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Clinical effect of operative vs nonoperative treatment on humeral shaft fractures: Systematic review and meta-analysis of clinical trials. 肱骨轴骨折手术治疗与非手术治疗的临床效果:临床试验的系统回顾和荟萃分析。
IF 2 Q2 ORTHOPEDICS Pub Date : 2024-08-18 DOI: 10.5312/wjo.v15.i8.783
Yang Li, Yi Luo, Jing Peng, Jun Fan, Xiao-Tao Long

Background: Whether operation is superior to non-operation for humeral shaft fracture remains debatable. We hypothesized that operation could decrease the nonunion and reintervention rates and increase the functional outcomes.

Aim: To compare the clinical efficacy between operative and nonoperative approaches for humeral shaft fractures.

Methods: We searched the PubMed, Web of Science, ScienceDirect, and Cochrane databases from 1990 to December 2023 for clinical trials and cohort studies comparing the effects of operative and conservative methods on humeral shaft fractures. Two investigators independently extracted data from the eligible studies, and the other two assessed the methodological quality of each study. The quality of the included studies was assessed using the Cochrane risk bias or Newcastle-Ottawa Scale. The nonunion, reintervention and the overall complications and functional scores were pooled and analyzed using Review Manager software (version 5.3).

Results: A total of four randomized control trials and 13 cohort studies were included, with 1285 and 1346 patients in the operative and nonoperative groups, respectively. Patients in the operative group were treated with a plate or nail, whereas those in the conservative group were managed with splint or functional bracing. Four studies were assessed as having a high risk of bias, and the other 13 were of a low risk of bias according to the Newcastle-Ottawa Scale or Cochrane risk bias tool. The operative group had a significantly decreased rate of nonunion [odds ratio (OR) 0.30; 95%CI: 0.23 to 0.40), reintervention (OR: 0.33; 95%CI: 0.24 to 0.47), and overall complications (OR: 0.62; 95%CI: 0.49 to 0.78)]. The pooled effect of the Disabilities of Arm, Shoulder, and Hand score showed a significant difference at 3 [mean difference (MD) -8.26; 95%CI: -13.60 to -2.92], 6 (MD: -6.72; 95%CI: -11.34 to -2.10), and 12 months (MD: -2.55; 95%CI: -4.36 to -0.74). The pooled effect of Visual Analog Scale scores and the Constant-Murley score did not significantly differ between the two groups.

Conclusion: This systematic review and meta-analysis revealed a trend of rapid functional recovery and decreased rates of nonunion and reintervention after operation for humeral shaft fracture compared to conservative treatment.

背景:手术治疗肱骨轴骨折是否优于非手术治疗仍存在争议。目的:比较肱骨轴骨折手术和非手术治疗的临床疗效:我们在 PubMed、Web of Science、ScienceDirect 和 Cochrane 数据库中搜索了 1990 年至 2023 年 12 月期间比较肱骨轴骨折手术和保守方法效果的临床试验和队列研究。两名研究人员独立从符合条件的研究中提取数据,另外两名研究人员对每项研究的方法学质量进行评估。纳入研究的质量采用 Cochrane 风险偏倚或纽卡斯尔-渥太华量表进行评估。使用Review Manager软件(5.3版)对不愈合、再介入以及总体并发症和功能评分进行汇总和分析:共纳入了 4 项随机对照试验和 13 项队列研究,手术组和非手术组分别有 1285 名和 1346 名患者。手术组患者接受钢板或钢钉治疗,而保守组患者则接受夹板或功能性支具治疗。根据纽卡斯尔-渥太华量表或科克伦偏倚风险工具,4项研究被评估为偏倚风险较高,其他13项研究的偏倚风险较低。手术组的不愈合率[几率比(OR)0.30;95%CI:0.23 至 0.40]、再介入率(OR:0.33;95%CI:0.24 至 0.47)和总体并发症率(OR:0.62;95%CI:0.49 至 0.78)均明显降低。]手臂、肩部和手部残疾评分的汇总效应显示,在 3 个月[平均差(MD)-8.26;95%CI:-13.60 至 -2.92]、6 个月(MD:-6.72;95%CI:-11.34 至 -2.10)和 12 个月(MD:-2.55;95%CI:-4.36 至 -0.74)有显著差异。视觉模拟量表评分和康斯坦茨-默里评分的汇总效应在两组之间没有显著差异:这项系统综述和荟萃分析显示,与保守治疗相比,肱骨轴骨折手术后功能恢复快,非愈合率和再介入率降低。
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引用次数: 0
Factors that influence the results of indirect decompression employing oblique lumbar interbody fusion. 影响采用斜腰椎椎间融合间接减压术效果的因素。
IF 2 Q2 ORTHOPEDICS Pub Date : 2024-08-18 DOI: 10.5312/wjo.v15.i8.734
Andrey E Bokov, Svetlana Y Kalinina, Mingiyan I Khaltyrov, Alexandr P Saifullin, Anatoliy A Bulkin

Background: Indirect decompression is one of the potential benefits of anterior reconstruction in patients with spinal stenosis. On the other hand, the reported rate of revision surgery after indirect decompression highlights the necessity of working out prediction models for the radiographic results of indirect decompression with assessing their clinical relevance.

