Pub Date : 2016-01-01DOI: 10.2209/tdcpublication.2016-1600
T. Sakamoto, Kotaro Hayakawa, Takenobu Ishii, K. Nojima, K. Sueishi
Scissor bite is defined as buccal displacement of the maxillary posterior teeth, with or without contact between the lingual surface of the maxillary lingual cusp and the buccal surface of the buccal cusp of its mandibular antagonist. Here we report treatment of bilateral scissor bite in the posterior region using rapid expansion following corticot-omy. The patient was a boy aged 17 years and 11 months in whom skeletal maxillary prognathism with bilateral scissor bite was diagnosed. The distance between the tips of canines and the mesial buccal cusps of the first molars was increased by use of a bonded rapid expansion appliance following corticotomy. Appropriate occlusion and lateral pro-file were obtained and maintained after retention. In addition, no gingival recession, hyperesthesia, or root surface caries occurred. These results suggest that mandibular lateral expansion following corticotomy is effective in young adult patients with a narrow mandibular arch.
{"title":"Bilateral Scissor Bite Treated by Rapid Mandibular Expansion Following Corticotomy.","authors":"T. Sakamoto, Kotaro Hayakawa, Takenobu Ishii, K. Nojima, K. Sueishi","doi":"10.2209/tdcpublication.2016-1600","DOIUrl":"https://doi.org/10.2209/tdcpublication.2016-1600","url":null,"abstract":"Scissor bite is defined as buccal displacement of the maxillary posterior teeth, with or without contact between the lingual surface of the maxillary lingual cusp and the buccal surface of the buccal cusp of its mandibular antagonist. Here we report treatment of bilateral scissor bite in the posterior region using rapid expansion following corticot-omy. The patient was a boy aged 17 years and 11 months in whom skeletal maxillary prognathism with bilateral scissor bite was diagnosed. The distance between the tips of canines and the mesial buccal cusps of the first molars was increased by use of a bonded rapid expansion appliance following corticotomy. Appropriate occlusion and lateral pro-file were obtained and maintained after retention. In addition, no gingival recession, hyperesthesia, or root surface caries occurred. These results suggest that mandibular lateral expansion following corticotomy is effective in young adult patients with a narrow mandibular arch.","PeriodicalId":45490,"journal":{"name":"Bulletin of Tokyo Dental College","volume":"57 4 1","pages":"269-280"},"PeriodicalIF":0.5,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2209/tdcpublication.2016-1600","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68185426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-01-01DOI: 10.2209/tdcpublication.2016-0100
Toshiyuki Handa, Takaaki Onodera, Y. Honda, Y. Koukita, T. Ichinohe
This study retrospectively compared blood loss during sagittal split ramus osteotomy in patients receiving propofol-remifentanil (R group) and those receiving propofol-fentanyl (F group). All patients underwent sagittal split ramus osteotomy under general anesthesia during the 3-year 4-month period between October 2007 and February 2011 in an operating room at Tokyo Dental College Suidobashi Hospital. Blood loss in the R group was significantly less than that in the F group. Mean arterial pressure and heart rate, measured at 20 and 15 min after tracheal intubation, respectively, were both lower in the R group. No marked change was observed in blood pressure in the R group under general anesthesia, however. Volume of urine was also larger in the R group. The results of this study suggest that remifentanil is effective in reducing intraoperative blood loss during sagittal split ramus osteotomy.
