This report describes a preterm male infant with phenotypic features of mild facial dysmorphism, congenital abnormalities of the hands and feet, corneal clouding, hypertonia, bilateral sensorineural hearing loss, and bilateral ventriculomegaly. His clinical course was significant for severe cyanotic episodes associated with the advancement of feed volume. Microarray analysis identified a large constitutional de novo deletion of 7q21.3q31.1. This rare deletion has never been reported in a preterm infant, and the management of this patient will help offer clinical guidance for this genetic condition.
{"title":"A case of 7q21.3q31.1 deletion in a preterm boy with feeding intolerance and cyanotic episodes","authors":"A. Jones","doi":"10.4103/jcn.jcn_119_21","DOIUrl":"https://doi.org/10.4103/jcn.jcn_119_21","url":null,"abstract":"This report describes a preterm male infant with phenotypic features of mild facial dysmorphism, congenital abnormalities of the hands and feet, corneal clouding, hypertonia, bilateral sensorineural hearing loss, and bilateral ventriculomegaly. His clinical course was significant for severe cyanotic episodes associated with the advancement of feed volume. Microarray analysis identified a large constitutional de novo deletion of 7q21.3q31.1. This rare deletion has never been reported in a preterm infant, and the management of this patient will help offer clinical guidance for this genetic condition.","PeriodicalId":45332,"journal":{"name":"Journal of Clinical Neonatology","volume":"11 1","pages":"136 - 138"},"PeriodicalIF":0.2,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47164303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bhoojata Gondi, S. Laxman, Venkata Rao Paturi, K. Maram
Umbilical cord with two umbilical veins is a rarely reported anomaly. Four-vessel cord is known to be associated with other congenital anomalies. Second umbilical vein is usually due to persistence of right umbilical vein. We report two cases of two umbilical veins; one newborn with four-vessel umbilical cord with two umbilical veins, who presented with severe pulmonary arterial hypertension, and another newborn with three-vessel umbilical cord with two umbilical veins, diagnosed to have transposition of great arteries. The presence of two umbilical veins mandates comprehensive workup to rule out other congenital anomalies. However, as highlighted by our first case, the presence of two umbilical veins is not always an ominous sign but could be seen in otherwise normal baby.
{"title":"Umbilical cord with two umbilical veins: A report of two cases","authors":"Bhoojata Gondi, S. Laxman, Venkata Rao Paturi, K. Maram","doi":"10.4103/jcn.jcn_100_21","DOIUrl":"https://doi.org/10.4103/jcn.jcn_100_21","url":null,"abstract":"Umbilical cord with two umbilical veins is a rarely reported anomaly. Four-vessel cord is known to be associated with other congenital anomalies. Second umbilical vein is usually due to persistence of right umbilical vein. We report two cases of two umbilical veins; one newborn with four-vessel umbilical cord with two umbilical veins, who presented with severe pulmonary arterial hypertension, and another newborn with three-vessel umbilical cord with two umbilical veins, diagnosed to have transposition of great arteries. The presence of two umbilical veins mandates comprehensive workup to rule out other congenital anomalies. However, as highlighted by our first case, the presence of two umbilical veins is not always an ominous sign but could be seen in otherwise normal baby.","PeriodicalId":45332,"journal":{"name":"Journal of Clinical Neonatology","volume":"11 1","pages":"55 - 57"},"PeriodicalIF":0.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45513945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I. Mahfouz, F. Asali, Tasneem Khalfieh, H. Saleem, Sereen Diab, Batool Samara, H. Jaber
Introduction: The World Health Organization recommends early initiation of breastfeeding (EIBF). This is because breastfeeding is important for the child's development and has maternal benefits. Current literature has focused on sociodemographic factors, and the evidence supporting antenatal, peripartum, and neonatal variables is limited and contradicting. The main aim of this study is to report the rates of early breastfeeding initiation and their antenatal, peripartum, and neonatal correlates. Materials and Methods: A prospective observational study of pregnant women who attended the labor ward of the Specialty Hospital in Amman, Jordan between September 1, 2019, and June 1, 2020, was conducted. Inclusion criteria required women to be 18 years of age or more. Demographic, antenatal, peripartum, and neonatal data were collected. The timing of breastfeeding initiation was recorded in the 1st h and between 1 and 24 h and then data were analyzed. Results: A total of 300 women were recruited with mean age of 29.5 years and mean gestational age being 38.6 weeks. In addition, breastfeeding initiation rates were 26.3% and 65.5% within the 1st h and between 1 and 24 h, respectively. Antenatal, peripartum, and neonatal variables that were associated with lower rates of EIBF (P < 0.05) include antenatal obstetrics complications, induction of labor, assisted vaginal delivery, caesarean section (CS), CS performed on maternal request, CS under general anesthesia, surgical site pain, mother's perception of inadequate pain management, preterm delivery, low Apgar scores, low birth weight, neonatal intensive care unit admission, and less frequent rooming-in. Conclusion: Rates of breastfeeding initiation within the first hour and between 1 and 24 h of delivery were 26.3% and 65.5%, respectively. Compared to antenatal variables, the peripartum and neonatal variables are more likely to have significant effects on EIBF. Therefore, more obstetric attention should focus on these factors to improve rates of initiating breastfeeding early.
