-31 eCollection Date: 2023-08-01 DOI: 10.3126/nje.v13i2.58243
Brijesh Sathian, Edwin van Teijlingen, Padam Simkhada, Indrajit Banerjee, Hemanth Kumar Manikyam, Russell Kabir
Academic and Industry Partnership Research Grants have a huge potential to improve healthcare in the UK and elsewhere. This potent partnership between academia and business can hasten medical innovation, strengthen patient-centered research, and close the gap between theoretical understanding and real-world implementations. We can make sure that the quest of scientific knowledge continues to be at the forefront of healthcare developments by welcoming this partnership while respecting ethical norms and transparency. The UK's dedication to developing long-term alliances based on mutual respect and open dialogue will help create a climate in which ground-breaking research may flourish and be transformed into affordable healthcare solutions.
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引用次数: 0
The effect of COVID-19 on the mental health of the people in the Indian subcontinent: A scoping review. 新冠肺炎对印度次大陆人民心理健康的影响:范围界定综述。
IF 1.7 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2023-08-31 eCollection Date: 2023-08-01 DOI: 10.3126/nje.v13i2.52766
Russell Kabir, Ancy Chandrababu Mercy Bai, Haniya Zehra Syed, Md Rakibul Hasan, Divya Vinnakota, Sujita Kumar Kar, Rakesh Singh, Brijesh Sathian, S M Yasir Arafat

Indian subcontinent has high mental heath burden and low resources to cope the mental health challenges. Assessment of impact of COVID-19 pandemic on the mental health would help to prioritize the resource allocations. We aimed to assess the impact of COVID-19 on the mental health of people in the Indian subcontinent. Following the PRISMA 2020 guideline, a scoping review was performed by systematically searching the PubMed, Scopus, and Embase databases to identify original studies that assessed mental health conditions during the COVID-19 pandemic in the Indian subcontinent. In this review, a total of 34 studies conducted between 2020 and 2022 were analyzed. The prevalence of anxiety disorders was found to range widely, from 2.5% in North Indian urban slum to 53% in Bangladesh and 21.7% in Pakistan. Similarly, the prevalence of depression varied widely, with rates ranging from 3.5% in North India to 29.8% in Pakistan. The prevalence of stress-related problems ranged from 18.3% in Pakistan to 59.7% in Bangladesh. Factors such as female gender, married status, healthcare workers, and mental illness were identified as important predictors of anxiety and depressive disorders. The impact of COVID-19 pandemic on mental health in Indian subcontinent varies widely based on study population and methods. Therefore, a cautious interpretation is needed while generalizing the study results.

印度次大陆的心理健康负担很高,应对心理健康挑战的资源很少。评估新冠肺炎大流行对心理健康的影响将有助于优先考虑资源分配。我们旨在评估新冠肺炎对印度次大陆人民心理健康的影响。根据PRISMA 2020指南,通过系统搜索PubMed、Scopus和Embase数据库进行范围界定审查,以确定评估新冠肺炎大流行期间印度次大陆心理健康状况的原始研究。在这篇综述中,对2020年至2022年间进行的34项研究进行了分析。焦虑症的患病率范围很广,从北印度城市贫民窟的2.5%到孟加拉国的53%和巴基斯坦的21.7%。同样,抑郁症的患病率差异很大,从北印度的3.5%到巴基斯坦的29.8%不等。压力相关问题的发生率从巴基斯坦的18.3%到孟加拉国的59.7%不等。女性、婚姻状况、医护人员和精神疾病等因素被确定为焦虑和抑郁障碍的重要预测因素。新冠肺炎大流行对印度次大陆心理健康的影响因研究人群和方法而异。因此,在概括研究结果的同时,需要谨慎解读。
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引用次数: 0
The Promising Future for Complex Innovative Trial Design in Clinical Research. 临床研究中复杂创新试验设计的前景。
IF 3.9 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2023-03-01 DOI: 10.3126/nje.v13i1.53722
Brijesh Sathian, Edwin van Teijlingen, Indrajit Banerjee, Mohammad Asim, Russell Kabir
Complex Innovative Trial Design (CID) offers several potential benefits for clinical research, including the use of novel statistical techniques such as adaptive designs and Bayesian methods that require computer simulation to determine operating characteristics. By leveraging these techniques, CID has the potential to increase the probability of success for clinical trials while simultaneously reducing the time and cost required for drug development.
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引用次数: 0
Pushing the Boundaries of Scientific Research with the use of Artificial Intelligence tools: Navigating Risks and Unleashing Possibilities. 利用人工智能工具推动科学研究的边界:导航风险和释放可能性。
IF 3.9 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2023-03-01 DOI: 10.3126/nje.v13i1.53721
Naushad Ahmad Khan, Kudaibergen Osmonaliev, Mohammad Zahed Sarwar

