Clinical Neurophysiology Practice最新文献

英文中文

Efficacy of cerebellar cathodal transcranial direct current stimulation for post-stroke aphasia: A randomized controlled trial 小脑阴极经颅直流电刺激治疗脑卒中后失语症的疗效：一项随机对照试验

IF 2 Q3 NEUROSCIENCES

Clinical Neurophysiology Practice

Pub Date : 2025-01-01 DOI: 10.1016/j.cnp.2025.10.001

Xiaoyi Xu , Shuping Chen , Zifan Li , Lijie Zhang , Tianjin Pan , Siying Long , Tingting Yang , Meng Li , Qianru Li , Na Chen , Shangjie Chen , Qing Zeng

Objective

Growing evidence highlights the cerebellum, particularly the right posterior lobule, in advanced language processes such as fluency, syntax, and phonological memory. However, its specific role in post-stroke aphasia recovery—especially its modulation of cortical networks and functional connectivity (FC)—remains unclear, which limits targeted intreventions.

Methods

Sixteen post-stroke aphasia patients were randomized to receive either cerebellar transcranial direct current stimulation (tDCS) with speech therapy or sham stimulation with therapy. Language performance was assessed via the Chinese Standard Aphasia Scale (CRRCAE), and brain activation was monitored using functional near-infrared spectroscopy (fNIRS).

Results

Both groups showed significant CRRCAE score improvements post-treatment (P < 0.05), without between-group differences (P > 0.05). FC reductions were noted across several interhemispheric and right-hemispheric pathways, while increased FC was observed in left hemisphere language-related areas.

Conclusion

After baseline adjustment, the intervention group showed superior gains. Cerebellar tDCS modulates FC, suggesting a potential mechanism for enhancing aphasia recovery.

Significance

Findings support the cerebellum as a promising neuromodulation target for post-stroke aphasia treatment.

目的：越来越多的证据表明，小脑，特别是右脑后小叶，在流利性、句法和语音记忆等高级语言过程中起着重要作用。然而，其在脑卒中后失语恢复中的具体作用——尤其是其对皮质网络和功能连接（FC）的调节——仍不清楚，这限制了有针对性的干预。方法将16例脑卒中后失语患者随机分为两组，一组接受经颅直流电刺激(tDCS) +言语治疗，另一组接受假刺激+言语治疗。采用中国标准失语量表（CRRCAE）评估语言表现，用功能近红外光谱（fNIRS）监测脑活动。结果两组患者治疗后CRRCAE评分均有显著改善（P < 0.05），组间差异无统计学意义（P < 0.05）。在几个半球间和右半球通路中发现FC减少，而在左半球语言相关区域观察到FC增加。结论经基线调整后，干预组疗效显著。小脑tDCS调节FC，提示其促进失语恢复的潜在机制。研究结果支持小脑作为脑卒中后失语治疗的一个有希望的神经调节靶点。

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引用次数: 0

The effects of multi-session dual-tDCS on the bilateral transfer of motor skill learning in patients with stroke 多期双tdcs对脑卒中患者双侧运动技能学习转移的影响

IF 2 Q3 NEUROSCIENCES

Clinical Neurophysiology Practice

Pub Date : 2025-01-01 DOI: 10.1016/j.cnp.2025.06.005

Mohammad Mahdi Talimkhani , Ailin Talimkhani , Vida Dinarvand , Somayeh Mohamadi , Hamzeh Baharlouei

Objective

This study investigates the potential effects of combining motor skill learning transfer from the unaffected to the affected hand with multiple sessions of dual-transcranial direct current stimulation (tDCS) over the primary motor cortex to enhance motor skills in stroke patients.

Methods

Eleven stroke patients participated in a randomized, sham-controlled, double-blind crossover study. Over two periods separated by a 3-week washout, participants underwent either sham or dual-tDCS concurrently with serial response time tasks (SRTT). Each intervention included 20 min of stimulation during SRTT for three consecutive days. The skill index, the primary variable, was assessed pre-intervention, immediately post-intervention, and 24 h later.

Results

Both groups showed significant improvement in motor skill learning across the three intervention days (P < 0.001). The dual-tDCS group demonstrated significantly greater skill improvement in the affected hand compared to the sham group (P < 0.01), while no significant differences were found for the unaffected hand (P = 0.98).

