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Ketamine–Dexmedetomidine sedation for pediatric difficult airway management: A case series from a Portuguese tertiary hospital 氯胺酮-右美托咪定镇静治疗小儿气道困难:来自葡萄牙三级医院的病例系列
IF 0.7 Q3 ANESTHESIOLOGY Pub Date : 2025-10-09 DOI: 10.1016/j.tacc.2025.101595
José Moreira , Cátia Martins , Rita Castro Fernandes , Patrícia Santos

Background

Airway management in pediatric patients with anticipated difficult airways (DA) remains challenging. The ketamine–dexmedetomidine combination offers a promising strategy, providing reliable sedation while maintaining respiratory function.

Methods

We retrospectively reviewed pediatric patients with anticipated DA managed at a Portuguese tertiary hospital (January 2023–January 2025). Sedation followed a standardized ketamine–dexmedetomidine protocol with incremental intravenous boluses. Sedation quality was assessed with the University of Michigan Sedation Scale (UMSS), electroencephalographic (EEG) patterns, and a cough index. Primary outcomes were adequate sedation (UMSS >2) and optimal intubation conditions (cough ≤2). Secondary outcomes included respiratory or hemodynamic adverse events.

Results

Ten pediatric patients (median age 1.0y; IQR 0.8–4.0) were included. 90 % of patients achieved adequate sedation. No patient had a cough score >2 during intubation. One brief desaturation (<10 s) and one bradycardia, unrelated to hypoxemia, occurred; no laryngospasm, bronchospasm, or sedation failure occurred.

Conclusion

Unlike previous case reports, this series demonstrates reproducible use of a standardized ketamine–dexmedetomidine protocol across a range of pediatric DA scenarios. By combining clinical scales, EEG monitoring, and airway reactivity metrics, our findings suggest that ketamine–dexmedetomidine may represent a feasible and potentially safe sedation strategy for this high-risk population.
背景:预期气道困难(DA)的儿科患者的气道管理仍然具有挑战性。氯胺酮-右美托咪定联合使用提供了一种很有前景的策略,在维持呼吸功能的同时提供可靠的镇静。方法回顾性分析了葡萄牙一家三级医院(2023年1月至2025年1月)预期DA的儿科患者。镇静遵循标准氯胺酮-右美托咪定方案,并增加静脉注射。采用密歇根大学镇静量表(UMSS)、脑电图(EEG)模式和咳嗽指数评估镇静质量。主要结局是足够的镇静(UMSS >2)和最佳插管条件(咳嗽≤2)。次要结局包括呼吸或血流动力学不良事件。结果纳入10例儿童患者,中位年龄1.0岁,IQR 0.8 ~ 4.0。90%的患者获得了足够的镇静。插管期间无患者咳嗽评分为2分。发生一次短暂的去饱和(10秒)和一次心动过缓,与低氧血症无关;未发生喉痉挛、支气管痉挛或镇静失败。与以往的病例报告不同,本系列研究证明了标准化氯胺酮-右美托咪定方案在一系列儿童DA方案中的可重复性使用。通过结合临床量表、脑电图监测和气道反应性指标,我们的研究结果表明,氯胺酮-右美托咪定可能是一种可行且潜在安全的高危人群镇静策略。
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引用次数: 0
Impact of different tube angles on intubation outcomes with C-MACR D-blade videolaryngoscope: A prospective randomized study 不同管角对C-MACR - d刀片视频喉镜插管结果的影响:一项前瞻性随机研究
IF 0.7 Q3 ANESTHESIOLOGY Pub Date : 2025-10-04 DOI: 10.1016/j.tacc.2025.101594
Alkim Gi̇zem Yılmaz Seli̇moğlu , Ezgi̇ Aytaç , Hati̇ce Türe , Ferdi̇ Menda

Background

The C-MACR D-blade videolaryngoscope provides better visualization of vocal cords via the blade angle, however, stylet is required. This study compares postoperative sore throat (POST), hoarseness, intubation period and ease, subglottic damage (SGD), and hemodynamic changes to orotracheal intubation using different angled (60°-80°-90°) endotracheal tubes (ETT) with C-MACR D-blade videolaryngoscope.