{"title":">Early initiation of breastfeeding: Antenatal, peripartum, and neonatal correlates","authors":"I. Mahfouz, F. Asali, Tasneem Khalfieh, H. Saleem, Sereen Diab, Batool Samara, H. Jaber","doi":"10.4103/jcn.jcn_25_21","DOIUrl":"https://doi.org/10.4103/jcn.jcn_25_21","url":null,"abstract":"Introduction: The World Health Organization recommends early initiation of breastfeeding (EIBF). This is because breastfeeding is important for the child's development and has maternal benefits. Current literature has focused on sociodemographic factors, and the evidence supporting antenatal, peripartum, and neonatal variables is limited and contradicting. The main aim of this study is to report the rates of early breastfeeding initiation and their antenatal, peripartum, and neonatal correlates. Materials and Methods: A prospective observational study of pregnant women who attended the labor ward of the Specialty Hospital in Amman, Jordan between September 1, 2019, and June 1, 2020, was conducted. Inclusion criteria required women to be 18 years of age or more. Demographic, antenatal, peripartum, and neonatal data were collected. The timing of breastfeeding initiation was recorded in the 1st h and between 1 and 24 h and then data were analyzed. Results: A total of 300 women were recruited with mean age of 29.5 years and mean gestational age being 38.6 weeks. In addition, breastfeeding initiation rates were 26.3% and 65.5% within the 1st h and between 1 and 24 h, respectively. Antenatal, peripartum, and neonatal variables that were associated with lower rates of EIBF (P < 0.05) include antenatal obstetrics complications, induction of labor, assisted vaginal delivery, caesarean section (CS), CS performed on maternal request, CS under general anesthesia, surgical site pain, mother's perception of inadequate pain management, preterm delivery, low Apgar scores, low birth weight, neonatal intensive care unit admission, and less frequent rooming-in. Conclusion: Rates of breastfeeding initiation within the first hour and between 1 and 24 h of delivery were 26.3% and 65.5%, respectively. Compared to antenatal variables, the peripartum and neonatal variables are more likely to have significant effects on EIBF. Therefore, more obstetric attention should focus on these factors to improve rates of initiating breastfeeding early.","PeriodicalId":45332,"journal":{"name":"Journal of Clinical Neonatology","volume":"11 1","pages":"30 - 37"},"PeriodicalIF":0.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49123350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Luca Bonadies, N. Doglioni, E. Cuppini, C. Minotti, Eugenio Baraldi
A newborn with microcephaly presented hemorrhagic bullous purpura triggered by heat in the 1st h of life. Doppler arterial and venous ultrasound excluded vascular complications. Cytomegalovirus was detected in blood, urine, and serum of the lesions. The final diagnosis was cytomegalovirus congenital infection due to reactivation in an immune mother, with associated purpuric rash, confirmed by cerebral magnetic resonance imaging.
