{"title":"Cistrome Data Browser and Toolkit: analyzing human and mouse genomic data using compendia of ChIP-seq and chromatin accessibility data","authors":"Rongbin Zheng, Xin Dong, Changxin Wan, Xiaoying Shi, Xiaoyan Zhang, Clifford A. Meyer","doi":"10.1007/s40484-020-0204-7","DOIUrl":"https://doi.org/10.1007/s40484-020-0204-7","url":null,"abstract":"","PeriodicalId":45660,"journal":{"name":"Quantitative Biology","volume":"8 1","pages":"267-276"},"PeriodicalIF":3.1,"publicationDate":"2020-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40484-020-0204-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48020516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-29DOI: 10.1007/s40484-020-0203-8
Xiaotu Ma, Sasi Arunachalam, Yanling Liu
{"title":"Applications of probability and statistics in cancer genomics","authors":"Xiaotu Ma, Sasi Arunachalam, Yanling Liu","doi":"10.1007/s40484-020-0203-8","DOIUrl":"https://doi.org/10.1007/s40484-020-0203-8","url":null,"abstract":"","PeriodicalId":45660,"journal":{"name":"Quantitative Biology","volume":"1 1","pages":"1-14"},"PeriodicalIF":3.1,"publicationDate":"2020-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40484-020-0203-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45840074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-13DOI: 10.21203/rs.3.rs-20030/v1
Wenli Jin, Yi Tao, Chen Wang, Lufei Wang, Xue Ao, Mingjie Su, Binwei Hu, Yuxiao Ouyang, Jiaxing Liu, Hui Li
BackgroundHuman meridian (Jingluo) system was hypothesized by traditional Chinese medicine (TCM) for thousands of years. In this hypothesis, there believed to be twelve formal meridian channels going through respective organs, carrying fluid and energy, and laying thermal effects. Some treatments based on meridians have been proved effective. However, existence of meridians has never been confirmed. The infrared photograph was employed to display the picture to the meridians since 1970. Unfortunately, no satisfactory results have been obtained. We think that only when a certain meridian is activated will there be thermal effect for successful infrared photograph.Methods We selected thirteen types of tea out of the herbs to activate the hypothesized twelve meridians for imagery taking. We collected 42 volunteers to drink teas and take infrared imageries in thirteen days. After every tea was drunk, infrared imageries of the human bodies were taken immediately. The highest temperatures of the fingers, palms, and above the organs were derived from the imageries. The averages and standard deviations of the standardized data of volunteers were calculated. Significances of the temperature difference among the body areas after drinking different teas were evaluated. ResultsWe found that the temperatures of the organs and fingers possibly connected by twelve hypothesized meridians rose together significantly, i.e., the thumbs and lung after white teas, index fingers and colon after blue teas, middle fingers and thymus after dark black teas, ring fingers and gallbladder after red black teas, little fingers and heart after yellow teas. The temperature distribution on the human bodies exhibited twelve patterns following the meridian hypothesis. Infrared imageries showed quite clear shapes of the organs activated by the teas, e.g., heart and kidneys by yellow teas, thymus by dark black teas, lungs and spleen by white teas, gallbladder and thyroid by red black teas, etc. Some high temperature lines also matched the hypothetic meridians. ConclusionsOur work displayed the imageries of the possible meridians for the first time, and proved with data that different foods may activate different organs following the meridian hypothesis, shedding light on a possible new method of targeted drug designs.
