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Ocular Findings among the Patients of Renal Transplantation 肾移植患者的眼部检查结果
IF 0.3 Pub Date : 2023-12-31 DOI: 10.3126/nepjoph.v15i1.52446
Madhu Thapa, G. B. Shrestha, Pragati Gautam, M. Sigdel
Introduction: Renal diseases are on rise globally due to increased incidence of non-communicable diseases as well as primary-kidney diseases and frequent use of nephrotoxic drugs. Only definite treatment of End-Stage-RenalDisease (ESRD) is renal transplantation. Immuno-suppressive-drugs are prescribed lifelong after renal transplantation especially steroids which can lead to various sight-threatening complications. Methods: This cross sectional, observational study included 62 eyes of 31 patients who had undergone renal transplantation, at least 3 months prior were referred from Nephrology Department. Comprehensive eye evaluation was done at B. P. Koirala Lions Centre for Ophthalmic Studies (BPKLCOS), Department of Ophthalmology, Institute of Medicine. Results: The average age of participants was 37 ±10.57 years with 77.4 % (n=24) male. Mean duration of renal transplant was 5.10 ± 3.61 years. Fifty-eight percent (n=18) had hypertensive kidney disease. Diabetes Kidney disease, recurrent UTI, CKD of unknown causes and combined case of diabetes plus hypertension were seen in 6.4% (n=2) each. Sixty percent of the patients had some kind of ocular involvement. Twenty-nine percent (n=18) had subnormal visual acuity of ≤ 6/9. Cataract was seen in 29% (n=18) of eyes followed by pinguecula (17.7%, n=11) and hypertensive-retinopathy (17.7%, n=11). Glaucoma and Diabetic-retinopathy were seen only in 6.4% (n= 4) of each eyes. There was no association seen between ocular findings with cause of renal transplant, duration of transplant and renal function status in bivariate analysis. Conclusions: Some form of ocular abnormality is commonly seen in patients of renal transplantation who are on immunosuppressive drugs. However, incidence of sight threatening complications are rare.
导言:由于非传染性疾病和原发性肾脏疾病发病率的增加以及肾毒性药物的频繁使用,肾脏疾病在全球范围内呈上升趋势。治疗终末期肾病(ESRD)的唯一确切方法是肾移植。肾移植后终身服用免疫抑制药物,尤其是类固醇类药物,这可能导致各种危及视力的并发症。研究方法这项横断面观察研究包括肾内科转来的至少 3 个月前接受过肾移植手术的 31 名患者的 62 只眼睛。医学研究所眼科系的 B. P. 柯伊拉腊狮子眼科研究中心(BPKLCOS)对他们的眼睛进行了全面评估。结果:参与者的平均年龄为 37 ±10.57 岁,其中男性占 77.4% (n=24)。平均肾移植时间为 5.10 ± 3.61 年。58%(18 人)患有高血压肾病。糖尿病肾病、复发性尿毒症、不明原因的慢性肾脏病和糖尿病加高血压合并病例各占 6.4%(n=2)。60%的患者有某种眼部受累。29%的患者(18 人)视力低于 6/9。29%(18 人)的眼睛患有白内障,其次是胬肉(17.7%,11 人)和高血压视网膜病变(17.7%,11 人)。青光眼和糖尿病视网膜病变仅占每只眼睛的 6.4%(4 例)。在双变量分析中,眼部检查结果与肾移植原因、移植时间和肾功能状况之间没有关联。结论使用免疫抑制剂的肾移植患者通常会出现某种形式的眼部异常。然而,危及视力的并发症很少发生。
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引用次数: 0
Indication and Outcome of Paediatric Keratoplasty at a Tertiary Referral Eye Hospital in Nepal 尼泊尔一家三级眼科转诊医院的儿科角膜移植手术的适应症和结果
IF 0.3 Pub Date : 2023-12-31 DOI: 10.3126/nepjoph.v15i1.50357
R. Rana, L. Bajracharya, Reeta Gurung, Radhika Upreti, Manish Poudel, Pradeep Banjara, S. Thapa
Introduction: Paediatric keratoplasty is rarely performed surgery with high risk of graft failure. Developing countries have not benefited due to lack of sufficient facilities and trained surgeons. Objectives: The objectives of the study were to analyze the indications and its outcome in terms of vision and graft survival. Materials and methods: This retrospective chart review used electronic medical records from January 2017 to December 2019 of all consecutive patients aged upto18 years or below that underwent paediatric keratoplasty after ethical approval at Tilganga Institute of Ophthalmology. Outcome was defined as anatomical or visual success and graft clarity. Different demographic and surgical parameters were studied among 59 eyes of 48 patients. Results: Mean age of recipient was 12.23± 3.81 years. Majority 