N. Girgin, R. İşçimen, İrem Aydoğmuş, S. Bora, A. A. Kocaeli, F. Kahveci
{"title":"Thyroid Storm in Postoperative Delirium Etiology: Case Report","authors":"N. Girgin, R. İşçimen, İrem Aydoğmuş, S. Bora, A. A. Kocaeli, F. Kahveci","doi":"10.4274/TYBDD.13007","DOIUrl":"https://doi.org/10.4274/TYBDD.13007","url":null,"abstract":"","PeriodicalId":448120,"journal":{"name":"Türk Yoğun Bakim Derneği Dergisi","volume":"152 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122043646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"What Does Change with Nutrition Team in Intensive Care Unit","authors":"A. Yilmaz, E. Kılıç, Sema Gürsel, Nazlı Tiryaki","doi":"10.4274/TYBDD.70299","DOIUrl":"https://doi.org/10.4274/TYBDD.70299","url":null,"abstract":"","PeriodicalId":448120,"journal":{"name":"Türk Yoğun Bakim Derneği Dergisi","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127942145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Babayiğit, Z. Tutal, N. Dereli, Handan Güleç, M. Babayigit, E. Horasanlı
{"title":"Are We Being Informed Correctly During the Patient Transfer to the Intensive Care Units","authors":"M. Babayiğit, Z. Tutal, N. Dereli, Handan Güleç, M. Babayigit, E. Horasanlı","doi":"10.4274/TYBDD.62207","DOIUrl":"https://doi.org/10.4274/TYBDD.62207","url":null,"abstract":"","PeriodicalId":448120,"journal":{"name":"Türk Yoğun Bakim Derneği Dergisi","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131282955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E-pos ta: esenf@istanbul.edu.tr Tel.: +90 532 362 77 64 OZ Akut beyin disfonksiyonu, yogun bakim unitesinde yaygin olarak gorulen ve deliryumdan komaya kadar degisen norolojik degisikliklerin izlendigi klinik bir tablodur. Kritik hastalarda genellikle sepsis sirasinda ortaya cikan bu sendrom “sepsis iliskili ensefalopati” olarak da adlandirilir ve bu durum, mortalite, morbidite artisi ve uzun donem kognitif bozukluk gelismesi ile iliskili oldugu icin onemlidir. Kritik hastalarda beyin fonksiyonlarinin monitorizasyonu, ayrintili norolojik muayene ile baslamalidir ve degerlendirme sirasinda norolojik yanitlari degistirebilecek sedatif ilaclarin etkileri dikkate alinmalidir. Beyin goruntuleme yontemleri ve elektrofizyolojik incelemeler ise norolojik muayeneyi tamamlayan tani yontemleridir. Bilgisayarli tomografi, yapisal intraserebral lezyonlarin tanisini saglarken, manyetik rezonans goruntuleme, sepsis iliskili ensefalopatinin primer patolojik mekanizmalarina ve beyinde gelisen yapisal degisikliklere iliskin onemli bilgiler saglar. Elektroensefalografi kullanimi ile akut beyin disfonksiyonunun tanisi ve prognozu hakkinda kanitlar elde edilebilir. Norolojik biyomarkirlarin tanida ve prognozun tayin edilmesinde yararli olabilecegi dusunulmekle beraber bu konuda daha fazla arastirmaya ihtiyac vardir. Anahtar Kelimeler: Akut beyin disfonksiyonu, sepsis iliskili ensefalopati, norolojik muayene, beyin manyetik rezonans goruntuleme, elektroensefalografi, norolojik biyomarkirlar SUMMARY Acute brain dysfunction is a clinical condition which is commonly observed in intensive care units and exhibits neurological changes ranging from delirium to coma. Typically observed during sepsis in critical patients, this syndrome is also named as “sepsis-associated encephalopathy” and this situation is of significance since it is related to mortality, increase of morbidity and longterm cognitive impairment. Monitorization of brain functions in critically ill patients should be commenced with detailed neurological examination and effects of sedative drugs, which can alter neurological responses during evaluation, should be taken into consideration. On the other hand, brain imaging methods and electrophysiological examinations are diagnostic procedures which complement neurological examination. While computed tomography enables diagnosis of structural intracerebral lesions, magnetic resonance imaging provides important information on primary pathological mechanisms of sepsisassociated encephalopathy and structural alterations developing in the brain. Evidence of diagnosis and prognosis of acute brain dysfunction can be acquired through use of electroencephalography for. Although it was believed that neurological biomarkers can be useful in determination of diagnosis and prognosis, further studies are needed in this subject.