{"title":"A bullous purpura triggered by warming in a newborn with congenital cytomegalovirus infection","authors":"Luca Bonadies, N. Doglioni, E. Cuppini, C. Minotti, Eugenio Baraldi","doi":"10.4103/jcn.jcn_37_21","DOIUrl":"https://doi.org/10.4103/jcn.jcn_37_21","url":null,"abstract":"A newborn with microcephaly presented hemorrhagic bullous purpura triggered by heat in the 1st h of life. Doppler arterial and venous ultrasound excluded vascular complications. Cytomegalovirus was detected in blood, urine, and serum of the lesions. The final diagnosis was cytomegalovirus congenital infection due to reactivation in an immune mother, with associated purpuric rash, confirmed by cerebral magnetic resonance imaging.","PeriodicalId":45332,"journal":{"name":"Journal of Clinical Neonatology","volume":"11 1","pages":"58 - 60"},"PeriodicalIF":0.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43578052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Mirnia, M. Kadivar, Razieh Sangsari, M. Saeedi, M. Kaveh, M. Maleki, Rangarirai Makuku
Objective: The objective of this study is aimed at investigating and evaluating respiratory patterns between infants hospitalized with brief resolved unexplained event (BRUE) and the control group. Methods: A convenient sampling method was used to select 52 patients presented at an urban, tertiary, and teaching pediatric hospital fitting the American Academy of Pediatrics' criteria of a lower-risk BRUE from December 2019 to December 2020. A random probability sampling method was used to select 52 patients as a control group. A NINIX apnea monitoring device was used to record respiratory time patterns and analyzed with SPSS 25. Results: A total of 104 participants participated in the study. Our study found that inspiration time (0.31 ± 0.04), expiratory time (0.93 ± 0.14), respiratory rate (38.48 ± 4.38), body temperature (37.11 ± 0.20), and heart rate (137.90 ± 6.60) were not statistically different between both groups. Mean birth weight in the control group and BRUE were respectively (3.43 ± 0.39, 3.23 ± 0.35). Mean gestational age in the control and BRUE groups were respectively (38.94 ± 1.01, 39.0 ± 1.04). Mean postnatal age in the control and BRUE groups were respectively (17.19 ± 6.07, 17.32 ± 7.35). Birth weight (P = 0.08) was statistically significant between both groups. In one patient, we recorded breath arrest for more than 20 s. Conclusion: There were no significant differences in respiratory patterns between infants hospitalized with BRUE and the control group. Low birth weight and low APGAR score are possible risk factors for infants experiencing BRUE, and more investigations are required to establish underlying causes.
{"title":"Respiratory patterns in neonates hospitalized with brief resolved unexplained events","authors":"K. Mirnia, M. Kadivar, Razieh Sangsari, M. Saeedi, M. Kaveh, M. Maleki, Rangarirai Makuku","doi":"10.4103/jcn.jcn_69_21","DOIUrl":"https://doi.org/10.4103/jcn.jcn_69_21","url":null,"abstract":"Objective: The objective of this study is aimed at investigating and evaluating respiratory patterns between infants hospitalized with brief resolved unexplained event (BRUE) and the control group. Methods: A convenient sampling method was used to select 52 patients presented at an urban, tertiary, and teaching pediatric hospital fitting the American Academy of Pediatrics' criteria of a lower-risk BRUE from December 2019 to December 2020. A random probability sampling method was used to select 52 patients as a control group. A NINIX apnea monitoring device was used to record respiratory time patterns and analyzed with SPSS 25. Results: A total of 104 participants participated in the study. Our study found that inspiration time (0.31 ± 0.04), expiratory time (0.93 ± 0.14), respiratory rate (38.48 ± 4.38), body temperature (37.11 ± 0.20), and heart rate (137.90 ± 6.60) were not statistically different between both groups. Mean birth weight in the control group and BRUE were respectively (3.43 ± 0.39, 3.23 ± 0.35). Mean gestational age in the control and BRUE groups were respectively (38.94 ± 1.01, 39.0 ± 1.04). Mean postnatal age in the control and BRUE groups were respectively (17.19 ± 6.07, 17.32 ± 7.35). Birth weight (P = 0.08) was statistically significant between both groups. In one patient, we recorded breath arrest for more than 20 s. Conclusion: There were no significant differences in respiratory patterns between infants hospitalized with BRUE and the control group. Low birth weight and low APGAR score are possible risk factors for infants experiencing BRUE, and more investigations are required to establish underlying causes.","PeriodicalId":45332,"journal":{"name":"Journal of Clinical Neonatology","volume":"11 1","pages":"13 - 18"},"PeriodicalIF":0.