Aim: To assess factors that influence radiographic and clinical results of the indirect decompression in patients with stenosis of the lumbar spine.

Methods: This study is a single-center cross-sectional evaluation of 80 consecutive patients (17 males and 63 females) with lumbar spinal stenosis combined with the instability of the lumbar spinal segment. Patients underwent single level or bisegmental spinal instrumentation employing oblique lumbar interbody fusion (OLIF) with percutaneous pedicle screw fixation. Radiographic results of the indirect decompression were assessed using computerized tomography, while MacNab scale was used to assess clinical results.

Results: After indirect decompression employing anterior reconstruction using OLIF, the statistically significant increase in the disc space height, vertebral canal square, right and left lateral canal depth were detected (Р < 0.0001). The median (M) relative vertebral canal square increase came to М = 24.5% with 25%-75% quartile border (16.3%; 33.3%) if indirect decompression was achieved by restoration of the segment height. In patients with the reduction of the upper vertebrae slip, the median of the relative increase in vertebral canal square accounted for 49.5% with 25%-75% quartile border (2.35; 99.75). Six out of 80 patients (7.5%) presented with unsatisfactory results because of residual nerve root compression. The critical values for lateral recess depth and vertebral canal square that were associated with indirect decompression failure were 3 mm and 80 mm2 respectively.

Conclusion: Indirect decompression employing anterior reconstruction is achieved by the increase in disc height along the posterior boarder and reduction of the slipped vertebrae in patients with degenerative spondylolisthesis. Vertebral canal square below 80 mm2 and lateral recess depth less than 3 mm are associated with indirect decompression failures that require direct microsurgical decompression.

背景:间接减压是椎管狭窄患者前路重建的潜在优势之一。目的:评估影响腰椎管狭窄患者间接减压术后影像学和临床效果的因素:本研究是一项单中心横断面评估,连续评估了 80 名腰椎管狭窄合并腰椎段不稳定的患者(男性 17 名,女性 63 名)。患者接受了单水平或双节段脊柱器械治疗,采用经皮椎弓根螺钉固定的斜行腰椎椎体间融合术(OLIF)。采用计算机断层扫描评估间接减压的影像学效果,同时使用 MacNab 量表评估临床效果:结果:采用 OLIF 前路重建间接减压后,椎间盘间隙高度、椎管方度、左右侧椎管深度均有显著增加(Р < 0.0001)。如果通过恢复节段高度实现间接减压,椎管方形相对增加的中位数(M)为М = 24.5%,25%-75%的四分位边界为(16.3%;33.3%)。在上椎体滑脱减少的患者中,椎管方形相对增加的中位数占49.5%,25%-75%四分位边界(2.35;99.75)。80 例患者中有 6 例(7.5%)因残留神经根压迫而效果不理想。与间接减压失败相关的侧凹深度和椎管平方的临界值分别为3毫米和80平方毫米:结论:对于退行性脊椎滑脱症患者,采用前路重建的间接减压术是通过增加后路椎间盘高度和减少滑脱椎体来实现的。椎管方形小于80平方毫米和侧凹深度小于3毫米与间接减压失败有关,需要进行显微外科直接减压。
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引用次数: 0
Intra-articular interventions in osteoarthritis: Navigating the landscape of hyaluronic acid, mesenchymal stem cells, and platelet-rich plasma. 骨关节炎的关节内干预:探索透明质酸、间充质干细胞和富血小板血浆的应用前景。
IF 2 Q2 ORTHOPEDICS Pub Date : 2024-08-18 DOI: 10.5312/wjo.v15.i8.704
Somar Soufan, Joenne Al Khoury, Zahi Hamdan, Mohamad Ali Rida

