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Surgical Management of Pachyonychia Congenita in a 3-Year-Old. 手术治疗一名 3 岁儿童的先天性甲状腺发育不全。
IF 1.5 Q3 SURGERY Pub Date : 2023-12-21 eCollection Date: 2023-11-01 DOI: 10.1055/s-0043-1771520
Jack D Sudduth, Christopher Clinker, Matthew Holdaway, Jessica L Marquez, Jacob Veith, Thomas Wright, W Bradford Rockwell

Pachyonychia congenita is a rare genetic disorder characterized by hypertrophic nail plates, hyperkeratotic nail beds, and thickened hyponychium of the fingers and toes, impairing manual dexterity and resulting in poor aesthetics. The current body of literature describes various treatment modalities, but no singular approach has been defined as the gold standard. In this case, the authors employed different surgical techniques for treating pachyonychia congenita to evaluate the most effective approach. A 3-year-old boy presented with hypertrophic nail growth involving all digits of both hands and feet. Three surgical procedures were performed on the patient's fingers and toes using germinal matrix excision (GME) alone, GME plus partial sterile matrix excision (pSME), or GME plus complete sterile matrix excision (cSME). The digits treated with GME + cSME exhibited no recurrence of nail growth. Those treated with GME alone exhibited recurrence of hypertrophic nail growth, although their growth slowed. Excision of GME + cSME prevented recurrence of hypertrophic nails, while GME alone or with pSME led to slower-growing hypertrophic nails. Complete excision of the germinal and sterile matrices with skin graft closure may be a definitive treatment for pachyonychia congenita, but further studies are needed to validate these findings.

先天性甲沟炎是一种罕见的遗传性疾病,其特征是甲板肥厚、甲床角化过度、手指和脚趾的下趾骨增厚,从而影响手的灵活性,并导致美观不佳。现有文献介绍了各种治疗方法,但没有一种方法被定义为黄金标准。在本病例中,作者采用了不同的手术技术来治疗先天性趾骨粗大症,以评估最有效的方法。一名 3 岁的男孩出现了肥厚性指甲增生,涉及双手和双脚的所有手指。对患者的手指和脚趾进行了三种手术,分别是单纯胚芽基质切除术(GME)、胚芽基质切除术加部分无菌基质切除术(pSME)或胚芽基质切除术加完全无菌基质切除术(cSME)。接受 GME + cSME 治疗的手指指甲生长没有复发。而只接受 GME 治疗的患者,虽然生长速度减慢,但增生的指甲仍会复发。切除 GME + cSME 可防止增生性指甲复发,而单独切除 GME 或同时切除 pSME 则会导致增生性指甲生长缓慢。完全切除生发基质和无菌基质并植皮闭合可能是治疗先天性甲沟炎的最终方法,但还需要进一步的研究来验证这些发现。
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引用次数: 0
Deep or Shallow, It's up to You. 深或浅,取决于你。
IF 1.5 Q3 SURGERY Pub Date : 2023-12-21 eCollection Date: 2023-11-01 DOI: 10.1055/s-0042-1756339
Kun Hwang
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引用次数: 0
Comparison of The Thickness of Free Anterolateral Thigh Flap in Different Fascial Planes: Clinical Results of Subfascial and Superficial Fat Flap. 不同筋膜平面的游离大腿前外侧皮瓣厚度比较:筋膜下皮瓣和浅层脂肪皮瓣的临床效果。
IF 1.5 Q3 SURGERY Pub Date : 2023-12-01 eCollection Date: 2023-11-01 DOI: 10.1055/s-0043-1772586
Yavuz Tuluy, Zülfükar Ulaş Bali, Merve Özkaya Ünsal, Aziz Parspancı, Levent Yoleri, Çağla Çiçek, Gaye Taylan Filinte

Background  The anterolateral thigh (ALT) flap is a preferred option in the reconstruction of a wide variety of defects, enabling multiple tissue components and thicknesses. Methods  This study was conducted to investigate the correlation of the thickness of the traditional subfascial ALT flap and superficial fat flap with age, gender, and body mass index (BMI). A total of 42 patients (28 males and 14 females) were included in the study. Results  Mean age was 50.2 (range, 16-75) years and mean BMI was 24.68 ± 4.02 (range, 16.5-34.7) kg/m 2 . The subfascial flap thickness was significantly thinner in male patients (16.07 ± 2.77 mm) than in female patients (24.07 ± 3.93 mm; p  < 0.05), whereas no significant difference was found between male (4.28 ± 1.15 mm) and female patients (4.85 ± 1.09 mm) regarding superficial fat flap thickness ( p  = 0.13). The thickness of both flaps had a positive correlation with BMI, and the strongest correlation was found for subfascial ALT thickness in female patients ( r  = 0.81). Age had no effect on both flap thickness measurements. The anterior thigh is thicker in women than in men, although it varies according to BMI. This shows that flap elevation is important in the superthin plane, especially if a thin flap is desired in female patients in defect reconstruction with the ALT flap. Thus, a single-stage reconstruction is achieved without the need for a defatting procedure after subfascial dissection or a second defatting procedure 3 to 6 months later. Conclusion  The appropriate ALT flap plane should be selected considering the gender and BMI of the patient.