{"title":"Infrared imageries of human body activated by teas indicate the existence of meridian system","authors":"Wenli Jin, Yi Tao, Chen Wang, Lufei Wang, Xue Ao, Mingjie Su, Binwei Hu, Yuxiao Ouyang, Jiaxing Liu, Hui Li","doi":"10.21203/rs.3.rs-20030/v1","DOIUrl":"https://doi.org/10.21203/rs.3.rs-20030/v1","url":null,"abstract":"\u0000 BackgroundHuman meridian (Jingluo) system was hypothesized by traditional Chinese medicine (TCM) for thousands of years. In this hypothesis, there believed to be twelve formal meridian channels going through respective organs, carrying fluid and energy, and laying thermal effects. Some treatments based on meridians have been proved effective. However, existence of meridians has never been confirmed. The infrared photograph was employed to display the picture to the meridians since 1970. Unfortunately, no satisfactory results have been obtained. We think that only when a certain meridian is activated will there be thermal effect for successful infrared photograph.Methods We selected thirteen types of tea out of the herbs to activate the hypothesized twelve meridians for imagery taking. We collected 42 volunteers to drink teas and take infrared imageries in thirteen days. After every tea was drunk, infrared imageries of the human bodies were taken immediately. The highest temperatures of the fingers, palms, and above the organs were derived from the imageries. The averages and standard deviations of the standardized data of volunteers were calculated. Significances of the temperature difference among the body areas after drinking different teas were evaluated. ResultsWe found that the temperatures of the organs and fingers possibly connected by twelve hypothesized meridians rose together significantly, i.e., the thumbs and lung after white teas, index fingers and colon after blue teas, middle fingers and thymus after dark black teas, ring fingers and gallbladder after red black teas, little fingers and heart after yellow teas. The temperature distribution on the human bodies exhibited twelve patterns following the meridian hypothesis. Infrared imageries showed quite clear shapes of the organs activated by the teas, e.g., heart and kidneys by yellow teas, thymus by dark black teas, lungs and spleen by white teas, gallbladder and thyroid by red black teas, etc. Some high temperature lines also matched the hypothetic meridians. ConclusionsOur work displayed the imageries of the possible meridians for the first time, and proved with data that different foods may activate different organs following the meridian hypothesis, shedding light on a possible new method of targeted drug designs.","PeriodicalId":45660,"journal":{"name":"Quantitative Biology","volume":"1 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2020-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45278489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-01DOI: 10.1007/s40484-020-0194-5
Minzhen Tao, Qiaochu Mu, Yurui Zhang, Zhen Xie
{"title":"Construction of a CRISPR-based paired-sgRNA library for chromosomal deletion of long non-coding RNAs","authors":"Minzhen Tao, Qiaochu Mu, Yurui Zhang, Zhen Xie","doi":"10.1007/s40484-020-0194-5","DOIUrl":"https://doi.org/10.1007/s40484-020-0194-5","url":null,"abstract":"","PeriodicalId":45660,"journal":{"name":"Quantitative Biology","volume":"8 1","pages":"31-42"},"PeriodicalIF":3.1,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40484-020-0194-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41852931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-01DOI: 10.1007/s40484-020-0197-2
Baizhu Chen, Zhuojun Dai
{"title":"Combination of versatile platforms for the development of synthetic biology","authors":"Baizhu Chen, Zhuojun Dai","doi":"10.1007/s40484-020-0197-2","DOIUrl":"https://doi.org/10.1007/s40484-020-0197-2","url":null,"abstract":"","PeriodicalId":45660,"journal":{"name":"Quantitative Biology","volume":"8 1","pages":"4-10"},"PeriodicalIF":3.1,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40484-020-0197-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45721415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-01DOI: 10.1007/s40484-020-0195-4
Jingxue Xin, Junjun Hao, Lang Chen, Tao Zhang, Lei Li, Luonan Chen, Wenming Zhao, Xuemei Lu, Peng Shi, Yong Wang
{"title":"ZokorDB: tissue specific regulatory network annotation for non-coding elements of plateau zokor","authors":"Jingxue Xin, Junjun Hao, Lang Chen, Tao Zhang, Lei Li, Luonan Chen, Wenming Zhao, Xuemei Lu, Peng Shi, Yong Wang","doi":"10.1007/s40484-020-0195-4","DOIUrl":"https://doi.org/10.1007/s40484-020-0195-4","url":null,"abstract":"","PeriodicalId":45660,"journal":{"name":"Quantitative Biology","volume":"8 1","pages":"43-50"},"PeriodicalIF":3.1,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40484-020-0195-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48873282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-20DOI: 10.1007/s40484-019-0182-9
Minghua Deng, Jianfeng Feng, Hong Qian, Lin Wan, Fengzhu Sun
{"title":"International Workshop on Applications of Probability and Statistics to Biology, July 11–13, 2019","authors":"Minghua Deng, Jianfeng Feng, Hong Qian, Lin Wan, Fengzhu Sun","doi":"10.1007/s40484-019-0182-9","DOIUrl":"https://doi.org/10.1007/s40484-019-0182-9","url":null,"abstract":"","PeriodicalId":45660,"journal":{"name":"Quantitative Biology","volume":"8 1","pages":"177-186"},"PeriodicalIF":3.1,"publicationDate":"2019-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40484-019-0182-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42598989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-01DOI: 10.1007/s40484-019-0189-2
Jie Zheng, Ke Wang
{"title":"Emerging deep learning methods for single-cell RNA-seq data analysis","authors":"Jie Zheng, Ke Wang","doi":"10.1007/s40484-019-0189-2","DOIUrl":"https://doi.org/10.1007/s40484-019-0189-2","url":null,"abstract":"","PeriodicalId":45660,"journal":{"name":"Quantitative Biology","volume":"7 1","pages":"247 - 254"},"PeriodicalIF":3.1,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40484-019-0189-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44179762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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