Osteoarthritis (OA) poses a substantial burden on patients, leading to pain, functional decline, and reduced quality of life. While conventional treatments focus on symptom management, disease-modifying interventions are yet to be established. This review explores the efficacy of intra-articular interventions, particularly hyaluronic acid (HA), mesenchymal stem cells (MSCs), and platelet-rich plasma (PRP), in the context of OA management. HA injections, with diverse formulations like Hylan G-F20, sodium hyaluronate, and hyaluronan, present varying outcomes, necessitating a nuanced understanding of their effectiveness and timing. MSC therapy, derived from adipose tissue, umbilical cord, or bone marrow, shows promising results in clinical improvement, with adipose-derived MSCs demonstrating efficacy in maintaining benefits over 6 mo. Conversely, bone-marrow-derived MSCs show limited effectiveness, highlighting the need for source-specific considerations. PRP has emerged as a superior option for long-term pain reduction and quality of life improvement, with leukocyte-poor formulations and a critical platelet count of 10 billion demonstrating optimal results. This comprehensive analysis underscores the potential of intra-articular interventions in OA management, emphasizing the need for personalized and evidence-based approaches to enhance treatment efficacy and patient outcomes.

骨关节炎(OA)给患者带来沉重负担,导致疼痛、功能衰退和生活质量下降。传统治疗侧重于症状控制,而改变疾病的干预措施尚未确立。本综述探讨了关节内干预措施,尤其是透明质酸(HA)、间充质干细胞(MSCs)和富血小板血浆(PRP)在治疗 OA 方面的疗效。HA注射剂的配方多种多样,如Hylan G-F20、透明质酸钠和透明质酸钠,其效果也各不相同,因此有必要对其有效性和时机进行细致的了解。源自脂肪组织、脐带或骨髓的间充质干细胞疗法在临床改善方面取得了可喜的成果,其中源自脂肪的间充质干细胞在维持疗效超过6个月方面表现出了疗效。相反,骨髓来源的间充质干细胞显示出有限的有效性,这突出表明需要考虑特定来源。PRP 已成为长期减轻疼痛和改善生活质量的上佳选择,白细胞贫乏的配方和 100 亿临界血小板数都能达到最佳效果。这项综合分析强调了关节内干预在治疗 OA 方面的潜力,同时也强调了采用个性化和循证方法提高治疗效果和患者预后的必要性。
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引用次数: 0
Readmission rate and early complications in patients undergoing total knee arthroplasty: A retrospective study. 全膝关节置换术患者的再入院率和早期并发症:回顾性研究
IF 2 Q2 ORTHOPEDICS Pub Date : 2024-08-18 DOI: 10.5312/wjo.v15.i8.713
Tushar Jethi, Deepak Jain, Rajnish Garg, Harpal Singh Selhi

Background: Total knee arthroplasty (TKA) can improve pain, quality of life, and functional outcomes. Although uncommon, postoperative complications are extremely consequential and thus must be carefully tracked and communicated to patients to assist their decision-making before surgery. Identification of the risk factors for complications and readmissions after TKA, taking into account common causes, temporal trends, and risk variables that can be changed or left unmodified, will benefit this process.

Aim: To assess readmission rates, early complications and their causes after TKA at 30 days and 90 days post-surgery.

Methods: This was a prospective and retrospective study of 633 patients who underwent TKA at our hospital between January 1, 2017, and February 28, 2022. Of the 633 patients, 28 were not contactable, leaving 609 who met the inclusion criteria. Both inpatient and outpatient hospital records were retrieved, and observations were noted in the data collection forms.

Results: Following TKA, the 30-day and 90-day readmission rates were determined to be 1.1% (n = 7) and 1.8% (n = 11), respectively. The unplanned visit rate at 30 days following TKA was 2.6% (n = 16) and at 90 days was 4.6% (n = 28). At 90 days, the unplanned readmission rate was 1.4% (n = 9). Reasons for readmissions included medical (27.2%, n = 3) and surgical (72.7%, n = 8). Unplanned readmissions and visits within 90 days of follow-up did not substantially differ by age group (P = 0.922), body mass index (BMI) (P = 0.633), unilateral vs bilateral TKA (P = 0.696), or patient comorbidity status (30-day P = 0.171 and 90-day P = 0.813). Reoperation rates after TKA were 0.66% (n = 4) at 30 days and 1.15% (n = 8) at 90 days. The average length of stay was 6.53 days.

Conclusion: In this study, there was a low readmission rate following TKA. There was no significant correlation between readmission rate and patient factors such as age, BMI, and co-morbidity status.