Conclusions

Multi-session dual-tDCS combined with motor learning tasks significantly enhances motor skill transfer to the affected hand in stroke patients, with greater and more durable effects compared to sham stimulation.

Significance

This approach may improve bilateral motor skill transfer and hand fatigue management in stroke rehabilitation.

目的探讨脑卒中患者运动技能学习转移与多期双经颅直流电刺激（tDCS）对初级运动皮质的潜在影响。方法采用随机、假对照、双盲交叉研究。在为期3周的洗脱期中，参与者接受假tdcs或双tdcs同时进行系列反应时间任务（SRTT）。每次干预包括连续三天SRTT期间20分钟的刺激。主要变量技能指数分别在干预前、干预后和24小时后进行评估。结果两组在干预3天内运动技能学习均有显著改善(P <；0.001)。与假手术组相比，双tdcs组在患手的技能提高明显更大(P <；0.01)，而未受影响的手无显著差异（P = 0.98）。结论多阶段双tdcs联合运动学习任务可显著提高脑卒中患者患手的运动技能转移，且效果比假刺激更显著、更持久。意义该方法可改善脑卒中康复患者的双侧运动技能转移和手部疲劳管理。

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引用次数: 0

Triphasic waves: To treat or not to treat? 三相波：治疗还是不治疗？

IF 2 Q3 NEUROSCIENCES

Clinical Neurophysiology Practice

Pub Date : 2025-01-01 DOI: 10.1016/j.cnp.2025.06.001

Brin E. Freund , Khalil S. Husari , José L. Fernández-Torre , Philippe Gélisse , Peter W. Kaplan

Generalized periodic discharges (GPDs) with triphasic morphology (triphasic waves, TWs) are EEG waveforms that have been a frequent topic of research evaluating their etiology and clinical correlates. More specifically, prior studies have tried to better elucidate their implications regarding seizures to help guide decision making regarding empiric treatment and EEG monitoring and in spite of multiple studies, controversies remain due to disparate findings. In this review we discuss the historical views of TWs and their clinical and radiographic correlates, highlight the typical and atypical features of TWs, discuss the controversy related to the association between TWs and seizures, and propose an approach to their management.

具有三相形态的广义周期性放电（gpd）（三相波，TWs）是脑电图波形，已成为评估其病因和临床相关性的研究热点。更具体地说，先前的研究试图更好地阐明它们对癫痫发作的影响，以帮助指导有关经验性治疗和脑电图监测的决策，尽管有多项研究，但由于不同的发现仍然存在争议。在这篇综述中，我们讨论了TWs的历史观点及其临床和影像学相关性，强调了TWs的典型和非典型特征，讨论了TWs与癫痫发作之间关系的争议，并提出了治疗方法。

引用次数: 0

When genetics prevail: brain stimulation fails to overcome learning deficits from brain-derived neurotrophic factor Val66Met 当遗传学占上风时：脑刺激无法克服脑源性神经营养因子Val66Met的学习缺陷

IF 2 Q3 NEUROSCIENCES

Clinical Neurophysiology Practice

Pub Date : 2025-01-01 DOI: 10.1016/j.cnp.2025.08.009

Perianen Ramasawmy , Krisztián Iszak , Steffen Brüshaber , Viktória Kállay , Géza Gergely Ambrus , Walter Paulus , Andrea Antal

Background

The dorsolateral prefrontal cortex (DLPFC) is a key contributor to memory categorization. Brain-Derived Neurotrophic Factor (BDNF) Val66Met polymorphism affects the efficacy of neuronal plasticity induction. We investigated whether DLPFC-transcranial direct current stimulation (tDCS) influences categorization performance, and whether BNDF genotype modulates this effect.

Methods

Sixty-two healthy individuals were randomized to receive 10 min of either anodal right DLPFC-tDCS at 1 mA, or sham tDCS during the training phase of a prototype distortion task. Categorization performance was assessed during, shortly after, and the morning following the stimulation. Val66Met polymorphism status was determined through BNDF genotyping.

Results

Val66Met carriers showed poorer categorization ability than Val/Val homozygotes (p < 0.0001). tDCS did not enhance categorization performance overall, or reduce genotype-associated differences with these specific stimulation parameters. However, tDCS extinguished the prototype effect of the categorization task observed in our sample.