背景 大腿前外侧(ALT)皮瓣是重建各种缺损的首选方法,可用于多种组织成分和厚度的重建。方法 本研究旨在探讨传统筋膜下 ALT 皮瓣和浅层脂肪皮瓣的厚度与年龄、性别和体重指数(BMI)的相关性。研究共纳入 42 名患者(28 名男性和 14 名女性)。结果 平均年龄为 50.2 岁(范围在 16-75 岁之间),平均体重指数为 24.68 ± 4.02(范围在 16.5-34.7 公斤/米 2 之间)。男性患者的筋膜下皮瓣厚度(16.07 ± 2.77 mm)明显薄于女性患者(24.07 ± 3.93 mm; p p = 0.13)。两种皮瓣的厚度与体重指数呈正相关,女性患者筋膜下 ALT 厚度的相关性最强(r = 0.81)。年龄对皮瓣厚度的测量没有影响。女性的大腿前侧比男性更厚,尽管这与体重指数有关。这表明皮瓣在超薄平面的抬高非常重要,尤其是如果女性患者希望使用 ALT 皮瓣进行缺损重建时皮瓣更薄。因此,单阶段重建无需在筋膜下剥离后进行脱脂手术,也无需在 3 至 6 个月后进行第二次脱脂手术。结论 应根据患者的性别和体重指数选择合适的 ALT 皮瓣平面。
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引用次数: 0
Massive Localized Abdominal Lymphedema: A Case Report with Literature Review. 大面积局部性腹部淋巴水肿:病例报告与文献综述
IF 1.5 Q3 SURGERY Pub Date : 2023-11-30 eCollection Date: 2023-11-01 DOI: 10.1055/a-2140-8589
Badri Gogia, Irina Chekmareva, Anastasiia Leonova, Rifat Alyautdinov, Grigory Karmazanovsky, Andrey Glotov, Dmitry Kalinin

Massive localized lymphedema (MLL) is a rare disease caused by the obstruction of lymphatic vessels with specific clinical morphological and radiological characteristics. People with morbid obesity are mainly affected by MLL. Lymphedema is easily confused with soft tissue sarcoma and requires differential diagnosis, both the possibility of an MLL and also carcinoma manifestations in the soft tissues. The possible causes of massive lymphedema include trauma, surgery, and hypothyroidism. This report is the first case of MLL treated surgically in the Russian Federation. Detailed computed tomography (CT) characteristics and an electron microscope picture of MLL are discussed. A 50-year-old woman (body mass index of 43 kg/m 2 ) with MLL arising from the anterior abdominal wall was admitted to the hospital for surgical treatment. Its mass was 22.16 kg. A morphological study of the resected mass confirmed the diagnosis of MLL. We review etiology, clinical presentation, diagnosis, and treatment of MLL. We also performed an electron-microscopic study that revealed interstitial Cajal-like cells telocytes not previously described in MLL cases. We did not find similar findings in the literature. It is possible that the conduction of an ultrastructural examination of MLL tissue samples will further contribute to the understanding of MLL pathogenesis.