背景:全膝关节置换术(TKA)可改善疼痛、生活质量和功能效果。术后并发症虽然并不常见,但后果极为严重,因此必须仔细追踪并告知患者,以帮助他们在术前做出决策。目的:评估 TKA 术后 30 天和 90 天的再入院率、早期并发症及其原因:这是一项前瞻性和回顾性研究,对象是2017年1月1日至2022年2月28日期间在我院接受TKA手术的633名患者。在这 633 名患者中,有 28 人无法取得联系,剩下的 609 人符合纳入标准。我们检索了住院和门诊病历,并在数据收集表中记录了观察结果:TKA术后,30天和90天的再入院率分别为1.1%(7例)和1.8%(11例)。TKA术后30天的计划外就诊率为2.6%(16人),90天的计划外就诊率为4.6%(28人)。90天后,非计划再入院率为1.4%(9人)。再入院的原因包括内科(27.2%,n = 3)和外科(72.7%,n = 8)。不同年龄组(P = 0.922)、体重指数 (BMI)(P = 0.633)、单侧与双侧 TKA(P = 0.696)或患者合并症状况(30 天 P = 0.171,90 天 P = 0.813)的非计划再入院率和随访 90 天内的就诊率没有显著差异。TKA 术后 30 天的再手术率为 0.66%(4 人),90 天的再手术率为 1.15%(8 人)。平均住院时间为 6.53 天:本研究中,TKA术后再入院率较低。结论:在这项研究中,TKA术后的再入院率较低,再入院率与患者的年龄、体重指数和并发症状况等因素之间没有明显的相关性。
{"title":"Readmission rate and early complications in patients undergoing total knee arthroplasty: A retrospective study.","authors":"Tushar Jethi, Deepak Jain, Rajnish Garg, Harpal Singh Selhi","doi":"10.5312/wjo.v15.i8.713","DOIUrl":"10.5312/wjo.v15.i8.713","url":null,"abstract":"<p><strong>Background: </strong>Total knee arthroplasty (TKA) can improve pain, quality of life, and functional outcomes. Although uncommon, postoperative complications are extremely consequential and thus must be carefully tracked and communicated to patients to assist their decision-making before surgery. Identification of the risk factors for complications and readmissions after TKA, taking into account common causes, temporal trends, and risk variables that can be changed or left unmodified, will benefit this process.</p><p><strong>Aim: </strong>To assess readmission rates, early complications and their causes after TKA at 30 days and 90 days post-surgery.</p><p><strong>Methods: </strong>This was a prospective and retrospective study of 633 patients who underwent TKA at our hospital between January 1, 2017, and February 28, 2022. Of the 633 patients, 28 were not contactable, leaving 609 who met the inclusion criteria. Both inpatient and outpatient hospital records were retrieved, and observations were noted in the data collection forms.</p><p><strong>Results: </strong>Following TKA, the 30-day and 90-day readmission rates were determined to be 1.1% (<i>n</i> = 7) and 1.8% (<i>n</i> = 11), respectively. The unplanned visit rate at 30 days following TKA was 2.6% (<i>n</i> = 16) and at 90 days was 4.6% (<i>n</i> = 28). At 90 days, the unplanned readmission rate was 1.4% (<i>n</i> = 9). Reasons for readmissions included medical (27.2%, <i>n</i> = 3) and surgical (72.7%, <i>n</i> = 8). Unplanned readmissions and visits within 90 days of follow-up did not substantially differ by age group (<i>P</i> = 0.922), body mass index (BMI) (<i>P</i> = 0.633), unilateral <i>vs</i> bilateral TKA (<i>P</i> = 0.696), or patient comorbidity status (30-day <i>P</i> = 0.171 and 90-day <i>P</i> = 0.813). Reoperation rates after TKA were 0.66% (<i>n</i> = 4) at 30 days and 1.15% (<i>n</i> = 8) at 90 days. The average length of stay was 6.53 days.</p><p><strong>Conclusion: </strong>In this study, there was a low readmission rate following TKA. There was no significant correlation between readmission rate and patient factors such as age, BMI, and co-morbidity status.</p>","PeriodicalId":47843,"journal":{"name":"World Journal of Orthopedics","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2024-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11331325/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142009717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Offset restoration in total hip arthroplasty: Important: A current review. 全髋关节置换术中的偏移修复:重要:最新综述。
IF 2 Q2 ORTHOPEDICS Pub Date : 2024-08-18 DOI: 10.5312/wjo.v15.i8.696
Anil Thomas Oommen

Normal vertical and horizontal offset is essential for hip biomechanics, muscle functioning and gait pattern. Total hip arthroplasty (THA) should aim to restore normal offset with implantation of femoral and acetabular components. This would be possible with proper preoperative planning, templating and ensuring implant options are available for offset restoration. Templating is essential for understanding the vertical and horizontal offset change, especially in hip arthritis presenting late with significant limb length discrepancy at THA. Planning should include appropriate soft tissue releases and the use of ideal implants to achieve restoration of horizontal and vertical offset. Under correction of horizontal offset at THA for fracture neck of femur could result in abductor fatigue, limp and increased wear. Restoration of horizontal offset is imperative at THA for a fractured neck of the femur to achieve optimal abductor function. Horizontal offset is necessary for optimal abductor muscle tension and function. Revision THA for acetabular bone loss would require hip center restoration with the acetabular and femoral offset correction to achieve limb length correction and abductor length. The inability to achieve vertical and horizontal offset correction could lead to dislocation or signs of abductor fatigue. Careful vertical and horizontal femur offset restoration is required for normal hip biomechanics, decreased wear and increased longevity.