37 (52.5%) had unilateral grafts with keratoconus being the most common 24 (40.6%) acquired non-traumatic indication. Mean post-operative best corrected visual acuity 0.6 Logmar was significantly (p <0.001) low as compared to preoperative 1.3 Logmar. Overall graft survival rate was 47 (78%) at one-year follow-up; keratoconus accounting for 24 (100%). Major factors in contributing for graft failure were rejection, infection, and glaucoma. Conclusion: A good outcome in terms of anatomical and visual success was achieved in our study. Keratoconus has an excellent graft survival. Visual rehabilitation by cycloplegic refraction should be done to prevent amblyopia. Enhancing the training of surgeons and addressing challenges faced in a paediatric population will help decrease corneal blindness among paediatric patients in the future.
介绍:小儿角膜移植术是一种很少实施的手术,移植失败的风险很高。由于缺乏足够的设施和训练有素的外科医生,发展中国家并未从中受益。研究目的本研究旨在分析适应症及其在视力和移植物存活率方面的结果。材料和方法:这项回顾性病历审查使用了2017年1月至2019年12月期间的电子病历,所有年龄在18岁或18岁以下、在蒂尔甘加眼科研究所经过伦理批准后接受小儿角膜移植术的连续患者的病历。手术结果定义为解剖或视觉成功率以及移植角膜的清晰度。研究了 48 名患者 59 只眼睛的不同人口统计学和手术参数。研究结果受术者的平均年龄为 12.23±3.81 岁。大多数患者(37 例,52.5%)为单侧移植,其中最常见的是角膜病,24 例(40.6%)为非创伤性适应症。术后平均最佳矫正视力为 0.6 Logmar,与术前的 1.3 Logmar 相比明显偏低(p <0.001)。在一年的随访中,移植物的总存活率为 47(78%);角膜病占 24(100%)。导致移植物失败的主要因素是排斥、感染和青光眼。结论我们的研究在解剖和视觉方面都取得了良好的效果。角膜塑形镜的移植物存活率非常高。应通过屈光环视进行视觉康复,以预防弱视。加强对外科医生的培训,应对儿科患者所面临的挑战,将有助于在未来减少儿科患者的角膜盲症。
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引用次数: 0
Developing Artificial Intelligence Model for Prediction of Diabetic Retinopathy and Delivering in a real-world Local Context: BP Eye Foundation’s Perspective 开发用于预测糖尿病视网膜病变的人工智能模型,并在现实世界的本地环境中实施:BP 眼科基金会的视角
IF 0.3 Pub Date : 2023-12-31 DOI: 10.3126/nepjoph.v15i1.59413
Arjun Shrestha, Pranita Upadhyaya, Madan P. Upadhyay
Not available.
不详。
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引用次数: 0
Retinal Nerve Fiber Layer and Macular Thickness in Patients with Type 2 Diabetes Mellitus without Retinopathy Using Optical Coherence Tomography: A Comparative Study 使用光学相干断层扫描测量无视网膜病变的 2 型糖尿病患者的视网膜神经纤维层和黄斑厚度:比较研究
IF 0.3 Pub Date : 2023-12-31 DOI: 10.3126/nepjoph.v15i1.47629
Samiksha Bhattarai, P. Lavaju, B. Badhu, Sangeeta Shah, Santosh Chaudhary, Robin Maskey, Ashesh Koirala
Introduction: Diabetes leads to an alteration in retinal nerve fiber layer (RNFL) thickness and macular thickness which can easily be detected with optical coherence tomography (OCT). Objectives: This study was done to compare the RNFL and macular thickness between diabetic patients without retinopathy and non-diabetic patients so that it would be useful in the early detection of retinal changes if present. The correlation between the RNFL and macular thickness with metabolic blood parameters of diabetic subjects was also studied. Materials and methods: This is an observational, cross-sectional, hospital-based study including 120 subjects who were further divided into two groups. Group A consisted of 60 diabetic patients without retinopathy and group B consisted of 60 non-diabetic patients. The blood parameters were recorded and the RNFL thickness and macular thickness were compared between the two groups after evaluation by OCT. Results: The average central macular thickness was found to be more in group A but was statistically insignificant (p=0.29). Macular thickness in the superior quadrant was significantly higher among group A when compared with group B (p=0.01). Whereas RNFL thickness difference between the two groups was statistically insignificant (p=0.53). Blood urea showed significant positive correlation (r=0.269) with central macular thickness (p=0.03). Conclusion: Our study showed that diabetic patients without retinopathy could have increased macular thickness in the superior quadrant when compared with normal people whereas RNFL thickness may not alter. The blood urea levels of the diabetic patients can provide us clues regarding possible retinal changes.