大面积局部淋巴水肿(MLL)是一种由淋巴管阻塞引起的罕见疾病,具有特殊的临床形态学和放射学特征。病态肥胖症患者主要受 MLL 影响。淋巴水肿很容易与软组织肉瘤混淆,需要进行鉴别诊断,既要考虑 MLL 的可能性,也要考虑软组织的癌变表现。导致大量淋巴水肿的可能原因包括创伤、手术和甲状腺功能减退。本报告是俄罗斯联邦首例通过手术治疗的 MLL 病例。本文讨论了 MLL 的详细计算机断层扫描(CT)特征和电子显微镜图片。一名 50 岁女性(体重指数为 43 kg/m 2)因腹壁前部出现 MLL 而入院接受手术治疗。其质量为 22.16 千克。切除肿块的形态学研究证实了 MLL 的诊断。我们回顾了 MLL 的病因、临床表现、诊断和治疗。我们还进行了一项电子显微镜研究,发现了间质卡贾尔样细胞端细胞,这是以前在 MLL 病例中没有发现过的。我们在文献中没有找到类似的发现。对 MLL 组织样本进行超微结构检查可能会进一步促进对 MLL 发病机制的了解。
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引用次数: 0
Abdominal Hypertension after Abdominal Plication in Postbariatric Patients: The Consequence in the Postoperative Recovery. 减肥术后患者腹腔穿刺术后腹部高血压:术后恢复的后果。
IF 1.5 Q3 SURGERY Pub Date : 2023-11-30 eCollection Date: 2023-11-01 DOI: 10.1055/s-0043-1772587
Martin Morales-Olivera, Erik Hanson-Viana, Armando Rodríguez-Segura, Marco A Rendón-Medina

Background  Abdominoplasty with abdominal plication increases intra-abdominal pressure (IAP) and has been previously associated with limited diaphragmatic excursion and respiratory dysfunctions. Many factors found in abdominoplasties and among postbariatric patients predispose them to a higher occurrence. This study aims to evaluate the impact of abdominal plication among postbariatric patients, assess whether the plication increases their IAP, and analyze how these IAP correlate to their postoperative outcome. Methods  This prospective study was performed on all patients who underwent circumferential Fleur-De-Lis abdominoplasty. For this intended study, the IAP was measured by an intravesical minimally invasive approach in three stages: after the initiation of general anesthesia, after a 10-cm abdominal wall plication and skin closure, and 24 hours after the procedure. Results  We included 46 patients, of which 41 were female and 5 were male. Before the bariatric procedure, these patients had an average maximum weight of 121.4 kg and an average maximum body mass index of 45.78 kg/m 2 ; 7 were grade I obese patients, 10 were grade II, and 29 were grade III. Only three patients were operated on with a gastric sleeve and 43 with gastric bypass. We presented six patients with transitory intra-abdominal hypertension in the first 24 hours, all of them from the grade I obesity group, the highest presented was 14.3 mm Hg. We presented 15% (7/46) of complication rates, which were only four seroma and five dehiscence; two patients presented both seroma and wound dehiscence. Conclusion  Performing a 10-cm abdominal wall plication or greater represents a higher risk for intra-abdominal hypertension, slower general recovery, and possibly higher complication rate in patients who presented a lower degree of obesity (grade I) at the moment of the bariatric surgery.

