Pub Date : 2016-01-01DOI: 10.1007/S13546-015-1147-2
G. Ledoux, N. Terzi, E. Jaillette, R. Lawson, N. Masli, R. Favory
{"title":"Sédation légère chez les patients en insuffisance respiratoire aiguë","authors":"G. Ledoux, N. Terzi, E. Jaillette, R. Lawson, N. Masli, R. Favory","doi":"10.1007/S13546-015-1147-2","DOIUrl":"https://doi.org/10.1007/S13546-015-1147-2","url":null,"abstract":"","PeriodicalId":43743,"journal":{"name":"Reanimation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/S13546-015-1147-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"53006853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-01-01DOI: 10.1007/s13546-015-1135-6
Srlf 2015
{"title":"Sécurité autour du patient","authors":"Srlf 2015","doi":"10.1007/s13546-015-1135-6","DOIUrl":"https://doi.org/10.1007/s13546-015-1135-6","url":null,"abstract":"","PeriodicalId":43743,"journal":{"name":"Reanimation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s13546-015-1135-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"53006157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-01-01DOI: 10.1007/S13546-015-1153-4
M. Meyer, M. Kernmarc, F. Manciet, I. Caminade, J. Diehl
{"title":"Rôle IDE dans la mise en place et la surveillance de l’ECCO2R","authors":"M. Meyer, M. Kernmarc, F. Manciet, I. Caminade, J. Diehl","doi":"10.1007/S13546-015-1153-4","DOIUrl":"https://doi.org/10.1007/S13546-015-1153-4","url":null,"abstract":"","PeriodicalId":43743,"journal":{"name":"Reanimation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/S13546-015-1153-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"53007340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-01-01Epub Date: 2016-03-11DOI: 10.1007/s13546-015-1168-x
P Seguin, Y Launey, N Nesseler, Y Malledant
Temperature control during severe sepsis is currently used in intensive care and involves 66% and 70% of severe sepsis and septic shock, respectively. Nevertheless, the conclusive evidence of the benefit of such a strategy is still lacking.We might wonder, with regards to experimental works and recent noninterventional studies, about the risk of a control strategy on an ongoing infectious process, the patient's outcome, and the safety of the means implemented to obtain temperature control. On the other hand, it is also demonstrated that fever increases oxygen consumption, which may lead in some clinical situations to tissular ischemia and that fever may be associated with a deleterious focal inflammatory process. Methods to control the temperature include external and/or internal cooling and/or antipyretic medications such as paracetamol and nonsteroidal antiinflammatory drugs. In septic patients, external cooling and paracetamol are the mains means used to control temperature. Despite the uncertainties about the benefit to control or not the temperature, it could be stated that extreme temperature (hypo- or hyperthermia) should be avoided and that the benefit/risk of temperature control must be individually weighted.
{"title":"[Is control fever mandatory in severe infections?]","authors":"P Seguin, Y Launey, N Nesseler, Y Malledant","doi":"10.1007/s13546-015-1168-x","DOIUrl":"10.1007/s13546-015-1168-x","url":null,"abstract":"<p><p>Temperature control during severe sepsis is currently used in intensive care and involves 66% and 70% of severe sepsis and septic shock, respectively. Nevertheless, the conclusive evidence of the benefit of such a strategy is still lacking.We might wonder, with regards to experimental works and recent noninterventional studies, about the risk of a control strategy on an ongoing infectious process, the patient's outcome, and the safety of the means implemented to obtain temperature control. On the other hand, it is also demonstrated that fever increases oxygen consumption, which may lead in some clinical situations to tissular ischemia and that fever may be associated with a deleterious focal inflammatory process. Methods to control the temperature include external and/or internal cooling and/or antipyretic medications such as paracetamol and nonsteroidal antiinflammatory drugs. In septic patients, external cooling and paracetamol are the mains means used to control temperature. Despite the uncertainties about the benefit to control or not the temperature, it could be stated that extreme temperature (hypo- or hyperthermia) should be avoided and that the benefit/risk of temperature control must be individually weighted.</p>","PeriodicalId":43743,"journal":{"name":"Reanimation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7117820/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37832416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-01-01Epub Date: 2016-04-07DOI: 10.1007/s13546-016-1188-1
J Poissy, O Terrier, B Lina, J Textoris, M Rosa-Calatrava
During the last decades, emergence and reemergence of viruses were responsible for epidemic and pandemic infectious diseases, with variable degrees of severity. Current preventive strategies are not sufficient at all, and available therapeutic drugs are very limited. Indeed, genetic variations of viruses can impair the efficacy of antiviral compounds by the apparition of resistance. Moreover, current delay needed for de novo development of drugs does not allow a rapid response in case of important epidemic or pandemic events. In this context, new therapeutic approaches are necessary. An innovative concept is to repurpose already marketed compounds that can reverse the host cellular transcriptomic response to the infection. By targeting the host, these molecules exhibit a broad-spectrum activity and are potentially effective even against new emergent strains. This strategy implements the characterization of specific host gene expression profiles, the in silico screening of drugs, and their validation in in vitro and in vivo models, until their evaluation in clinical trials. Here, we will present this approach, with the example of the flu.