Conclusions

Our findings underscore the importance of BDNF polymorphism in category learning. 1 mA anodal right DLPFC over the right DLPFC does not improve performance or offset genotype differences under tested conditions.

Significance

BDNF Val66Met polymorphism influences category learning, and low-intensity tDCS does not counteract this effect, emphasizing the need to refine stimulation protocols for genotype-specific cognitive enhancement.

背外侧前额叶皮层（DLPFC）是记忆分类的关键贡献者。脑源性神经营养因子（BDNF） Val66Met多态性影响神经元可塑性诱导的效果。我们研究了dlpfc -经颅直流电刺激（tDCS）是否影响分类性能，以及BNDF基因型是否调节这种影响。方法在原型扭曲任务的训练阶段，将62名健康个体随机分为两组，分别接受10 min的1 mA正极右DLPFC-tDCS和假tDCS。在刺激期间、刺激后不久和刺激后的早晨分别评估了分类性能。通过BNDF基因分型确定Val66Met多态性状态。结果val66met携带者的分类能力较Val/Val纯合子差（p < 0.0001）。tDCS总体上没有提高分类性能，也没有减少与这些特定刺激参数相关的基因型差异。然而，tDCS消除了我们样本中观察到的分类任务的原型效应。结论BDNF多态性在类别学习中的重要作用。在测试条件下，1 mA阳极右DLPFC优于右DLPFC并不能改善性能或抵消基因型差异。bdnf Val66Met多态性影响类别学习，而低强度tDCS并不能抵消这种影响，这强调了完善基因型特异性认知增强刺激方案的必要性。

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引用次数: 0

Comparison of lateralization and spatial patterns of hemodynamic and neuromagnetic language brain mapping 血流动力学和神经磁语言脑图的偏侧和空间模式的比较

IF 2 Q3 NEUROSCIENCES

Clinical Neurophysiology Practice

Pub Date : 2025-01-01 DOI: 10.1016/j.cnp.2025.10.007

Tim Coolen , Alexandru Mihai Dumitrescu , Vincent Wens , Mathieu Bourguignon , Antonin Rovai , Niloufar Sadeghi , Charline Urbain , Xavier De Tiège

Objective

To compare and integrate hemispheric lateralization and spatial patterns of language mapping derived from functional magnetic resonance imaging (fMRI) and magnetoencephalography (MEG).

Method

Twenty right-handed healthy adults performed three language tasks (verb/noun generation, phonological/semantic fluency, and sentence completion). A unified framework ensured methodological consistency across modalities: (i) identical tasks; (ii) individual mapping of block-level signal changes in fMRI and broadband (4–40 Hz) oscillatory power decreases in MEG; (iii) subject-level spatial extent-based thresholding of intramodality maps and quantification of intermodality overlap. Laterality indices (LI) were compared and combined across tasks and modalities to assess lateralization discordances. Spatial patterns were obtained by averaging individual maps, while permutation statistics evaluated intermodality spatial differences.

Results

Task- and modality-combined LI reduced intermodality lateralization discordance from 45% to 10%. MEG showed twice the LI variability of fMRI. Overlap was concentrated in left fronto-temporal regions, while spatial differences emerged in left fronto-parietal areas (fMRI) and temporal/opercular regions (MEG).

Conclusion

Although core language areas were identified in both modalities, modality- and task-integration may enhance robustness of language mapping in healthy subjects.

Significance

Lateralization discordances and modality-specific spatial patterns, along with MEG’s higher lateralization variability, suggest that multimodal integration could aid in presurgical clinical decision-making.

目的比较和整合功能性磁共振成像（fMRI）和脑磁图（MEG）获得的半球侧化和语言映射的空间模式。方法20名健康的右撇子成人进行了三个语言任务（动词/名词生成、语音/语义流畅性和句子完成）。统一的框架确保了各模式方法的一致性：(i)相同的任务；（ii） fMRI中块级信号变化和MEG中宽带（4-40 Hz）振荡功率下降的个体映射；（iii）基于主体层面空间范围的模态内地图阈值划分和模态间重叠的量化。横向指数（LI）进行比较，并结合跨任务和模式来评估横向不一致。空间格局是通过平均个体地图获得的，而排列统计则评估了多式联运的空间差异。结果任务和模式联合LI将模式间偏侧不一致性从45%降低到10%。MEG显示的LI变异性是fMRI的两倍。重叠集中在左侧额颞区，而左侧额顶区（fMRI）和颞/眼区（MEG）出现空间差异。结论虽然在两种模式下都确定了核心语言区域，但情态和任务整合可以增强健康受试者语言映射的稳健性。侧化不一致和模式特异性空间模式，以及MEG较高的侧化变异性，表明多模式整合可以帮助术前临床决策。