背景腹部成形术会增加腹内压(IAP),以前曾被认为与膈肌外展受限和呼吸功能障碍有关。在腹部整形手术和减肥后患者中发现的许多因素都会导致其发生率升高。本研究旨在评估腹部成形术对减肥后患者的影响,评估腹部成形术是否会增加他们的 IAP,并分析这些 IAP 与他们的术后结果有何关联。方法 这项前瞻性研究针对所有接受环形 Fleur-De-Lis 腹部整形术的患者。在这项预期研究中,IAP 通过膀胱内微创方法分三个阶段进行测量:开始全身麻醉后、10 厘米腹壁成形和皮肤闭合后以及术后 24 小时。结果 我们纳入了 46 名患者,其中 41 人为女性,5 人为男性。减肥手术前,这些患者的平均最大体重为 121.4 千克,平均最大体重指数为 45.78 千克/米 2;其中 7 人为 I 级肥胖患者,10 人为 II 级肥胖患者,29 人为 III 级肥胖患者。只有 3 名患者接受了胃袖状手术,43 名患者接受了胃旁路手术。有 6 名患者在术后 24 小时内出现短暂的腹腔内高压,他们都属于 I 级肥胖组,最高为 14.3 mm Hg。并发症发生率为 15%(7/46),其中只有 4 例血清肿和 5 例伤口裂开;2 例患者同时出现血清肿和伤口裂开。结论 对于减肥手术时肥胖程度较轻(I 级)的患者来说,进行 10 厘米或更大的腹壁成形术代表着更高的腹内高压风险、更慢的全身恢复速度以及可能更高的并发症发生率。
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引用次数: 0
Management of ptosis in Kearns Sayre syndrome (KSS): a case report and Literature review on Management of ptosis in KSS 卡恩斯·塞尔综合征(KSS)上睑下垂的处理:1例报告及文献综述
Q3 SURGERY Pub Date : 2023-11-09 DOI: 10.1055/a-2207-7587
MOULAY OMAR MOUSTAINE, Zakaria Azmour, Mohamed Frarrchi, Othman Benenda, Hicham Nassik, Mahdi Karkouri
Kearns Sayre syndrome (KSS) is a rare mitochondrial disease that affects young adults, due to a deletion of mitochondrial DNA and characterized by the triad: age of onset lower than 20 years, chronic progressive external ophthalmoplegia and an atypical pigmentary retinopathy. It’s also characterized by other endocrine, neurological and especially cardiac impairment with a very high risk of cardiac complications during surgical procedures under all types of anesthesia. We report a case of KSS revealed by sever bilateral ptosis and confirmed by a muscle biopsy with “ragged red fibers”. The ptosis was surgically managed by cautious Frontal suspension under local anesthesia “Frontal nerve block”. Through this case we discuss challenges in the management of KSS patients.
Kearns Sayre综合征(KSS)是一种罕见的线粒体疾病,影响年轻人,由于线粒体DNA的缺失,其特征为:发病年龄低于20岁,慢性进行性外眼麻痹和非典型色素视网膜病变。它的特点还包括其他内分泌,神经系统,尤其是心脏损伤在各种麻醉下的手术过程中心脏并发症的风险非常高。我们报告一例KSS表现为严重的双侧上睑下垂,并通过肌肉活检证实为“粗糙的红色纤维”。在局部麻醉“额神经阻滞”下,采用谨慎的额神经悬吊术治疗上睑下垂。通过这个案例,我们讨论了管理KSS患者所面临的挑战。
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引用次数: 0
Identifying Barriers Faced by Applicants without a Home Residency Program when Matching into Plastic Surgery 确定没有家庭住院医师计划的申请人在匹配整形手术时面临的障碍
Q3 SURGERY Pub Date : 2023-11-02 DOI: 10.1055/a-2202-9219
Steven Zeng, Gloria Zhang, Denisse Fimbres, Caitrin Curtis, Adam Glener, Andres J Hernandez, William Tian, Emmanuel O Emovon, Brett Phillips
BACKGROUND Applying into plastic surgery is competitive. Lacking a home residency program (HRP) is another barrier. Our goal is to characterize challenges faced by plastic surgery (PS) applicants without HRPs and identify solutions. METHODS Surveys were designed for current integrated PS residents and applicants in the 2022 Match without HRPs. Surveys were distributed electronically. Only U.S. allopathic graduate responses were included. RESULTS Of 182 individuals surveyed, 74 responded (39%, 33-residents, 41-applicants). Sixty-six percent reported feeling disadvantaged due to lacking an HRP. 76% of applicants successfully matched. Of these, 48% felt they required academic time off (research year) vs 10% of unmatched applicants. 97% of matched applicants identified a mentor vs 40% of unmatched applicants (p<0.05). Matched applicants identified mentors through research (29%) and cold calling/emailing (25%). Matched vs unmatched applicants utilized the following resources: senior students (74vs10%), (p<0.05) and social media (52vs10%), (p<0.05). Among residents, sixteen had PS divisions (48%). Thirty-six percent with divisions felt they had opportunities to explore PS, compared to 12% without divisions. Residents without divisions felt disadvantaged in finding research (94vs65%, p<0.05), delayed in deciding on PS (50vs28%), and obtaining mentors (44vs35%) and letters of recommendation (LOR) (31vs24%). CONCLUSIONS PS residents and applicants without HRPs reported feeling disadvantaged when matching. The data suggest access to departments or divisions assists in matching. We identified external outreach and research were successful strategies to obtain mentorship. To increase awareness for unaffiliated applicants, we should increase networking opportunities during local, regional, and national meetings.