{"title":"Propofol-remifentanil is More Effective than Propofol-fentanyl in Decreasing Intraoperative Blood Loss during Sagittal Split Ramus Osteotomy.","authors":"Toshiyuki Handa, Takaaki Onodera, Y. Honda, Y. Koukita, T. Ichinohe","doi":"10.2209/tdcpublication.2016-0100","DOIUrl":"https://doi.org/10.2209/tdcpublication.2016-0100","url":null,"abstract":"This study retrospectively compared blood loss during sagittal split ramus osteotomy in patients receiving propofol-remifentanil (R group) and those receiving propofol-fentanyl (F group). All patients underwent sagittal split ramus osteotomy under general anesthesia during the 3-year 4-month period between October 2007 and February 2011 in an operating room at Tokyo Dental College Suidobashi Hospital. Blood loss in the R group was significantly less than that in the F group. Mean arterial pressure and heart rate, measured at 20 and 15 min after tracheal intubation, respectively, were both lower in the R group. No marked change was observed in blood pressure in the R group under general anesthesia, however. Volume of urine was also larger in the R group. The results of this study suggest that remifentanil is effective in reducing intraoperative blood loss during sagittal split ramus osteotomy.","PeriodicalId":45490,"journal":{"name":"Bulletin of Tokyo Dental College","volume":"57 3 1","pages":"169-73"},"PeriodicalIF":0.5,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2209/tdcpublication.2016-0100","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68185673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-01-01DOI: 10.2209/tdcpublication.57.1
Takeshi Wada, Tomofumi Takano, T. Ueda, K. Sakurai
The purpose of this study was to compare the adhesiveness of chewing gum to acrylic resin, cobalt-chromium alloy, and zirconia. Test specimens were fabricated using acrylic resin (resin), cobalt-chromium alloy (Co-Cr), and Ceria stabilized tetragonal zirconia polycrystal-based nanostructured zirconia/alumina composite (zirconia). Specimens of each material were attached to the upper and lower terminals of a digital force gauge. The operator masticated chewing gum, wiped off any saliva, and placed the gum on the lower specimen. The gum was compressed to a thickness of 1 mm between the upper and lower specimens. Thereafter, traction was applied to the upper specimen at a cross-head speed of 100 mm/min under 3 different conditions (dry, wet with distilled water, and wet with artificial saliva) to determine the maximum adhesive strength of the chewing gum. The statistical analysis was performed using the Bonferroni test after a one-way analysis of variance (α=0.05). Under dry conditions, adhesive force was 14.8±6.8 N for resin, 14.0±4.8 N for Co-Cr, and 4.3±2.3 N for zirconia. Significant differences were noted between resin and zirconia, and between Co-Cr and zirconia. When distilled water was applied to the specimen surface, the adhesive strength was 16.8±1.7 N for resin, 8.3±2.1 N for Co-Cr, and 2.7±0.8 N for zirconia. Significant differences were noted between resin and Co-Cr, resin and zirconia, and Co-Cr and zirconia. When artificial saliva was applied to the specimen surface, the adhesive force was 18.5±2.8 N for resin, 5.3±0.8 N for Co-Cr, and 3.0±1.7 N for zirconia. Significant differences were noted between resin and Co-Cr, and resin and zirconia. Chewing gum adhered less strongly to zirconia than to acrylic resin or cobalt-chromium alloy.
本研究的目的是比较口香糖与丙烯酸树脂、钴铬合金和氧化锆的黏附性。采用丙烯酸树脂(resin)、钴铬合金(Co-Cr)和铈稳定的四边形氧化锆多晶纳米结构氧化锆/氧化铝复合材料(zirconia)制备了测试样品。将每种材料的试样分别连接到数字测力计的上下两端。操作人员咀嚼口香糖，擦去任何唾液，并将口香糖放在较低的标本上。上下试件之间的胶被压缩至1mm厚度。然后，在3种不同的条件下(干法、蒸馏水湿法、人工唾液湿法)，以100 mm/min的十字头速度对上试样进行牵引，测定口香糖的最大粘接强度。单因素方差分析后，采用Bonferroni检验进行统计学分析(α=0.05)。在干燥条件下，树脂的粘附力为14.8±6.8 N, Co-Cr为14.0±4.8 N，氧化锆为4.3±2.3 N。树脂和氧化锆、钴铬和氧化锆之间存在显著差异。当蒸馏水作用于试样表面时，树脂的粘附强度为16.8±1.7 N, Co-Cr为8.3±2.1 N，氧化锆为2.7±0.8 N。树脂与Co-Cr、树脂与氧化锆、Co-Cr与氧化锆之间存在显著差异。当人工唾液作用于试样表面时，树脂的粘附力为18.5±2.8 N, Co-Cr为5.3±0.8 N，氧化锆为3.0±1.7 N。树脂与Co-Cr、树脂与氧化锆之间存在显著差异。口香糖对氧化锆的粘附力不如丙烯酸树脂或钴铬合金强。
