Pub Date : 2010-12-31DOI: 10.4078/JKRA.2010.17.4.337
Tae-Hwan Kim
{"title":"Anti TNF Therapy and Serious Infection in Rheumatologic Field","authors":"Tae-Hwan Kim","doi":"10.4078/JKRA.2010.17.4.337","DOIUrl":"https://doi.org/10.4078/JKRA.2010.17.4.337","url":null,"abstract":"","PeriodicalId":448877,"journal":{"name":"The Journal of The Korean Rheumatism Association","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122999094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-12-01DOI: 10.4078/JKRA.2010.17.4.360
J. Hwang, Ju-Kyoung Song, I. Yoo, S. Song, Jinhyun Kim, Y. Lee, Y. Bae, H. Choi, H. Baek, S. Kang
{"title":"Associations between TBX21 Gene Polymorphisms and Korean Patients with Behçet's Disease","authors":"J. Hwang, Ju-Kyoung Song, I. Yoo, S. Song, Jinhyun Kim, Y. Lee, Y. Bae, H. Choi, H. Baek, S. Kang","doi":"10.4078/JKRA.2010.17.4.360","DOIUrl":"https://doi.org/10.4078/JKRA.2010.17.4.360","url":null,"abstract":"","PeriodicalId":448877,"journal":{"name":"The Journal of The Korean Rheumatism Association","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129030994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-12-01DOI: 10.4078/JKRA.2010.17.4.454
Hae-Rim Kim, Jeeyoung Oh, Sang-Heon Lee
환 자: 78세 여자 주 소: 1년간의 왼손 저림 현병력: 1년 전부터 시작된 왼쪽 1∼3번째 손가락 저림으로 타병원에서 경구약제 투여 받았으나 밤에 잠을 못 잘 정도로 통증과 저림이 더 심해져 내원하 였다. 과거력: 특이소견 없었다. 이학적 소견: 좌측 손의 티넬 징후 및 팔렌씨 징 후가 양성이었고, 엄지두덩의 근위축이 관찰되었다. 손목 관절의 종창, 압통이나 관절운동 제한 등은 관 찰되지 않았다. 검사실 소견: 혈액 검사상 이상소견 없었으며, 신 경전도 검사상 손목 부분의 좌측 정중신경의 종말잠 시(terminal latency)가 지연되어 있었다. 방사선 소견: 초음파(7∼15 MHz transducer, EnVisor, Phillips Medical Systems, Bothell, WA, USA)상 손목 굴 내부에 12×6 mm 크기의 고에코성 타원형 종괴 가 관찰되었고, 이 종괴에 의해 정중신경이 압박되 었다(그림 1). 자기공명영상 결과 손목굴 내 12×12× 6 mm 크기의 타원형 석회성 병변이 조영 증강된 정 중신경을 압박하고 있었고, 손목굴 내부의 굽힘 힘 줄의 조영 증강 및 손목굴 입구의 정중 신경에는 종 창이 관찰되었다(그림 2). 진 단: 석회성 건염에 동반된 석회화 침착 종괴 에 의한 손목굴증후군으로 진단하였다. 치료 및 경과: 환자가 고령임을 이유로 수술적 제 거를 거부하여 대증적인 약물 투여 중이다.