背景:进入整形外科行业竞争激烈。缺乏家庭居留计划(HRP)是另一个障碍。我们的目标是描述没有HRPs的整形手术(PS)申请者所面临的挑战,并找出解决方案。方法对目前综合PS居民和2022年比赛中没有HRPs的申请人进行调查。调查以电子方式分发。仅包括美国对抗疗法毕业生的反应。结果在182名被调查者中,74人回复(39%,33名居民,41名申请者)。66%的人表示由于缺乏HRP而处于不利地位。76%的申请者成功匹配。在这些人中,48%的人认为他们需要学习时间(研究年),而不匹配的申请人中只有10%。97%匹配的申请人找到了导师,而40%不匹配的申请人找到了导师(p<0.05)。匹配的申请人通过研究(29%)和陌生电话/电子邮件(25%)来确定导师。匹配和不匹配的申请人利用了以下资源:高年级学生(74%对10%),(p<0.05)和社交媒体(52%对10%),(p<0.05)。在居民中,有16人患有PS症(48%)。36%有部门的人认为他们有机会探索PS,而没有部门的只有12%。没有分部的居民在寻找研究(94比65%,p<0.05),决定PS(50比28%),获得导师(44比35%)和推荐信(LOR)(31比24%)方面处于劣势。结论:PS居民和无HRPs的申请人在匹配时感觉处于不利地位。数据表明,进入部门或部门有助于匹配。我们发现外部推广和研究是获得指导的成功策略。为了提高对非附属申请人的认识,我们应该在地方、区域和国家会议期间增加交流机会。
{"title":"Identifying Barriers Faced by Applicants without a Home Residency Program when Matching into Plastic Surgery","authors":"Steven Zeng, Gloria Zhang, Denisse Fimbres, Caitrin Curtis, Adam Glener, Andres J Hernandez, William Tian, Emmanuel O Emovon, Brett Phillips","doi":"10.1055/a-2202-9219","DOIUrl":"https://doi.org/10.1055/a-2202-9219","url":null,"abstract":"BACKGROUND Applying into plastic surgery is competitive. Lacking a home residency program (HRP) is another barrier. Our goal is to characterize challenges faced by plastic surgery (PS) applicants without HRPs and identify solutions. METHODS Surveys were designed for current integrated PS residents and applicants in the 2022 Match without HRPs. Surveys were distributed electronically. Only U.S. allopathic graduate responses were included. RESULTS Of 182 individuals surveyed, 74 responded (39%, 33-residents, 41-applicants). Sixty-six percent reported feeling disadvantaged due to lacking an HRP. 76% of applicants successfully matched. Of these, 48% felt they required academic time off (research year) vs 10% of unmatched applicants. 97% of matched applicants identified a mentor vs 40% of unmatched applicants (p<0.05). Matched applicants identified mentors through research (29%) and cold calling/emailing (25%). Matched vs unmatched applicants utilized the following resources: senior students (74vs10%), (p<0.05) and social media (52vs10%), (p<0.05). Among residents, sixteen had PS divisions (48%). Thirty-six percent with divisions felt they had opportunities to explore PS, compared to 12% without divisions. Residents without divisions felt disadvantaged in finding research (94vs65%, p<0.05), delayed in deciding on PS (50vs28%), and obtaining mentors (44vs35%) and letters of recommendation (LOR) (31vs24%). CONCLUSIONS PS residents and applicants without HRPs reported feeling disadvantaged when matching. The data suggest access to departments or divisions assists in matching. We identified external outreach and research were successful strategies to obtain mentorship. To increase awareness for unaffiliated applicants, we should increase networking opportunities during local, regional, and national meetings.","PeriodicalId":47543,"journal":{"name":"Archives of Plastic Surgery-APS","volume":"14 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135972910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nasal Osteotomies Revisited in Asian: Surface Aesthetics, Anatomical and Technical Considerations 亚洲的鼻截骨术:表面美学、解剖和技术考虑
Q3 SURGERY Pub Date : 2023-10-31 DOI: 10.1055/a-2201-8219