{"title":"Comparison of Adhesive Resistance to Chewing Gum among Denture Base Acrylic Resin, Cobalt-Chromium Alloy, and Zirconia.","authors":"Takeshi Wada, Tomofumi Takano, T. Ueda, K. Sakurai","doi":"10.2209/tdcpublication.57.1","DOIUrl":"https://doi.org/10.2209/tdcpublication.57.1","url":null,"abstract":"The purpose of this study was to compare the adhesiveness of chewing gum to acrylic resin, cobalt-chromium alloy, and zirconia. Test specimens were fabricated using acrylic resin (resin), cobalt-chromium alloy (Co-Cr), and Ceria stabilized tetragonal zirconia polycrystal-based nanostructured zirconia/alumina composite (zirconia). Specimens of each material were attached to the upper and lower terminals of a digital force gauge. The operator masticated chewing gum, wiped off any saliva, and placed the gum on the lower specimen. The gum was compressed to a thickness of 1 mm between the upper and lower specimens. Thereafter, traction was applied to the upper specimen at a cross-head speed of 100 mm/min under 3 different conditions (dry, wet with distilled water, and wet with artificial saliva) to determine the maximum adhesive strength of the chewing gum. The statistical analysis was performed using the Bonferroni test after a one-way analysis of variance (α=0.05). Under dry conditions, adhesive force was 14.8±6.8 N for resin, 14.0±4.8 N for Co-Cr, and 4.3±2.3 N for zirconia. Significant differences were noted between resin and zirconia, and between Co-Cr and zirconia. When distilled water was applied to the specimen surface, the adhesive strength was 16.8±1.7 N for resin, 8.3±2.1 N for Co-Cr, and 2.7±0.8 N for zirconia. Significant differences were noted between resin and Co-Cr, resin and zirconia, and Co-Cr and zirconia. When artificial saliva was applied to the specimen surface, the adhesive force was 18.5±2.8 N for resin, 5.3±0.8 N for Co-Cr, and 3.0±1.7 N for zirconia. Significant differences were noted between resin and Co-Cr, and resin and zirconia. Chewing gum adhered less strongly to zirconia than to acrylic resin or cobalt-chromium alloy.","PeriodicalId":45490,"journal":{"name":"Bulletin of Tokyo Dental College","volume":"1 1","pages":"1-5"},"PeriodicalIF":0.5,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2209/tdcpublication.57.1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68187216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-01-01DOI: 10.2209/tdcpublication.2016-0001
M. N. Alhajj, Nassir J Musaad, I. A. Ismail
The objective of this study was to investigate the correlation between the length of each of three fingers (the index finger, 2D; ring finger, 4D; and little finger, 5D) and the occlusal vertical dimension (OVD). If such a relationship were established, it would simplify and facilitate the prediction and reestablishment of the OVD in the construction of complete dentures. The correlation between the OVD and the length of 2D or 5D has already been investigated in a number of studies. However, to our knowledge, no study has investigated the relationship between the length of 4D and the OVD. A total of 117 adult Sudanese women were enrolled in this study. The distance from tip of the finger to the second crease was measured using a digital caliper. The OVD was established based on two measurements: one from the septum of the nose to the menton of the chin; and the other from the tip of the nose (N) to the gnathion at the tip of the chin (Gn). All data were analyzed using the SPSS program. The Pearson correlation coefficient was used to determine the relationship between variables. Differences between means were determined using a paired-sample t-test. The p-value was set at 0.05. A significant correlation was found between finger length and the OVD. However, this correlation was significantly higher between 2D and the OVD based on N-Gn. The present findings indicate that 2D can be used to predict the OVD in adult Sudanese women.