{"title":"Differential Diagnosis for the Cause of Carpal Tunnel Syndrome Using Musculoskeletal Ultrasound","authors":"Hae-Rim Kim, Jeeyoung Oh, Sang-Heon Lee","doi":"10.4078/JKRA.2010.17.4.454","DOIUrl":"https://doi.org/10.4078/JKRA.2010.17.4.454","url":null,"abstract":"환 자: 78세 여자 주 소: 1년간의 왼손 저림 현병력: 1년 전부터 시작된 왼쪽 1∼3번째 손가락 저림으로 타병원에서 경구약제 투여 받았으나 밤에 잠을 못 잘 정도로 통증과 저림이 더 심해져 내원하 였다. 과거력: 특이소견 없었다. 이학적 소견: 좌측 손의 티넬 징후 및 팔렌씨 징 후가 양성이었고, 엄지두덩의 근위축이 관찰되었다. 손목 관절의 종창, 압통이나 관절운동 제한 등은 관 찰되지 않았다. 검사실 소견: 혈액 검사상 이상소견 없었으며, 신 경전도 검사상 손목 부분의 좌측 정중신경의 종말잠 시(terminal latency)가 지연되어 있었다. 방사선 소견: 초음파(7∼15 MHz transducer, EnVisor, Phillips Medical Systems, Bothell, WA, USA)상 손목 굴 내부에 12×6 mm 크기의 고에코성 타원형 종괴 가 관찰되었고, 이 종괴에 의해 정중신경이 압박되 었다(그림 1). 자기공명영상 결과 손목굴 내 12×12× 6 mm 크기의 타원형 석회성 병변이 조영 증강된 정 중신경을 압박하고 있었고, 손목굴 내부의 굽힘 힘 줄의 조영 증강 및 손목굴 입구의 정중 신경에는 종 창이 관찰되었다(그림 2). 진 단: 석회성 건염에 동반된 석회화 침착 종괴 에 의한 손목굴증후군으로 진단하였다. 치료 및 경과: 환자가 고령임을 이유로 수술적 제 거를 거부하여 대증적인 약물 투여 중이다.","PeriodicalId":448877,"journal":{"name":"The Journal of The Korean Rheumatism Association","volume":"136 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114739061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-12-01DOI: 10.4078/JKRA.2010.17.4.386
Chae Ik Ra, Ki Hwan Kim, Jong Gyun Ahn, D. S. Kim
Objective: Controversies exist as to whether early treatment for Kawasaki disease might increase the need for additional intravenous immunoglobulin (IVIG) treatment and whether it could reduce cardiac complications. We conducted this study to add useful clues, which could be helpful when setting up a treatment plan. Methods: 359 patients who were newly diagnosed with Kawasaki disease at Severance Hospital were divided into two groups; patients who received IVIG treatment within 3 days (group A) and those who received IVIG treatment after 3 days (groups B and C). We compared the laboratory data, fever duration, frequency of additional IVIG treatment, and echocardiography follow-up results. Results: IVIG was administered 1.11±0.34 (mean±SD), 1.15±0.39, and 1.17±0.42 times in groups A, B, and C, respectively; p=0.29 (A vs. B), p=0.21 (A vs. C). The incidence of cardiac complications checked within the first 2 weeks from disease onset was 3.6%, 5.2%, and 5.1% in groups A, B, and C, respectively; p=0.52 (A vs. B), p=0.55 (A vs. C), and the values checked at 2 months were 3.6%, 5.6%, and 5.7% in groups A, B, and C, respectively; p=0.43 (A vs. B), p=0.43 (A vs. C). Conclusion: Early IVIG treatment in patients with Kawasaki disease decreased fever duration and may prevent cardiac complications by limiting inflammation.