Methods

After Ethics Committee approval and consents taken, study was conducted in Yeditepe University Medical Faculty between June and December 2022. This prospective study involved 162 patients; who were planned to undergo general anesthesia with ASA score I-II (18–65years), randomized into three groups with closed envelope technique. In Group A ETT is bent into 90°, Group B 80° and Group C 60° using stylets. C-MACR D-blade videolaryngoscope was used. Hemodynamic data, intubation period and ease were recorded. SGD was examined with fiberoptic bronchoscope. Patients were evaluated regarding POST and hoarseness at 30 min, 4, 12, and 24 h postoperatively.

Results

Study showed intubation period was longest in Group A and shortest in Group C (p < 0.001). Group B had more POST incidence at 30 min (p = 0.040) and had the highest POST incidence in total 24 h (p = 0.040). There were no difference regarding SGD (p = 0.300) and hoarseness (30th minute p:0.610, 4th hour p:0.350, 12th hour p:0.130 and 24th hour p:0.130). In Group C intubations were easiest according to modified intubation difficulty scale (p = 0,020) however, hemodynamic response was highest (p < 0.001).

Conclusion

We recommend using 60° angled ETTs in rapid sequence intubations. However, we do not recommend it in the population with low tolerance for hemodynamic instability.

Clinical trials registration number

NCT06011967.
C-MACR - d刀片式视频喉镜可通过刀片角度更好地显示声带,但需要有导管。本研究比较不同角度(60°-80°-90°)气管内管(ETT)在C-MACR - d叶片视频喉镜下气管插管的术后喉咙痛(POST)、沙哑、插管时间和缓解程度、声门下损伤(SGD)和血流动力学变化。方法经伦理委员会批准和同意,研究于2022年6月至12月在Yeditepe大学医学院进行。这项前瞻性研究涉及162名患者;ASA评分为I-II级,年龄18 - 65岁,随机分为三组,采用封闭包膜技术。A组ETT弯曲成90°,B组弯曲成80°,C组弯曲成60°。采用C-MACR - d刀片式视频喉镜。记录血流动力学数据、插管时间及缓解程度。纤维支气管镜检查SGD。分别于术后30分钟、4小时、12小时和24小时对患者进行POST和沙哑评估。结果A组插管时间最长,C组插管时间最短(p < 0.001)。B组30 min POST发生率最高(p = 0.040), 24 h POST发生率最高(p = 0.040)。SGD (p = 0.300)和沙哑(第30分钟p:0.610,第4小时p:0.350,第12小时p:0.130,第24小时p:0.130)无差异。根据修改后的插管难度量表,C组插管最容易(p = 0.020),但血流动力学反应最高(p < 0.001)。结论:我们推荐在快速插管中使用60°夹角的气管导管。然而,我们不推荐对血流动力学不稳定耐受性低的人群使用。临床试验注册号bernct06011967。
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引用次数: 0
The long-term influence of green nudges on the consumption of desflurane and on the carbon footprint of general anaesthesia: A retrospective study 绿色轻推对地氟醚消费和全身麻醉碳足迹的长期影响:一项回顾性研究
IF 0.7 Q3 ANESTHESIOLOGY Pub Date : 2025-10-01 DOI: 10.1016/j.tacc.2025.101592
Leonard Santen , Florian Windler , Mark Coburn , Birgit Bette , Se-Chan Kim , Christian Bode , Philippe Kruse

Introduction

The medical sector is responsible for a significant share of greenhouse gas emissions. It is imperative that a transition towards ecological sustainability takes place. Nevertheless, initiatives for healthcare providers to reduce emissions remain limited in clinical practice, and climate-damaging behaviour persists. A salient example is the regular use of desflurane in anaesthesia. In order to promote sustainable clinical practice, the implementation of behavioural decision support mechanisms, so called nudges, could be a promising approach.

Methods

A retrospective study was conducted to analyse the effectiveness of nudges to reduce the consumption of desflurane. The nudges comprised structural modifications to the workplace, with desflurane vaporisers being replaced with those for sevoflurane and isoflurane. The effectiveness of the nudges was evaluated by analysis of the desflurane's order volume. In addition, the emissions of greenhouse gases were normalised to the number of surgical procedures performed. Finally, the economic benefit of reduced desflurane consumption was investigated based on the purchase price.