{"title":"Correlation between Finger Length and Occlusal Vertical Dimension in Adult Sudanese Women.","authors":"M. N. Alhajj, Nassir J Musaad, I. A. Ismail","doi":"10.2209/tdcpublication.2016-0001","DOIUrl":"https://doi.org/10.2209/tdcpublication.2016-0001","url":null,"abstract":"The objective of this study was to investigate the correlation between the length of each of three fingers (the index finger, 2D; ring finger, 4D; and little finger, 5D) and the occlusal vertical dimension (OVD). If such a relationship were established, it would simplify and facilitate the prediction and reestablishment of the OVD in the construction of complete dentures. The correlation between the OVD and the length of 2D or 5D has already been investigated in a number of studies. However, to our knowledge, no study has investigated the relationship between the length of 4D and the OVD. A total of 117 adult Sudanese women were enrolled in this study. The distance from tip of the finger to the second crease was measured using a digital caliper. The OVD was established based on two measurements: one from the septum of the nose to the menton of the chin; and the other from the tip of the nose (N) to the gnathion at the tip of the chin (Gn). All data were analyzed using the SPSS program. The Pearson correlation coefficient was used to determine the relationship between variables. Differences between means were determined using a paired-sample t-test. The p-value was set at 0.05. A significant correlation was found between finger length and the OVD. However, this correlation was significantly higher between 2D and the OVD based on N-Gn. The present findings indicate that 2D can be used to predict the OVD in adult Sudanese women.","PeriodicalId":45490,"journal":{"name":"Bulletin of Tokyo Dental College","volume":"57 4 1","pages":"215-221"},"PeriodicalIF":0.5,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2209/tdcpublication.2016-0001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68185635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-01-01DOI: 10.2209/tdcpublication.2010-0029
Tomoyoshi Saitoh, Kazumichi Sato, M. Tonogi, Yoichi Tanaka, G. Yamane
The management of epithelial dysplastic spread around an oral squamous cell carci-noma is very important, particularly intraoperatively. Both cytokeratin (CK) 14 and CK19 are believed to be involved in the development of precancerous lesions, and their expression profiles are quite specific in these and early cancer lesions. Here, expression of CK13, 14, 17, and 19 was investigated in a rat model of 4-nitroquinoline-1-oxide-induced tongue cancer during a series of carcinogenetic processes to determine their value in assessing the features of epithelial dysplastic spread around a cancer. Based on tissue conditions, the results showed that expression levels of CK13 and 14 decreased in the order of no change, dysplasia, and cancer, whereas those of CK17 and 19 increased in the same order. Expression of CK13 showed a significant difference among no change, dysplasia, and cancer. This indicates that comparing the immunohistochemical staining profiles of CKs, especially CK13, could help in assessing the characteristics of epithelial dysplastic spread around a cancer.
{"title":"Expression of Cytokeratin 13, 14, 17, and 19 in 4-nitroquinoline-1-oxide-induced Oral Carcinogenesis in Rat.","authors":"Tomoyoshi Saitoh, Kazumichi Sato, M. Tonogi, Yoichi Tanaka, G. Yamane","doi":"10.2209/tdcpublication.2010-0029","DOIUrl":"https://doi.org/10.2209/tdcpublication.2010-0029","url":null,"abstract":"The management of epithelial dysplastic spread around an oral squamous cell carci-noma is very important, particularly intraoperatively. Both cytokeratin (CK) 14 and CK19 are believed to be involved in the development of precancerous lesions, and their expression profiles are quite specific in these and early cancer lesions. Here, expression of CK13, 14, 17, and 19 was investigated in a rat model of 4-nitroquinoline-1-oxide-induced tongue cancer during a series of carcinogenetic processes to determine their value in assessing the features of epithelial dysplastic spread around a cancer. Based on tissue conditions, the results showed that expression levels of CK13 and 14 decreased in the order of no change, dysplasia, and cancer, whereas those of CK17 and 19 increased in the same order. Expression of CK13 showed a significant difference among no change, dysplasia, and cancer. This indicates that comparing the immunohistochemical staining profiles of CKs, especially CK13, could help in assessing the characteristics of epithelial dysplastic spread around a cancer.","PeriodicalId":45490,"journal":{"name":"Bulletin of Tokyo Dental College","volume":"57 4 1","pages":"241-251"},"PeriodicalIF":0.5,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2209/tdcpublication.2010-0029","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68184912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-01-01DOI: 10.2209/tdcpublication.2016-1900
Rie Fujii, M. Suehara, Sayo Sekiya, Norihito Miyayoshi, Tomohiro Asai, K. Morinaga, T. Muramatsu, M. Furusawa
Apical periodontitis is usually diagnosed based on clinical findings and dental X-rays. Recently, however, dental cone beam computed tomography (CBCT), which provides 3-D images of the maxillofacial region, has enabled dentists to examine patients undergoing endodontic therapy more effectively, improving diagnostic accuracy. Here, we describe a positive treatment outcome achieved using CBCT to diagnose apical periodontitis of the maxillary premolars, which had proven difficult to diagnose based on clinical findings and dental radiography alone. The patient was a 42-year-old Japanese man who presented with the chief complaint of gingival swelling in the maxillary right premolar region. Our initial diagnosis, based on clinical findings and dental X-ray, was apical periodontitis of the maxillary right second premolar, and treatment was started. However, after the patient failed to respond to the treatment, CBCT was performed. Based on these new findings, the diagnosis was changed to one of apical periodontitis of the upper right first premolar, and the patient was treated accordingly. Previous studies have described the complex anatomical morphology of the upper premolars, noting multiple roots and variation in the morphology of the root canals. The 3-D images provided by dental CBCT allow better assessment of oral conditions than the traditional 2-D images provided by dental X-rays, which in turn enables the dentist to better select the most appropriate treatment. Here, the patient showed no symptoms and was progressing well at a 6-month follow-up visit. The present results indicate that when clinical findings and dental X-rays alone are insufficient to allow a secure diagnosis, CBCT offers an effective alternative which will enable the appropriate treatment to be selected more reliably.
