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The Protective Role of Hydrogen Sulfide and Its Impact on Gene Expression Profiling in Rat Model of COPD. 硫化氢的保护作用及其对慢性阻塞性肺病大鼠模型基因表达谱的影响
Q4 BUSINESS, FINANCE Pub Date : 2022-03-18 eCollection Date: 2022-01-01 DOI: 10.1155/2022/9407927
Yanjing He, Yun Sun, Chengcheng Liao, Fan Lin, Zhengyuan Xia, Yongfen Qi, Yahong Chen

Chronic obstructive pulmonary disease (COPD) is a leading cause of death worldwide, which is usually caused by exposure to noxious particles or gases. Hydrogen sulfide (H2S), as an endogenous gasotransmitter, is involved in the pathogenesis of COPD, but its role in COPD is little known. To investigate the role of H2S in COPD, a rat model of COPD was established by cigarette smoking (CS) and intratracheal instillation of lipopolysaccharide (LPS). Rats were randomly divided into 4 groups: control, CS + LPS, CS + LPS + sodium hydrosulfide (NaHS, H2S donor), and CS + LPS + propargylglycine (PPG, inhibitor of cystathionine-γ-lyase, and CTH). Lung function in vivo, histology analysis of lung sections, malondialdehyde (MDA) concentration, CTH protein, total superoxide dismutase (T-SOD), and catalase (CAT) activity in lung tissues were assessed. Gene expression profiling of lung was assessed by microarray analysis. The results showed that rats in the CS + LPS group had lower body weight and lung function but higher lung pathological scores, MDA concentration, CTH protein, T-SOD, and CAT activity compared with the control. Compared with CS + LPS group, NaHS treatment decreased lung pathological scores and MDA concentration, while PPG treatment decreased body weight of rats and T-SOD activity, and no significant differences were detected in pathological scores by PPG treatment. Microarray analysis identified multiple differentially expressed genes, and some genes regulated by H2S were involved in oxidative stress, apoptosis, and inflammation pathways. It indicates that H2S may play a protective role in COPD via antioxidative stress and antiapoptosis pathway.

慢性阻塞性肺病(COPD)是全球死亡的主要原因之一,通常是由于暴露于有害颗粒或气体而引起的。硫化氢(H2S)作为一种内源性气体递质,参与了慢性阻塞性肺病的发病机制,但其在慢性阻塞性肺病中的作用却鲜为人知。为了研究 H2S 在慢性阻塞性肺病中的作用,研究人员通过吸烟(CS)和气管内灌注脂多糖(LPS)建立了慢性阻塞性肺病大鼠模型。大鼠被随机分为 4 组:对照组、CS + LPS 组、CS + LPS + 硫氢化钠组(NaHS,H2S 供体)和 CS + LPS + 丙炔甘氨酸组(PPG,胱硫醚-γ-赖氨酸酶和 CTH 的抑制剂)。评估了体内肺功能、肺切片组织学分析、肺组织中丙二醛(MDA)浓度、CTH 蛋白、总超氧化物歧化酶(T-SOD)和过氧化氢酶(CAT)活性。通过芯片分析评估了肺部基因表达谱。结果显示,与对照组相比,CS + LPS 组大鼠的体重和肺功能较低,但肺病理评分、MDA 浓度、CTH 蛋白、T-SOD 和 CAT 活性较高。与 CS + LPS 组相比,NaHS 处理降低了肺病理评分和 MDA 浓度,而 PPG 处理降低了大鼠体重和 T-SOD 活性,PPG 处理在病理评分方面未发现显著差异。微阵列分析发现了多个差异表达基因,其中一些受 H2S 调控的基因涉及氧化应激、细胞凋亡和炎症通路。这表明 H2S 可通过抗氧化应激和抗细胞凋亡途径对慢性阻塞性肺病起到保护作用。
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引用次数: 0
On the impact of outliers in loss reserving 论异常值对损失准备金的影响
IF 1.2 Q4 BUSINESS, FINANCE Pub Date : 2022-03-01 DOI: 10.1007/s13385-023-00356-2
Benjamin Avanzi, Mark Lavender, G. Taylor, Bernard Wong
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引用次数: 2
Derivation of biometrically dependent cash flows 生物计量依赖现金流的推导
IF 1.2 Q4 BUSINESS, FINANCE Pub Date : 2022-02-18 DOI: 10.1007/s13385-021-00303-z
M. Schmitt
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引用次数: 0
Premium rating without losses 无损失保费
IF 1.2 Q4 BUSINESS, FINANCE Pub Date : 2022-01-24 DOI: 10.1007/s13385-021-00302-0
Michael Fackler

In insurance and even more in reinsurance it occurs that about a risk you only know that it has suffered no losses in the past, e.g. seven years. Some of these risks are furthermore such particular or novel that there are no similar risks to infer the loss frequency from. In this paper we propose a loss frequency estimator that copes with such situations, by just relying on the information coming from the risk itself: the “amended sample mean”. It is derived from a number of practice-oriented first principles and turns out to have desirable statistical properties. Some variants are possible, enabling insurers to align the method to their preferred business strategy, by trading off between low initial premiums for new business and moderate premium increases after a loss for renewal business. We further give examples where it is possible to assess the average loss from some market or portfolio information, such that overall one has an estimator of the risk premium.

