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Short term Outcomes of left main coronary artery Percutaneous Coronary Intervention A large tertiary care dedicated Cardiac Centre experience. 左冠状动脉主干经皮冠状动脉介入治疗的短期结果一个大型三级保健专门的心脏中心经验。
Pub Date : 2022-12-01 DOI: 10.58889/pjcvi.3.24.30
A. Ullah, M. Ishaq, Rafiullah Jan, A. Raza
Background: Left main coronary artery intervention is getting common throughout the world. Data in our local population are still lacking. Our aim was to study the short-term outcomes after revascularization of left main coronary artery (LMCA) at a tertiary care Centre at public sector hospital in Pakistan. Methodology: In this descriptive study conducted at Peshawar Institute of Cardiology, we enrolled consecutive patients who underwent LMCA intervention from January 2021 till November 2021. Direct patients’ interviews, reviewing charts and records were used for in-hospital outcomes and telephonic and physical follow up were used to document three months outcome. Results were expressed as means, standard deviations and percentages for different variables. Results: Total number of patients in the study were 68. The mean age was 61 ± 11.7 years, 73.5% (50 cases) were males. Six patients (8.8%) were in cardiogenic shock and five of them were put on mechanical ventilation. Thirty-two (47.1%) patients had presentation as acute coronary syndrome (ACS) within the last seven days. Mean follow up time was 170 ± 71 days. Mortality in-hospital was 5.8%, at the mean follow up it was 8.8%. Conclusion: Comparable short-term outcomes of left main coronary artery PCI, to national and international data can be achieved in a public sector hospital in our country where resources are scarce. Hence LMCA PCI is an acceptable alternative to CABG in suitable patients.
背景:冠状动脉左主干介入治疗在世界范围内越来越普遍。我们当地人口的数据仍然缺乏。我们的目的是研究巴基斯坦公立医院三级保健中心左冠状动脉主干(LMCA)血运重建术后的短期结果。方法:在白沙瓦心脏病研究所进行的这项描述性研究中,我们招募了2021年1月至2021年11月连续接受LMCA干预的患者。直接与患者面谈,回顾图表和记录用于住院结果,电话和物理随访用于记录三个月的结果。结果以不同变量的均值、标准差和百分比表示。结果:本组患者共68例。平均年龄61±11.7岁,男性50例,占73.5%。心源性休克6例(8.8%),其中机械通气5例。32例(47.1%)患者在最近7天内出现急性冠脉综合征(ACS)。平均随访时间170±71 d。住院死亡率为5.8%,平均随访死亡率为8.8%。结论:在我国资源匮乏的公立医院,冠状动脉左主干PCI短期疗效可与国内外数据相比较。因此,在合适的患者中,LMCA PCI是CABG的可接受替代方案。
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引用次数: 0
Chronic ischemia in Left anterior descending artery territory presenting as intractable hiccups: An unusual symptom of coronary artery disease. 左前降支区域慢性缺血表现为顽固性打嗝:冠状动脉疾病的一种不寻常症状。
Pub Date : 2022-12-01 DOI: 10.58889/pjcvi.3.77.79
S. Khan, A. Khan, Syed Abid Habib
Classical symptoms of ischemic heart disease include exertional chest pain associated diaphoresis, palpitations or shortness of breath. Yet, it can also present unusually with symptoms ranging from epigastric discomfort, fatigue and vomiting. A 48 years old male presented to the hospital with severe retrosternal chest pain for 6 hours duration. ECG showed acute anterior wall STEMI. Primary PCI to LAD was performed successfully. He had been complaining of intractable hiccups for the past one year for which he had been seen in gastroenterology clinics multiple times with no relief in hiccups. After we performed primary PCI to LAD, he had complete resolution of hiccups. He is still under regular follow up with us for the past 4 months with no active complaints of hiccups. This case conclude that Intractable hiccups can be the only symptomatic manifestation of coronary artery disease (CAD) in some patients. Therefore, a high suspicion of CAD should be kept in mind especially in patients with risk factors for CAD.  