{"title":"CBCT-based Diagnosis of Periapical Lesion of Maxillary First Premolar Mimicking That of Second Premolar.","authors":"Rie Fujii, M. Suehara, Sayo Sekiya, Norihito Miyayoshi, Tomohiro Asai, K. Morinaga, T. Muramatsu, M. Furusawa","doi":"10.2209/tdcpublication.2016-1900","DOIUrl":"https://doi.org/10.2209/tdcpublication.2016-1900","url":null,"abstract":"Apical periodontitis is usually diagnosed based on clinical findings and dental X-rays. Recently, however, dental cone beam computed tomography (CBCT), which provides 3-D images of the maxillofacial region, has enabled dentists to examine patients undergoing endodontic therapy more effectively, improving diagnostic accuracy. Here, we describe a positive treatment outcome achieved using CBCT to diagnose apical periodontitis of the maxillary premolars, which had proven difficult to diagnose based on clinical findings and dental radiography alone. The patient was a 42-year-old Japanese man who presented with the chief complaint of gingival swelling in the maxillary right premolar region. Our initial diagnosis, based on clinical findings and dental X-ray, was apical periodontitis of the maxillary right second premolar, and treatment was started. However, after the patient failed to respond to the treatment, CBCT was performed. Based on these new findings, the diagnosis was changed to one of apical periodontitis of the upper right first premolar, and the patient was treated accordingly. Previous studies have described the complex anatomical morphology of the upper premolars, noting multiple roots and variation in the morphology of the root canals. The 3-D images provided by dental CBCT allow better assessment of oral conditions than the traditional 2-D images provided by dental X-rays, which in turn enables the dentist to better select the most appropriate treatment. Here, the patient showed no symptoms and was progressing well at a 6-month follow-up visit. The present results indicate that when clinical findings and dental X-rays alone are insufficient to allow a secure diagnosis, CBCT offers an effective alternative which will enable the appropriate treatment to be selected more reliably.","PeriodicalId":45490,"journal":{"name":"Bulletin of Tokyo Dental College","volume":"57 4 1","pages":"291-297"},"PeriodicalIF":0.5,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2209/tdcpublication.2016-1900","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68185485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-01-01DOI: 10.2209/tdcpublication.2016-0600
Shinya Takahashi, Ryuta Kikuchi, K. Ambe, Toshihiro Nakagawa, S. Takada, T. Ohno, Hiroki Watanabe
Type I diabetes, an autoimmune disease, induces insulin deficiency, which then disrupts vascular endothelial cell function, affecting blood and lymphatic vessels. Nitric oxide (NO) is an immune-induced destructive mediator in type I diabetes, and inhibition of its production promotes arteriosclerosis. In this study, lymphangiogenesis and expression of NO synthase (NOS) during the healing process after tooth extraction were investigated immunohistochemically in control (C57BL) and Akita mice as a diabetes model. Between 1, 4, and 10 days after extraction, expression of NOS, vascular endothelial growth factor-C (VEGF-C), VEGF receptor-3 (VEGFR-3), and von Willebrand factor was strongest during the granulation tissue phase. This suggests that severe inflammation triggers regulation of NOS and these other angiogenic and lymphangiogenic factors. During the callus phase, a few days after extraction, induced osteoblasts were positive for VEGF-C and VEGFR-3 in both the control and Akita mice, suggesting that bone formation is active in this period. Bone formation in the Akita group exceeded that in the controls. Bone tissue formation was disrupted under hyperglycemic conditions, however, suggesting that such activity would be insufficient to produce new bone.