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引用次数: 0

Switch-Off response to mid-cingulate cortex stimulation: a video case report 中扣带皮层刺激的关闭反应：一个视频病例报告

IF 2 Q3 NEUROSCIENCES

Clinical Neurophysiology Practice

Pub Date : 2025-01-01 DOI: 10.1016/j.cnp.2025.10.008

Paola Vassallo , Olivia Poole , Xiaodong Guan , Davide Giampiccolo , Eduardo Marques , Umesh Vivekananda , John S. Duncan , Beate Diehl

Background

Electrical cortical stimulation (ECS) is commonly used during invasive presurgical evaluation of drug-resistant focal epilepsy for functional mapping and delineation of the epileptogenic zone.

Case presentation

A 31-year-old woman underwent stereo-EEG evaluation for presurgical assessment of drug-resistant focal epilepsy, likely left frontal or multifocal. During 50 Hz ECS of the right mid-cingulate cortex, a reproducible behavioural response was observed, characterised by left ear popping, head drop, eye closure, and speech/motor arrest, without loss of awareness. This semiology differed from her habitual seizures, and the region was not considered part of the presumed epileptogenic zone.

Conclusion

This case represents a rare video-documentation of stimulation-induced complex motor and behavioural response localised to the mid-cingulate cortex and supports mid-cingulate’s role as connection hub for volitional control and sensorimotor integration.

背景：皮层电刺激（ECS）常用于有创性术前评估耐药局灶性癫痫的功能定位和癫痫区描绘。一名31岁女性接受了立体脑电图评估，用于术前评估耐药局灶性癫痫，可能是左额叶或多灶性癫痫。在右侧扣带皮层中部50 Hz的ECS中，观察到可重复的行为反应，其特征是左耳突起，头下垂，闭上眼睛，语言/运动停止，没有意识丧失。这种符号学不同于她的习惯性癫痫发作，该区域不被认为是假定的癫痫发病区。结论本病例是一个罕见的视频记录，表明刺激诱导的复杂运动和行为反应定位于中扣带皮层，并支持中扣带作为意志控制和感觉运动整合的连接枢纽的作用。

{"title":"Switch-Off response to mid-cingulate cortex stimulation: a video case report","authors":"Paola Vassallo , Olivia Poole , Xiaodong Guan , Davide Giampiccolo , Eduardo Marques , Umesh Vivekananda , John S. Duncan , Beate Diehl","doi":"10.1016/j.cnp.2025.10.008","DOIUrl":"10.1016/j.cnp.2025.10.008","url":null,"abstract":"<div><h3>Background</h3><div>Electrical cortical stimulation (ECS) is commonly used during invasive presurgical evaluation of drug-resistant focal epilepsy for functional mapping and delineation of the epileptogenic zone.</div></div><div><h3>Case presentation</h3><div>A 31-year-old woman underwent stereo-EEG evaluation for presurgical assessment of drug-resistant focal epilepsy, likely left frontal or multifocal. During 50 Hz ECS of the right mid-cingulate cortex, a reproducible behavioural response was observed, characterised by left ear popping, head drop, eye closure, and speech/motor arrest, without loss of awareness. This semiology differed from her habitual seizures, and the region was not considered part of the presumed epileptogenic zone.</div></div><div><h3>Conclusion</h3><div>This case represents a rare video-documentation of stimulation-induced complex motor and behavioural response localised to the mid-cingulate cortex and supports mid-cingulate’s role as connection hub for volitional control and sensorimotor integration.</div></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"10 ","pages":"Pages 524-526"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145578898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beyond the triad: Review of Miller Fisher Syndrome in a tertiary neurological centre 超越三联征：三级神经学中心对米勒-费雪综合征的回顾

