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Wernicke’s encephalopathy as a presentation of severe thiamine deficiency after cardiac valve surgery: A case report and narrative review 心脏瓣膜手术后出现严重硫胺素缺乏的韦尼克脑病:一例报告和叙述回顾
Pub Date : 2019-04-04 DOI: 10.18502/IJNL.V18I2.1294
P. Sarraf, D. Motamedi, A. Habibi, S. Bitarafan
The article's abstract is no available.
这篇文章的摘要没有。
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引用次数: 1
Changes in trend of cerebral venous sinus thrombosis 脑静脉窦血栓形成趋势的变化
Pub Date : 2019-01-05 DOI: 10.18502/IJNL.V18I1.944
Banafsheh Shakibajahromi, N. Ashjazadeh, A. Safari, A. Borhani-Haghighi
The abstract not available.
摘要不可用。
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引用次数: 2
Combined central and peripheral demyelination: A case report and literature review 中央与外周合并脱髓鞘:1例报告及文献复习
Pub Date : 2019-01-05 DOI: 10.18502/IJNL.V18I1.945
H. Nouha, H. Olfa, F. Nouha, F. Sawsan, S. Salma, H. K. Hanen, D. Mariem, M. Chokri
The abstract not available.
摘要没有。
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引用次数: 2
Neuronal autoantibodies in focal epilepsy with or without mesial temporal sclerosis 局灶性癫痫伴或不伴内侧颞叶硬化的神经元自身抗体
Pub Date : 2019-01-05 DOI: 10.18502/IJNL.V18I1.941
B. Ansari, M. Etemadifar, Mohammad Reza Najafi, Maryam Nasri, Rokhsareh Meamar
Background: This study was designed to investigate the difference in the prevalence of neuronal autoantibodies in patients diagnosed with established temporal lobe epilepsy (TLE) of unknown cause with mesial temporal sclerosis (MTS) and patients with TLE without MTS. Methods: In an observational cohort study design, we included thirty-three consecutive adult patients and divided them into two groups with and without MTS. We evaluated anti-neuronal and nuclear antibodies with immunofluorescence (IF) and enzyme-linked immunosorbent assay (ELISA), respectively. Results: From the thirty-three consecutive patients with epilepsy 17 (51.1%) had MTS of which 12 had unilateral and 5 had bilateral MTS. No significant difference was detected between seropositive and seronegative patients in MTS versus non-MTS groups. The studied autoantibodies were present in 16 patients, including gamma-aminobutyric acid receptor (GABA-R) antibodies being the most common in 11 (33.3%), followed by N-methyl-D-aspartate receptor (NMDA-R) in 2 (6.1%), glutamic acid decarboxylase receptor (GAD-R) in 1 (3.0%), anti-phospholipid (APL) antibody in 1 (3.0%), CV2 in 1 (3.0%), Tr in 1 (3.0%), recoverin in 1 (3.0%), and double-stranded deoxyribonucleic acid (dsDNA) antibody in 1 (3.0%) of our patients with focal epilepsy. In both MTS and non-MTS groups, eight patients were positive for antibodies; four patients were positive for GABA in the MTS group and seven for GABA in the non-MTS group. Conclusion: Neuronal antibodies were presented in half of patients with focal epilepsy, GABA antibody being the leading one. No specific magnetic resonance imaging (MRI) findings were found in the seropositive group. Our results suggest that screening for relevant antibodies may enable us to offer a possible treatment to this group of patients.