目的:关于川崎病的早期治疗是否会增加静脉注射免疫球蛋白(IVIG)治疗的需要以及是否可以减少心脏并发症存在争议。我们进行这项研究是为了增加有用的线索，这可能有助于制定治疗计划。方法:将Severance医院新诊断的川崎病患者359例分为两组;3天内接受IVIG治疗的患者(A组)和3天后接受IVIG治疗的患者(B组和C组)。我们比较了实验室数据、发烧持续时间、额外IVIG治疗的频率和超声心动图随访结果。结果:A、B、C组IVIG给药次数分别为1.11±0.34次(mean±SD)、1.15±0.39次、1.17±0.42次;p=0.29 (A组vs. B组)，p=0.21 (A组vs. C组)。A、B、C组发病后2周内检查心脏并发症的发生率分别为3.6%、5.2%和5.1%;p=0.52 (A vs. B)， p=0.55 (A vs. C)， 2个月时A、B、C组的检查值分别为3.6%、5.6%、5.7%;p=0.43 (A vs B)， p=0.43 (A vs C)。结论:川崎病患者早期IVIG治疗可减少发热时间，并可通过限制炎症预防心脏并发症。
{"title":"The Effect of Early Immunoglobulin Treatment on the Course of Kawasaki Disease","authors":"Chae Ik Ra, Ki Hwan Kim, Jong Gyun Ahn, D. S. Kim","doi":"10.4078/JKRA.2010.17.4.386","DOIUrl":"https://doi.org/10.4078/JKRA.2010.17.4.386","url":null,"abstract":"Objective: Controversies exist as to whether early treatment for Kawasaki disease might increase the need for additional intravenous immunoglobulin (IVIG) treatment and whether it could reduce cardiac complications. We conducted this study to add useful clues, which could be helpful when setting up a treatment plan. Methods: 359 patients who were newly diagnosed with Kawasaki disease at Severance Hospital were divided into two groups; patients who received IVIG treatment within 3 days (group A) and those who received IVIG treatment after 3 days (groups B and C). We compared the laboratory data, fever duration, frequency of additional IVIG treatment, and echocardiography follow-up results. Results: IVIG was administered 1.11±0.34 (mean±SD), 1.15±0.39, and 1.17±0.42 times in groups A, B, and C, respectively; p=0.29 (A vs. B), p=0.21 (A vs. C). The incidence of cardiac complications checked within the first 2 weeks from disease onset was 3.6%, 5.2%, and 5.1% in groups A, B, and C, respectively; p=0.52 (A vs. B), p=0.55 (A vs. C), and the values checked at 2 months were 3.6%, 5.6%, and 5.7% in groups A, B, and C, respectively; p=0.43 (A vs. B), p=0.43 (A vs. C). Conclusion: Early IVIG treatment in patients with Kawasaki disease decreased fever duration and may prevent cardiac complications by limiting inflammation.","PeriodicalId":448877,"journal":{"name":"The Journal of The Korean Rheumatism Association","volume":"05 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127434243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-12-01DOI: 10.4078/JKRA.2010.17.4.431
Y. Jeong, H. S. Kim, Eun Jeong Kim, Yunsuek Kim, Chiyoung Park, B. Shin, G. Park
The development of malignant tumors is a more frequent finding in lupus patients than the general population. However, the incidence of multiple myeloma associated with systemic lupus erythematosus (SLE) is a rare manifestation. SLE is an autoimmune disease characterized by B cell hyperactivity, formation of autoantibodies, and multi-clonal hypergammaglobulinemia. Serum immunoglobulin increases, with a specific increase in IgG, which is due to an increase in autoantibody formation related to extrinsic and intrinsic antigens. We report on a patient with SLE combined with IgG, lambda type nonsecretory multiple myeloma, which was diagnosed with refractory anemia and hypergammaglobulinemia.
{"title":"A Case of Non Secretory Type Multiple Myeloma Associated with Systemic Lupus Erythematosus","authors":"Y. Jeong, H. S. Kim, Eun Jeong Kim, Yunsuek Kim, Chiyoung Park, B. Shin, G. Park","doi":"10.4078/JKRA.2010.17.4.431","DOIUrl":"https://doi.org/10.4078/JKRA.2010.17.4.431","url":null,"abstract":"The development of malignant tumors is a more frequent finding in lupus patients than the general population. However, the incidence of multiple myeloma associated with systemic lupus erythematosus (SLE) is a rare manifestation. SLE is an autoimmune disease characterized by B cell hyperactivity, formation of autoantibodies, and multi-clonal hypergammaglobulinemia. Serum immunoglobulin increases, with a specific increase in IgG, which is due to an increase in autoantibody formation related to extrinsic and intrinsic antigens. We report on a patient with SLE combined with IgG, lambda type nonsecretory multiple myeloma, which was diagnosed with refractory anemia and hypergammaglobulinemia.","PeriodicalId":448877,"journal":{"name":"The Journal of The Korean Rheumatism Association","volume":"111 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116574263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-12-01DOI: 10.4078/JKRA.2010.17.4.426
J. Im, M. Park, Tae Wook Kim, Min Jeong Jeong, Jae Shik Jeong, C. Lee
Human immunodeficiency virus infection is associated with a variety of rheumatic manifestations. The pathogenic mechanisms are not well defined, but evidences suggests multiple mechanisms, including direct or indirect human immunodeficiency virus involvement with a genetic, immunological, and environmental basis. Rheumatic manifestations can occur during the course of human immunodeficiency virus infection, and their presence is associated with an overall poor prognosis for the underlying human immunodeficiency virus infection. We report a case of a 37-year-old male who had ankylosing spondylitis with a human immunodeficiency virus infection.