缺血性心脏病的典型症状包括运动性胸痛相关出汗、心悸或呼吸短促。然而,它也可能表现出不同寻常的症状,包括上腹不适、疲劳和呕吐。48岁男性,因严重胸骨后胸痛6小时就诊。心电图显示急性前壁STEMI。主PCI转LAD成功。在过去的一年里,他一直在抱怨顽固性打嗝,为此他曾多次在胃肠科诊所就诊,但打嗝没有缓解。在我们对LAD进行初级PCI后,他的打嗝完全解决了。在过去的4个月里,他仍在接受我们的定期随访,没有主动抱怨打嗝。本病例提示顽固性呃逆可能是冠心病(CAD)患者的唯一症状表现。因此,对冠心病的高度怀疑应牢记在心,特别是对有冠心病危险因素的患者。
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引用次数: 0
Left Main Coronary Artery Stenosis following Bentall Procedure: A case report. 本特尔手术后左主干冠状动脉狭窄1例报告。
Pub Date : 2022-12-01 DOI: 10.58889/pjcvi.3.60.64
Hannah Hameed, Tara Anne John, M. Tahirkheli, Bruce Cannon, Julie Ellen White, Hussnain Zafar, M. Baig, Zarrar Sani, A. Chohan, A. Weitzel, Humza Razaq, A. Siddiqi, Mehak Ali, Ilsa Rizvi, Arslan Ahmad, Bireera Muzaffar, Sakina Batool, Riyan Imtiaz Karamat, Qasim Manzoor Amjad, A. Karim, N. Tahirkheli
Since its introduction, Bentall procedure has remained the standard of care for management of ascending aortic aneurysms with associated aortic valve pathologies. It involves replacement of aortic root, ascending aorta and the aortic valve, using a hybrid vascular graft with built in valves. The openings of the main coronary arteries are then rejoined with the graft. The procedure has satisfactory long term survival rate. However, there are some complications including graft infection, stroke from dislodged plaques and coronary insufficiency due to kinking of the reconnected main coronary arteries. Here, we report a rare and life-threatening complication following Bentall procedure. A 76-year-old female developed left main stenosis following Bentall procedure, successfully treated with percutaneous coronary intervention (PCI). We discuss various etiologies and treatment options for this complication. We recommend routine surveillance with coronary angiography at six months post Bentall.
自引入以来,本特尔手术一直是治疗伴有主动脉瓣病变的升主动脉瘤的标准治疗方法。它包括替换主动脉根部、升主动脉和主动脉瓣,使用内置瓣膜的混合血管移植物。然后用移植物重新连接主冠状动脉的开口。该手术具有令人满意的长期生存率。然而,也有一些并发症,包括移植物感染、斑块移位引起的中风以及由于重新连接的冠状动脉主干扭结而导致的冠状动脉功能不全。在此,我们报告一罕见且危及生命的本特尔手术并发症。一位76岁女性在本特尔手术后出现左主干狭窄,经皮冠状动脉介入治疗(PCI)成功。我们讨论了这种并发症的各种病因和治疗方案。我们建议在本特尔治疗后6个月进行常规冠状动脉造影监测。
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引用次数: 0
Comparative outcomes of MACE after Drug eluting balloon Vs. Drug Eluting Stent in treatment of in-stent restenosis (ISR) patients presented with acute coronary syndrome. 药物洗脱球囊与药物洗脱支架治疗急性冠脉综合征支架内再狭窄(ISR)患者的疗效比较
Pub Date : 2022-12-01 DOI: 10.58889/pjcvi.3.31.36
S. Khan, A. Khan, Jasia Bukhari, Muhammad Idrees Khan, Imad Uddin
Background: Currently, patients with coronary artery disease are advised to use coronary stenting as their primary revascularization method. This study aims to compare outcome of MACE after DEB Vs DES in treatment of patients within stent restenosis (ISR) presented with chest pain. Methodology: The current study was Quasi experimental study carried out at the Department of Cardiology, MTI-HMC Peshawar for duration of six months from 21 April 2021 to 21 Nov 2021. In this study, 94 patients in DEB group and 94 patients in DES group were followed for 06 months to look for development of MACE.  All data was collected through a well-defined proforma. Data was entered on computer software SPSS version 22. Results: In DEB group, 52 (55.3%) male patients and 42 (44.7%) female patients were recorded whereas in DES group, 57 (60.6%) male patients while 37 (39.4%) female patients were recorded. In DEB group, 15 (16.0%) patients were recorded with MACE whereas in DES group, 38 (40.4%) patients were recorded with MACE. Conclusion: Our study showed that DEB is superior to DES in the management of in-stent restenosis and results in fewer major adverse cardiovascular events (MACE), so DEB may be considered as a treatment option for CAD patients admitted to our setting in in order to reduce mortality and morbidity associated to restenosis in such patients.
