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Q
Pub Date : 2018-12-14 DOI: 10.1201/9781315384313-17
A. Earl‐Slater
This article discusses the challenges faced by modern schools in providing quality education and the challenges they must overcome to address these issues. Common problems in modern schools include overloaded curriculum, technological dominance, excessive workload, and limited facilities and infrastructure. One major issue is an overloaded curriculum, where students face pressure to absorb a vast amount of information within limited timeframes, leaving little room for the development of their interests and talents. Technological dominance also has a significant impact, as excessive reliance on technology can reduce social interaction and hinder students' critical thinking abilities. Excessive workload is another commonly faced problem for students in modern schools, resulting in stress and an imbalance between academic activities and personal life. Additionally, limitations in facilities and infrastructure, such as inadequate facilities and insufficient infrastructure, can restrict students' learning experiences. The challenges faced by modern schools include the development of relevant and flexible curricula, as well as the wise integration of technology to optimize learning. Managing a balanced workload for students and improving school facilities and infrastructure are also challenges that need to be addressed. In addressing these challenges, collaboration among schools, teachers, parents, and relevant stakeholders is key. Continuous teacher training, the implementation of innovative teaching models, and adequate funding are necessary to achieve sustainable improvements in education. Through a deep understanding of the problems faced by modern schools and the challenges they encounter, it is hoped that this article will provide valuable insights for stakeholders in addressing educational issues and promoting better progress for students and society as a whole.
本文讨论了现代学校在提供优质教育方面所面临的挑战,以及他们为解决这些问题所必须克服的挑战。现代学校普遍存在的问题包括课程超载、技术优势、课业负担过重、设施和基础设施有限。一个主要问题是课业过重,学生面临着在有限的时间内吸收大量信息的压力,几乎没有给他们的兴趣和才能发展留下空间。技术优势也有显著的影响,过度依赖技术会减少社会互动,阻碍学生的批判性思维能力。过多的工作量是现代学校学生普遍面临的另一个问题,它导致了压力和学业活动与个人生活之间的不平衡。此外,设施和基础设施的限制,如设施不足和基础设施不足,会限制学生的学习体验。现代学校面临的挑战包括开发相关和灵活的课程,以及明智地整合技术以优化学习。为学生管理平衡的工作量和改善学校设施和基础设施也是需要解决的挑战。在应对这些挑战时,学校、教师、家长和相关利益相关者之间的合作是关键。持续的教师培训、创新教学模式的实施和充足的资金是实现教育可持续改进的必要条件。透过深入了解现代学校所面临的问题和挑战,希望本文能为持份者提供宝贵的见解,以解决教育问题,促进学生和整个社会的进步。
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引用次数: 0
S 年代
Pub Date : 2018-12-14 DOI: 10.1201/9781315384313-19
A. Earl‐Slater
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引用次数: 0
M
Pub Date : 2018-12-14 DOI: 10.1201/9781315384313-13
A. Earl‐Slater
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引用次数: 0
R R
Pub Date : 2018-12-14 DOI: 10.1201/9781315384313-18
A. Earl‐Slater