Results

Following the implementation, desflurane was no longer utilised in the long term. Overall, these nudges resulted in a 91 % reduction in emissions of volatile anaesthetics per quarter, equivalent to 219 t CO2e. Consequently, the average greenhouse gas emissions per surgical procedure were reduced by 42.2 kg CO2e. Furthermore, the costs for volatile anaesthetics decreased by 63.9 %, amounting to a reduction of €18,237.28.

Discussion

The implementation of nudges has been demonstrated to lead to a cessation of desflurane consumption, thereby supporting the green transformation of the healthcare sector. In the future, green nudges favouring sustainable clinical practice are poised to assume greater significance as a cost-effective and readily implementable sustainability measure.
医疗部门对温室气体排放的很大一部分负有责任。向生态可持续性的过渡势在必行。然而,在临床实践中,医疗保健提供者减少排放的举措仍然有限,破坏气候的行为仍然存在。一个突出的例子是在麻醉中经常使用地氟醚。为了促进可持续的临床实践,实施行为决策支持机制,即所谓的“轻推”,可能是一种很有前途的方法。方法回顾性分析轻推减少地氟醚用量的效果。这些改进包括对工作场所的结构修改,将地氟烷蒸发器替换为七氟烷和异氟烷蒸发器。通过对地氟醚订单量的分析来评价微推的有效性。此外,温室气体的排放量与外科手术次数归一化。最后,根据收购价格,对降低地氟醚用量的经济效益进行了研究。结果实施后,地氟醚不再长期使用。总体而言,这些措施导致每季度挥发性麻醉剂的排放量减少91%,相当于219吨二氧化碳当量。因此,每次手术的平均温室气体排放量减少了42.2公斤二氧化碳当量。此外,挥发性麻醉剂的费用下降了63.9%,减少了18,237.28欧元。已经证明,实施轻推可以停止地氟醚的消费,从而支持医疗保健部门的绿色转型。在未来,绿色推动有利于可持续临床实践准备承担更大的意义,作为一个具有成本效益和易于实施的可持续发展措施。
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引用次数: 0
Reflection on “Recto-intercostal fascial plane block: A scoping review” 关于“直肠-肋间筋膜面阻滞:范围回顾”的思考
IF 0.7 Q3 ANESTHESIOLOGY Pub Date : 2025-10-01 DOI: 10.1016/j.tacc.2025.101593
Tuhin Mistry , Abhijit Sukumaran Nair
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引用次数: 0
Comparison of the efficiency of high flow nasal cannula oxygen and conventional nasal cannula oxygen in pediatric patients under sedation for gastrointestinal endoscopy: A prospective observational study 高流量鼻插管供氧与常规鼻插管供氧在镇静患儿胃肠内镜检查中的效果比较:一项前瞻性观察研究
IF 0.7 Q3 ANESTHESIOLOGY Pub Date : 2025-09-19 DOI: 10.1016/j.tacc.2025.101591
Sami Olcay Ozbay , Mehmet Yilmaz , Merve Yazici Kara , Ayse Zeynep Turan Civraz , Nurseda Dundar , Ayten Saracoglu , Kemal Tolga Saracoglu

Background

Oxygenation during upper gastrointestinal (GI) endoscopy in pediatric patients is essential to prevent hypoxia and complications. High-flow nasal cannula oxygenation (HFNO) effectively improves oxygenation compared to conventional nasal cannula oxygenation (NCO). This study compares the efficacy of HFNO and NCO in minimizing hypoxia during sedation.

Methods

This prospective observational study included 82 pediatric patients aged 4–18 years with ASA scores I or II, all undergoing upper GI endoscopy under sedation. Patients received either HFNO or NCO, maintaining SpO2 above 93 %. The primary outcome was hypoxia incidence, while secondary outcomes included hypoxia duration, minimum SpO2 levels, and recovery measures. Statistical significance was set at p < 0.05.