导言:糖尿病会导致视网膜神经纤维层(RNFL)厚度和黄斑厚度发生变化,而光学相干断层扫描(OCT)很容易检测到这一变化。研究目的本研究旨在比较无视网膜病变的糖尿病患者和非糖尿病患者的视网膜神经纤维层和黄斑厚度,以便及早发现视网膜病变。此外,还研究了 RNFL 和黄斑厚度与糖尿病患者血液代谢参数之间的相关性。材料和方法:这是一项以医院为基础的横断面观察性研究,包括 120 名受试者,并将他们分为两组。A 组包括 60 名无视网膜病变的糖尿病患者,B 组包括 60 名非糖尿病患者。研究人员记录了两组患者的血液参数,并通过 OCT 评估比较了两组患者的 RNFL 厚度和黄斑厚度。结果发现 A 组的黄斑中心平均厚度更大,但在统计学上并不显著(P=0.29)。与 B 组相比,A 组上象限的黄斑厚度明显更高(P=0.01)。两组的 RNFL 厚度差异无统计学意义(P=0.53)。血尿素与黄斑中心厚度呈显著正相关(r=0.269)(p=0.03)。结论我们的研究表明,与正常人相比,无视网膜病变的糖尿病患者上象限黄斑厚度可能会增加,而 RNFL 厚度可能不会改变。糖尿病患者的血尿素水平可为我们提供视网膜可能发生变化的线索。
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引用次数: 0
Surgical Outcomes of Ahmed Glaucoma Valve and Aurolab Aqueous Drainage Implant in Nepalese Eyes: Comparison in the First Year 在尼泊尔人眼中使用 Ahmed 青光眼瓣膜和 Aurolab 眼液引流植入物的手术效果:第一年的比较
IF 0.3 Pub Date : 2023-12-31 DOI: 10.3126/nepjoph.v15i1.52436
Anil Parajuli, I. Paudyal, P. Joshi, S. Thapa
Introduction: Glaucoma is the leading cause of irreversible blindness worldwide. Though trabeculectomy still remains the surgical modality of choice for the management of glaucoma, the outcome of glaucoma drainage devices (GDDs) too has been encouraging in recent years. Objectives: To compare the surgical outcomes of Ahmed glaucoma valve (AGV) and Aurolab aqueous drainage implant (AADI) in cases of refractory glaucoma in Nepalese eyes. Materials and methods: We retrospectively studied the charts of the patients with refractory glaucoma who had undergone GDD implantation at Tilganga Institute of Ophthalmology (TIO), Kathmandu, Nepal. Depending on which GDD was implanted, the eyes of the patients were divided into: AGV group and AADI group. The outcome measures of the study were intraocular pressure (IOP), requirement of antiglaucoma medications (AGMs), surgical success and complications. Results: There were 24 eyes of 23 patients in AGV group and 31 eyes of 30 patients in AADI group with a median (quartiles) follow-up of 12 (12,12) months. In the final visit, IOP and AGMs were both significantly lower than the baseline in both the groups (P <0.001). The median IOP in mmHg and AGMs were both significantly lower in the AADI group compared to AGV group in the final visit, p <0.001 and p=0.002, respectively. The overall success was similar in both the groups: AGV (n=22, 91.67%) and AADI (n=29, 93.55%), p=1.0. However, complete success was significantly more in AADI group (n=16, 51.61%) compared to AGV group (n=6, 25%), p=0.046. Complications and their rates were comparable between the two groups (p=0.4). Conclusion: Both AGV and AADI safely and effectively reduced the IOP and the number of AGMs in cases of refractory glaucoma in Nepalese eyes.
引言青光眼是导致全球不可逆失明的主要原因。尽管小梁切除术仍是治疗青光眼的首选手术方式,但近年来青光眼引流装置(GDDs)的疗效也令人鼓舞。研究目的比较 Ahmed 青光眼瓣膜(AGV)和 Aurolab 眼液引流植入器(AADI)在尼泊尔难治性青光眼病例中的手术效果。材料和方法:我们回顾性研究了在尼泊尔加德满都 Tilganga 眼科研究所(TIO)接受 GDD 植入术的难治性青光眼患者的病历。根据植入的 GDD 不同,患者的眼睛被分为:AGV 组和 AADI 组:AGV组和AADI组。研究的结果指标包括眼压(IOP)、抗青光眼药物(AGMs)需求、手术成功率和并发症。结果:AGV组23名患者共24只眼,AADI组30名患者共31只眼,随访中位数(四分位数)为12(12,12)个月。在最后一次随访中,两组患者的眼压和 AGM 均明显低于基线值(P <0.001)。与 AGV 组相比,AADI 组的中位眼压(以毫米汞柱为单位)和 AGMs 在最后随访时均明显降低,分别为 P <0.001 和 P=0.002。两组的总体成功率相似:AGV(22 人,91.67%)和 AADI(29 人,93.55%),P=1.0。然而,与 AGV 组(6 例,25%)相比,AADI 组的完全成功率明显更高(16 例,51.61%),P=0.046。两组的并发症及其发生率相当(P=0.4)。结论:AGV和AADI都能安全有效地降低尼泊尔难治性青光眼患者的眼压和AGM数量。
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引用次数: 0
Intravitreal Bevacizumab in Management of Persistent Secondary Macular Hole with Epiretinal Proliferation. 玻璃体内贝伐单抗治疗伴有视网膜外增殖的持续性继发性黄斑孔。
IF 0.3 Q4 OPHTHALMOLOGY Pub Date : 2023-07-01 DOI: 10.3126/nepjoph.v15i2.55033
Ugyen Zangmo, Sushma Jayanna, Mahesh P Shanmugam