I型糖尿病是一种自身免疫性疾病，它会导致胰岛素缺乏，从而破坏血管内皮细胞的功能，影响血液和淋巴管。一氧化氮(NO)是I型糖尿病中一种免疫诱导的破坏性介质，抑制其产生可促进动脉硬化。本研究采用免疫组织化学方法研究了正常对照(C57BL)和糖尿病模型秋田小鼠拔牙后愈合过程中淋巴管生成和NO合成酶(NOS)的表达。提取后1、4和10 d, NOS、血管内皮生长因子- c (VEGF- c)、VEGF受体-3 (VEGFR-3)和血管性血变因子的表达在肉芽组织期最强。这表明严重的炎症会触发NOS和其他血管生成和淋巴管生成因子的调节。在骨痂期，提取后几天，对照小鼠和秋田小鼠的诱导成骨细胞VEGF-C和VEGFR-3均呈阳性，表明骨形成在这一时期很活跃。秋田组的骨形成超过了对照组。然而，在高血糖条件下，骨组织的形成被破坏，这表明这种活动不足以产生新的骨骼。
{"title":"Lymphangiogenesis and NOS Localization in Healing Process after Tooth Extraction in Akita Mouse.","authors":"Shinya Takahashi, Ryuta Kikuchi, K. Ambe, Toshihiro Nakagawa, S. Takada, T. Ohno, Hiroki Watanabe","doi":"10.2209/tdcpublication.2016-0600","DOIUrl":"https://doi.org/10.2209/tdcpublication.2016-0600","url":null,"abstract":"Type I diabetes, an autoimmune disease, induces insulin deficiency, which then disrupts vascular endothelial cell function, affecting blood and lymphatic vessels. Nitric oxide (NO) is an immune-induced destructive mediator in type I diabetes, and inhibition of its production promotes arteriosclerosis. In this study, lymphangiogenesis and expression of NO synthase (NOS) during the healing process after tooth extraction were investigated immunohistochemically in control (C57BL) and Akita mice as a diabetes model. Between 1, 4, and 10 days after extraction, expression of NOS, vascular endothelial growth factor-C (VEGF-C), VEGF receptor-3 (VEGFR-3), and von Willebrand factor was strongest during the granulation tissue phase. This suggests that severe inflammation triggers regulation of NOS and these other angiogenic and lymphangiogenic factors. During the callus phase, a few days after extraction, induced osteoblasts were positive for VEGF-C and VEGFR-3 in both the control and Akita mice, suggesting that bone formation is active in this period. Bone formation in the Akita group exceeded that in the controls. Bone tissue formation was disrupted under hyperglycemic conditions, however, suggesting that such activity would be insufficient to produce new bone.","PeriodicalId":45490,"journal":{"name":"Bulletin of Tokyo Dental College","volume":"57 3 1","pages":"121-31"},"PeriodicalIF":0.5,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2209/tdcpublication.2016-0600","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68185776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-01-01DOI: 10.2209/tdcpublication.2016-1400
Yasutaka Nakamura, Michinaga Samejima, K. Minaguchi, P. Nambiar
Short tandem repeat (STR) polymorphisms were investigated in 341 unrelated Malay individuals (218 males and 123 females) living in or around Kuala Lumpur by using a forensic analysts kit. The following STRs were targeted: D8S1179, D21S11, D7S820, CSF1PO, D3S1358, TH01, D13S317, D16S539, D2S1338, D19S433, vWA, TPOX, D18S51, D5S818, and FGA. The purpose of this study was to elucidate population genetics in Malaysia and calculate statistical parameters for forensic and anthropological research. Data on these STRs in the target population were obtained and subjected to statistical analysis. Accordance with the Hardy-Weinberg equilibrium was proven for all the loci targeted. The combined power of discrimination was greater than 0.9999999999, indicating that this multiplex system is an excellent tool for forensic casework. The allele frequency in the data were weighed against that in four other local populations (Chinese, Iranian, Belgian, and African). The average coefficient of correlation was strongest in the order of Africa (0.092522), Belgium (0.264822), Iran (0.404363), and China (0.706661). These results are consistent with what is known about the anthropological history of and prehistoric human migration in the Malay region. We believe that these data offer a valuable anthropological resource, being applicable to the statistical evaluation of DNA evidence in human identification, as well as the determination of ethnicity in healthy populations.