IF 2 Q3 NEUROSCIENCES

Clinical Neurophysiology Practice

Pub Date : 2025-01-01 DOI: 10.1016/j.cnp.2025.06.006

Muhammad Rehman , Chris Gyan , Chinar Osman , Ramamurthy Arunachalam

引用次数: 0

Spinal excitability is enhanced by transcranial magnetic stimulation of the motor cortex in children and adolescents 脊髓兴奋性增强经颅磁刺激运动皮层在儿童和青少年

IF 2 Q3 NEUROSCIENCES

Clinical Neurophysiology Practice

Pub Date : 2025-01-01 DOI: 10.1016/j.cnp.2025.06.009

Essi J. Marttinen Rossi , Päivi Nevalainen , Jussi Toppila , Helena Mäenpää , Jessica Guzmán-López , Harri Piitulainen , Leena Lauronen

Objective

To investigate the modulation of spinal excitability to sub-motor threshold transcranial magnetic stimulation (TMS) in healthy children and adolescents.

Methods

We paired sub-motor threshold TMS (conditioning) with electrical tibial nerve stimulation (test) to assess changes in the soleus H-reflex at eleven conditioning-test (C-T) intervals. Eleven participants (7.5–16.2 years) were studied under three conditions: rest, voluntary agonist activation (ankle plantar flexion), and voluntary antagonist activation (ankle dorsiflexion).

Results

TMS-induced supraspinal volley facilitated the soleus H-reflex amplitude significantly during rest and agonist activation, but not during antagonist activation. The facilitation of H-reflex was similar during rest and agonist activation between C-T intervals from –2 ms (i.e. peripheral stimulation before cortical) to +18 ms (i.e. cortical stimulation before peripheral). Specific to rest condition, a later facilitation occurred at C-T intervals of approximately +60 ms.

Conclusions

Spinal excitability modulation in children and adolescents showed similarities to earlier evidence in adults, with the distinction that, unlike in the adults, agonist activity did not further enhance the supraspinal facilitation of the H-reflex compared to the rest condition in children.

Significance

These results provide insight into the maturation of motor control and regulation of spinal excitability, offering possibilities to identify typical and atypical developmental trajectories.

目的探讨经颅磁刺激（TMS）对健康儿童和青少年脊髓兴奋性的调节作用。方法将亚运动阈值TMS（条件反射）与胫神经电刺激（测试）配对，观察11次条件反射测试（C-T）间隔时比目鱼h反射的变化。11名参与者（7.5-16.2岁）在三种条件下进行了研究：休息，自愿激动剂激活（踝关节足底屈曲）和自愿拮抗剂激活（踝关节背屈）。结果stms诱导的棘上截射在休息和激动剂激活时显著促进比目鱼h反射振幅，而在拮抗剂激活时无明显促进作用。从-2 ms（外周刺激前皮层刺激）到+18 ms（外周刺激前皮层刺激）的C-T间隔中，休息和激动剂激活时h反射的促进作用相似。结论：儿童和青少年的脊髓兴奋性调节与成人的早期证据相似，不同的是，与儿童的休息条件相比，激动剂活性并没有进一步增强h反射的棘上促进作用。这些结果为运动控制和脊髓兴奋性调节的成熟提供了见解，为识别典型和非典型发育轨迹提供了可能性。