Results

Hypoxia occurred significantly less in the HFNO group (4.9 %) than in the NCO group (22.0 %, p = 0.023). HFNO also led to shorter hypoxia duration and higher minimum SpO2 values (88.5 % vs. 68.4 %, p = 0.034). There were no significant differences in procedure or recovery times, or vomiting rates. The HFNO group maintained better hemodynamic stability, including mean arterial pressure and respiratory rate.

Conclusion

HFNO proved more effective in reducing hypoxia incidence and duration compared to NCO in pediatric patients undergoing upper GI endoscopy. It also enhanced respiratory and hemodynamic stability, indicating its promise as a safer oxygenation method in practice.
背景:儿科患者上消化道内镜检查时的氧合对防止缺氧和并发症至关重要。高流量鼻插管氧合(HFNO)与常规鼻插管氧合(NCO)相比,能有效改善氧合。本研究比较HFNO和NCO在减少镇静过程中缺氧的效果。方法本前瞻性观察研究纳入82例4-18岁ASA评分为I或II的儿科患者,均在镇静状态下接受上消化道内镜检查。患者接受HFNO或NCO治疗,SpO2均维持在93%以上。主要终点是缺氧发生率,次要终点包括缺氧持续时间、最低SpO2水平和恢复措施。p <; 0.05为统计学意义。结果HFNO组缺氧发生率(4.9%)明显低于NCO组(22.0%,p = 0.023)。高氧缺氧也导致缺氧持续时间缩短和最低SpO2值升高(88.5%比68.4%,p = 0.034)。在手术过程、恢复时间或呕吐率方面没有显著差异。HFNO组血流动力学稳定性较好,包括平均动脉压和呼吸频率。结论hfno比NCO更能有效降低上消化道内镜患儿缺氧发生率和持续时间。它还增强了呼吸和血流动力学的稳定性,表明它在实践中是一种更安全的氧合方法。
{"title":"Comparison of the efficiency of high flow nasal cannula oxygen and conventional nasal cannula oxygen in pediatric patients under sedation for gastrointestinal endoscopy: A prospective observational study","authors":"Sami Olcay Ozbay ,&nbsp;Mehmet Yilmaz ,&nbsp;Merve Yazici Kara ,&nbsp;Ayse Zeynep Turan Civraz ,&nbsp;Nurseda Dundar ,&nbsp;Ayten Saracoglu ,&nbsp;Kemal Tolga Saracoglu","doi":"10.1016/j.tacc.2025.101591","DOIUrl":"10.1016/j.tacc.2025.101591","url":null,"abstract":"<div><h3>Background</h3><div>Oxygenation during upper gastrointestinal (GI) endoscopy in pediatric patients is essential to prevent hypoxia and complications. High-flow nasal cannula oxygenation (HFNO) effectively improves oxygenation compared to conventional nasal cannula oxygenation (NCO). This study compares the efficacy of HFNO and NCO in minimizing hypoxia during sedation.</div></div><div><h3>Methods</h3><div>This prospective observational study included 82 pediatric patients aged 4–18 years with ASA scores I or II, all undergoing upper GI endoscopy under sedation. Patients received either HFNO or NCO, maintaining SpO2 above 93 %. The primary outcome was hypoxia incidence, while secondary outcomes included hypoxia duration, minimum SpO2 levels, and recovery measures. Statistical significance was set at p &lt; 0.05.</div></div><div><h3>Results</h3><div>Hypoxia occurred significantly less in the HFNO group (4.9 %) than in the NCO group (22.0 %, p = 0.023). HFNO also led to shorter hypoxia duration and higher minimum SpO2 values (88.5 % vs. 68.4 %, p = 0.034). There were no significant differences in procedure or recovery times, or vomiting rates. The HFNO group maintained better hemodynamic stability, including mean arterial pressure and respiratory rate.</div></div><div><h3>Conclusion</h3><div>HFNO proved more effective in reducing hypoxia incidence and duration compared to NCO in pediatric patients undergoing upper GI endoscopy. It also enhanced respiratory and hemodynamic stability, indicating its promise as a safer oxygenation method in practice.</div></div>","PeriodicalId":44534,"journal":{"name":"Trends in Anaesthesia and Critical Care","volume":"64 ","pages":"Article 101591"},"PeriodicalIF":0.7,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145118516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recto-intercostal fascial plane block: A scoping review 直肠-肋间筋膜平面阻滞:范围回顾
IF 0.7 Q3 ANESTHESIOLOGY Pub Date : 2025-08-29 DOI: 10.1016/j.tacc.2025.101590
Prashant Sirohiya , Ram Singh , Brajesh Kumar Ratre , Balbir Kumar