Background: Aetiology for non-closure of full-thickness macular hole (FTMH) becomes crucial in determining the method of effective mode of intervention. Association of epiretinal proliferation (ERP) along with full-thickness macular hole (FTMH) have shown poorer anatomic and visual outcomes after surgical intervention. Various surgical techniques have been described in literature for treatment of persistent MH.

Case: We report a A 60-year-old female patient with FTMH secondary to branched retinal vein occlusion (BRVO) initially associated with ERP.

Observations: She was successfully managed by treating with combination of intravitreal injection of off label bevacizumab (Avastin) (1.25 mg/0.05 ml) and pure gas of SF6 (1 cc) under topical anaesthesia after an initial surgical intervention.

Conclusion: Presence of ERP in retinal vein occlusion cases needs closer and frequent follow up. IVB can be used as an adjunct in treating secondary MH.

背景:全厚黄斑孔(FTMH)不闭合的病因对于确定有效的干预方法至关重要。伴有视网膜上皮增生(ERP)的全厚性黄斑孔(FTMH)在手术干预后的解剖和视觉效果较差。文献中描述了多种治疗顽固性黄斑裂孔的手术方法:我们报告了一名 60 岁女性患者的病例,她因支行视网膜静脉闭塞(BRVO)继发 FTMH,最初与 ERP 相关:我们报告了一名 60 岁女性 FTMH 患者,她因视网膜分支静脉闭塞(BRVO)最初伴有 ERP,接受了非标签贝伐单抗(安维汀)(1.25 毫克/0.05 毫升)和 SF6 纯气体(1 毫升)的联合静脉注射治疗:结论:视网膜静脉闭塞病例中出现的ERP需要更密切和频繁的随访。IVB可作为治疗继发性MH的辅助手段。
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引用次数: 0
Pterygium Surgery with Autologous Graft with Glue versus Sutures. 翼状胬肉手术中的自体移植与胶合与缝合
IF 0.3 Q4 OPHTHALMOLOGY Pub Date : 2023-07-01 DOI: 10.3126/nepjoph.v15i2.64638
Dikshya Bohara
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引用次数: 0
Surgeries and Outcomes in Subluxated and Dislocated Lens in Eastern Nepal. 尼泊尔东部晶状体半脱位和脱位的手术及结果。
IF 0.3 Q4 OPHTHALMOLOGY Pub Date : 2023-07-01 DOI: 10.3126/nepjoph.v15i2.56396
Pranav Shrestha, Sadhana Sharma, Rinkal Suwal, Purushottam Joshi, Prava Subedi