{"title":"Monitorization of Acute Brain Dysfunction in Critical Illness","authors":"G. Orhun, F. Esen","doi":"10.4274/TYBDD.53825","DOIUrl":"https://doi.org/10.4274/TYBDD.53825","url":null,"abstract":"E-pos ta: esenf@istanbul.edu.tr Tel.: +90 532 362 77 64 OZ Akut beyin disfonksiyonu, yogun bakim unitesinde yaygin olarak gorulen ve deliryumdan komaya kadar degisen norolojik degisikliklerin izlendigi klinik bir tablodur. Kritik hastalarda genellikle sepsis sirasinda ortaya cikan bu sendrom “sepsis iliskili ensefalopati” olarak da adlandirilir ve bu durum, mortalite, morbidite artisi ve uzun donem kognitif bozukluk gelismesi ile iliskili oldugu icin onemlidir. Kritik hastalarda beyin fonksiyonlarinin monitorizasyonu, ayrintili norolojik muayene ile baslamalidir ve degerlendirme sirasinda norolojik yanitlari degistirebilecek sedatif ilaclarin etkileri dikkate alinmalidir. Beyin goruntuleme yontemleri ve elektrofizyolojik incelemeler ise norolojik muayeneyi tamamlayan tani yontemleridir. Bilgisayarli tomografi, yapisal intraserebral lezyonlarin tanisini saglarken, manyetik rezonans goruntuleme, sepsis iliskili ensefalopatinin primer patolojik mekanizmalarina ve beyinde gelisen yapisal degisikliklere iliskin onemli bilgiler saglar. Elektroensefalografi kullanimi ile akut beyin disfonksiyonunun tanisi ve prognozu hakkinda kanitlar elde edilebilir. Norolojik biyomarkirlarin tanida ve prognozun tayin edilmesinde yararli olabilecegi dusunulmekle beraber bu konuda daha fazla arastirmaya ihtiyac vardir. Anahtar Kelimeler: Akut beyin disfonksiyonu, sepsis iliskili ensefalopati, norolojik muayene, beyin manyetik rezonans goruntuleme, elektroensefalografi, norolojik biyomarkirlar SUMMARY Acute brain dysfunction is a clinical condition which is commonly observed in intensive care units and exhibits neurological changes ranging from delirium to coma. Typically observed during sepsis in critical patients, this syndrome is also named as “sepsis-associated encephalopathy” and this situation is of significance since it is related to mortality, increase of morbidity and longterm cognitive impairment. Monitorization of brain functions in critically ill patients should be commenced with detailed neurological examination and effects of sedative drugs, which can alter neurological responses during evaluation, should be taken into consideration. On the other hand, brain imaging methods and electrophysiological examinations are diagnostic procedures which complement neurological examination. While computed tomography enables diagnosis of structural intracerebral lesions, magnetic resonance imaging provides important information on primary pathological mechanisms of sepsisassociated encephalopathy and structural alterations developing in the brain. Evidence of diagnosis and prognosis of acute brain dysfunction can be acquired through use of electroencephalography for. Although it was believed that neurological biomarkers can be useful in determination of diagnosis and prognosis, further studies are needed in this subject.","PeriodicalId":448120,"journal":{"name":"Türk Yoğun Bakim Derneği Dergisi","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124334430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Non-invasive Mechanic Ventilation During the “Weaning”","authors":"Murat Ünsel, P. E. Özcan","doi":"10.4274/tybdd.92486","DOIUrl":"https://doi.org/10.4274/tybdd.92486","url":null,"abstract":"","PeriodicalId":448120,"journal":{"name":"Türk Yoğun Bakim Derneği Dergisi","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123662573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Invasive Pulmonary Aspergillosis in the Intensive Care Unit: A Case Report","authors":"M. A. Yazar, Aytuna Kuzucuoğlu, M. Açıkgöz","doi":"10.4274/TYBDD.93063","DOIUrl":"https://doi.org/10.4274/TYBDD.93063","url":null,"abstract":"","PeriodicalId":448120,"journal":{"name":"Türk Yoğun Bakim Derneği Dergisi","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130532840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Z. Tutal, Esra Özayar, I. Kenan, M. Babayiğit, Mehmet Şirin Gökhaner, E. Horasanlı