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47483386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Surfactant replacement therapy is a major cornerstone in the successful management of neonates with respiratory distress syndrome. Until recently, the INtubate, SURfactant, Extubate protocol was the best a trade-off achieved to deliver the surfactant to the air exchanging respiratory epithelium against the barotrauma of prolonged intubation and ventilation. Minimal or Less Invasive Surfactant Therapy (MIST or LISA) was adapted in clinical practice as a gentler and a gentler way of delivering surfactant. LISA or MIST is associated with a significant reduction in the oxygen days and chronic lung disease, intraventricular hemorrhage of grade 2 or above, retinopathy of prematurity and other key neonatal outcomes. This translates into shortened neonatal intensive care unit stay and a significant reduction in the stress levels of neonatal nurses, parents, and caregivers. This procedure needs to be performed by skilled professionals with appropriate training to achieve the desired results.
{"title":"Minimally or less invasive surfactant replacement therapy in neonates: A narrative review","authors":"Gengaimuthu Karthikeyan","doi":"10.4103/jcn.jcn_2_21","DOIUrl":"https://doi.org/10.4103/jcn.jcn_2_21","url":null,"abstract":"Surfactant replacement therapy is a major cornerstone in the successful management of neonates with respiratory distress syndrome. Until recently, the INtubate, SURfactant, Extubate protocol was the best a trade-off achieved to deliver the surfactant to the air exchanging respiratory epithelium against the barotrauma of prolonged intubation and ventilation. Minimal or Less Invasive Surfactant Therapy (MIST or LISA) was adapted in clinical practice as a gentler and a gentler way of delivering surfactant. LISA or MIST is associated with a significant reduction in the oxygen days and chronic lung disease, intraventricular hemorrhage of grade 2 or above, retinopathy of prematurity and other key neonatal outcomes. This translates into shortened neonatal intensive care unit stay and a significant reduction in the stress levels of neonatal nurses, parents, and caregivers. This procedure needs to be performed by skilled professionals with appropriate training to achieve the desired results.","PeriodicalId":45332,"journal":{"name":"Journal of Clinical Neonatology","volume":"11 1","pages":"45 - 51"},"PeriodicalIF":0.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45451087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Hegde, S. Mohanty, Bharathi Balachander, A. Shubha
Newborns, especially preterms, have a higher risk of developing pneumothorax. We report a 33-week preemie who presented with recurrent, persistent right pneumothorax, which failed to resolve with standard treatment. The child underwent surgical removal of a suspect nonexpanding upper lobe of the right lung with clinical improvement. Histopathology was atypical but nearly consistent with congenital pulmonary airway malformation (CPAM). This report highlights the clinicopathological discordance noted and aims to draw an embryological explanation toward the atypical histomorphology of CPAM in preemies.
{"title":"Recurrent, persistent pneumothorax in a neonate: A cryptic cause","authors":"S. Hegde, S. Mohanty, Bharathi Balachander, A. Shubha","doi":"10.4103/jcn.jcn_133_21","DOIUrl":"https://doi.org/10.4103/jcn.jcn_133_21","url":null,"abstract":"Newborns, especially preterms, have a higher risk of developing pneumothorax. We report a 33-week preemie who presented with recurrent, persistent right pneumothorax, which failed to resolve with standard treatment. The child underwent surgical removal of a suspect nonexpanding upper lobe of the right lung with clinical improvement. Histopathology was atypical but nearly consistent with congenital pulmonary airway malformation (CPAM). This report highlights the clinicopathological discordance noted and aims to draw an embryological explanation toward the atypical histomorphology of CPAM in preemies.","PeriodicalId":45332,"journal":{"name":"Journal of Clinical Neonatology","volume":"11 1","pages":"61 - 63"},"PeriodicalIF":0.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45574340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Instrumental delivery is the most common cause of skull fracture in neonates. We report a depressed fracture with massive intracranial hemorrhage in a term female infant born by unassisted cesarean section after unremarkable pregnancy.
