{"title":"Investigation of the Use of Marble Powder in Production of High Strength Concretes","authors":"Tuba Demir, K. E. Alyamaç","doi":"10.56171/ojn.1034691","DOIUrl":"https://doi.org/10.56171/ojn.1034691","url":null,"abstract":"","PeriodicalId":448411,"journal":{"name":"Open Journal of Nano","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127167804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bahri Barış Vatandaş, Recep Gümrük, Altuğ Uşun, N. Yildiz
- This study investigated the effects of different heat treatments on continuous fiber-reinforced thermoplastic (CFRTP) 's. CFRTP composite is produced using fused deposition modeling (FDM), which is one of the additive manufacturing methods. Polylactic acid (PLA) was used as a matrix, and carbon fibers (3K) were utilized as reinforcement material. First, CFRTP filament was produced on a specially designed melt impregnation line. Afterward, test samples were manufactured via a conventional 3D printer. Then, heat treatments (re-melting in salt, microwave oven, oven) were applied to the produced samples, and the effects of these processes on mechanical properties were investigated. Three-point bending tests were used to investigate the mechanical properties of the test samples. As a result of the heat treatments applied to the CFRTP specimens, flexural stresses between 200 and 220 MPa was achieved. The highest bending stress was obtained by re-melting in salt. As a result of the heat treatments, the stress values are similar, but the re-melting in salt application exhibited a more rigid behavior.
{"title":"The Effect of Heat Treatments Applied to Continuous Fiber Reinforced Thermoplastic Composites on Mechanical Properties","authors":"Bahri Barış Vatandaş, Recep Gümrük, Altuğ Uşun, N. Yildiz","doi":"10.56171/ojn.1034323","DOIUrl":"https://doi.org/10.56171/ojn.1034323","url":null,"abstract":"- This study investigated the effects of different heat treatments on continuous fiber-reinforced thermoplastic (CFRTP) 's. CFRTP composite is produced using fused deposition modeling (FDM), which is one of the additive manufacturing methods. Polylactic acid (PLA) was used as a matrix, and carbon fibers (3K) were utilized as reinforcement material. First, CFRTP filament was produced on a specially designed melt impregnation line. Afterward, test samples were manufactured via a conventional 3D printer. Then, heat treatments (re-melting in salt, microwave oven, oven) were applied to the produced samples, and the effects of these processes on mechanical properties were investigated. Three-point bending tests were used to investigate the mechanical properties of the test samples. As a result of the heat treatments applied to the CFRTP specimens, flexural stresses between 200 and 220 MPa was achieved. The highest bending stress was obtained by re-melting in salt. As a result of the heat treatments, the stress values are similar, but the re-melting in salt application exhibited a more rigid behavior.","PeriodicalId":448411,"journal":{"name":"Open Journal of Nano","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116136021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Çelik, A. Demi̇rag, Samet Arslan, A. Özel, S. Akyüz
{"title":"Conformational, Toxic, Physicochemical and Molecular Docking Analysis of the Anticancer Acalabrutinib Molecule","authors":"S. Çelik, A. Demi̇rag, Samet Arslan, A. Özel, S. Akyüz","doi":"10.56171/ojn.1004702","DOIUrl":"https://doi.org/10.56171/ojn.1004702","url":null,"abstract":"","PeriodicalId":448411,"journal":{"name":"Open Journal of Nano","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125153016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bu çalışmada yüksek yoğunluklu polietilen (HDPE) malzemeye farklı oranlarda tek yönlü basma işlemi uygulanarak sertlik ölçümleri gerçekleştirilmiştir. Şekil değişim miktarları %10, %20, %30, %40, %50, %60, %70 ve %80 oranlarında oda şartlarında yaklaşık 23 °C and %50 nemde gerçekleştirilmiştir. Basma işlemleri plaka şeklinde 3 mm kalınlığında numunelere yapılmıştır. Basma yönü kalınlık doğrultusunda gerçekleştirilmiştir. Basma işlemleri yapılan numunelerin sertlik değerleri ve gerilme değerleri tespit edilmiştir. Ayrıca her bir sıkıştırma oranı için plastik deformasyon oranları hesaplanmıştır. %10 basma oranında en yüksek sertlik değeri tespit edilmiş olup artan basma oranlarında sertlik değerlerinin düştüğü gözlemlenmiştir. Plastik deformasyon oranlarında ise %10 ve %20 oranlarında kalıcı şekil değişimi çok düşük değerlerde olup artan deformasyon oranlarında dikkate değer bir artış görülmüştür.