{"title":"A Case of Ankylosing Spondylitis in a Patient with Human Immunodeficiency Virus","authors":"J. Im, M. Park, Tae Wook Kim, Min Jeong Jeong, Jae Shik Jeong, C. Lee","doi":"10.4078/JKRA.2010.17.4.426","DOIUrl":"https://doi.org/10.4078/JKRA.2010.17.4.426","url":null,"abstract":"Human immunodeficiency virus infection is associated with a variety of rheumatic manifestations. The pathogenic mechanisms are not well defined, but evidences suggests multiple mechanisms, including direct or indirect human immunodeficiency virus involvement with a genetic, immunological, and environmental basis. Rheumatic manifestations can occur during the course of human immunodeficiency virus infection, and their presence is associated with an overall poor prognosis for the underlying human immunodeficiency virus infection. We report a case of a 37-year-old male who had ankylosing spondylitis with a human immunodeficiency virus infection.","PeriodicalId":448877,"journal":{"name":"The Journal of The Korean Rheumatism Association","volume":"146 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116477284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-12-01DOI: 10.4078/JKRA.2010.17.4.400
Dong Chan Kim, D. Rim, Youngtong Kim, J. Ko, Chan Kum Park, Sung Soo Park, J. Jun
A 62-year-old Korean woman was admitted to our department to evaluate a chronic cough and sputum, which had begun several weeks ago. The patient had been diagnosed with systemic sclerosis in 2004. Autoantibody screening tests were negative for the anticentromere and antitopoisomerase antibodies. She received therapy with combined cyclophosphamide, a calcium channel blocker, D-penicillamine, and low dose steroid. In 2006, a pulmonary function test (PFT) showed a restrictive pattern, and a computed tomography (CT) scan of the lungs revealed interstitial lung disease, but no symptoms were present, so we maintained her on the medication. In October 2008, a chest x-ray and CT scan of the lungs demonstrated aggravation with bilateral basal interstitial infiltrates and hilar lymphadenopathy. Cyclophosphamide pulse therapy was conducted six times during 6 months, but there was no change on her chest CT and PFT, and she had no symptoms, so we decided to follow up. On admission, no significant interval change in the reticular opacity of both lower lungs was observed, but several lymph nodes were enlarged on a chest and neck CT. The skin showed multiple large polygonal-shaped scaled lesions on her upper and lower extremities. Biopsies were taken from the skin of the lower extremities and the left cervical lymph node. Typical non-caseating granulomas corresponding to sarcoidosis were found along with systemic sclerosis findings.