{"title":"Population Genetics of Identifiler System in Malaysia.","authors":"Yasutaka Nakamura, Michinaga Samejima, K. Minaguchi, P. Nambiar","doi":"10.2209/tdcpublication.2016-1400","DOIUrl":"https://doi.org/10.2209/tdcpublication.2016-1400","url":null,"abstract":"Short tandem repeat (STR) polymorphisms were investigated in 341 unrelated Malay individuals (218 males and 123 females) living in or around Kuala Lumpur by using a forensic analysts kit. The following STRs were targeted: D8S1179, D21S11, D7S820, CSF1PO, D3S1358, TH01, D13S317, D16S539, D2S1338, D19S433, vWA, TPOX, D18S51, D5S818, and FGA. The purpose of this study was to elucidate population genetics in Malaysia and calculate statistical parameters for forensic and anthropological research. Data on these STRs in the target population were obtained and subjected to statistical analysis. Accordance with the Hardy-Weinberg equilibrium was proven for all the loci targeted. The combined power of discrimination was greater than 0.9999999999, indicating that this multiplex system is an excellent tool for forensic casework. The allele frequency in the data were weighed against that in four other local populations (Chinese, Iranian, Belgian, and African). The average coefficient of correlation was strongest in the order of Africa (0.092522), Belgium (0.264822), Iran (0.404363), and China (0.706661). These results are consistent with what is known about the anthropological history of and prehistoric human migration in the Malay region. We believe that these data offer a valuable anthropological resource, being applicable to the statistical evaluation of DNA evidence in human identification, as well as the determination of ethnicity in healthy populations.","PeriodicalId":45490,"journal":{"name":"Bulletin of Tokyo Dental College","volume":"57 4 1","pages":"233-239"},"PeriodicalIF":0.5,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2209/tdcpublication.2016-1400","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68185418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-01-01DOI: 10.2209/tdcpublication.2016-1700
K. Imamura, Yuri Okamura, Yasugi Matsumoto, Yuko Mashimo, Sachiyo Tomita, H. Sugito, A. Saito
We report a case of generalized aggressive periodontitis (AgP) requiring periodontal treatment including flap surgery and ridge augmentation. The patient was a 39-year-old woman who presented with the chief complaint of pus discharge from tooth #36. No other obvious signs of gingival inflammation were observed. Periodontal examination revealed multiple sites with a probing depth of ≥10 mm. Radiography showed pro-nounced bone defects in the maxillary incisors and molar region. Real-time PCR was used to detect Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, and Tannerella forsythia in subgingival plaque; all 3 pathogens were found. Based on a clinical diagnosis of generalized AgP, periodontal therapy was initiated, which resulted in an improvement in clinical and microbiological parameters. A modified Widman flap procedure was then performed on sites with residual periodontal pockets. Next, a connective tissue graft was performed for ridge augmentation at #22, which had shown evidence of ridge resorption. Postoperative reevaluation revealed a reduction in probing depth and an improvement in marginal bone levels. Oral function was then restored using a fixed bridge prosthesis and maintenance therapy initiated. The periodontal condition has remained stable over a 2.5-year period. In the present case of AgP, surgical intervention reduced periodontal pockets and periodontal pathogens and improved the architecture of both the hard and soft tissues, allowing subsequent care of the periodontium to be performed efficiently by the patient.