The language of science is communicated through various modes, such as lectures, informal discussions, conferences, and peer-reviewed publications. Artificial Intelligence (AI) based writing tools, like ChatGPT, have recently become increasingly popular due to natural language processing technology advancements. ChatGPT is an AI language model that can generate text close to human writing, making it suitable for tasks such as summarizing literature, composing essays, and producing statistical studies. This technology has the potential to transform scientific communication, but concerns have been raised about its impact on the integrity of research and the role of human researchers. While this technology has advantages such as accelerating the innovation process and enhancing diversity in scientific viewpoints, it is important for the scientific community to debate and envision the consequences of its use. Publishers are working to develop guidelines for its application, which may be capable of future activities such as experiment design and peer review. As we enter the early stages of the AI revolution, it is imperative that the scientific community engages in discourse and contemplate the potential outcomes of this potentially transformative technology. With this in mind, we have outlined relevant topics as a starting point for discussion.

科学语言通过各种方式传播,如讲座、非正式讨论、会议和同行评议的出版物。由于自然语言处理技术的进步,基于人工智能(AI)的写作工具,如ChatGPT,最近变得越来越受欢迎。ChatGPT是一种人工智能语言模型,可以生成接近人类写作的文本,适用于总结文献、撰写论文和进行统计研究等任务。这项技术有可能改变科学传播,但是有人担心它会影响研究的完整性和人类研究人员的作用。虽然这种技术具有加速创新过程和增强科学观点多样性等优点,但科学界必须辩论和设想使用这种技术的后果。出版商正在努力为其应用制定指导方针,这可能有助于未来的活动,如实验设计和同行评审。当我们进入人工智能革命的早期阶段时,科学界必须参与讨论并思考这种潜在的变革性技术的潜在结果。考虑到这一点,我们概述了相关主题,作为讨论的起点。
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引用次数: 1
Dentists' perception of health-risk associated with cigarettes and alternative tobacco products: A descriptive study. 牙医对与香烟和替代烟草制品有关的健康风险的看法:一项描述性研究。
IF 3.9 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2022-12-01 DOI: 10.3126/nje.v12i4.48488
Danavanthi S Bangera, Mohamed Tahir Takana, Aji Gopakumar, Jayakumary Muttappallymyalil

Cigarettes and alternative tobacco products cause various oral health issues ranging from minor tooth decay/gum-diseases to oral cancer. According to the Centre for Disease Control (CDC), over 40% of adult cigarette smokers have untreated tooth decay which later leads to severe oral health problems. The present study intended to assess the impact of dentists' perceived risk of smoking tobacco products on their attitude and practice toward tobacco cessation advice. It was a cross-sectional study to collect data on the perception of dentists who are smokers, regarding smoking-related health risks. Dentists' attitude was measured using a questionnaire with a 5-point rating scale and a practice list of items with a 3-point rating scale. Descriptive/inferential techniques were applied, and a significance level was fixed at 5%. Among the 31 tobacco users, 80.6% of dentists perceived severe risk with cigarette use as compared to alternative tobacco products (71%). Positive attitude and good practice were observed among those who perceived severe risk; however, no statistical significance was observed (p-value >0.05). Young dentists, males, Arab nationals, highly educated and specialists had a positive attitude toward smoking cessation activities. Among the smokers, dentists recognize their role and responsibility very seriously in building a smoke-free community, but their risk perception and good attitude did not positively reflect on their clinical practice in smoking cessation programs. Though the dentists had a better perception and attitude towards smoking cessation, their clinical practice in offering advising sessions is inversely related to their perception/attitude.