Jae-Yong Jeong, Taek-Kyun Kim, Inhoe Ku, Bakhtiyor Najmiddinov
Background: Although osteotomy is commonly performed in rhinoplasty, it is difficult for less experienced surgeon to understand mechanism of the procedure. The primary goal of this study is to improve understanding of nasal osteotomy in Asians by considering the surface aesthetics and anatomy of the nose as well as their relationships with the surgical procedure. Methods: Surface aesthetics, anatomic considerations, kinetics of medial and lateral osteotomy, fracture levels of osteotomy were discussed in detail by reviewing the previous publications and 18 years of our experience. Moreover, the technical details of osteotomy were explained and personal tips for performing successful osteotomy were described. Results: Dorsal and lateral aesthetic lines, dorsal and basal widths are main characteristics related to the surface aesthetics of nose to perform the osteotomy. In addition, these features are different in Asian population due to the anatomic difference with Caucasians, which makes the procedure difficult and requires more attention to perform osteotomy. Conclusion: Because osteotomy is one of the most traumatic and invasive part of the rhinoplasty, it is crucial for the rhinoplasty surgeon to understand the relationship between surface aesthetics and osteotomy techniques to produce consistent and reproducible results.
背景:虽然截骨术在鼻整形术中很常见,但缺乏经验的外科医生很难理解截骨术的原理。本研究的主要目的是通过考虑鼻子的表面美学和解剖结构以及它们与手术过程的关系,提高对亚洲人鼻截骨术的理解。方法:通过回顾以往的出版物和我们18年的经验,详细讨论了表面美学,解剖学考虑,内侧和外侧截骨动力学,截骨骨折水平。此外,本文还介绍了截骨术的技术细节和成功截骨术的个人技巧。结果:鼻背侧美学线、鼻背宽度和鼻基底宽度是影响鼻面美学的主要特征。此外,由于亚洲人与高加索人的解剖差异,这些特征在亚洲人群中有所不同,这使得手术困难,需要更多的注意进行截骨。结论:截骨术是鼻整形术中最具创伤性和侵入性的部分之一,对于鼻整形外科医生来说,了解表面美学与截骨术之间的关系对于获得一致和可重复的结果至关重要。
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引用次数: 0
Serial Tissue Expansion and Skin Grafts in the Management of a Giant Congenital Nevus of the Face: Review of Literature and Case Report 连续组织扩张和皮肤移植治疗面部巨大先天性痣:文献回顾和病例报告
Q3 SURGERY Pub Date : 2023-10-31 DOI: 10.1055/a-2201-8061
Thiết Sơn Trần, Tuấn Nghĩa Phan, Pham Thi Viet Dung, Hồng Thúy Tạ Thị, Tuấn Anh Hoàng, Anh Huy Lê
Giant congenital nevi, especially on the head and neck, pose a challenge for plastic surgeons. This requires extensive experience in detailed planning, combining different techniques, and selecting appropriate materials for reconstruction. There have been reports of using a tissue expander, serial resection method, and full-thickness skin grafts for this type of nevus. However, the best way availabl to completely remove a giant congenital nevus is endless. In this article, we would like to present a case of a left hemifacial giant congenital nevus in which we used multiple tissue expansion to fully replace the nevus along with some of our modification techniques.
巨大的先天性痣,尤其是头部和颈部的痣,对整形外科医生来说是一个挑战。这需要在详细规划、结合不同技术和选择合适的重建材料方面有丰富的经验。已有报道使用组织扩张器、连续切除法和全层皮肤移植治疗这种类型的痣。然而,完全切除巨大先天性痣的最佳方法是无穷无尽的。在这篇文章中,我们想要提出一个左半面巨大先天性痣的病例,我们使用多种组织扩张来完全取代痣以及一些我们的修饰技术。
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引用次数: 0
Does lympho-venous anastomosis effect for mTOR inhibitor-associated lymphedema patients? 淋巴-静脉吻合术对mTOR抑制剂相关性淋巴水肿患者有效吗?