{"title":"Periodontal Surgery Involving Modified Widman Flap Procedure and Connective Tissue Graft for Generalized Aggressive Periodontitis: A Case Report.","authors":"K. Imamura, Yuri Okamura, Yasugi Matsumoto, Yuko Mashimo, Sachiyo Tomita, H. Sugito, A. Saito","doi":"10.2209/tdcpublication.2016-1700","DOIUrl":"https://doi.org/10.2209/tdcpublication.2016-1700","url":null,"abstract":"We report a case of generalized aggressive periodontitis (AgP) requiring periodontal treatment including flap surgery and ridge augmentation. The patient was a 39-year-old woman who presented with the chief complaint of pus discharge from tooth #36. No other obvious signs of gingival inflammation were observed. Periodontal examination revealed multiple sites with a probing depth of ≥10 mm. Radiography showed pro-nounced bone defects in the maxillary incisors and molar region. Real-time PCR was used to detect Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, and Tannerella forsythia in subgingival plaque; all 3 pathogens were found. Based on a clinical diagnosis of generalized AgP, periodontal therapy was initiated, which resulted in an improvement in clinical and microbiological parameters. A modified Widman flap procedure was then performed on sites with residual periodontal pockets. Next, a connective tissue graft was performed for ridge augmentation at #22, which had shown evidence of ridge resorption. Postoperative reevaluation revealed a reduction in probing depth and an improvement in marginal bone levels. Oral function was then restored using a fixed bridge prosthesis and maintenance therapy initiated. The periodontal condition has remained stable over a 2.5-year period. In the present case of AgP, surgical intervention reduced periodontal pockets and periodontal pathogens and improved the architecture of both the hard and soft tissues, allowing subsequent care of the periodontium to be performed efficiently by the patient.","PeriodicalId":45490,"journal":{"name":"Bulletin of Tokyo Dental College","volume":"57 4 1","pages":"259-268"},"PeriodicalIF":0.5,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2209/tdcpublication.2016-1700","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68185471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-01-01DOI: 10.2209/tdcpublication.57.43
T. Shibui, T. Nomura, N. Takano, A. Katakura, Y. Nakano, K. Suga, M. Narita, Akira Watanabe, Kyotaro Muramatsu, K. Takamatsu
Remarkable technological advances have been made in the field of medicine in recent years, one result of which is that a prenatal diagnosis of cleft lip and/or cleft palate (CL/P) is now possible. In this situation, it is extremely important to provide the parents with mental care from the moment they are informed. Here, we describe cases of CL/P treated at our hospital and how such a diagnosis and prenatal counseling are handled. A survey was carried out on 4 cases seen at our department between April 2013 and March 2014. Patients are referred to our department from local or our own obstetrics clinics on a prenatal diagnosis of CL/P based on findings from ultrasonography. If the case is a referral from outside, the patient will first be seen at our own obstetrics department. Our department may then be subsequently requested to provide the parents with prenatal counseling. Effort is made to reassure the parents that postnatal support will be provided, right from the start. Next, the multidisciplinary nature of the treatment process is explained. However, only the essential outline is given at first so as to avoid inducing unnecessary anxiety. A response is also given to any questions the parents may have. Our experience of giving such care leads us to believe that improvements are required in the way that explanations and assistance are provided. The number of cases in which prenatal counseling is required is expected to increase in future.
{"title":"Prenatal Counseling on Prenatal Diagnosis of Cleft Lip and/or Cleft Palate at Tokyo Dental College Ichikawa General Hospital.","authors":"T. Shibui, T. Nomura, N. Takano, A. Katakura, Y. Nakano, K. Suga, M. Narita, Akira Watanabe, Kyotaro Muramatsu, K. Takamatsu","doi":"10.2209/tdcpublication.57.43","DOIUrl":"https://doi.org/10.2209/tdcpublication.57.43","url":null,"abstract":"Remarkable technological advances have been made in the field of medicine in recent years, one result of which is that a prenatal diagnosis of cleft lip and/or cleft palate (CL/P) is now possible. In this situation, it is extremely important to provide the parents with mental care from the moment they are informed. Here, we describe cases of CL/P treated at our hospital and how such a diagnosis and prenatal counseling are handled. A survey was carried out on 4 cases seen at our department between April 2013 and March 2014. Patients are referred to our department from local or our own obstetrics clinics on a prenatal diagnosis of CL/P based on findings from ultrasonography. If the case is a referral from outside, the patient will first be seen at our own obstetrics department. Our department may then be subsequently requested to provide the parents with prenatal counseling. Effort is made to reassure the parents that postnatal support will be provided, right from the start. Next, the multidisciplinary nature of the treatment process is explained. However, only the essential outline is given at first so as to avoid inducing unnecessary anxiety. A response is also given to any questions the parents may have. Our experience of giving such care leads us to believe that improvements are required in the way that explanations and assistance are provided. The number of cases in which prenatal counseling is required is expected to increase in future.","PeriodicalId":45490,"journal":{"name":"Bulletin of Tokyo Dental College","volume":"57 1 1","pages":"43-50"},"PeriodicalIF":0.5,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2209/tdcpublication.57.43","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68187037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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