香烟和替代烟草产品会引起各种口腔健康问题,从轻微的蛀牙/牙龈疾病到口腔癌。根据疾病控制中心(CDC)的数据,超过40%的成年吸烟者有未经治疗的蛀牙,这会导致严重的口腔健康问题。本研究旨在评估牙医对吸烟产品的感知风险对他们对戒烟建议的态度和实践的影响。这是一项横断面研究,旨在收集吸烟者牙医对吸烟相关健康风险的看法的数据。牙医的态度是用一份5分制的问卷和一份3分制的练习清单来衡量的。采用描述/推理技术,显著性水平固定为5%。在31名烟草使用者中,与其他烟草制品相比,80.6%的牙医认为使用香烟存在严重风险(71%)。在那些认为存在严重风险的人群中观察到积极的态度和良好的行为习惯;但差异无统计学意义(p值>0.05)。年轻牙医、男性、阿拉伯国民、受过高等教育的人和专家对戒烟活动持积极态度。在吸烟者中,牙医非常重视他们在建立无烟社区中的作用和责任,但他们的风险认知和良好态度并没有积极反映他们在戒烟项目中的临床实践。虽然牙医对戒烟的认知和态度较好,但他们提供戒烟建议的临床实践与他们的认知/态度呈负相关。
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引用次数: 0
Guidance to applying for health research grants in the UK. 英国卫生研究资助申请指南。
IF 3.9 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2022-12-01 DOI: 10.3126/nje.v12i4.50998
Brijesh Sathian, Edwin van Teijlingen, Indrajit Banerjee, Russell Kabir
Applying for a research grant is one of the skills new researchers need to learn.  Writing a grant application can be an intimidating process.  Most research funders have either an online application system or a standard application form that can be emailed to the funder.  Although the length and layout of a grant application can vary between funding bodies, most ask for similar details, including a research proposal, the nature of the research team, a budget, a timeline, and often a risk assessment. This paper summarises key funding agencies in the health research field.  Furthermore, it briefly outlines the general process of applying for grants related to health and health services research in the UK.  To highlight some of the issues that can occur in the grant application process, we provide two examples of applications for international research grants from UK-based funding bodies, each had to be resubmitted before of it was successful in receiving funding.
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引用次数: 0
Dengue Dilemma in Nepal. 尼泊尔的登革热困境。
IF 3.9 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2022-12-01 DOI: 10.3126/nje.v12i4.50764
Indrajit Banerjee, Jared Robinson, Brijesh Sathian
The first case of Dengue in Nepal  was reported in 2004, after a traveller returned from India. Dengue has since then been an endemic disease within the country with all 4 serotypes (DENV-1,DENV-2,DENV-3 and DENV-4) being known to exist and circulate within the region. Based on epidemiological records the DENV-1 and DENV-2 serotypes have traditionally been the most incriminated serovars in terms of national disease burden according to the Epidemiology and the disease control division (EDCD). Since the beginning of January 2022 up until the 28th of September 2022 over 28000 cases of confirmed and suspected cases of dengue fever have been reported to the WHO with a total of 38 deaths being documented across all of Nepal’s provinces. To date the predominant implicated serotype or serotypes have not been identified. The province most adversely affected is the Bagmati province which accounts for 78.2% of the cases and 68.4% of the fatalities noted in Nepal. A further rise in cases has been noted as of the 8th of August 2022. This dengue outbreak is the largest recorded outbreak within the small mountainous regions recent history. The latest data released by the Ministry of health and population of Nepal (11th December 2022), has recorded a total of 54232 cases with the Bagmati province accounting for 42143 thereof and Lumbini province 4984 respectively. To date a total of 67 deaths have been confirmed. The top 10 reporting districts are namely: 1.Kathmandu (14165) 2.Lalitpur (9614) 3.Bhaktapur(6145) 4.Mawkanpur (5830) 5.Chitawan (3188) 6.Dang (2405) 7. Dhading(1678) 8. Rupandehi (1203) 9. Kavrepalanchok (536) and 10. Surkhet (470) cases respectively. Due to the treatment of the disease being predominantly supportive, the prevention of the spread through enhanced and improved vector control and elimination is recommended. The use of eradication programs, impregnated mosquito nets, larvicidal and chromosomal manipulation therapies are the most effective methods to aid and abet the control of this deadly virus. The coming months and response of the spread of the virus to the intimated control programs implemented in Nepal will act as a yardstick for the future development and course of the outbreak of Dengue within the mountainous region.
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引用次数: 1
The emergence of novel infectious diseases and the public health impact of mass gathering events: risks and challenges. 新型传染病的出现和大规模聚集事件的公共卫生影响:风险和挑战。
IF 3.9 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2022-12-01 DOI: 10.3126/nje.v12i4.50997
Mohammad Asim, Naushad Ahmad Khan, Kudaibergen Osmonaliev, Brijesh Sathian
To date, there is the continuous emergence of novel infectious diseases endangering individuals' health and well-being worldwide. Over the past few decades, around forty contagious diseases, such as Severe Acute Respiratory Syndrome coronavirus-1 (SARS), Middle East Respiratory Syndrome coronavirus (MERS), Ebola, Zika, and newly, COVID-19 and Monkeypox outbreaks, have been reported globally. Zoonotic transmission is the major cause of these emerging infections in humans. These, whether caused by previously unknown pathogens or by those already well-known to science, heighten global concerns about the spread of communicable diseases and the resulting increase in death and disability.
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引用次数: 0
Exploring UK Knife crime and its associated factors: A content analysis of online newspapers. 探究英国持刀犯罪及其相关因素:在线报纸的内容分析。
IF 3.9 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2022-12-01 DOI: 10.3126/nje.v12i4.49994
Divya Vinnakota, Q M Rahman, Brijesh Sathian, Ancy Chandrababu Mercy Bai, Nikulin Deividas, Maneesha-Varghese Pellissery, Sajna Kizhackanaly Abdul Kareem, Md Rakibul Hasan, Ali Davod Parsa, Russell Kabir