<div><h3>Background</h3><div>The recto-intercostal fascial plane block (RIFPB) is a novel ultrasound-guided regional anesthesia technique intended to provide analgesia for the anterior thoracoabdominal wall, particularly the subxiphoid and epigastric regions. Unlike established modalities such as thoracic epidural, transversus abdominis plane (TAP) block, or parasternal intercostal plane block (PIPB)—which are limited by side-effect profiles or incomplete cranial/epigastric spread—RIFPB seeks to target intercostal nerves in a safe and relatively avascular plane. Early case reports suggest potential benefits in patients undergoing sternotomy or upper abdominal surgery, but the evidence base remains preliminary.</div></div><div><h3>Objectives</h3><div>This scoping review aimed to systematically map and synthesize the current evidence on RIFPB, focusing on its anatomical basis, technical feasibility, clinical applications, dermatomal coverage, and safety considerations.</div></div><div><h3>Eligibility criteria</h3><div>Eligible sources included cadaveric studies, letters, case reports, case series, abstracts, and conceptual reports describing the anatomical spread, technique, or clinical utility of RIFPB. Only studies published in English were considered. Randomized controlled trials were not identified.</div></div><div><h3>Sources of evidence</h3><div>A comprehensive search was conducted across PubMed, Embase, Scopus, Cochrane Library, and Google Scholar from database inception to June 2025. Grey literature, including professional society proceedings (ASRA, ESRA) and preprint servers (medRxiv, Research Square), was also screened.</div></div><div><h3>Charting methods</h3><div>Records were imported into EndNote, then transferred to Rayyan.ai for screening. Duplicates were removed manually. Title/abstract and full-text screening were independently performed by two reviewers, with discrepancies resolved by consensus or a third reviewer. A standardized data extraction form (Microsoft Excel) was used to capture study characteristics, technique details, dermatomal coverage, and outcomes.</div></div><div><h3>Results</h3><div>Ten publications were included: six case reports/letters, one cadaveric study, one conceptual description, one case series, and one conference abstract. Most clinical reports described use in cardiac surgery, typically in combination with a PIPB for sternotomy analgesia. Two reports involved upper abdominal surgery. The cadaveric study demonstrated consistent dye spread between T6–T9, supporting the anatomical rationale for epigastric analgesia. Clinical studies variably reported sensory involvement from T5–T11, although testing methods were inconsistent. No randomized controlled trials were identified. Across available evidence, RIFPB was consistently described as technically feasible, safe, and free from major complications, including in pediatric patients.</div></div><div><h3>Conclusions</h3><div>RIFPB appears to be a feasible, anat
背景直肠-肋间筋膜平面阻滞(RIFPB)是一种新型超声引导区域麻醉技术,旨在为前胸腹壁,特别是剑突下和上腹部区域提供镇痛。与诸如胸椎硬膜外阻滞、经腹阻滞或胸骨旁肋间阻滞(PIPB)等已建立的模式不同,这些模式受副作用或颅/腹壁不完全扩张的限制,rifpb寻求在一个安全和相对无血管的平面上靶向肋间神经。早期病例报告表明,接受胸骨切开术或上腹部手术的患者可能受益,但证据基础仍处于初步阶段。本综述旨在系统地绘制和综合目前关于RIFPB的证据,重点关注其解剖学基础、技术可行性、临床应用、皮肤覆盖范围和安全性考虑。合格来源包括尸体研究、信件、病例报告、病例系列、摘要和描述RIFPB解剖分布、技术或临床应用的概念性报告。只考虑了用英语发表的研究。没有确定随机对照试验。证据来源从数据库建立到2025年6月,对PubMed、Embase、Scopus、Cochrane Library和b谷歌Scholar进行了全面检索。灰色文献,包括专业学会会刊(ASRA, ESRA)和预印本服务器(medRxiv, Research Square)也被筛选。绘制图表的方法记录被导入到EndNote,然后转移到Rayyan。我要筛选。已手动删除重复项。标题/摘要和全文筛选由两位审稿人独立完成,差异由共识或第三方审稿人解决。使用标准化数据提取表(Microsoft Excel)捕获研究特征、技术细节、皮肤覆盖和结果。结果共收录文献6篇:病例报告/信函1篇,尸体研究1篇,概念描述1篇,病例系列1篇,会议摘要1篇。大多数临床报告描述了在心脏手术中使用,通常与PIPB联合用于胸骨切开镇痛。两份报告涉及上腹部手术。尸体研究表明T6-T9之间的染色分布一致,支持上腹部镇痛的解剖学原理。尽管测试方法不一致,但临床研究报告T5-T11的感觉受累情况不一。未发现随机对照试验。在现有的证据中,RIFPB一直被描述为技术上可行、安全、无主要并发症,包括在儿科患者中。结论rifpb似乎是一种可行的、解剖学上合理的、潜在的有价值的前胸腹壁阻滞的辅助手段。其提供上腹部镇痛的能力使其成为PIPB和TAP阻滞的补充,特别是在心脏和上腹部手术中。然而,目前的证据仅限于初步的基于病例的报告,没有标准化的结果测量或比较数据。未来的研究应侧重于前瞻性、随机试验,包括经过验证的疼痛评分、阿片类药物消耗指标和安全终点,以确定疗效和普遍性。在此之前,RIFPB应被视为一种实验性但有前途的技术,而不是替代现有模式。
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引用次数: 0
Methodological considerations regarding “A novel negative pressure isolation device reduces aerosol exposure: A randomized controlled trial” 关于“一种新型负压隔离装置减少气溶胶暴露:一项随机对照试验”的方法学考虑
IF 0.7 Q3 ANESTHESIOLOGY Pub Date : 2025-08-23 DOI: 10.1016/j.tacc.2025.101589
Musawer Khan, Nauman Khan, Asif Ullah Khan, Javed Iqbal, Brijesh Sathian
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引用次数: 0
Comparative effects of dexmedetomidine versus labetalol on hemodynamic stress response to laryngoscopy and tracheal intubation: A systematic review and meta-analysis of randomized controlled trials 右美托咪定与拉贝他洛尔对喉镜和气管插管后血流动力学应激反应的比较作用:随机对照试验的系统回顾和荟萃分析
IF 0.7 Q3 ANESTHESIOLOGY Pub Date : 2025-08-20 DOI: 10.1016/j.tacc.2025.101588
Milton Morais Correia Neto , Mauricio Cardoso Paz , Ana Carolina Oliveira Crisóstomo , Isabella Soares Marques Rabelo , Beatriz Guimarães Amorim Luna , Priscila Ferreira de Lima e Souza