背景:目前,建议冠状动脉疾病患者使用冠状动脉支架植入术作为其主要的血运重建方法。本研究旨在比较DEB与DES治疗支架再狭窄(ISR)患者胸痛的效果。方法学:目前的研究是在MTI-HMC白沙瓦心脏病学系进行的准实验研究,为期六个月,从2021年4月21日至2021年11月21日。本研究对DEB组94例患者和DES组94例患者进行随访,随访时间为06个月,观察MACE的发展情况。所有数据都是通过定义明确的形式收集的。数据在计算机软件SPSS version 22中输入。结果:DEB组男性52例(55.3%),女性42例(44.7%);DES组男性57例(60.6%),女性37例(39.4%)。DEB组有15例(16.0%)患者发生MACE, DES组有38例(40.4%)患者发生MACE。结论:我们的研究表明,DEB在处理支架内再狭窄方面优于DES,并且导致更少的主要不良心血管事件(MACE),因此DEB可以作为我们收治的CAD患者的治疗选择,以降低此类患者与再狭窄相关的死亡率和发病率。
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引用次数: 0
Recurrent coronary spasm presenting as acute STEMI; To stent or not to stent? 复发性冠状动脉痉挛表现为急性STEMI;支架还是不支架?
Pub Date : 2022-12-01 DOI: 10.58889/pjcvi.3.69.76
A. Ullah, F. Keshavarzi, D. Fraser
Coronary artery spasm is a relatively uncommon cause of ST segment elevation myocardial infarction. However, the clinical presentation and electrocardiographic findings are remarkably similar to STEMI secondary to plaque rupture. Recurrent presentation with coronary vasospasm as STEMI presents a unique clinical dilemma especially if they present to different centers where the previous history is not well known. Management in the acute settings continue to pose significant challenges in these acutely unwell patients. We describe and explore a similar clinical situation in which a patient with severe recurrent STEMI presentations was found to have coronary artery vasospasms. The case was twice misinterpreted as having plaque rupture STEMI leading to percutaneous coronary intervention and then further difficulties in long term management in view of need for long term antiplatelet and suspected association of eosinophilia with coronary vasospasm which in turn can be caused by Aspirin.
冠状动脉痉挛是一种相对少见的ST段抬高型心肌梗死的病因。然而,临床表现和心电图表现与继发于斑块破裂的STEMI非常相似。反复出现的冠状血管痉挛作为STEMI提出了一个独特的临床困境,特别是如果他们出现在不同的中心,以前的历史不清楚。在这些急性不适患者的急性设置管理继续构成重大挑战。我们描述和探讨一个类似的临床情况,其中患者严重复发STEMI表现被发现有冠状动脉血管痉挛。该病例两次被误解为有斑块破裂STEMI导致经皮冠状动脉介入治疗,然后考虑到需要长期抗血小板和怀疑嗜酸性粒细胞增多与冠状血管痉挛的关联,进一步的长期管理困难,而冠状血管痉挛又可由阿司匹林引起。
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引用次数: 0
Stress cardiomyopathy: Same pathology caused by variety of triggers. 应激性心肌病:由多种诱因引起的相同病理。
Pub Date : 2022-12-01 DOI: 10.58889/pjcvi.3.7.16
A. Ullah, N. Malik, D. Fraser, A. Raza, F. Ordoubadi, M. Omar
Stress cardiomyopathy (SCM), also known as Takatsubo cardiomyopathy or broken heart syndrome has been well documented in literature since its first description. With more awareness of the condition and increasing evidence base, the reported incidence of SCM has steadily increased over years and currently estimated at 1-2 % of the patients presenting with acute coronary syndrome. There are different criteria proposed for diagnosis of stress cardiomyopathy and this address more or less the same clinical questions while diagnosing this not so uncommon condition. Despite extensive research , there has been a lack of understanding on the exact mechanism and causative factors leading to SCM. We report a variety of cases where  a different trigger appears to have been responsible for causation of SCM. It would seem that irrespective of the original trigger, the final clinical picture and course remains identical. These further strengths the idea that the condition is mediated by a common neurocardiovacular pathway in susceptible individuals. Further exploration of these mechanisms would be crucial to improve our strategies to try to prevent and effectively manage this potentially disabling condition.