正常的垂直和水平偏移对髋关节生物力学、肌肉功能和步态至关重要。全髋关节置换术(THA)应旨在通过植入股骨和髋臼组件来恢复正常偏移。通过适当的术前规划、模板制作和确保植入物可用于恢复偏移,就可以实现这一目标。模板设计对于了解垂直和水平偏移变化至关重要,尤其是在髋关节炎晚期出现明显肢长不一致时。规划应包括适当的软组织松解和理想植入物的使用,以实现水平和垂直偏移的恢复。股骨颈骨折患者在进行全髋关节置换术时,如果水平偏移矫正不足,可能会导致内收肌疲劳、跛行和磨损加剧。股骨颈骨折的 THA 手术必须恢复水平偏移,以实现最佳的外展功能。水平偏移是实现最佳外展肌张力和功能的必要条件。髋臼骨缺失的翻修全髋关节置换术需要恢复髋关节中心,同时进行髋臼和股骨偏移校正,以实现肢体长度校正和外展长度。无法实现垂直和水平偏移校正可能会导致脱位或外展肌疲劳症状。为了实现正常的髋关节生物力学、减少磨损和延长寿命,需要进行仔细的股骨垂直和水平偏移修复。
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引用次数: 0
Foot and ankle surgery: Tourniquet placement site to cause as little postoperative pain as possible. 足踝手术:止血带放置部位应尽可能减少术后疼痛。
IF 2 Q2 ORTHOPEDICS Pub Date : 2024-06-18 DOI: 10.5312/wjo.v15.i6.498
Emerito Carlos Rodriguez-Merchan

There is controversy in the literature on where to place the tourniquet (thigh, calf, ankle) for foot and ankle surgery. While some authors prefer the ankle tourniquet to the calf tourniquet, others state that the surgeon can decide between using the thigh tourniquet or the ankle tourniquet, since there was no difference in postoperative pain between them. Where to place the tourniquet during foot and ankle surgery to cause the least possible postoperative pain to the patient as a result of the tourniquet is a common question in clinical practice. The reality is that, unfortunately, there is no consensus on this issue. Perhaps the only possible way to answer this question would be to conduct a comparative study with sufficient statistical power to reach scientifically sound conclusions. It does not seem easy to carry out such a study, but it would be important to be able to answer the question posed in the title of this Editorial once and for all.