{"title":"Systemic Sclerosis Coincidence with Sarcoidosis: A Case Report and Review of the Literature","authors":"Dong Chan Kim, D. Rim, Youngtong Kim, J. Ko, Chan Kum Park, Sung Soo Park, J. Jun","doi":"10.4078/JKRA.2010.17.4.400","DOIUrl":"https://doi.org/10.4078/JKRA.2010.17.4.400","url":null,"abstract":"A 62-year-old Korean woman was admitted to our department to evaluate a chronic cough and sputum, which had begun several weeks ago. The patient had been diagnosed with systemic sclerosis in 2004. Autoantibody screening tests were negative for the anticentromere and antitopoisomerase antibodies. She received therapy with combined cyclophosphamide, a calcium channel blocker, D-penicillamine, and low dose steroid. In 2006, a pulmonary function test (PFT) showed a restrictive pattern, and a computed tomography (CT) scan of the lungs revealed interstitial lung disease, but no symptoms were present, so we maintained her on the medication. In October 2008, a chest x-ray and CT scan of the lungs demonstrated aggravation with bilateral basal interstitial infiltrates and hilar lymphadenopathy. Cyclophosphamide pulse therapy was conducted six times during 6 months, but there was no change on her chest CT and PFT, and she had no symptoms, so we decided to follow up. On admission, no significant interval change in the reticular opacity of both lower lungs was observed, but several lymph nodes were enlarged on a chest and neck CT. The skin showed multiple large polygonal-shaped scaled lesions on her upper and lower extremities. Biopsies were taken from the skin of the lower extremities and the left cervical lymph node. Typical non-caseating granulomas corresponding to sarcoidosis were found along with systemic sclerosis findings.","PeriodicalId":448877,"journal":{"name":"The Journal of The Korean Rheumatism Association","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116859197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-12-01DOI: 10.4078/JKRA.2010.17.4.376
H. Jung, Hwajeong Lee, J. Choe, Sung-Hoon Park, Seong-Kyu Kim, Sang-Hyon Kim, Ju-youn kim, S. Han, Seong-Ho Kim
Objective: This study was designed to identify prognostic determinants of radiographical severity in patients with ankylosing spondylitis (AS) living in Daegu and Kyungpook territories. Methods: One hundred-nineteen patients with AS were consecutively enrolled from four regional general hospitals. Clinical data including smoking habits, alcohol intake, disease duration, HLA-B27 positivity, involvement of peripheral joints, occupational activity, and regular exercise were investigated. Radiographical severity was assessed by the Modified Stoke Ankylosing Spondylitis Spinal Score (mSASSS). Statistical analyses were performed using the independent Student's t-test, Pearson's correlation coefficient analysis, and multivariate re- gression analysis. Results: Radiographical severity, as evaluated with the mSASSS, was associated with age of disease onset (p=0.011) and disease duration (p<0.001). Additionally, mSASSS was signifi-
{"title":"Determining Clinical Risk Factors for Radiographical Severity in Patients with Ankylosing Spondylitis in Daegu and Kyungpook Territories","authors":"H. Jung, Hwajeong Lee, J. Choe, Sung-Hoon Park, Seong-Kyu Kim, Sang-Hyon Kim, Ju-youn kim, S. Han, Seong-Ho Kim","doi":"10.4078/JKRA.2010.17.4.376","DOIUrl":"https://doi.org/10.4078/JKRA.2010.17.4.376","url":null,"abstract":"Objective: This study was designed to identify prognostic determinants of radiographical severity in patients with ankylosing spondylitis (AS) living in Daegu and Kyungpook territories. Methods: One hundred-nineteen patients with AS were consecutively enrolled from four regional general hospitals. Clinical data including smoking habits, alcohol intake, disease duration, HLA-B27 positivity, involvement of peripheral joints, occupational activity, and regular exercise were investigated. Radiographical severity was assessed by the Modified Stoke Ankylosing Spondylitis Spinal Score (mSASSS). Statistical analyses were performed using the independent Student's t-test, Pearson's correlation coefficient analysis, and multivariate re- gression analysis. Results: Radiographical severity, as evaluated with the mSASSS, was associated with age of disease onset (p=0.011) and disease duration (p<0.001). Additionally, mSASSS was signifi-","PeriodicalId":448877,"journal":{"name":"The Journal of The Korean Rheumatism Association","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130178052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-12-01DOI: 10.4078/JKRA.2010.17.4.406
S. Chang, Hyewon Kim, C. Yun, E. Kang, E. Lee, Y. Lee, Eun‐Bong Lee, Y. Song
Wegener’s grandulomatosis (WG) is a systemic small-vessel vasculitis characterized by necrotizing granulomatous lesions and anti-neutrophil cytoplasmic antibodies (ANCA). WG frequently affects the upper and lower respiratory tracts and kidney but involvement of the pachymeninges or large vessels has rarely been reported. We report the first case of WG with periaortitis and pachymeningitis in Korea. A 57-year-old female complained of a stabbing headache, paresthesia below the thoracic 4th nerve level, and lower extremity weakness. During her course, she developed otitis media with sensorineural hearing loss, nodular scleritis, and microhematuria. A neuroimaging study showed an intradural mass in the area from the cervical 7th spine to the thoracic 5th spine, left cerebral convexity, and the left petrous area. A chest computed tomography scan revealed an enhanced and thickened aortic arch. A dural biopsy showed necrotizing granulomatous inflammation, and anti-MPO ANCA was positive. Under a diagnosis of WG, she received high-dose glucocorticoid and oral cyclophosphamide with improvement.