Q3 SURGERY Pub Date : 2023-10-30 DOI: 10.1055/a-2201-5881
Inah Yoon, HyungBae Kim, Jeongmok Cho, Changsik John Pak, Hyunsuk Peter Suh, Jae Yong Jeon, Jp Hong
The mTOR inhibitors are used to prevent organ transplant rejection and is preferred over other immunosuppressants due to its low nephrotoxicity. However, mTOR inhibitors have been associated with various adverse effects including lymphedema. Although rare in incidence, previously known treatments for mTOR inhibitor induced lymphedema were limited to discontinuation of related drugs and complex disruptive therapy with variable results. In this article, three patients who developed lymphedema in their lower limbs after using mTOR inhibitors, including two bilateral and one unilateral case, were treated with physiologic surgery methods such as lympho-venous anastomosis and lymph node transfer. The efficacy of the treatment was evaluated. In the three cases described, cessation of the drug did not lead to any reduction in edema. The use of lympho-venous anastomosis (LVA) and lymph node transfer resulted in early reductions in volume but failed to sustain over time. All patients underwent secondary nonphysiologic surgery such as liposuction resulting in sustained improvement. This series presents the first physiologic approach to mTOR inhibitor induced lymphedema. Although further study is warranted, the physiologic surgical options may have limited success and nonphysiologic options may offer better sustainable results.
mTOR抑制剂用于预防器官移植排斥反应,由于其肾毒性低,因此比其他免疫抑制剂更受欢迎。然而,mTOR抑制剂与包括淋巴水肿在内的各种不良反应有关。虽然发病率很少,但以前已知的治疗mTOR抑制剂诱导淋巴水肿的方法仅限于停止相关药物和复杂的破坏性治疗,结果不一。本文对3例使用mTOR抑制剂后出现下肢淋巴水肿的患者,包括2例双侧和1例单侧,采用淋巴-静脉吻合和淋巴结转移等生理性手术方法进行治疗。对治疗效果进行评价。在上述三个病例中,停药并没有导致水肿的任何减少。使用淋巴静脉吻合(LVA)和淋巴结转移导致早期体积减少,但未能持续一段时间。所有患者都进行了二次非生理性手术,如吸脂术,导致持续改善。这一系列提出了mTOR抑制剂诱导淋巴水肿的第一个生理学方法。虽然需要进一步研究,但生理性手术选择的成功可能有限,而非生理性手术选择可能提供更好的可持续结果。
{"title":"Does lympho-venous anastomosis effect for mTOR inhibitor-associated lymphedema patients?","authors":"Inah Yoon, HyungBae Kim, Jeongmok Cho, Changsik John Pak, Hyunsuk Peter Suh, Jae Yong Jeon, Jp Hong","doi":"10.1055/a-2201-5881","DOIUrl":"https://doi.org/10.1055/a-2201-5881","url":null,"abstract":"The mTOR inhibitors are used to prevent organ transplant rejection and is preferred over other immunosuppressants due to its low nephrotoxicity. However, mTOR inhibitors have been associated with various adverse effects including lymphedema. Although rare in incidence, previously known treatments for mTOR inhibitor induced lymphedema were limited to discontinuation of related drugs and complex disruptive therapy with variable results. In this article, three patients who developed lymphedema in their lower limbs after using mTOR inhibitors, including two bilateral and one unilateral case, were treated with physiologic surgery methods such as lympho-venous anastomosis and lymph node transfer. The efficacy of the treatment was evaluated. In the three cases described, cessation of the drug did not lead to any reduction in edema. The use of lympho-venous anastomosis (LVA) and lymph node transfer resulted in early reductions in volume but failed to sustain over time. All patients underwent secondary nonphysiologic surgery such as liposuction resulting in sustained improvement. This series presents the first physiologic approach to mTOR inhibitor induced lymphedema. Although further study is warranted, the physiologic surgical options may have limited success and nonphysiologic options may offer better sustainable results.","PeriodicalId":47543,"journal":{"name":"Archives of Plastic Surgery-APS","volume":"6 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136104650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Archives of Plastic Surgery-APS
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