应激性心肌病(SCM),也被称为Takatsubo心肌病或心碎综合征,自其第一次被描述以来,文献中已经有了很好的记录。随着对该病认识的提高和证据基础的增加,近年来报道的SCM发病率稳步上升,目前估计为急性冠脉综合征患者的1- 2%。有不同的标准提出诊断应激性心肌病和这解决或多或少相同的临床问题,而诊断这并不罕见的条件。尽管进行了广泛的研究,但对SCM的确切机制和致病因素仍缺乏了解。我们报告的各种情况下,一个不同的触发似乎已经负责SCM的因果关系。似乎不管最初的诱因是什么,最终的临床表现和过程都是一样的。这些进一步加强了这种情况是由易感个体的共同神经心血管途径介导的观点。进一步探索这些机制对于改善我们的策略,试图预防和有效地管理这种潜在的致残状况至关重要。
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引用次数: 0
History of PTMC at National Institute of Cardiovascular Diseases Karachi. 卡拉奇国立心血管疾病研究所PTMC的历史。
Pub Date : 2022-12-01 DOI: 10.58889/pjcvi.3.1.6
Khan Shah Zaman
Rheumatic mitral stenosis (MS) incidence and severity rates have decreased in the developed world, but the condition is still very common in many nations. Since its invention, percutaneous mitral balloon valvuloplasty has transformed the therapy of mitral stenosis, shown promising short- and long-term outcomes, and taken the role of surgical mitral commissurotomy as the preferred method of managing rheumatic mitral stenosis in suitable patients. The morphologic characteristics of the valve leaflets and sub valvular structures can be used to predict the possibility of hemodynamic benefit and the danger of complications with balloon valvuloplasty. The results will be less than ideal if the valves are hard, thickened, and extensively calcified. We presented the retrospective data of approximately 500 patients from March 2001 to June 2006 in this paper.
风湿性二尖瓣狭窄(MS)的发病率和严重程度在发达国家已经下降,但在许多国家仍然很常见。自其发明以来,经皮二尖瓣球囊成形术已经改变了二尖瓣狭窄的治疗方法,显示出良好的短期和长期效果,并将手术二尖瓣合并术作为治疗风湿性二尖瓣狭窄的首选方法。瓣叶和瓣下结构的形态学特征可用于预测球囊瓣膜成形术中血流动力学获益的可能性和并发症的危险。如果瓣膜变硬、变厚和广泛钙化,结果将不太理想。本文回顾了2001年3月至2006年6月约500例患者的资料。
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引用次数: 0
STEMI Pakistan; A National Heart Attack Management Program. STEMI巴基斯坦;全国心脏病发作管理计划。
Pub Date : 2022-12-01 DOI: 10.58889/pjcvi.3.17.23
Salman S Nishtar
Coronary artery disease (CAD) accounts for more than two-thirds of these deaths. It is indicated per the latest information that one in four Pakistani adults over 40 has CAD. The stable coronary disease has a relatively low annual mortality, while acute myocardial infarction (MI) carries a high mortality and morbidity. Though recent advancements in coronary interventions have however revolutionized the management of acute myocardial infarction, resulting in a significant reduction of cardiovascular morbidity and mortality in the developed world but  in Pakistan, the majority of ST-elevation myocardial infarction (STEMI) patients still remain sub-optimally managed. Urban areas are relatively better equipped, but this does not necessarily translate into universal access to quality and timely cardiac care. There is not only substantial variation in accessibility and practices amongst cardiac healthcare facilities between rural and urban areas but also amongst major city hospitals.  Such variations clearly indicate an urgent need for a nationwide standardized STEMI management program to ensure that everyone with an acute STEMI will have speedy access to quality and standard acute care without being economically burdened.
冠状动脉疾病(CAD)占这些死亡人数的三分之二以上。根据最新资料显示,四分之一的40岁以上巴基斯坦成年人患有CAD。稳定性冠状动脉疾病的年死亡率相对较低,而急性心肌梗死(MI)的死亡率和发病率较高。尽管最近冠状动脉介入治疗的进展彻底改变了急性心肌梗死的治疗,导致发达国家心血管发病率和死亡率显著降低,但在巴基斯坦,大多数st段抬高型心肌梗死(STEMI)患者仍未得到最佳治疗。城市地区的设备相对较好,但这并不一定意味着普遍获得高质量和及时的心脏护理。不仅农村和城市地区之间心脏保健设施的可及性和做法存在很大差异,而且大城市医院之间也存在很大差异。这些差异清楚地表明,迫切需要一个全国性的标准化STEMI管理计划,以确保每个急性STEMI患者都能迅速获得高质量和标准的急性护理,而不会造成经济负担。
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引用次数: 0
rare case of pericardial tamponade during Transthoracic Echocardiogram. 经胸超声心动图发现心包填塞一例。
Pub Date : 2022-12-01 DOI: 10.58889/pjcvi.3.65.68
A. Ullah, Colin Cunningham
Pericardial effusion is not an uncommon finding in cardiology practice and the clinical picture depends on various factors including size of the effusion, etiology and speed of accumulation. Significant hemodynamic abnormalities, including cardiac arrest, can result from pericardial tamponade. We report a case of pericardial tamponade in a patient precipitated by added pressure from a transthoracic echo probe. Hemodynamic changes occurred unexpectedly during acquisition of subcostal echo images. The patient was promptly resuscitated and urgent pericardiocentesis was performed. Soon after the pericardiocentesis, hemodynamic indicators improved, and the patient achieved a satisfactory clinical recovery.