{"title":"Spinal excitability is enhanced by transcranial magnetic stimulation of the motor cortex in children and adolescents","authors":"Essi J. Marttinen Rossi , Päivi Nevalainen , Jussi Toppila , Helena Mäenpää , Jessica Guzmán-López , Harri Piitulainen , Leena Lauronen","doi":"10.1016/j.cnp.2025.06.009","DOIUrl":"10.1016/j.cnp.2025.06.009","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the modulation of spinal excitability to sub-motor threshold transcranial magnetic stimulation (TMS) in healthy children and adolescents.</div></div><div><h3>Methods</h3><div>We paired sub-motor threshold TMS (conditioning) with electrical tibial nerve stimulation (test) to assess changes in the soleus H-reflex at eleven conditioning-test (C-T) intervals. Eleven participants (7.5–16.2 years) were studied under three conditions: rest, voluntary agonist activation (ankle plantar flexion), and voluntary antagonist activation (ankle dorsiflexion).</div></div><div><h3>Results</h3><div>TMS-induced supraspinal volley facilitated the soleus H-reflex amplitude significantly during rest and agonist activation, but not during antagonist activation. The facilitation of H-reflex was similar during rest and agonist activation between C-T intervals from –2 ms (i.e. peripheral stimulation before cortical) to +18 ms (i.e. cortical stimulation before peripheral). Specific to rest condition, a later facilitation occurred at C-T intervals of approximately +60 ms.</div></div><div><h3>Conclusions</h3><div>Spinal excitability modulation in children and adolescents showed similarities to earlier evidence in adults, with the distinction that, unlike in the adults, agonist activity did not further enhance the supraspinal facilitation of the H-reflex compared to the rest condition in children.</div></div><div><h3>Significance</h3><div>These results provide insight into the maturation of motor control and regulation of spinal excitability, offering possibilities to identify typical and atypical developmental trajectories.</div></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"10 ","pages":"Pages 278-285"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144632001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The underlying mechanism of mirror visual feedback in stroke. In reply to: challenging the electrophysiological interpretation of mirror visual feedback in stroke 卒中中镜像视觉反馈的潜在机制。回应：挑战脑卒中中镜像视觉反馈的电生理解释

IF 2 Q3 NEUROSCIENCES

Clinical Neurophysiology Practice

Pub Date : 2025-01-01 DOI: 10.1016/j.cnp.2025.08.007

Jinyang Zhuang

引用次数: 0

Cortical response to proprioceptive stimulation in primary orthostatic tremor – a magnetoencephalography study 原发性直立性震颤的皮层对本体感觉刺激的反应-脑磁图研究

IF 2 Q3 NEUROSCIENCES

Clinical Neurophysiology Practice

Pub Date : 2025-01-01 DOI: 10.1016/j.cnp.2025.04.002

Karolina af Edholm , Mikkel C. Vinding , Christoph Pfeiffer , Anders Svenningsson , Erik Fransén , Mathias Sundgren , Henrik Sjöström , Niklas Edvall , Daniel Lundqvist , Josefine Waldthaler

Objective

Patients with primary orthostatic tremor (OT) are affected by a strong feeling of instability. Our aim was to investigate whether cortical response to proprioceptive information is altered in OT compared with healthy control subjects (HC) using magnetoencephalography (MEG).

Methods

Fifteen OT patients and 15 HCs were examined using whole-head MEG. Proprioceptive stimulation was evoked by passive movements of the right index finger and right foot. Time-frequency responses were extracted in the frequency range of 8–30 Hz. The MEG sensor with the highest amplitude change time-locked to the proprioceptive stimulus was used to calculate the amplitude of event-related desynchronization (ERD) and subsequent event-related re-synchronization (ERS).

Results

Finger stimulation induced reliable ERD and ERS, as expected, in both OT patients and HC. Foot stimulation induced weaker ERS in both groups. Cluster-based permutation tests did not reveal any significant differences between the OT and HC groups.

Discussion

We did not find evidence supporting a generally altered cortical response to proprioceptive stimulation in patients with OT.

Significance

This is the first study on proprioceptive cortical processing in OT. The results do not support the interpretation that the characteristic intense feeling of instability in OT is linked to altered cortical response to proprioceptive information.

目的原发性直立性震颤（OT）患者有强烈的不稳定感。我们的目的是利用脑磁图（MEG）研究与健康对照组（HC）相比，OT患者对本体感觉信息的皮质反应是否发生了改变。方法对15例OT患者和15例hc患者进行全头部MEG检查。右食指和右脚被动运动可诱发本体感觉刺激。提取8 ~ 30 Hz频率范围内的时频响应。利用本体感觉刺激时振幅变化最大的MEG传感器计算事件相关去同步（ERD）和随后的事件相关再同步（ERS）的振幅。结果如预期的那样，手指刺激在OT患者和HC患者中均可诱导可靠的ERD和ERS。两组足部刺激均引起较弱的ERS。基于簇的排列测试没有发现OT组和HC组之间的任何显著差异。讨论：我们没有发现证据支持OT患者对本体感觉刺激的皮层反应普遍改变。意义本研究首次对OT中本体感觉皮层加工进行了研究。结果不支持OT中特征性的强烈不稳定感与皮层对本体感觉信息的反应改变有关的解释。

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