{"title":"[Modulation of transcriptomic signature of the infected host: a new therapeutic strategy for the management of severe viral infections? Example of the flu].","authors":"J Poissy, O Terrier, B Lina, J Textoris, M Rosa-Calatrava","doi":"10.1007/s13546-016-1188-1","DOIUrl":"https://doi.org/10.1007/s13546-016-1188-1","url":null,"abstract":"<p><p>During the last decades, emergence and reemergence of viruses were responsible for epidemic and pandemic infectious diseases, with variable degrees of severity. Current preventive strategies are not sufficient at all, and available therapeutic drugs are very limited. Indeed, genetic variations of viruses can impair the efficacy of antiviral compounds by the apparition of resistance. Moreover, current delay needed for de novo development of drugs does not allow a rapid response in case of important epidemic or pandemic events. In this context, new therapeutic approaches are necessary. An innovative concept is to repurpose already marketed compounds that can reverse the host cellular transcriptomic response to the infection. By targeting the host, these molecules exhibit a broad-spectrum activity and are potentially effective even against new emergent strains. This strategy implements the characterization of specific host gene expression profiles, the in silico screening of drugs, and their validation in in vitro and in vivo models, until their evaluation in clinical trials. Here, we will present this approach, with the example of the flu.</p>","PeriodicalId":43743,"journal":{"name":"Reanimation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s13546-016-1188-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37832417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-01-01DOI: 10.1007/S13546-015-1155-2
D. Chatellier, S. Cabasson, R. Robert
{"title":"Les pneumonies d’inhalation","authors":"D. Chatellier, S. Cabasson, R. Robert","doi":"10.1007/S13546-015-1155-2","DOIUrl":"https://doi.org/10.1007/S13546-015-1155-2","url":null,"abstract":"","PeriodicalId":43743,"journal":{"name":"Reanimation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/S13546-015-1155-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"53007472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-01-01DOI: 10.1007/S13546-015-1152-5
Serge Carreira, S. Lavault, A. Demoule
{"title":"Sommeil en réanimation et impact de la ventilation mécanique","authors":"Serge Carreira, S. Lavault, A. Demoule","doi":"10.1007/S13546-015-1152-5","DOIUrl":"https://doi.org/10.1007/S13546-015-1152-5","url":null,"abstract":"","PeriodicalId":43743,"journal":{"name":"Reanimation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/S13546-015-1152-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"53007232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-01-01DOI: 10.1007/S13546-015-1145-4
J. Diehl, N. Aissaoui, C. Hauw-Berlemont, F. Boissier, Alexandra Monnier, A. Novara, J. Fagon, E. Guérot
{"title":"Les dispositifs d’épuration extracorporelle du CO2 en réanimation : principes, indications potentielles, résultats actuels","authors":"J. Diehl, N. Aissaoui, C. Hauw-Berlemont, F. Boissier, Alexandra Monnier, A. Novara, J. Fagon, E. Guérot","doi":"10.1007/S13546-015-1145-4","DOIUrl":"https://doi.org/10.1007/S13546-015-1145-4","url":null,"abstract":"","PeriodicalId":43743,"journal":{"name":"Reanimation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/S13546-015-1145-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"53006719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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