As a sensor of cytosolic DNA, the role of cyclic GMP-AMP synthase (cGAS) in innate immune response is well established, yet how its functions in different biological conditions remain to be elucidated. Here, we identify cGAS as an essential regulator in inhibiting mitotic DNA double-strand break (DSB) repair and protecting short telomeres from end-to-end fusion independent of the canonical cGAS-STING pathway. cGAS associates with telomeric/subtelomeric DNA during mitosis when TRF1/ TRF2/POT1 are de fi cient on telomeres. Depletion of cGAS leads to mitotic chromosome end-to-end fusions predominantly occurring between short telomeres. Mechanistically, cGAS interacts with CDK1 and posi-tions them to chromosome ends. Thus, CDK1 inhibits mitotic non-homologous end joining (NHEJ) by blocking the recruitment of RNF8. cGAS-de fi cient human primary cells are defective in entering replicative senescence and display chromosome end-to-end fusions, genome instability and prolonged growth arrest. Altogether, cGAS safeguards genome stability by controlling mitotic DSB repair to inhibit mitotic chromosome end-to-end fusions, thus facilitating replicative senescence
环GMP-AMP合成酶(cyclic GMP-AMP synthase, cGAS)作为细胞质DNA的传感器,在先天免疫应答中的作用已被证实,但其在不同生物学条件下的功能仍有待阐明。在这里,我们发现cGAS是抑制有丝分裂DNA双链断裂(DSB)修复和保护短端粒端到端融合的重要调节因子,独立于典型的cGAS- sting途径。当TRF1/ TRF2/POT1在端粒缺失时,有丝分裂期间cGAS与端粒/亚端粒DNA相关。cGAS的缺失导致有丝分裂染色体端到端融合主要发生在短端粒之间。从机制上讲,cGAS与CDK1相互作用并将它们定位到染色体末端。因此,CDK1通过阻断RNF8的募集来抑制有丝分裂非同源末端连接(NHEJ)。缺乏cgas的人类原代细胞在进入复制衰老和表现出染色体端到端融合、基因组不稳定和长时间生长停滞方面存在缺陷。总之,cGAS通过控制有丝分裂DSB修复来抑制有丝分裂染色体端到端融合,从而促进复制性衰老,从而维护基因组稳定性
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引用次数: 0
H H
Pub Date : 2018-12-14 DOI: 10.1201/9781315384313-8
A. Earl‐Slater
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引用次数: 0
O O
Pub Date : 2018-12-14 DOI: 10.1201/9781315384313-15
A. Earl‐Slater
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引用次数: 0
W W
Pub Date : 2018-12-14 DOI: 10.1201/9781315384313-23
A. Earl‐Slater
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引用次数: 0
Y Y
Pub Date : 2018-12-14 DOI: 10.1201/9781315384313-25
A. Earl‐Slater
Para poner en marcha una estrategia de comunicación debes tener claros los contenidos que deseas transmitir. Y para ello, necesitamos previamente manejar abundante información: listados de empresas, información profesional, ofertas de trabajo, etc. En definitiva, estar al día en lo que sucede en nuestro entorno profesional. Eso requiere realizar búsquedas eficaces y usar mecanismos para su adecuada organización.
要实施沟通策略,你必须清楚你想要传达的内容。要做到这一点,我们首先需要处理大量的信息:公司上市、专业信息、工作邀请等。简而言之,就是要及时了解我们职业环境中的最新情况。这需要有效的搜索和适当的组织机制。
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引用次数: 0
N N
Pub Date : 2018-12-14 DOI: 10.1201/9781315384313-14
A. Earl‐Slater
VISTO il D.P.R. 10 Gennaio 1957, n. 3; VISTO il D.P.R. 3.5.1957, n. 686; VISTA la Legge 9.5.1989, n. 168; VISTA la Legge 7.8.1990, n. 241; VISTA la Legge 10.4.1991, n. 125; VISTA la Legge 5.2.1992, n. 104; VISTA la Legge 24.12.1993, n. 537 ed in particolare l’art. 5; VISTO il D.P.C.M. 7.2.1994, n. 174; VISTO il D.P.R. 9.5.1994, n. 487 e successive modificazioni ed integrazioni; VISTA la Legge 31 Dicembre 1996, n. 675 e successive modificazione ed integrazioni; VISTA