Background

Laryngoscopy and tracheal intubation provoke a sympathetic surge, leading to transient elevations in heart rate, systolic blood pressure, diastolic blood pressure, and mean arterial pressure, potentially increasing perioperative cardiovascular risk. Dexmedetomidine and labetalol are both used to attenuate this response, but their comparative efficacy remains unclear. This study aimed to synthesize current evidence comparing their effects on peri-intubation hemodynamic responses.

Methods

We conducted a systematic review and meta-analysis following PRISMA 2020 guidelines. PubMed, Embase, Scopus, Web of Science, Cochrane, and Google Scholar were searched for randomized controlled trials comparing dexmedetomidine with labetalol. Primary outcomes were heart rate and systolic blood pressure; secondary outcomes included diastolic blood pressure and mean arterial pressure. Data were analyzed using random-effects models. Risk of bias was assessed using the RoB 2 tool, and certainty of evidence was evaluated with the GRADE framework.

Results

Eight randomized trials involving 514 patients were included. Dexmedetomidine significantly reduced systolic blood pressure at 3, 5, and 10 min post-intubation (mean difference −7.46 to −8.62 mmHg) compared to labetalol; the difference at 1 min (−3.96 mmHg) was not statistically significant. Heart rate was significantly reduced at all timepoints (mean difference −10.59 to −14.05 bpm). Reductions in diastolic blood pressure and mean arterial pressure were also consistent and statistically significant. Adverse events were infrequently reported. Two studies documented bradycardia and hypotension, with slightly higher rates in the dexmedetomidine group in one study and in the labetalol group in another. The remaining studies reported no adverse events, though definitions varied substantially.