{"title":"Neurological Recovery after Amantadine Treatment in a Patient with Septic Arthritis: A Case Report","authors":"Z. Tutal, Esra Özayar, I. Kenan, M. Babayiğit, Mehmet Şirin Gökhaner, E. Horasanlı","doi":"10.4274/tybdd.52244","DOIUrl":"https://doi.org/10.4274/tybdd.52244","url":null,"abstract":"","PeriodicalId":448120,"journal":{"name":"Türk Yoğun Bakim Derneği Dergisi","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125402578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Semiha Solak Grassi̇e, B. Kayaaslan, Sümeyra Çetin Gevrek, Dilber Kumral, C. Emre
{"title":"In Our Intensive Care Unit the Experience of the Checklist Use to Prevent Ventilator Associated Pneumonia","authors":"Semiha Solak Grassi̇e, B. Kayaaslan, Sümeyra Çetin Gevrek, Dilber Kumral, C. Emre","doi":"10.4274/tybdd.63644","DOIUrl":"https://doi.org/10.4274/tybdd.63644","url":null,"abstract":"","PeriodicalId":448120,"journal":{"name":"Türk Yoğun Bakim Derneği Dergisi","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130329574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Senay Canikli Adiguzel, A. Pirat, S. Turkoglu, N. Bayraktar, O. Ozen, M. Kaya
E-pos ta: drsenaycanikli@yahoo.com Tel.: +90 533 543 54 22 ÖZ Amaç: Çalışmamızda çekal ligasyon ve perforasyon yöntemi kullanılarak akut akciğer hasarı gelişimini sağladığımız sıçanlarda Silimarin’in anti-inflamatuvar ve antioksidan özelliklerini değerlendirmeyi amaçladık. Gereç ve Yöntem: Toplam 46 sıçanın kullanıldığı çalışmamızda sham (n=14), kontrol (n=16) ve silimarin (n=16) grupları ve her bir grubun erken ve geç alt grupları vardı. Silimarin grubundaki sıçanlara silimarin, kontrol ve sham grubuna ise salin verildi. Kontrol ve silimarin grubundaki sıçanlarda çekal ligasyon ve perforasyon yöntemi ile sepsise bağlı akciğer hasarı gelişimi sağlandı. Erken gruptaki sıçanlar 12. saatte sonlandırılırken geç gruptakiler takibe alındı. Sıçanların serum ve bronkoalveolar lavaj sıvısı (BAL) tümör nekroz faktör alfa (TNF-α), interlökin (İL)-1, İL-6 seviyeleri, akciğer dokusunda malondialdehit (MDA) ve glutatyon sülfidril (GSH) seviyeleri, akciğer dokusunun histopatolojik incelemesi ve yaş/kuru ağırlık oranına bakıldı. Bulgular: Çalışmanın sonucunda 72. saatte silimarin grubunda sağkalım oranı %62,5, kontrol grubunda %12,5 bulundu (p=0,0506). Silimarin grubunda kontrol grubuna göre yaş/ kuru ağırlık oranı (p=0,019), serum ve BAL, TNF-α, İL-1, İL-6 seviyeleri (her biri için p<0,05) ve histopatolojik skorlama anlamlı olarak daha düşük bulundu (p=0,001). Doku MDA seviyesinin kontrol grubundan daha düşük (p=0,011) ve GSH seviyesinin daha yüksek (p=0,001) olduğu tespit edildi. Sonuç: Silimarin sepsise bağlı akut akciğer hasarı gelişimini önlemede yararlı olmuştur. Bu etkinin anti-inflamatuvar ve antioksidan özellikleri sayesinde olduğunu düşünmekteyiz. Anahtar Kelimeler: Silimarin, akut akciğer hasarı, antioksidan, anti-inflamatuvar SUMMARY Objective: In this study, it was aimed to evaluate the anti-inflammatory and antioxidative effects of Silymarin in rats in whom artificial acute pulmonary damage was provided with caecal ligation-perforation method. Material and Method: Forty-six rats were randomized to sham (n=14), control (n=16), silymarin (n=16) groups. Each group had early and late subgroups. Silimarin was administered in the silimarin group and saline was administerd in control and sham groups. Artificial acute pulmonary damage associated with sepsis was provided with caecal ligationperforation method in control and silimarin groups. Rats in the early subgroup Were terminated at the end of the 12th hour and threats in the late group were followed-up. Serum and bronchoalveolar lavage fluid (BAL) tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, and IL-6; lung tissue malondialdehyde (MDA) and glutathione (GSH) levels; lung histopathologic examination; and lung wet-to-dry (w/d) weight ratio measurements were used to compare and evaluate the severity of lung injury between the groups. Results: Mortality rates for silymarin and control groups were 62.5% and 12.5%, respectively (log-rank p=0.0506). Compared with the silymarin group, the control g