{"title":"Tek Yönlü Basma İşleminin Yüksek Yoğunluklu Polietilen Malzemelerin Sertliğine Etkisinin Araştırılması","authors":"Erkin Akdoğan","doi":"10.56171/ojn.1110326","DOIUrl":"https://doi.org/10.56171/ojn.1110326","url":null,"abstract":"Bu çalışmada yüksek yoğunluklu polietilen (HDPE) malzemeye farklı oranlarda tek yönlü basma işlemi uygulanarak sertlik ölçümleri gerçekleştirilmiştir. Şekil değişim miktarları %10, %20, %30, %40, %50, %60, %70 ve %80 oranlarında oda şartlarında yaklaşık 23 °C and %50 nemde gerçekleştirilmiştir. Basma işlemleri plaka şeklinde 3 mm kalınlığında numunelere yapılmıştır. Basma yönü kalınlık doğrultusunda gerçekleştirilmiştir. Basma işlemleri yapılan numunelerin sertlik değerleri ve gerilme değerleri tespit edilmiştir. Ayrıca her bir sıkıştırma oranı için plastik deformasyon oranları hesaplanmıştır. %10 basma oranında en yüksek sertlik değeri tespit edilmiş olup artan basma oranlarında sertlik değerlerinin düştüğü gözlemlenmiştir. Plastik deformasyon oranlarında ise %10 ve %20 oranlarında kalıcı şekil değişimi çok düşük değerlerde olup artan deformasyon oranlarında dikkate değer bir artış görülmüştür.","PeriodicalId":448411,"journal":{"name":"Open Journal of Nano","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130944061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Synthesis and Photophysical Properties of Pyrene-BODIPY Functionalized Subphthalocyanine Dyad","authors":"Seda Çetindere","doi":"10.56171/ojn.1053225","DOIUrl":"https://doi.org/10.56171/ojn.1053225","url":null,"abstract":"","PeriodicalId":448411,"journal":{"name":"Open Journal of Nano","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127340275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nanoparticles increase their availability and diversity in the environment day by day with the natural formation processes of the world geography and the development of advanced technological industry. Due to their intelligent and kaleidoscopic physico-chemical structural forms, they can cause toxic effects in various metabolic steps (in structural proteins, genetic structure, organelles, cells, tissues, organs, metabolic systems) in the organism. Despite these harmful situations some magnetite nanoparticles such as gold nanoparticles, silver nanoparticles, nanodiamonds, dendrimers, polymeric and liposomic smart nanoparticles can be used in medical studies, pharmaceutical industry, nanotheranostic studies and molecular methods. Zebrafish (Danio rerio), which is used a model species in many study disciplines, has been used in many studies to reveal the potential toxic effects and positive effects of the tested nanoparticles. Both in vivo and in vitro test systems and interdisciplinary studies conducted in recent years were analyzed and evaluated via the traditional review method in the current study. Besides, many studies were grouped in order to obtain fast and efficient results on the characterization of nanoparticles and understanding their mechanism of action. A systematic search was conducted based on the keywords of this study in databases such as PubMed, Google Scholar, Web of Science and Carrot², in May 2022. In addition to recognizing the toxic effects of nanoparticles, several studies were emphasized, in which the utilitarian status of nanoparticles in medical, pharmaceutical, molecular and genetic applied studies was understood more clearly day by day.