背景:本研究旨在探讨诊断为不明原因颞叶癫痫(TLE)合并内侧颞叶硬化(MTS)的患者与未诊断为颞叶癫痫(TLE)的患者神经元自身抗体患病率的差异。在一项观察性队列研究设计中,我们纳入了33名连续的成年患者,并将他们分为两组,分别用免疫荧光(IF)和酶联免疫吸附试验(ELISA)评估抗神经元抗体和核抗体。结果:33例癫痫患者中发生MTS 17例(51.1%),其中单侧MTS 12例,双侧MTS 5例,MTS血清阳性、阴性组与非MTS组间无显著性差异。研究自身抗体的出现在16个病人,其中包括γ-氨基丁酸受体(GABA-R)抗体在11(33.3%),最常见的是由n -甲基- d受体(NMDA-R) 2(6.1%)、谷氨酸脱羧酶受体(GAD-R) 1(3.0%)、anti-phospholipid (APL)抗体在1(3.0%)、CV2 1例(3.0%),Tr 1例(3.0%),recoverin 1例(3.0%),双链脱氧核糖核酸(dsDNA)抗体在1局灶性癫痫患者(3.0%)。在MTS组和非MTS组中,8例患者抗体阳性;MTS组4例GABA阳性,非MTS组7例GABA阳性。结论:半数局灶性癫痫患者出现神经元抗体,以GABA抗体为主。血清阳性组未见特异性磁共振成像(MRI)表现。我们的结果表明,筛选相关抗体可能使我们能够为这组患者提供可能的治疗。
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引用次数: 2
Historical perspective of neurology in Iran 伊朗神经病学的历史视角
Pub Date : 2019-01-05 DOI: 10.18502/IJNL.V18I1.943
Shri K. Mishra, Hadi Mohammad Khanli, Golnoush Akhlaghipour, Ghazaleh Ahmadi Jazi, S. Khosa
Iran is an ancient country, known as the cradle of civilization. The history of medicine in Iran goes back to the existence of a human in this country, divided into three periods: pre-Islamic, medieval, and modern period. There are records of different neurologic terms from the early period, while Zoroastrian (religious) prescription was mainly used until the foundation of the first medical center (Gondishapur). In the medieval period, with the conquest of Islam, prominent scientists were taught in Baghdad, like Avicenna, who referred to different neurologic diseases including stroke, paralysis, tremor, and meningitis. Several outstanding scientists developed the medical science of neurology in Iran, the work of whom has been used by other countries in the past and present. In the modern era, the Iranian Neurological Association was established with the efforts of Professor Jalal Barimani in 1991.
伊朗是一个古老的国家,被誉为文明的摇篮。伊朗的医学史可以追溯到一个人在这个国家的存在,分为三个时期:前伊斯兰时期、中世纪和现代时期。早期有不同神经术语的记录,而琐罗亚斯德教(宗教)处方主要用于第一个医疗中心(贡迪沙普尔)的建立。在中世纪,随着伊斯兰教的征服,巴格达的著名科学家受到了教育,比如阿维森纳,他提到了不同的神经系统疾病,包括中风、瘫痪、震颤和脑膜炎。几位杰出的科学家在伊朗发展了神经病学的医学,他们的工作在过去和现在都被其他国家所使用。在现代,在Jalal Barimani教授的努力下,伊朗神经病学协会于1991年成立。
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引用次数: 1
Migraine, dyspepsia, and Helicobacter pylori: Zeroing in on the culprit 偏头痛、消化不良和幽门螺杆菌:锁定罪魁祸首
Pub Date : 2019-01-05 DOI: 10.18502/IJNL.V18I1.942
N. Akbari, A. Hormati, E. Sharifipour, S. Hejazi, F. Jafari, Seyed Ali Mousavi-Aghdas, S. Golzari
Background: Numerous studies have evaluated the impact of Helicobacter pylori (H. pylori) eradication on the number, severity, and recurrence of migraine attacks. But the association of migraine, H. pylori, and gastrointestinal (GI) presentation is challenging. The aim of the current study was to investigate the correlation between migraine, H. pylori, and peptic ulcers among patients with dyspepsia undergoing upper GI endoscopy. Methods: 305 patients with dyspepsia referring to our endoscopy ward, Shahid Beheshti Hospital affiliated to Qom University of Medical Sciences, Qom, Iran, for upper GI endoscopy filled out the study questionnaire. If a patient was experiencing headaches and the migraine was confirmed by neurologists, he/she was asked to answer the questions related to migraine, which were prepared exactly from Migraine Disability Assessment (MIDAS) questionnaire. The relation between migraine and confirmed H. pylori contamination was investigated using statistical models. Results: Of all the 305 patients, 133 (43.6%) had confirmed episodic migraine headaches (MHs) and 177 patients (58.04%) had positive RUT for confirming H. pylori contamination, of which 123 (69.5%) had confirmed migraine. 52 (17.0%) had duodenal peptic ulcer(s), of which, 49 (94.2%) had a positive rapid urease test (RUT) (P < 0.001). 20 (6.5%) of all patients had the gastric peptic ulcer(s) which did not have a significant relation with H. pylori contamination. There was a significant relationship between the peptic ulcer site and migraine. In total, 177 patients (58.0%) had a positive RUT. History of migraine was significantly positive in those with positive H. Pylori contamination. Notably, multivariable analysis demonstrated a significant relation of H. pylori and migraine at younger ages. Conclusion: The prevalence of H. pylori and migraine in patients with dyspepsia seems to be high. Moreover, there is a meaningful association between migraine, duodenal peptic ulcers, and H. pylori infection, too.