心包积液在心脏病学实践中并不罕见,其临床表现取决于各种因素,包括积液的大小、病因和积聚速度。心包填塞可导致显著的血流动力学异常,包括心脏骤停。我们报告一个病例心包填塞在一个病人沉淀的压力增加从经胸回声探头。在肋下回波图像采集过程中出现了意想不到的血流动力学变化。患者及时复苏,并进行了紧急心包穿刺。心包穿刺后,血流动力学指标改善,患者临床恢复满意。
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引用次数: 0
Correlation of TIMI score with severity of coronary artery disease in acute coronary syndrome 急性冠状动脉综合征患者TIMI评分与冠状动脉疾病严重程度的相关性
Pub Date : 2022-12-01 DOI: 10.58889/pjcvi.3.52.59
Ahmad Q. Hasan, A. Iqbal, S. Tawab, I. Hussain
Background: ACS presents as wide range of clinical ailments that requires prompt treatment to avoid unforeseen circumstances. As noninvasive strategy, TIMI risk assessment is a widely accepted tool for risk stratification of ACS patient to initiate timely management. Purpose of the present study is to determine the association of TIMI score in predicting the severity of coronary artery disease in ACS. Methodology: A cross-sectional study was conducted in specialized tertiary care cardiac hospital on 255 patients from January 2021 to June 2021. For all patients, TIMI score calculated based on all the seven variables. Confidentiality of the participants was maintained. Ethical approval was obtained from review board of concerned hospital. Data was analyzed on SPSS version 23.0. One way ANOVA was used to compare categorical variables. Chi square test used to reveal difference in proportion to three TIMI groups. Results: Finding show that ST segment deviation was evident in 51.5% patients. Out of 37 patients in group-III with ST segment changes, 91.8% were found of having significant CAD. Results show that in group-III, 54.1% had significant three vessel CAD compared to 17.6% group-II & 7.5% group-I patients. Also, p-value of <0.001 depict significant association between TIMI score and severity of CAD. Conclusion: A significant association from this study gives a notion that TIMI score is valuable tool in clinical setting to make urgent decision regarding the management of CAD. Also, it was concluded from current study that patients with higher TIMI score had additional risk of three vessel CAD and left main vessel CAD in patients with ACS.
背景:ACS表现为广泛的临床疾病,需要及时治疗以避免不可预见的情况。TIMI风险评估作为一种无创策略,已被广泛接受为ACS患者风险分层的工具,以便及时进行管理。本研究的目的是确定TIMI评分与ACS患者冠状动脉疾病严重程度的相关性。方法:于2021年1月至2021年6月在心脏专科三级保健医院对255例患者进行横断面研究。对于所有患者,TIMI评分基于所有7个变量计算。与会者的保密工作得到了维护。已获得相关医院审查委员会的伦理批准。数据分析采用SPSS 23.0版本。单因素方差分析用于比较分类变量。卡方检验用于揭示三个TIMI组的比例差异。结果:51.5%的患者有明显的ST段偏离。在37例ST段改变的iii组患者中,91.8%发现有明显的CAD。结果显示,在iii组中,54.1%的患者有明显的三支血管CAD,而ii组为17.6%,i组为7.5%。此外,p值<0.001描述TIMI评分与CAD严重程度之间的显著关联。结论:本研究的重要关联表明TIMI评分是临床环境中对CAD管理做出紧急决策的有价值的工具。同时,从目前的研究中得出结论,TIMI评分越高的ACS患者发生三支血管CAD和左主血管CAD的风险越高。
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引用次数: 0
期刊
Pakistan Journal of Cardiovascular Intervention
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