Introduction: Many ocular or systemic conditions can cause weakening of the zonules, leading to subluxation or complete dislocation of lens into the anterior chamber or vitreous cavity.

Objectives: To evaluate the outcome of surgery in cases with subluxated and dislocated lens.

Materials and methods: Retrospective chart review of all cases with subluxated and dislocated lens who underwent surgery in a one-year period from 2019 January to 2019 December was conducted. Demographic profile, systemic comorbidities, initial and final best corrected visual acuity (BCVA), surgical procedure were recorded along with all the intraoperative and post-operative complications.

Results: A total of 62 eyes of 60 patients with mean age of 50.18 ± 15.18 years (18 to 87 years) were included with the modal duration of presentation of one week. Among these, trauma was found to be the most common etiology. Subluxation was present in 55 eyes and seven eyes had dislocation. Intracapsular Cataract Extraction (ICCE) was performed in 41 while 21 underwent Extracapsular Cataract Extraction (ECCE); and surgical intervention elicited a statistically significant (p < 0.05) improvement in the visual acuity. The BCVA was statistically better among the pseudophakic patient. Most common complication encountered intraoperatively was vitreous loss and post operatively was significant corneal edema.

Conclusion: Cataract extraction in cases with subluxated and dislocated lens due to different etiology results in the improvement in the visual acuity of the patient. In cases where ECCE cannot be performed, ICCE also results in comparable visual improvement.

导言:许多眼部或全身性疾病都可能导致晶状体带功能减弱,导致晶状体半脱位或完全脱位进入前房或玻璃体腔:评估晶状体半脱位和脱位病例的手术效果:对2019年1月至2019年12月一年内接受手术的所有晶状体半脱位和脱位病例进行回顾性病历审查。记录了患者的人口统计学特征、全身合并症、初始和最终最佳矫正视力(BCVA)、手术过程以及所有术中和术后并发症:共纳入了 60 名患者的 62 只眼睛,平均年龄为(50.18 ± 15.18)岁(18 至 87 岁),平均发病时间为一周。其中,外伤是最常见的病因。55只眼睛出现半脱位,7只眼睛脱位。41只眼睛接受了白内障囊内摘除术(ICCE),21只眼睛接受了白内障囊外摘除术(ECCE)。据统计,假性白内障患者的 BCVA 更佳。术中最常见的并发症是玻璃体脱落,术后则是明显的角膜水肿:结论:不同病因导致的晶状体下移和脱位的白内障摘除术可改善患者的视力。在无法进行 ECCE 的情况下,ICCE 也能改善视力。
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引用次数: 0
Bilateral Optic Neuritis in a Patient with Enteric Fever: A Case Report. 肠炎患者的双侧视神经炎:病例报告。
IF 0.3 Q4 OPHTHALMOLOGY Pub Date : 2023-07-01 DOI: 10.3126/nepjoph.v15i2.55281
Sundip Dware Chhetri, Keepa Vaidya, Suman Lamichhane, Sudeep Lal Rajbhandari, Shailendra Katwal

Background: Bilateral optic neuritis following enteric fever is a rare condition requiring early evaluation by an ophthalmologist and prompt treatment for visual rehabilitation.

Case: A 31-year-old female diagnosed with enteric fever presented to the Neuro-ophthalmology department with sudden painful loss of vision in both eyes for 10 days.

Observations: Her Best Corrected Visual Acuity (BCVA) was counting fingers close to face in left eye and 6/18 in right eye. Posterior segment examination showed blurring of disc margin on both eyes. On Magnetic Resonance Imaging (MRI) of brain and orbit there was mild thickening of retro-orbital portions of both optic nerves. She was started on steroid therapy which resulted in marked improvement of vision in both eyes.