在保险行业,尤其是再保险行业,你只知道一种风险在过去的七年里没有遭受损失。此外,其中一些风险是如此特殊或新颖,以至于没有类似的风险来推断损失频率。在本文中,我们提出了一种损失频率估计器来处理这种情况,它只依赖于来自风险本身的信息:“修正样本均值”。它来源于许多面向实践的第一原则,并被证明具有理想的统计特性。有些变体是可能的,通过在新业务的低初始保费和续订业务损失后的适度保费增长之间进行权衡,使保险公司能够使方法与他们首选的业务策略保持一致。我们进一步给出了一些例子,在这些例子中,可以从一些市场或投资组合信息中评估平均损失,这样总体上就有了风险溢价的估计值。
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引用次数: 1
Efficient evaluation of alternative reinsurance strategies using control variates 利用控制变量对可选再保险策略进行有效评估
IF 1.2 Q4 BUSINESS, FINANCE Pub Date : 2022-01-20 DOI: 10.1007/s13385-022-00304-6
Ioannis Kyriakou, Andreas Tsanakas

In this short communication, we present a new, simple control-variate Monte Carlo procedure for enhancing the evaluation accuracy of alternative reinsurance strategies that an insurance company might adopt.

在这篇简短的文章中,我们提出了一种新的、简单的控制变量蒙特卡罗程序,用于提高保险公司可能采用的替代再保险策略的评估准确性。
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引用次数: 0
Extremes for a general contagion risk measure 一般传染风险度量的极值
IF 1.2 Q4 BUSINESS, FINANCE Pub Date : 2022-01-10 DOI: 10.1007/s13385-021-00301-1
C. Ling, Jiajun Liu
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引用次数: 0
Pricing participating longevity-linked life annuities: a Bayesian Model Ensemble approach. 定价参与寿命挂钩人寿年金:贝叶斯模型集成方法。
IF 1.2 Q4 BUSINESS, FINANCE Pub Date : 2022-01-01 Epub Date: 2021-05-13 DOI: 10.1007/s13385-021-00279-w
Jorge Miguel Bravo

Participating longevity-linked life annuities (PLLA) in which benefits are updated periodically based on the observed survival experience of a given underlying population and the performance of the investment portfolio are an alternative insurance product offering consumers individual longevity risk protection and the chance to profit from the upside potential of financial market developments. This paper builds on previous research on the design and pricing of PLLAs by considering a Bayesian Model Ensemble of single population generalised age-period-cohort stochastic mortality models in which individual forecasts are weighted by their posterior model probabilities. For the valuation, we adopt a longevity option decomposition approach with risk-neutral simulation and investigate the sensitivity of results to changes in the asset allocation by considering a more aggressive lifecycle strategy. We calibrate models using Taiwanese (mortality, yield curve and stock market) data from 1980 to 2019. The empirical results provide significant valuation and policy insights for the provision of a cost effective and efficient risk pooling mechanism that addresses the individual uncertainty of death, while providing appropriate retirement income and longevity protection.

参与式长寿相连人寿年金(PLLA)是一种另类保险产品,根据观察到的特定潜在人群的生存经验和投资组合的表现定期更新收益,为消费者提供个人长寿风险保障,并有机会从金融市场发展的上升潜力中获利。本文在前人对plas的设计和定价研究的基础上,考虑了单个人口广义年龄-时期-队列随机死亡率模型的贝叶斯模型集合,其中个体预测由其后验模型概率加权。对于估值,我们采用风险中性模拟的长寿期权分解方法,并通过考虑更积极的生命周期策略来研究结果对资产配置变化的敏感性。我们使用台湾1980年至2019年的数据(死亡率、收益率曲线和股票市场)校准模型。实证结果为提供具有成本效益和高效率的风险分担机制提供了重要的评估和政策见解,该机制可以解决个人死亡的不确定性,同时提供适当的退休收入和长寿保护。
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引用次数: 18
The only constant is change: opportunities and challenges for actuaries in a changing world. 唯一不变的是变化:在不断变化的世界中,精算师面临的机遇和挑战。
IF 1.2 Q4 BUSINESS, FINANCE Pub Date : 2022-01-01 Epub Date: 2022-10-10 DOI: 10.1007/s13385-022-00331-3
Frank Schiller, Jérôme Crugnola-Humbert

In a world threatened by climate warming and where Environmental, Social and Governance (ESG) issues are gaining increasing prominence, actuaries and other finance professionals need to adapt and support the transition to a more sustainable economy. This article examines how they can contribute to protect financial stability through forward-looking risk management, how they can help the insurance sector play an important role to support climate and environmental sustainability, and how climate protection gaps should be monitored and addressed.

在一个受到气候变暖威胁的世界,环境、社会和治理(ESG)问题日益突出,精算师和其他金融专业人士需要适应并支持向更可持续的经济转型。本文探讨了它们如何通过前瞻性风险管理为保护金融稳定做出贡献,它们如何帮助保险业在支持气候和环境可持续性方面发挥重要作用,以及如何监测和解决气候保护缺口。
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引用次数: 1
Best upper and lower bounds on Spearman’s rho for zero-inflated continuous variables and their application to insurance 零膨胀连续变量Spearmanρ的最佳上下限及其在保险中的应用
IF 1.2 Q4 BUSINESS, FINANCE Pub Date : 2021-11-10 DOI: 10.1007/s13385-021-00296-9
M. Mesfioui, J. Trufin
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引用次数: 1
The effect of risk constraints on the optimal insurance policy 风险约束对最优保险政策的影响
IF 1.2 Q4 BUSINESS, FINANCE Pub Date : 2021-11-02 DOI: 10.1007/s13385-021-00300-2
Wenjun Jiang, Jiandong Ren
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引用次数: 1
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