Conclusions

Dexmedetomidine was associated with greater attenuation of the hemodynamic response to intubation compared to labetalol. However, the certainty of evidence ranged from low to moderate and safety data were limited. Further high-quality trials are warranted to refine dosing strategies and assess applicability in broader patient populations.

Trial registration

The protocol for this meta-analysis has been registered in PROSPERO (CRD420251007007).
背景:喉镜检查和气管插管引起交感神经激增,导致心率、收缩压、舒张压和平均动脉压的短暂升高,潜在地增加围手术期心血管风险。右美托咪定和拉贝他洛尔都用于减轻这种反应,但它们的相对疗效尚不清楚。本研究旨在综合目前的证据,比较它们对围插管期血流动力学反应的影响。方法:我们按照PRISMA 2020指南进行了系统评价和荟萃分析。检索PubMed、Embase、Scopus、Web of Science、Cochrane和谷歌Scholar,比较右美托咪定和拉贝他洛尔的随机对照试验。主要结局是心率和收缩压;次要结局包括舒张压和平均动脉压。数据分析采用随机效应模型。使用RoB 2工具评估偏倚风险,使用GRADE框架评估证据的确定性。结果纳入8项随机试验,共514例患者。与拉贝他洛尔相比,右美托咪定在插管后3、5和10分钟显著降低收缩压(平均差值为- 7.46至- 8.62 mmHg);1 min时(−3.96 mmHg)差异无统计学意义。心率在所有时间点均显著降低(平均差值为- 10.59至- 14.05 bpm)。舒张压和平均动脉压的降低也一致且具有统计学意义。不良事件很少报道。两项研究记录了心动过缓和低血压,其中一项研究右美托咪定组和另一项研究拉贝他洛尔组的发生率略高。其余的研究没有报告不良事件,尽管定义差异很大。结论与拉贝他洛尔相比,右美托咪定对插管血流动力学反应的衰减更大。然而,证据的确定性从低到中等,安全性数据有限。需要进一步的高质量试验来完善给药策略并评估在更广泛患者群体中的适用性。试验注册本荟萃分析的方案已在PROSPERO注册(CRD420251007007)。
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引用次数: 0
The modified renal angina index and renal outcomes in critically ill patients: a prospective cohort study 危重病人改良的肾性心绞痛指数和肾脏预后:一项前瞻性队列研究
IF 0.7 Q3 ANESTHESIOLOGY Pub Date : 2025-08-19 DOI: 10.1016/j.tacc.2025.101587
Mohamed Anas P. , Vishal Shanbhag , Attur Ravindra Prabhu , Shankar Prasad Nagaraju , Dharshan Rangaswamy , Srinivas Vinayak Shenoy , Mohan Varadarayanahalli Bhojaraja , Indu Ramachandra Rao

Introduction

Existing risk prediction tools for acute kidney injury (AKI) have focused on the prediction of AKI occurrence, but few have addressed clinically meaningful outcomes such as the need for dialysis, mortality and kidney recovery. We sought to study the performance of the modified renal angina index (mRAI) for prediction of major adverse kidney events 30 (MAKE30).

Methodology

This prospective single-centre observational study was conducted in the medical ICUs of a tertiary care hospital in India from March 2023 to July 2024. We included consecutive adult ICU patients with hospital stays ≥48 h, excluding those with end-stage kidney disease, prior kidney transplantation, or needing dialysis at admission. The mRAI was calculated 24 h after ICU admission based on condition scores and changes in serum creatinine, as described by Matsuura et al. The primary outcome was MAKE30, a composite of in-hospital mortality, new renal replacement therapy (RRT) initiation, or persistent renal dysfunction by discharge or day 30. The area under the receiver operating curve (AUROC) was used to assess the performance of the mRAI for MAKE30 prediction and compared with other scores.