Conclusion: Optic neuritis following enteric fever is a rare entity and requires early diagnosis with prompt treatment for improvement of visual acuity and prevention of visual impairment.

背景:肠热病后引起的双侧视神经炎是一种罕见病,需要眼科医生及早进行评估,并及时进行视力康复治疗:病例:一名 31 岁的女性被诊断患有肠热病,因双眼视力突然丧失 10 天,疼痛难忍而到神经眼科就诊:她的左眼最佳矫正视力(BCVA)为近脸数手指,右眼为 6/18。后段检查显示双眼视盘边缘模糊。脑部和眼眶磁共振成像(MRI)显示,双眼视神经眶后部分轻度增厚。她开始接受类固醇治疗,双眼视力明显改善:结论:肠热引起的视神经炎非常罕见,需要早期诊断和及时治疗,以改善视力和预防视力损伤。
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引用次数: 0
Comparability of Measurement of Astigmatism between URk-800F Auto Refracto-keratometer and MS-39 Anterior Segment Optical Coherence Tomography in Patients with Refractive Error. URk-800F 自动屈光角膜仪和 MS-39 光学相干断层扫描对屈光不正患者散光测量的可比性。
IF 0.3 Q4 OPHTHALMOLOGY Pub Date : 2023-07-01 DOI: 10.3126/nepjoph.v15i2.57044
Namrata Gupta, Samrina Maharjan, Suman Sapkota

Introduction: Accurate refractive error assessment is the first and the most important step of ocular examination. A reliable screening method of refractive status is important for early detection and prevention of blinding complications of uncorrected refractive error.

Objectives: To evaluate the comparability of astigmatism measured by an auto-refractometer (URk-800F) with the measurements of the gold standard anterior segment optical coherence tomography (AS-OCT).

Materials and methods: This cross-sectional observational study was conducted in a tertiary eye centre in Kathmandu from February 2023 to June 2023. A total of 100 patients with best corrected visual acuity of ≥ 20/20, spherical refractive error with cylindrical error of more than and equal to -0.75 and no pathology detected on slit lamp examination were taken by consecutive sampling method. Ethical approval was taken for the study. The data were entered into Microsoft Excel and analysed using Bland-Altman analysis.

Results: The mean cylindrical power and axis was -2.33 D and 88 degrees for the right eye and -2.32 D and 122 degrees for the left eye respectively, as measured by MS-39 AS-OCT. For URK 800-F Auto-refracto Keratometer, the mean cylindrical power and axis was -2.31 D and 89 degrees for the right eye and -2.27 D and 124 degrees for the left eye.

Conclusion: The findings of this study conclude that an auto-refractometer can be used as an effective tool for identification of spherical refractive error as well as measurement of accurate cylindrical power and cylindrical axis in low resource primary care settings.

简介准确评估屈光不正是眼科检查的第一步,也是最重要的一步。可靠的屈光状态筛查方法对于早期发现和预防未矫正屈光不正的致盲并发症非常重要:评估自动屈光仪(URk-800F)与金标准眼前节光学相干断层扫描(AS-OCT)所测散光的可比性:这项横断面观察研究于 2023 年 2 月至 2023 年 6 月在加德满都的一家三级眼科中心进行。研究采用连续抽样法,共抽取了 100 名最佳矫正视力≥ 20/20、球面屈光不正且圆柱误差大于等于-0.75、裂隙灯检查未发现病变的患者。研究已获得伦理批准。数据输入 Microsoft Excel,并使用 Bland-Altman 分析法进行分析:通过 MS-39 AS-OCT 测量,右眼的平均圆柱力和轴分别为-2.33 D 和 88 度,左眼的平均圆柱力和轴分别为-2.32 D 和 122 度。用 URK 800-F 自动屈光角膜仪测量,右眼的平均圆柱力和轴分别为-2.31 D 和 89 度,左眼的平均圆柱力和轴分别为-2.27 D 和 124 度:本研究的结论是,自动屈光仪可作为一种有效的工具,在资源匮乏的初级医疗机构中用于识别球面屈光不正以及测量准确的圆柱力和圆柱轴。
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引用次数: 0
期刊
Nepalese Journal of Ophthalmology
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