随着世界地理的自然形成过程和先进技术产业的发展，纳米粒子在环境中的可用性和多样性日益增加。由于其智能和千变万化的物理化学结构形式，它们可以在生物体的各个代谢步骤(结构蛋白、遗传结构、细胞器、细胞、组织、器官、代谢系统)中产生毒性作用。尽管存在这些有害的情况，一些磁铁矿纳米颗粒，如金纳米颗粒、银纳米颗粒、纳米钻石、树状大分子、聚合物和脂质体智能纳米颗粒可用于医学研究、制药工业、纳米治疗研究和分子方法。斑马鱼(Danio rerio)是许多研究学科中使用的模型物种，已在许多研究中使用斑马鱼来揭示被测纳米颗粒的潜在毒性和积极作用。本研究采用传统的综述方法，对近年来开展的体内和体外试验系统以及跨学科研究进行分析和评价。此外，为了获得快速有效的纳米颗粒表征结果和了解其作用机制，对研究进行了分组。以该研究的关键词为基础，于2022年5月在PubMed、Google Scholar、Web of Science、Carrot²等数据库中进行了系统检索。除了认识到纳米粒子的毒性作用外，还强调了几项研究，其中越来越清楚地认识到纳米粒子在医学、制药、分子和遗传应用研究中的实用地位。
{"title":"Toxicological Aspects and Bioanalysis of Nanoparticles: Zebrafish Model","authors":"B. Yeşi̇lbudak","doi":"10.56171/ojn.1189800","DOIUrl":"https://doi.org/10.56171/ojn.1189800","url":null,"abstract":"Nanoparticles increase their availability and diversity in the environment day by day with the natural formation processes of the world geography and the development of advanced technological industry. Due to their intelligent and kaleidoscopic physico-chemical structural forms, they can cause toxic effects in various metabolic steps (in structural proteins, genetic structure, organelles, cells, tissues, organs, metabolic systems) in the organism. Despite these harmful situations some magnetite nanoparticles such as gold nanoparticles, silver nanoparticles, nanodiamonds, dendrimers, polymeric and liposomic smart nanoparticles can be used in medical studies, pharmaceutical industry, nanotheranostic studies and molecular methods. Zebrafish (Danio rerio), which is used a model species in many study disciplines, has been used in many studies to reveal the potential toxic effects and positive effects of the tested nanoparticles. Both in vivo and in vitro test systems and interdisciplinary studies conducted in recent years were analyzed and evaluated via the traditional review method in the current study. Besides, many studies were grouped in order to obtain fast and efficient results on the characterization of nanoparticles and understanding their mechanism of action. A systematic search was conducted based on the keywords of this study in databases such as PubMed, Google Scholar, Web of Science and Carrot², in May 2022. In addition to recognizing the toxic effects of nanoparticles, several studies were emphasized, in which the utilitarian status of nanoparticles in medical, pharmaceutical, molecular and genetic applied studies was understood more clearly day by day.","PeriodicalId":448411,"journal":{"name":"Open Journal of Nano","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114588122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Fractal adsorption characteristics and statistical analysis approach of complex dye molecule on metal oxide particles—A case study of Reactive Black 5(RB 5) adsorption onto NiO nanoparticles","authors":"Ferda Gonen, Gizem Bi̇çer","doi":"10.56171/ojn.1065924","DOIUrl":"https://doi.org/10.56171/ojn.1065924","url":null,"abstract":"","PeriodicalId":448411,"journal":{"name":"Open Journal of Nano","volume":"120 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127278564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Demi̇rag, S. Çelik, Samet Arslan, A. Özel, S. Akyüz
Ruxolitinib (C17H18N6) is a Janus kinase (JAK) inhibitor that inhibits JAK1, JAK2, and JAK3 and with its tyrosine kinase inhibitor function It is the first drug approved for use in the treatment of myelofibrosis. The possible conformations of the ruxolitinib molecule were searched using PM3 technique and the Spartan06 software. The estimated molecular energies of the Ruxolitinib conformers, obtained by the variations in dihedral angles, were compared, and the most stable conformer was determined. To enlighten the inhibitory activity of Ruxolitinib agaist the apo (PDB ID: 6M03) and holo (PDB ID: 6LU7) forms of the main protease enzyme (Mpro) of COVID-19 and the SARSCoV-2 spike glycoprotein (PDB ID: 6VXX), molecular docking simulations were performed. The binding affinities and binding modes were determined. The binding free energies of ruxolitinib and 6M03, 6LU7, 6VXX targets calculated by the combination of Molecular Mechanics/Generalized Born Surface Area (MMGBSA) and Molecular Mechanics/Poisson-Boltzmann Surface Area (MM-PBSA) methods {MM/PB(GB)SA approach}, were found to be -22.24, -19.96 and -22.44 kcal/mol, respectively.