{"title":"Spontaneous skull fracture in a term infant","authors":"Wegdan Mawlana, M. Gharib, A. Osman","doi":"10.4103/jcn.jcn_109_21","DOIUrl":"https://doi.org/10.4103/jcn.jcn_109_21","url":null,"abstract":"Instrumental delivery is the most common cause of skull fracture in neonates. We report a depressed fracture with massive intracranial hemorrhage in a term female infant born by unassisted cesarean section after unremarkable pregnancy.","PeriodicalId":45332,"journal":{"name":"Journal of Clinical Neonatology","volume":"11 1","pages":"52 - 54"},"PeriodicalIF":0.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45149864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Nandy, T. Mondal, Divyoshanu M Ivan, Tapti Sengupta, Sanjusree Das, D. Goldar, A. Hazra, R. Mondal
Objective: We aimed to measure the joint angles of major joints in newborn babies to explore their association with gestational age (GA). Materials and Methods: This observational study was conducted to evaluate joint angles in healthy newborn infants, born between 28 and 41 completed weeks of gestation. Healthy and hemodynamically stable babies were selected by purposive sampling up to the 2nd day of life. Six major joints of upper and lower limbs (shoulder, elbow, wrist, hip, knee, and ankle) were assessed on either side. The joint angles and range of motion (ROM) achieved through predefined passive movements were measured by a single observer using a manual acrylic goniometer. The positioning of the joints during measurement was standardized. Results: A total of 433 newborn babies, belonging to different GA, were evaluated. The joint angles and ROM did not show any significant differences between right and left sides and between male and female babies. The ROM of flexion-extension and adduction-abduction movement at shoulder, angle of palmer-flexion at wrist, and angle of dorsiflexion at ankle, were observed to correlate strongly with GA (correlation coefficient r of –0.75, –0.74, –0.73, and –0.73, respectively). The relationships were inverse. A mathematical model based upon multiple regression analysis is proposed to predict GA from these four measurements. Conclusions: Structured clinical assessment of major joint angles in newborn babies has the potential to provide relatively precise estimation of GA, which may be used to add accuracy to modified New Ballard Score.
{"title":"Assessment of gestational age by new-born joint angles","authors":"A. Nandy, T. Mondal, Divyoshanu M Ivan, Tapti Sengupta, Sanjusree Das, D. Goldar, A. Hazra, R. Mondal","doi":"10.4103/jcn.jcn_116_21","DOIUrl":"https://doi.org/10.4103/jcn.jcn_116_21","url":null,"abstract":"Objective: We aimed to measure the joint angles of major joints in newborn babies to explore their association with gestational age (GA). Materials and Methods: This observational study was conducted to evaluate joint angles in healthy newborn infants, born between 28 and 41 completed weeks of gestation. Healthy and hemodynamically stable babies were selected by purposive sampling up to the 2nd day of life. Six major joints of upper and lower limbs (shoulder, elbow, wrist, hip, knee, and ankle) were assessed on either side. The joint angles and range of motion (ROM) achieved through predefined passive movements were measured by a single observer using a manual acrylic goniometer. The positioning of the joints during measurement was standardized. Results: A total of 433 newborn babies, belonging to different GA, were evaluated. The joint angles and ROM did not show any significant differences between right and left sides and between male and female babies. The ROM of flexion-extension and adduction-abduction movement at shoulder, angle of palmer-flexion at wrist, and angle of dorsiflexion at ankle, were observed to correlate strongly with GA (correlation coefficient r of –0.75, –0.74, –0.73, and –0.73, respectively). The relationships were inverse. A mathematical model based upon multiple regression analysis is proposed to predict GA from these four measurements. Conclusions: Structured clinical assessment of major joint angles in newborn babies has the potential to provide relatively precise estimation of GA, which may be used to add accuracy to modified New Ballard Score.","PeriodicalId":45332,"journal":{"name":"Journal of Clinical Neonatology","volume":"11 1","pages":"23 - 29"},"PeriodicalIF":0.