关于足踝手术止血带的放置位置(大腿、小腿、踝关节),文献中存在争议。一些作者倾向于使用踝部止血带,而不是小腿止血带,而另一些作者则表示,外科医生可以自行决定使用大腿止血带还是踝部止血带,因为两者在术后疼痛方面没有区别。在足踝外科手术中,止血带应该放在哪里才能尽可能减少止血带给患者带来的术后疼痛,这是临床实践中的一个常见问题。遗憾的是,现实中对这一问题并没有达成共识。要回答这个问题,也许唯一可行的方法就是进行一项具有足够统计能力的比较研究,从而得出科学合理的结论。要进行这样的研究似乎并不容易,但重要的是能够一劳永逸地回答本社论标题中提出的问题。
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引用次数: 0
Addressing metallosis in knee arthroplasty: From diagnostic challenges to innovative treatments 解决膝关节置换术中的金属中毒问题:从诊断难题到创新疗法
IF 1.9 Q2 Medicine Pub Date : 2024-05-18 DOI: 10.5312/wjo.v15.i5.386
Yvon Maurice Bogdonoff, Farid Amirouche
In this editorial, we comment on the article by Toro et al published in the recent issue of World Journal of Orthopedics . This editorial review provides a comprehensive exploration of the landscape surrounding knee arthroplasty metallosis, focusing on key aspects ranging from the mechanisms influencing susceptibility to clinical implications and advanced treatment strategies. We elucidate the complex interplay of implant design, patient-specific variables, and wear-related processes contributing to metallosis. Furthermore, we seek to shed light on diagnostic challenges, the necessity of a multidisciplinary approach, and the imperative for vigilant implant surveillance. Uni-on-uni revision, as a targeted treatment modality, is discussed, highlighting its potential to address metallosis in unicompartmental knee arthroplasty (UKA). There is a need for heightened awareness among clinicians regarding the subtle presentations of metallosis, coupled with the limitations of traditional imaging techniques. Addressing metallosis requires a collaborative, multidisciplinary approach to effectively navigate the complexities associated with this complication. Furthermore, the review emphasizes the evolving paradigm of personalized care, with uni-on-uni revision emerging as a promising surgical solution. In conclusion, the editorial outlines the dynamic nature of knee arthroplasty metallosis and its multifaceted impact on clinical practice. It calls for ongoing collaboration, education, and integration of innovative solutions to enhance diagnostic accuracy, proactive management, and overall patient outcomes in the realm of UKA.
在这篇社论中,我们对托罗等人发表在最近一期《世界矫形外科杂志》上的文章进行了评论。这篇社论综述全面探讨了膝关节置换术金属病的相关情况,重点关注从影响易感性的机制到临床影响和先进治疗策略等关键方面。我们阐明了导致金属中毒的植入物设计、患者特异性变量和磨损相关过程之间复杂的相互作用。此外,我们还试图阐明诊断方面的挑战、多学科方法的必要性以及对种植体进行警惕性监测的必要性。作为一种有针对性的治疗方式,我们讨论了 "膝上翻修",强调了它在解决单关节膝关节置换术(UKA)中金属化病症的潜力。临床医生需要对金属化病的微妙表现以及传统成像技术的局限性提高警惕。解决金属化病问题需要多学科合作的方法,以有效地应对这一复杂的并发症。此外,这篇综述还强调了不断发展的个性化护理模式,其中 "一对一 "翻修术是一种很有前景的手术解决方案。最后,社论概述了膝关节置换术金属化的动态性质及其对临床实践的多方面影响。社论呼吁继续开展合作、教育和整合创新解决方案,以提高UKA领域的诊断准确性、前瞻性管理和患者的整体治疗效果。
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引用次数: 0
Autologous peripheral blood-derived orthobiologics: Different types and their effectiveness in managing knee osteoarthritis 源自外周血的自体生物制剂:不同类型及其在治疗膝关节骨关节炎方面的功效
IF 1.9 Q2 Medicine Pub Date : 2024-05-18 DOI: 10.5312/wjo.v15.i5.400
Ashim Gupta, V. Jain
Knees are the most commonly impacted weight-bearing joints in osteoarthritis (OA), affecting millions of people worldwide. With increasing life spans and obesity rates, the incidence of knee OA will further increase, leading to a significant increase in the economic burden. Conventional treatment modalities utilized to manage knee OA have limitations. Over the last decade, the role of various autologous peripheral blood-derived orthobiologics (APBOs) for the treatment of knee OA has been extensively investigated. This editorial provided an overview and focused on defining and shedding light on the current state of evidence based on the most recent published clinical studies concerning the use of APBO for the management of knee OA. While numerous studies have demonstrated promising results for these preparations, a notable gap exists in the comparative analysis of these diverse formulations. This absence of head-to-head studies poses a considerable challenge for physicians/surgeons in determining the optimal preparation for managing knee OA and achieving sustained long-term results. Thus, more adequately powered, multicenter, prospective, double-blind, randomized controlled trials with longer follow-ups are needed to establish the long-term efficacy and to aid physicians/surgeons in determining the optimal APBO for the management of knee OA.