背景:许多研究已经评估了根除幽门螺杆菌(h.p ylori)对偏头痛发作次数、严重程度和复发的影响。但是偏头痛、幽门螺杆菌和胃肠道(GI)表现之间的联系是具有挑战性的。本研究的目的是研究在接受上消化道内镜检查的消化不良患者中偏头痛、幽门螺杆菌和消化性溃疡之间的相关性。方法:在伊朗库姆医科大学附属Shahid Beheshti医院内镜病房接受上消化道内镜检查的305例消化不良患者填写调查问卷。如果患者正在经历头痛,并经神经科医生确诊为偏头痛,他/她被要求回答与偏头痛相关的问题,这些问题完全是根据偏头痛残疾评估(MIDAS)问卷准备的。用统计模型研究偏头痛与幽门螺杆菌污染之间的关系。结果:305例患者中,确诊发作性偏头痛133例(43.6%),幽门螺杆菌污染RUT阳性177例(58.04%),其中确诊偏头痛123例(69.5%)。十二指肠消化性溃疡52例(17.0%),其中快速脲酶试验(RUT)阳性49例(94.2%)(P < 0.001)。20例(6.5%)患者发生消化性溃疡,与幽门螺杆菌污染无显著关系。消化性溃疡部位与偏头痛有显著关系。总共有177例(58.0%)患者有RUT阳性。幽门螺杆菌感染阳性的患者有明显的偏头痛病史。值得注意的是,多变量分析显示幽门螺杆菌与年轻偏头痛有显著关系。结论:幽门螺杆菌和偏头痛在消化不良患者中的患病率较高。此外,偏头痛、十二指肠消化性溃疡和幽门螺杆菌感染之间也存在有意义的联系。
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引用次数: 14
Involvement of cerebellum in frontotemporal dementia: A case presentation using fluorodeoxyglucose positron emission tomography/magnetic resonance imaging (FDG-PET/MRI) 小脑参与额颞叶痴呆:一例应用氟脱氧葡萄糖正电子发射断层扫描/磁共振成像(FDG-PET/MRI)的病例
Pub Date : 2019-01-05 DOI: 10.18502/IJNL.V18I1.946
S. Nivins, S. Berkins
The abstract not available.
摘要没有。
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引用次数: 0
Direct and indirect cost of managing Alzheimer’s disease in the Islamic Republic of Iran 伊朗伊斯兰共和国管理阿尔茨海默病的直接和间接费用
Pub Date : 2019-01-05 DOI: 10.18502/IJNL.V18I1.940
Zahra Aajami, A. Kebriaeezadeh, S. Nikfar
Background: Alzheimer’s disease (AD) affects a large number of adults annually all around the world. The monetary cost of this disorder is huge. This study aims to estimate the cost of AD in Iran by considering stages of disease. Methods: A cross-sectional study was designed from July to December 2017 on 300 AD cases who referred to the Iran Alzheimer’s Association, Tehran, Iran. To calculate costs at different stages of disease, patients were assigned into three groups, based on the Mini-Mental State Exam (MMSE) score. A list of medicines’ prices and health care service costs were prepared. Health care services’ cost was acquired from the book of “Relative value units of health care services in Iran” and the price of medicines was extracted from "Iran’s medicine triple prices list". Patients’ medical records and face to face interview with their caregivers were used for data collection. The perspective of present research was societal. Results: Annually, per person cost of AD in mild, moderate, and severe stages of disease were 434 United States dollars (USD), 1313 USD, and 2480 USD, respectively. Direct non-medical costs (DNMC) had the greatest share of total costs (near half of the whole costs) including 263 USD, 641 USD, and 1257 USD for mild, moderate, and severe stages, respectively. Conclusion: The cost of AD in Iran is lower than the average cost of dementia in upper middle-income countries. In all stages, the biggest part of the cost is associated with patient care and nursing services because patients suffering from AD usually require specialized cares.