la Legge 15 Maggio 1997, n. 127; VISTO il D.P.R. 28.12.2000, n. 445; VISTO il D.Lgs. 30.3.2001, n. 165 e successive modificazioni ed integrazioni; VISTO il Contratto Collettivo Nazionale dei Dipendenti del comparto dell’Università 20062009; VISTO il Contratto Collettivo Nazionale di Lavoro relativo al Personale del Comparto Istruzione e Ricerca Triennio 2016-2018; VISTO il D.Lgs. 15 marzo 2010, n. 66 Codice dell’ordinamento militare ed in particolare gli artt. 1014 comma 1 e 678 comma 9 (già D. Lgs. 215/2001, art. 18 comma 6); VISTO il Regolamento in materia di accesso dall'esterno ai ruoli del personale tecnicoamministrativo a tempo indeterminato di questa Università approvato con D.R. 4 aprile 2017, n. 495; VISTA la Legge 16.1.2003, n. 3; VISTO il Regolamento (UE) 2016/679 del Parlamento europeo e del Consiglio del 27 aprile 2016 relativo alla protezione delle persone fisiche con riguardo al trattamento dei dati personali, nonché alla libera circolazione di tali dati e che abroga la direttiva 95/46/CE; VISTA la Legge 12 ottobre 1993 n. 413, Norme sull'obiezione di coscienza alla sperimentazione animale; VISTO l’avviso di mobilità volontaria ai sensi dell’art. 30 del Decreto Legislativo 30 marzo 2001, n. 165 e ai sensi dell’art. 57 del C.C.N.L. 2006-2009 del personale del comparto Università pubblicato all’Albo ufficiale di Ateneo Rep. n. 568/2022 Prot n. 245865 del 29/07/2022; CONSIDERATO che con nota Prot. 248281 del 01/08/2022 è stato data attuazione a quanto disposto dall'art. dall'art. 34 bis del Decreto Legislativo 30 marzo 2001, n. 165; VISTO il Decreto del Direttore Generale n. 1175/2022 Prot n. 244063 del 27/07/2022; VISTO il Decreto legge 1 aprile 2021, n. 44; ACCERTATA la copertura finanziaria sul bilancio dell’Ateneo; VISTO lo Statuto dell’Università degli Studi di Ferrara;
考虑到1957年1月10日第3号总统令;考虑到1957年5月3日第686号法令;考虑到1989年5月9日第168号法律;考虑到1990年8月7日第241号法律;考虑到1991年4月10日第125号法律;考虑到1992年2月5日第104号法律;考虑到1993年12月24日第537号法律,特别是其中第2条,5;考虑到d.p.c.m. 1994年2月7日第174号;考虑到经修订和增补的1994年5月9日第487号法令;考虑到1996年12月31日第675号法律及其后的修订和增补;考虑到1997年5月15日第127号法律;考虑到2000年12月28日第445号法令;看到d.g.了。30.3.2001,第165号及其后的修订和补充;考虑到2006 - 2009年全国大学部门雇员集体协议;考虑到关于教育和研究部门工作人员的国家集体协定,为期2016-2018年;看到d.g.了。2010年3月15日第1014条第1款和第678条第9款18 (6);考虑到2017年4月4日第495号法令通过的关于从外部进入这所大学常设技术和行政工作人员职位的规定;考虑到2003年1月16日第3号法律;考虑到欧洲议会和理事会2016年4月27日关于在处理个人资料方面保护个人以及这些资料的自由流动和废除第95/46/ ec号指令的第206 /679号条例;考虑到1993年10月12日第413号法律,关于出于良心反对动物实验的规定;考虑到《欧洲共同体条约》第48条规定的自愿调动通知,2001年3月30日第165号法令第30条2006年7月29日至2022日,《高等教育学院工作人员条例》第57号(2006-2009年高等教育学院工作人员条例第57号(2006-2009年高等教育学院工作人员条例第57号(2006-2009年高等教育学院工作人员条例第57号(2006-2009年高等教育学院工作人员条例第57号(2006-2009年高等教育学院工作人员条例第56 /2022号)第248281 / 01/08/2022号文件条。2001年3月30日第165号法令第34a条;考虑到总干事第117 /2022号法令第244063 / 27/ 2022号;考虑到2021年4月1日第44号法令;确定大学预算的财政范围;考虑到费拉拉大学的章程;
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引用次数: 0
Z Z
Pub Date : 2018-12-14 DOI: 10.1201/9781315384313-26
A. Earl‐Slater
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引用次数: 0
期刊
Dictionary of Health Economics
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