Results

Among 750 eligible patients, 326 (43.4 %) experienced MAKE30. The mRAI had an AUROC of 0.75 (95 % CI: 0.70–0.78) for MAKE30 prediction, which was numerically higher than that of the SEA-MAKE score (AUROC 0.70), SOFA score (AUROC 0.70) and APACHE II score (AUROC 0.68).

Conclusion

The mRAI demonstrated good discriminative ability for MAKE30 prediction in critically ill patients. While this may be a promising tool to guide clinical decision-making, further research is warranted.

Trial registration

Clinical Trial Registry Identifier: CTRI/2023/04/051884.
现有的急性肾损伤(AKI)风险预测工具侧重于预测AKI的发生,但很少涉及有临床意义的结果,如透析需求、死亡率和肾脏恢复。我们试图研究改良肾性心绞痛指数(mRAI)预测主要肾脏不良事件30 (MAKE30)的性能。方法:本前瞻性单中心观察性研究于2023年3月至2024年7月在印度一家三级医院的内科icu进行。我们纳入住院≥48小时的连续成人ICU患者,排除了患有终末期肾病、既往肾移植或入院时需要透析的患者。根据Matsuura等人的描述,在ICU入院后24小时,根据病情评分和血清肌酐的变化计算mRAI。主要终点是MAKE30,住院死亡率、新肾替代治疗(RRT)开始、出院或第30天持续肾功能不全的综合指标。采用受试者工作曲线下面积(AUROC)评价mRAI预测MAKE30的效果,并与其他评分进行比较。结果750例符合条件的患者中,326例(43.4%)经历了MAKE30。mRAI预测MAKE30的AUROC为0.75 (95% CI: 0.70 - 0.78),数值上高于SEA-MAKE评分(AUROC 0.70)、SOFA评分(AUROC 0.70)和APACHE II评分(AUROC 0.68)。结论mRAI对危重患者的MAKE30预测具有较好的判别能力。虽然这可能是指导临床决策的一个有前途的工具,但进一步的研究是有必要的。临床试验注册号:CTRI/2023/04/051884。
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引用次数: 0
Beyond the conventional: Adapting the EZ-blocker® for one-lung ventilation in a tracheostomized patient 超越传统:适应ez受体阻滞剂®在气管造口患者的单肺通气
IF 0.7 Q3 ANESTHESIOLOGY Pub Date : 2025-08-12 DOI: 10.1016/j.tacc.2025.101585
Sara Neves , Inês Correia , António Carlos Fiuza
Managing one-lung ventilation (OLV) in tracheostomized patients presents distinct challenges due to altered airway anatomy and limited device compatibility, particularly when complete pulmonary exclusion is required. Standard techniques may be inadequate or impractical in such complex cases. This case report describes an adaptation of the EZ-Blocker® in a tracheostomized patient undergoing right lower lobectomy. By strategically adjusting the positioning of the endobronchial cuffs and integrating a continuous aspiration system, successful and complete right lung exclusion was achieved, facilitating ideal surgical exposure. This tailored approach not only preserved airway stability but also minimized the risk of complications associated with alternative methods. Our experience highlights the versatility of the EZ-Blocker® and expands its potential application in nontraditional airway management scenarios, offering a valuable option for anesthesiologists facing similar challenges in thoracic surgery.
由于气道解剖结构的改变和设备兼容性的限制,特别是当需要完全肺排除时,气管造口患者的单肺通气(OLV)管理面临着明显的挑战。在这种复杂的情况下,标准技术可能是不充分的或不切实际的。本病例报告描述了EZ-Blocker®在气管造口术患者接受右下肺叶切除术的适应性。通过有策略地调整支气管内袖口的位置和整合一个连续的抽吸系统,实现了成功和完全的右肺排除,促进了理想的手术暴露。这种量身定制的方法不仅保持了气道的稳定性,而且最大限度地降低了与其他方法相关的并发症的风险。我们的经验强调了EZ-Blocker®的多功能性,并扩展了其在非传统气道管理场景中的潜在应用,为面临胸外科类似挑战的麻醉师提供了一个有价值的选择。
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引用次数: 0
期刊
Trends in Anaesthesia and Critical Care
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