The therapeutic effects of biophilia have garnered increasing attention in hospital settings, as recent research highlights its impact on psychological metrics such as anxiety, depression, pain, and patient satisfaction. In their 2024 study, Guidolin et al. present compelling data supporting the role of nature exposure in improving patient outcomes. Building on this, we explore a possible link between biophilia and brain plasticity. The human brain's neuroplasticity, particularly adult hippocampal neurogenesis, responds dynamically to environmental stimuli, including enriched environments. Studies suggest that biophilic design, by integrating natural elements to built spaces, can positively influence brain function and mental health. Furthermore, interactions with nature may upregulate neurogenesis in the hippocampus, a region critical for memory and emotional regulation. These findings support the integration of biophilia as a potential non-pharmacological approach to enhance cognitive and psychological health. We propose that future architectural projects should leverage biophilic design to harness these therapeutic benefits, particularly in healthcare environments, to promote well-being and brain function.