膝关节是骨关节炎(OA)中最常受影响的负重关节,影响着全球数百万人。随着寿命的延长和肥胖率的增加,膝关节 OA 的发病率将进一步上升,从而导致经济负担大幅增加。用于治疗膝关节 OA 的传统治疗方法存在局限性。在过去十年中,各种自体外周血衍生骨生物制品(APBOs)在治疗膝关节 OA 方面的作用已得到广泛研究。这篇社论提供了一个概览,重点是根据最新发表的有关使用 APBO 治疗膝关节 OA 的临床研究来定义和阐明目前的证据状况。虽然许多研究都证明了这些制剂具有良好的疗效,但在对这些不同制剂进行比较分析方面还存在明显的差距。缺乏头对头的研究给内科医生/外科医生确定治疗膝关节 OA 的最佳制剂并获得长期持续的疗效带来了巨大挑战。因此,需要更多有充分支持的多中心、前瞻性、双盲、随机对照试验和更长时间的随访,以确定长期疗效,并帮助内科医生/外科医生确定治疗膝关节 OA 的最佳 APBO。
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引用次数: 0
Congenital absence of the lateral meniscus: A case report 先天性外侧半月板缺失:病例报告
IF 1.9 Q2 Medicine Pub Date : 2024-05-18 DOI: 10.5312/wjo.v15.i5.477
Hamad Alkhunayfir, A. Alqahtani, A. Korkoman
BACKGROUND Congenital absence of the menisci is a rare anatomical variation characterized by the absence or underdevelopment of one or both menisci in the knee joint. The menisci are crucial in load distribution, joint stability, and shock absorption. Understanding the clinical presentation, diagnosis, and management of this condition is important for optimal patient care. CASE SUMMARY A 27-year-old male with a long-standing history of knee pain underwent diagnostic arthroscopy, revealing a congenital absence of the meniscus. The patient's clinical findings, imaging results, surgical procedures, and pertinent images are detailed. This case presents a unique aspect with the congenital absence of the meniscus, contributing valuable insights to the literature on rare anatomical anomalies. CONCLUSION This case of congenital absence of the menisci highlights the diagnostic challenges posed by rare anomalies. The diagnostic arthroscopy played a crucial role in identifying the absence of the meniscus and providing an explanation for the patient's persistent knee pain. The case underscores the importance of individualized treatment approaches, including physical therapy, for optimal management of rare meniscal anomalies. Further research is warranted to explore effective management strategies for the aforementioned cases and to expand our knowledge of these rare conditions.
背景 先天性半月板缺失是一种罕见的解剖变异,其特点是膝关节中一个或两个半月板缺失或发育不全。半月板对负荷分配、关节稳定性和减震至关重要。了解这种病症的临床表现、诊断和处理方法对于优化患者护理非常重要。病例摘要 一名 27 岁的男性患者,长期以来一直有膝关节疼痛的病史,在接受关节镜诊断时发现他患有先天性半月板缺失症。本文详细介绍了患者的临床表现、影像学检查结果、手术过程和相关图像。本病例展示了先天性半月板缺失的独特之处,为有关罕见解剖异常的文献提供了宝贵的见解。结论 本例先天性半月板缺失病例凸显了罕见异常所带来的诊断挑战。关节镜诊断在确定半月板缺失和解释患者持续膝关节疼痛方面发挥了关键作用。该病例强调了个体化治疗方法(包括物理治疗)对于优化罕见半月板异常治疗的重要性。我们有必要开展进一步研究,探索上述病例的有效治疗策略,并扩大我们对这些罕见病症的认识。
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引用次数: 0
Efficacy of stromal vascular fraction for knee osteoarthritis: A prospective, single-centre, non-randomized study with 2 years follow-up 基质血管成分对膝关节骨性关节炎的疗效:一项为期两年的前瞻性单中心非随机研究
IF 1.9 Q2 Medicine Pub Date : 2024-05-18 DOI: 10.5312/wjo.v15.i5.457
Madhan Jeyaraman, Naveen Jeyaraman, Tarun Jayakumar, Swaminathan Ramasubramanian, Rajni Ranjan, S. Jha, Ashim Gupta
BACKGROUND Current osteoarthritis (OA) treatments focus on symptom relief without addressing the underlying disease process. In regenerative medicine, current treatments have limitations. In regenerative medicine, more research is needed for intra-articular stromal vascular fraction (SVF) injections in OA, including dosage optimization, long-term efficacy, safety, comparisons with other treatments, and mechanism exploration. AIM To compare the efficacy of intra-articular SVF with corticosteroid (ICS) injections in patients with primary knee OA. METHODS The study included 50 patients with Kellgren-Lawrence grades II and III OA. Patients were randomly assigned (1:1) to receive either a single intra-articular SVF injection (group A) or a single intra-articular ICS (triamcinolone) (group B) injection. Patients were followed up at 1, 3, 6, 12, and 24 months. Visual analog score (VAS) and International Knee Documentation Committee (IKDC) scores were administered before the procedure and at all follow-ups. The safety of SVF in terms of adverse and severe adverse events was recorded. Statistical analysis was performed with SPSS Version 26.0, IBM Corp, Chicago, IL, United States. RESULTS Both groups had similar demographics and baseline clinical characteristics. Follow-up showed minor patient loss, resulting in 23 and 24 in groups A and B respectively. Group A experienced a notable reduction in pain, with VAS scores decreasing from 7.7 to 2.4 over 24 months, compared to a minor reduction from 7.8 to 6.2 in Group B. This difference in pain reduction in group A was statistically significant from the third month onwards. Additionally, Group A showed significant improvements in knee functionality, with IKDC scores rising from 33.4 to 83.10, whereas Group B saw a modest increase from 36.7 to 45.16. The improvement in Group A was statistically significant from 6 months and maintained through 24 months. CONCLUSION Our study demonstrated that intra-articular administration of SVF can lead to reduced pain and improved knee function in patients with primary knee OA. More adequately powered, multi-center, double-blinded, randomised clinical trials with longer follow-ups are needed to further establish safety and justify its clinical use.