{"title":"A Case of Wegener's Granulomatosis with Periaortitis and Pachymeningitis","authors":"S. Chang, Hyewon Kim, C. Yun, E. Kang, E. Lee, Y. Lee, Eun‐Bong Lee, Y. Song","doi":"10.4078/JKRA.2010.17.4.406","DOIUrl":"https://doi.org/10.4078/JKRA.2010.17.4.406","url":null,"abstract":"Wegener’s grandulomatosis (WG) is a systemic small-vessel vasculitis characterized by necrotizing granulomatous lesions and anti-neutrophil cytoplasmic antibodies (ANCA). WG frequently affects the upper and lower respiratory tracts and kidney but involvement of the pachymeninges or large vessels has rarely been reported. We report the first case of WG with periaortitis and pachymeningitis in Korea. A 57-year-old female complained of a stabbing headache, paresthesia below the thoracic 4th nerve level, and lower extremity weakness. During her course, she developed otitis media with sensorineural hearing loss, nodular scleritis, and microhematuria. A neuroimaging study showed an intradural mass in the area from the cervical 7th spine to the thoracic 5th spine, left cerebral convexity, and the left petrous area. A chest computed tomography scan revealed an enhanced and thickened aortic arch. A dural biopsy showed necrotizing granulomatous inflammation, and anti-MPO ANCA was positive. Under a diagnosis of WG, she received high-dose glucocorticoid and oral cyclophosphamide with improvement.","PeriodicalId":448877,"journal":{"name":"The Journal of The Korean Rheumatism Association","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126665429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2010-12-01DOI: 10.4078/JKRA.2010.17.4.422
Seongsoo Park, J. Lee
Bullous pemphigoid is an autoimmune, subepidermal blistering disease commonly seen in the elderly. It is known as autoimmune bullous dermatoses with an estimated prevalence of 1 in 40,000 and shows no gender or racial predilection. It has an autoimmune nature with immunoglobulin (Ig) G and/or C3 complement targeting hemidesmosomal antigens located in the epidermal basement membrane zone. Drug-induced pemphigoid, although rare, can occur in patients taking penicillamine, furosemide, captopril, penicillin, or sulfasalazine, but infliximabinduced pemphigoid has not been reported. We experienced a case of infliximab-induced pemphigoid in 54-year-old woman with a 17-year history of rheumatoid arthritis.
{"title":"A Case of Bullous Pemphigoid Arising after Infliximab Therapy in a Patient with Rheumatoid Arthritis","authors":"Seongsoo Park, J. Lee","doi":"10.4078/JKRA.2010.17.4.422","DOIUrl":"https://doi.org/10.4078/JKRA.2010.17.4.422","url":null,"abstract":"Bullous pemphigoid is an autoimmune, subepidermal blistering disease commonly seen in the elderly. It is known as autoimmune bullous dermatoses with an estimated prevalence of 1 in 40,000 and shows no gender or racial predilection. It has an autoimmune nature with immunoglobulin (Ig) G and/or C3 complement targeting hemidesmosomal antigens located in the epidermal basement membrane zone. Drug-induced pemphigoid, although rare, can occur in patients taking penicillamine, furosemide, captopril, penicillin, or sulfasalazine, but infliximabinduced pemphigoid has not been reported. We experienced a case of infliximab-induced pemphigoid in 54-year-old woman with a 17-year history of rheumatoid arthritis.","PeriodicalId":448877,"journal":{"name":"The Journal of The Korean Rheumatism Association","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131268150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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