{"title":"The inhibitory activity of Ruxolitinib against COVID-19 major protease enzyme and SARS CoV-2 spike glycoprotein: A molecular docking study","authors":"A. Demi̇rag, S. Çelik, Samet Arslan, A. Özel, S. Akyüz","doi":"10.56171/ojn.1134119","DOIUrl":"https://doi.org/10.56171/ojn.1134119","url":null,"abstract":"Ruxolitinib (C17H18N6) is a Janus kinase (JAK) inhibitor that inhibits JAK1, JAK2, and JAK3 and with its tyrosine kinase inhibitor function It is the first drug approved for use in the treatment of myelofibrosis. The possible conformations of the ruxolitinib molecule were searched using PM3 technique and the Spartan06 software. The estimated molecular energies of the Ruxolitinib conformers, obtained by the variations in dihedral angles, were compared, and the most stable conformer was determined. To enlighten the inhibitory activity of Ruxolitinib agaist the apo (PDB ID: 6M03) and holo (PDB ID: 6LU7) forms of the main protease enzyme (Mpro) of COVID-19 and the SARSCoV-2 spike glycoprotein (PDB ID: 6VXX), molecular docking simulations were performed. The binding affinities and binding modes were determined. The binding free energies of ruxolitinib and 6M03, 6LU7, 6VXX targets calculated by the combination of Molecular Mechanics/Generalized Born Surface Area (MMGBSA) and Molecular Mechanics/Poisson-Boltzmann Surface Area (MM-PBSA) methods {MM/PB(GB)SA approach}, were found to be -22.24, -19.96 and -22.44 kcal/mol, respectively.","PeriodicalId":448411,"journal":{"name":"Open Journal of Nano","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127380667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Modification of PVDF Membranes Using Dopamine/Zinc Oxide for Lead Removal from Aqueous Media","authors":"İrem Sevim Üçel, E. Demirel","doi":"10.56171/ojn.1058222","DOIUrl":"https://doi.org/10.56171/ojn.1058222","url":null,"abstract":"","PeriodicalId":448411,"journal":{"name":"Open Journal of Nano","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121242540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Çelik, A. Demi̇rag, Ali Osman Coşgun, A. Özel, S. Akyüz
The molecular structures of the lowest-energy conformers of donepezil (C24H29NO3), rivastigmine (C14H22N2O2), and galantamine (C17H21NO3), which are extensively used in Alzheimer's disease and other memory disorders, were identified using the Spartan06 program and the MMFF method. The optimized geometries, obtained with the same method, were used as initial data in molecular docking investigations with the Acetylcholinesterase enzyme. The binding modes, binding affinities, and interactions were comparatively determined as consequence of the calculations.
{"title":"Computational Investigation of the Interaction Mechanism of Some anti-Alzheimer Drugs with the Acetylcholinesterase Enzyme","authors":"S. Çelik, A. Demi̇rag, Ali Osman Coşgun, A. Özel, S. Akyüz","doi":"10.56171/ojn.1109606","DOIUrl":"https://doi.org/10.56171/ojn.1109606","url":null,"abstract":"The molecular structures of the lowest-energy conformers of donepezil (C24H29NO3), rivastigmine (C14H22N2O2), and galantamine (C17H21NO3), which are extensively used in Alzheimer's disease and other memory disorders, were identified using the Spartan06 program and the MMFF method. The optimized geometries, obtained with the same method, were used as initial data in molecular docking investigations with the Acetylcholinesterase enzyme. The binding modes, binding affinities, and interactions were comparatively determined as consequence of the calculations.","PeriodicalId":448411,"journal":{"name":"Open Journal of Nano","volume":"16 4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125757246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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