背景 目前的骨关节炎(OA)治疗主要集中在缓解症状上,而没有从根本上解决疾病过程。在再生医学方面,目前的治疗方法存在局限性。在再生医学领域,需要对关节内基质血管成分(SVF)注射治疗 OA 进行更多研究,包括剂量优化、长期疗效、安全性、与其他治疗方法的比较以及机制探索。目的 比较原发性膝关节 OA 患者关节内 SVF 与皮质类固醇(ICS)注射的疗效。方法 该研究包括 50 名凯尔格伦-劳伦斯 II 级和 III 级 OA 患者。患者被随机分配(1:1)接受单次关节内 SVF 注射(A 组)或单次关节内 ICS(曲安奈德)注射(B 组)。患者分别在 1、3、6、12 和 24 个月时接受随访。术前和所有随访期间均进行了视觉模拟评分(VAS)和国际膝关节文献委员会(IKDC)评分。记录了 SVF 在不良和严重不良事件方面的安全性。统计分析采用美国伊利诺伊州芝加哥市 IBM 公司的 SPSS 26.0 版本进行。结果 两组的人口统计学和基线临床特征相似。随访结果显示,A 组和 B 组分别有 23 名和 24 名病人流失。A 组疼痛明显减轻,24 个月内 VAS 评分从 7.7 分降至 2.4 分,而 B 组仅从 7.8 分降至 6.2 分。此外,A 组的膝关节功能也有明显改善,IKDC 评分从 33.4 分上升到 83.10 分,而 B 组则从 36.7 分略微上升到 45.16 分。A 组的改善从 6 个月起就具有统计学意义,并持续了 24 个月。结论 我们的研究表明,关节内注射 SVF 可以减轻原发性膝关节 OA 患者的疼痛并改善膝关节功能。要进一步确定 SVF 的安全性并证明其临床应用的合理性,还需要进行更多充分有效的多中心、双盲、随机临床试验和更长时间的随访。
{"title":"Efficacy of stromal vascular fraction for knee osteoarthritis: A prospective, single-centre, non-randomized study with 2 years follow-up","authors":"Madhan Jeyaraman, Naveen Jeyaraman, Tarun Jayakumar, Swaminathan Ramasubramanian, Rajni Ranjan, S. Jha, Ashim Gupta","doi":"10.5312/wjo.v15.i5.457","DOIUrl":"https://doi.org/10.5312/wjo.v15.i5.457","url":null,"abstract":"BACKGROUND\u0000 Current osteoarthritis (OA) treatments focus on symptom relief without addressing the underlying disease process. In regenerative medicine, current treatments have limitations. In regenerative medicine, more research is needed for intra-articular stromal vascular fraction (SVF) injections in OA, including dosage optimization, long-term efficacy, safety, comparisons with other treatments, and mechanism exploration.\u0000 AIM\u0000 To compare the efficacy of intra-articular SVF with corticosteroid (ICS) injections in patients with primary knee OA.\u0000 METHODS\u0000 The study included 50 patients with Kellgren-Lawrence grades II and III OA. Patients were randomly assigned (1:1) to receive either a single intra-articular SVF injection (group A) or a single intra-articular ICS (triamcinolone) (group B) injection. Patients were followed up at 1, 3, 6, 12, and 24 months. Visual analog score (VAS) and International Knee Documentation Committee (IKDC) scores were administered before the procedure and at all follow-ups. The safety of SVF in terms of adverse and severe adverse events was recorded. Statistical analysis was performed with SPSS Version 26.0, IBM Corp, Chicago, IL, United States.\u0000 RESULTS\u0000 Both groups had similar demographics and baseline clinical characteristics. Follow-up showed minor patient loss, resulting in 23 and 24 in groups A and B respectively. Group A experienced a notable reduction in pain, with VAS scores decreasing from 7.7 to 2.4 over 24 months, compared to a minor reduction from 7.8 to 6.2 in Group B. This difference in pain reduction in group A was statistically significant from the third month onwards. Additionally, Group A showed significant improvements in knee functionality, with IKDC scores rising from 33.4 to 83.10, whereas Group B saw a modest increase from 36.7 to 45.16. The improvement in Group A was statistically significant from 6 months and maintained through 24 months.\u0000 CONCLUSION\u0000 Our study demonstrated that intra-articular administration of SVF can lead to reduced pain and improved knee function in patients with primary knee OA. More adequately powered, multi-center, double-blinded, randomised clinical trials with longer follow-ups are needed to further establish safety and justify its clinical use.","PeriodicalId":47843,"journal":{"name":"World Journal of Orthopedics","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140961735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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World Journal of Orthopedics
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