{"title":"A Rat Model of Acute Respiratory Distress Silymarin's Antiinflamatory and Antioxidant Effect","authors":"Senay Canikli Adiguzel, A. Pirat, S. Turkoglu, N. Bayraktar, O. Ozen, M. Kaya","doi":"10.4274/tybdd.71501","DOIUrl":"https://doi.org/10.4274/tybdd.71501","url":null,"abstract":"E-pos ta: drsenaycanikli@yahoo.com Tel.: +90 533 543 54 22 ÖZ Amaç: Çalışmamızda çekal ligasyon ve perforasyon yöntemi kullanılarak akut akciğer hasarı gelişimini sağladığımız sıçanlarda Silimarin’in anti-inflamatuvar ve antioksidan özelliklerini değerlendirmeyi amaçladık. Gereç ve Yöntem: Toplam 46 sıçanın kullanıldığı çalışmamızda sham (n=14), kontrol (n=16) ve silimarin (n=16) grupları ve her bir grubun erken ve geç alt grupları vardı. Silimarin grubundaki sıçanlara silimarin, kontrol ve sham grubuna ise salin verildi. Kontrol ve silimarin grubundaki sıçanlarda çekal ligasyon ve perforasyon yöntemi ile sepsise bağlı akciğer hasarı gelişimi sağlandı. Erken gruptaki sıçanlar 12. saatte sonlandırılırken geç gruptakiler takibe alındı. Sıçanların serum ve bronkoalveolar lavaj sıvısı (BAL) tümör nekroz faktör alfa (TNF-α), interlökin (İL)-1, İL-6 seviyeleri, akciğer dokusunda malondialdehit (MDA) ve glutatyon sülfidril (GSH) seviyeleri, akciğer dokusunun histopatolojik incelemesi ve yaş/kuru ağırlık oranına bakıldı. Bulgular: Çalışmanın sonucunda 72. saatte silimarin grubunda sağkalım oranı %62,5, kontrol grubunda %12,5 bulundu (p=0,0506). Silimarin grubunda kontrol grubuna göre yaş/ kuru ağırlık oranı (p=0,019), serum ve BAL, TNF-α, İL-1, İL-6 seviyeleri (her biri için p<0,05) ve histopatolojik skorlama anlamlı olarak daha düşük bulundu (p=0,001). Doku MDA seviyesinin kontrol grubundan daha düşük (p=0,011) ve GSH seviyesinin daha yüksek (p=0,001) olduğu tespit edildi. Sonuç: Silimarin sepsise bağlı akut akciğer hasarı gelişimini önlemede yararlı olmuştur. Bu etkinin anti-inflamatuvar ve antioksidan özellikleri sayesinde olduğunu düşünmekteyiz. Anahtar Kelimeler: Silimarin, akut akciğer hasarı, antioksidan, anti-inflamatuvar SUMMARY Objective: In this study, it was aimed to evaluate the anti-inflammatory and antioxidative effects of Silymarin in rats in whom artificial acute pulmonary damage was provided with caecal ligation-perforation method. Material and Method: Forty-six rats were randomized to sham (n=14), control (n=16), silymarin (n=16) groups. Each group had early and late subgroups. Silimarin was administered in the silimarin group and saline was administerd in control and sham groups. Artificial acute pulmonary damage associated with sepsis was provided with caecal ligationperforation method in control and silimarin groups. Rats in the early subgroup Were terminated at the end of the 12th hour and threats in the late group were followed-up. Serum and bronchoalveolar lavage fluid (BAL) tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, and IL-6; lung tissue malondialdehyde (MDA) and glutathione (GSH) levels; lung histopathologic examination; and lung wet-to-dry (w/d) weight ratio measurements were used to compare and evaluate the severity of lung injury between the groups. Results: Mortality rates for silymarin and control groups were 62.5% and 12.5%, respectively (log-rank p=0.0506). Compared with the silymarin group, the control g","PeriodicalId":448120,"journal":{"name":"Türk Yoğun Bakim Derneği Dergisi","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130735949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Investigation of Ventilator Associated Pneumoniae in Intensive Care Patients","authors":"Hakan Tağrıkulu, D. Memiş, M. Inal, N. Turan","doi":"10.4274/tybdd.30602","DOIUrl":"https://doi.org/10.4274/tybdd.30602","url":null,"abstract":"","PeriodicalId":448120,"journal":{"name":"Türk Yoğun Bakim Derneği Dergisi","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133955417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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