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Exploring the Diagnostic Role of Spectral Doppler as a Predictor of Malignancy Within Thyroid Nodules 探讨谱多普勒作为甲状腺结节内恶性肿瘤预测因子的诊断作用
IF 0.3 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2023-08-24 DOI: 10.1177/87564793231194645
N. Akhoundi, Zahra Naseri, Alireza Siami, S. Hazara, Mahta Noorbakhsh, Kobra Hazara, Elmira Rezazadeh
In recent years, spectral Doppler has become a valuable diagnostic tool for assessing suspected thyroid nodules. The aim of this study was to assess the clinical use of spectral Doppler in managing thyroid nodules. This prospective cohort study included 153 patients who underwent thyroid nodule evaluation, using sonography. Peak systolic velocity, end-diastolic velocity (EDV), resistive index (RI), and pulsatility index (PI) were measured, within the suspected lesions. Among the 209 identified thyroid nodules, 193 (92%) were benign and 16 (7.6%) were malignant. The RI and PI values of malignant nodules were significantly higher than measured within benign nodules. There was also a significant difference in the EDV between benign and malignant nodules ( P = .012). The RI had the highest diagnostic accuracy, with an area under the receiver operating characteristic, area under the curve, of 0.839 (95% confidence interval, 0.748–0.930). The optimal cutoff value for RI was 0.73. The results indicate that the RI with an odds ratio (OR) of 2.64, in the univariate analysis, and an OR of 2.31, in the multivariate analysis, might be successful in predicting a malignant thyroid nodule. This cohort study demonstrated a high sensitivity and specificity for RI and PI as predictors of malignancy in thyroid nodules, with diagnostic cutoff points of 0.73 and 1.37, respectively.
近年来,谱多普勒已成为评估可疑甲状腺结节的有价值的诊断工具。本研究的目的是评估谱多普勒在甲状腺结节治疗中的临床应用。这项前瞻性队列研究包括153名接受甲状腺结节评估的患者,使用超声检查。在疑似病变范围内测量峰值收缩速度、舒张末期速度(EDV)、阻力指数(RI)和脉搏指数(PI)。209例确诊甲状腺结节中,良性193例(92%),恶性16例(7.6%)。恶性结节的RI和PI值明显高于良性结节。良、恶性结节的EDV差异有统计学意义(P = 0.012)。RI的诊断准确率最高,其曲线下面积为0.839(95%可信区间0.748 ~ 0.930)。RI的最佳临界值为0.73。结果表明,在单因素分析中,RI的比值比(OR)为2.64,在多因素分析中,OR为2.31,可以成功预测恶性甲状腺结节。该队列研究表明,RI和PI作为甲状腺结节恶性预测指标具有很高的敏感性和特异性,诊断截止点分别为0.73和1.37。
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