Knife crime has become a common phrase used by the media, but it is not always clear what it refers to or what they mean when they use the term. Knife crime can cover many offences, making it challenging to define and estimate its prevalence. This review aimed to evaluate potential knife crimes in the UK from 2011 to 2021 and analyse the causes and risk factors associated with the crimes. Six UK online news portals were purposefully chosen to be included in the study, and knife crime news was searched retrospectively. The term "knife crime" was used to search. The news portals were the: Metro, the Sun, the Guardian, Daily Mail, Daily Mirror and the Evening Standard. In the assigned news portals, 692 reports were found between January 2011 and December 2021. The study revealed that the 11-20 years of age group individuals are more vulnerable as victims, and males are more reported as victims when compared to females. About 61.8% of knife crimes are reported from South England. Knife crime risk is higher in early adulthood and among males. Street violence, fights/gang attacks, family issues and robbery are the leading causes of knife crime and have all been identified as risk factors that must be addressed with caution.

持刀犯罪已经成为媒体使用的一个常见短语,但人们并不总是清楚它指的是什么,或者他们使用这个词的时候是什么意思。持刀犯罪可以涵盖许多罪行,因此很难界定和估计其流行程度。本综述旨在评估2011年至2021年英国潜在的持刀犯罪,并分析与犯罪相关的原因和风险因素。有目的地选择了六家英国在线新闻门户网站作为研究对象,并对持刀犯罪新闻进行回顾性搜索。“持刀犯罪”一词被用于搜查。新闻门户是:《地铁报》、《太阳报》、《卫报》、《每日邮报》、《每日镜报》和《旗帜晚报》。在指定的新闻门户中,2011年1月至2021年12月共发现692篇报道。研究表明,11-20岁年龄组的个体更容易成为受害者,与女性相比,男性更容易成为受害者。据报道,大约61.8%的持刀犯罪发生在英格兰南部。持刀犯罪的风险在成年早期和男性中更高。街头暴力、打斗/帮派袭击、家庭问题和抢劫是持刀犯罪的主要原因,这些都被确定为必须谨慎处理的风险因素。
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引用次数: 0
期刊
Nepal Journal of Epidemiology
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