背景:阿尔茨海默病(AD)每年影响全球大量成年人。这种疾病的经济成本是巨大的。这项研究的目的是通过考虑疾病的阶段来估计伊朗AD的成本。方法:对2017年7月至12月向伊朗德黑兰伊朗阿尔茨海默病协会转诊的300例AD患者进行横断面研究。为了计算不同疾病阶段的费用,根据迷你精神状态检查(MMSE)评分,将患者分为三组。编制了药品价格和保健服务费用清单。保健服务的费用取自"伊朗保健服务的相对价值单位",药品的价格取自"伊朗药品三重价目表"。数据收集采用患者病历和与护理人员的面对面访谈。当前研究的视角是社会性的。结果:每年轻度、中度和重度AD的人均成本分别为434美元、1313美元和2480美元。直接非医疗费用(DNMC)在总费用中所占比例最大(接近总费用的一半),轻度、中度和重度分别为263美元、641美元和1257美元。结论:伊朗AD的费用低于中高收入国家痴呆的平均费用。在所有阶段,成本的最大一部分与患者护理和护理服务有关,因为患有AD的患者通常需要专门的护理。
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引用次数: 11
The “coma sign”: An iatrogenic complication of neurological assessment “昏迷征”:神经系统评估的医源性并发症
Pub Date : 2019-01-05 DOI: 10.18502/IJNL.V18I1.947
B. Lucke-Wold, Christopher Robinson DO
The abstract not available.
摘要不可用。
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引用次数: 0
Occupational performance of individuals with Multiple Sclerosis based on disability level in Iran 伊朗基于残疾水平的多发性硬化症患者的职业表现
Pub Date : 2019-01-05 DOI: 10.18502/IJNL.V18I1.939
Leila Dehghan, F. Faraji, Hamid Dalvand, Shamsoddini Alireza, Mohammad Reza Hadian-Rasanani
Background: Multiple sclerosis (MS) is a common disease across the world as well as in Iran. Individuals with MS usually experience occupational performance problems that result in limitations in their daily life. This study aimed to determine the occupational performance of individuals with MS based on the disability level in Iran. Methods: In this cross-sectional study, 50 individuals with MS (20 to 50 years old) were recruited through a convenience sampling strategy from different clinics in Arak City, Iran, during 2016-2017. The Persian versions of Canadian Occupational Performance Measure (COPM) and Expanded Disability Status Scale (EDSS) were used to assess the status of occupational performance and level of disability. The data were analyzed using chi-square, Spearman's rank correlation, and Mann-Whitney U tests. Results: The total number of 248 occupations were identified as difficult to perform in the following areas: 125 (50.40%) in self-care, 58 (23.38%) in productivity, and 65 (26.20%) in leisure. In addition, the prioritized occupations (n = 149, median: 3, range: 1-4) had significant difference in the distribution of occupations compared with the non-prioritized occupations (P < 0.0001) and the ratings for performances and satisfactions were generally low. There were significant differences between the occupational performance and level of EDSS. Conclusion: The findings of current study suggest that individuals with MS suffer from widespread problems in the areas of occupational performance, particularly in self-care. The findings emphasize the need for identifying the problems of daily occupations in individuals with MS.
背景:多发性硬化症(MS)是世界各地以及伊朗的一种常见疾病。患有多发性硬化症的人通常会遇到职业表现问题,导致他们的日常生活受到限制。本研究的目的是根据残疾水平确定伊朗多发性硬化症患者的职业表现。方法:在这项横断面研究中,通过方便抽样策略,从2016-2017年伊朗阿拉克市的不同诊所招募了50名MS患者(20至50岁)。采用波斯语版本的加拿大职业表现量表(COPM)和扩展残疾状态量表(EDSS)来评估职业表现状态和残疾水平。采用卡方检验、Spearman秩相关检验和Mann-Whitney U检验对数据进行分析。结果:248个职业中,自我护理类有125个(50.40%),生产力类有58个(23.38%),休闲类有65个(26.20%)。此外,优先职业(n = 149,中位数:3,范围:1-4)与非优先职业在职业分布上存在显著差异(P < 0.0001),对绩效和满意度的评分普遍较低。职业绩效与EDSS水平之间存在显著差异。结论:目前的研究结果表明,多发性硬化症患者在职业表现方面普遍存在问题,特别是在自我保健方面。研究结果强调了识别多发性硬化症患者日常工作问题的必要性。
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引用次数: 2
期刊
Iranian Journal of Neurology
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