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48721123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Neonatal bronchopulmonary dysplasia (BPD) is a chronic neonatal respiratory disease that is precipitated by prolonged oxygenation and mechanical ventilation (MV), leading to respiratory distress (RD). Aim of Study: The aim of the study is to assess the role of Vitamin D as adjuvant treatment in the prevention and management of BPD in neonates. Patients and Methods: Prospective randomized controlled trial with identification number TCTR20210622001 on 100 premature neonates who had RD and were put on MV. The examined neonates were classified into 2 groups: Group 1, which received Vitamin D (Vit D), and Group 2, which had placebo. Urinary β2-microglobulin (B2M) in addition to plasma Krebs von den Lungen-6 (KL-6) levels were measured on the 1st and the 14th day of hospitalization. Results: There was a decrease in urinary B2M and plasma KL-6 levels in Group 1, if compared with Group 2 neonates (P < 0.05). There was a decrease in hospitalization in Group 1 neonates (P < 0.05). Group 1 neonates showed a decrease of the developed BPD cases (P < 0.05). Conclusion: Vit D supplementation may help in the prevention of BPD in neonates, but further studies with larger number of neonates should be done. Recommendation: Routine Vit D supplementation in a dose of 800 IU to preterm who are susceptible to develop BPD.
背景：新生儿支气管肺发育不良（BPD）是一种慢性新生儿呼吸系统疾病，由长期氧合和机械通气（MV）引起，导致呼吸窘迫（RD）。研究目的：本研究的目的是评估维生素D作为辅助治疗在新生儿BPD预防和管理中的作用。患者和方法：识别号为TCTR20210622001的前瞻性随机对照试验，对100名患有RD并接受MV的早产儿进行研究。受试新生儿分为2组：第1组接受维生素D（Vit D）治疗，第2组接受安慰剂治疗。在住院第1天和第14天测量尿β2-微球蛋白（B2M）和血浆Krebs-von den Lungen-6（KL-6）水平。结果：与2组新生儿相比，1组新生儿尿B2M和血浆KL-6水平下降（P＜0.05）。1组新生儿住院率下降（P＞0.05），但还需要对更多新生儿进行进一步的研究。建议：对易患BPD的早产儿常规补充维生素D，剂量为800IU。
{"title":"Vitamin D supplementation in the prevention of neonatal bronchopulmonary dysplasia: Is it beneficial?","authors":"M. Elfarargy, G. Al-Ashmawy, Hany El Hady","doi":"10.4103/jcn.jcn_114_21","DOIUrl":"https://doi.org/10.4103/jcn.jcn_114_21","url":null,"abstract":"Background: Neonatal bronchopulmonary dysplasia (BPD) is a chronic neonatal respiratory disease that is precipitated by prolonged oxygenation and mechanical ventilation (MV), leading to respiratory distress (RD). Aim of Study: The aim of the study is to assess the role of Vitamin D as adjuvant treatment in the prevention and management of BPD in neonates. Patients and Methods: Prospective randomized controlled trial with identification number TCTR20210622001 on 100 premature neonates who had RD and were put on MV. The examined neonates were classified into 2 groups: Group 1, which received Vitamin D (Vit D), and Group 2, which had placebo. Urinary β2-microglobulin (B2M) in addition to plasma Krebs von den Lungen-6 (KL-6) levels were measured on the 1st and the 14th day of hospitalization. Results: There was a decrease in urinary B2M and plasma KL-6 levels in Group 1, if compared with Group 2 neonates (P < 0.05). There was a decrease in hospitalization in Group 1 neonates (P < 0.05). Group 1 neonates showed a decrease of the developed BPD cases (P < 0.05). Conclusion: Vit D supplementation may help in the prevention of BPD in neonates, but further studies with larger number of neonates should be done. Recommendation: Routine Vit D supplementation in a dose of 800 IU to preterm who are susceptible to develop BPD.","PeriodicalId":45332,"journal":{"name":"Journal of Clinical Neonatology","volume":"11 1","pages":"1 - 6"},"PeriodicalIF":0.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45047899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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