Pub Date : 2024-03-20DOI: 10.1177/00914150241240122
Neshat Yazdani, Francesca Falzarano, Jillian Minahan Zucchetto, Karen L Siedlecki
Stress associated with the COVID-19 pandemic and the measures implemented to prevent its spread dramatically shifted our social networks, interactions, and contexts, all of which influence the assessment of one's subjective well-being (SWB). Drawing on data collected from 1,318 adults between April and May 2020, we used structural equation modeling to analyze the relationship between pandemic-related stress and SWB (life satisfaction, positive affect, negative affect), and examined how these relationships vary across age. Pandemic-related stress was associated with lower life satisfaction and higher negative affect. However, no evidence of age moderation emerged. Subsequent analysis examined different aspects of social resources as potential mediating variables. Loneliness fully mediated the relationship between stress and life satisfaction, while social support demonstrated evidence of partial mediation. Further, loneliness and social support partially mediated the relationship between stress and negative affect. Findings suggest that pandemic-related stress impacts SWB, and social resources help explain these impacts.
{"title":"COVID-19 Pandemic-Related Stress and Subjective Well-Being Across Age: The Mediating Role of Social Resources.","authors":"Neshat Yazdani, Francesca Falzarano, Jillian Minahan Zucchetto, Karen L Siedlecki","doi":"10.1177/00914150241240122","DOIUrl":"https://doi.org/10.1177/00914150241240122","url":null,"abstract":"<p><p>Stress associated with the COVID-19 pandemic and the measures implemented to prevent its spread dramatically shifted our social networks, interactions, and contexts, all of which influence the assessment of one's subjective well-being (SWB). Drawing on data collected from 1,318 adults between April and May 2020, we used structural equation modeling to analyze the relationship between pandemic-related stress and SWB (life satisfaction, positive affect, negative affect), and examined how these relationships vary across age. Pandemic-related stress was associated with lower life satisfaction and higher negative affect. However, no evidence of age moderation emerged. Subsequent analysis examined different aspects of social resources as potential mediating variables. Loneliness fully mediated the relationship between stress and life satisfaction, while social support demonstrated evidence of partial mediation. Further, loneliness and social support partially mediated the relationship between stress and negative affect. Findings suggest that pandemic-related stress impacts SWB, and social resources help explain these impacts.</p>","PeriodicalId":47878,"journal":{"name":"International Journal of Aging & Human Development","volume":" ","pages":"914150241240122"},"PeriodicalIF":2.0,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140177172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-01Epub Date: 2023-06-19DOI: 10.1177/00914150231183139
Andrew Steward, Leslie Hasche
This cross-sectional study examined whether internalized age stereotypes mediate the relationship between volunteering and self-efficacy for adults 50+ years of age. A convenience sample of volunteers (n = 173) residing in the United States of America Mountain West completed a 15-min, online survey. The independent variable was number of volunteer hours per week (mean = 6.44, SD = 5.50). The dependent variable was self-efficacy measured by five, four-point items from the general self-efficacy scale (α = .83; mean = 3.57, SD = .38). The indirect effects of five internalized positive and five negative age stereotypes were tested. Results indicate that increased internalized positive, but not negative, age stereotypes partially mediated the relationship between volunteer hours and self-efficacy. Although positive age stereotypes have long been considered a form of ageism, the findings suggest that internalized positive age stereotypes may function as a form of esteem to enhance psychosocial well-being.
{"title":"Do Internalized Age Stereotypes Mediate the Relationship Between Volunteering and Self-Efficacy for Adults 50+ Years of Age?","authors":"Andrew Steward, Leslie Hasche","doi":"10.1177/00914150231183139","DOIUrl":"10.1177/00914150231183139","url":null,"abstract":"<p><p>This cross-sectional study examined whether internalized age stereotypes mediate the relationship between volunteering and self-efficacy for adults 50+ years of age. A convenience sample of volunteers (n = 173) residing in the United States of America Mountain West completed a 15-min, online survey. The independent variable was number of volunteer hours per week (mean = 6.44, SD = 5.50). The dependent variable was self-efficacy measured by five, four-point items from the general self-efficacy scale (<i>α</i> = .83; mean = 3.57, SD = .38). The indirect effects of five internalized positive and five negative age stereotypes were tested. Results indicate that increased internalized positive, but not negative, age stereotypes partially mediated the relationship between volunteer hours and self-efficacy. Although positive age stereotypes have long been considered a form of ageism, the findings suggest that internalized positive age stereotypes may function as a form of esteem to enhance psychosocial well-being.</p>","PeriodicalId":47878,"journal":{"name":"International Journal of Aging & Human Development","volume":" ","pages":"135-158"},"PeriodicalIF":2.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9663475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Older adults often experience an increase in low-grade chronic inflammation. Purpose in life could act as a protective factor as it is associated with beneficial health outcomes. Purpose in life may exert part of its adaptive function by promoting persistence in goal pursuit. During older adulthood, however, when many individuals experience an increase in intractable stressors and declining resources, the adaptive function of purpose could become reduced. Purpose: We examined whether the association between inter- and intra-individual differences in purpose in life and chronic inflammation differed across older adulthood. Method: We assessed four waves of data among 129 older adults (63-91 years old) across 6 years. Results: Hierarchical linear modeling demonstrated that within-person increases in purpose in life predicted reduced levels of chronic inflammation in early old age (25th percentile or 73 years, coefficient = -.016, p < .01), but not in advanced old age (75th percentile or 81 years, coefficient = .002, p = .67). Between-person differences in purpose were not related to chronic inflammation. Conclusions: These results suggest that greater within-person increases in purpose may protect health processes particularly in early old age but become less effective in advanced old age.
{"title":"Changes in Purpose in Life and Low-Grade Chronic Inflammation Across Older Adulthood.","authors":"Irene Giannis, Carsten Wrosch, Heather Herriot, Jean-Philippe Gouin","doi":"10.1177/00914150231196098","DOIUrl":"10.1177/00914150231196098","url":null,"abstract":"<p><p><b>Background:</b> Older adults often experience an increase in low-grade chronic inflammation. Purpose in life could act as a protective factor as it is associated with beneficial health outcomes. Purpose in life may exert part of its adaptive function by promoting persistence in goal pursuit. During older adulthood, however, when many individuals experience an increase in intractable stressors and declining resources, the adaptive function of purpose could become reduced. <b>Purpose:</b> We examined whether the association between inter- and intra-individual differences in purpose in life and chronic inflammation differed across older adulthood. <b>Method:</b> We assessed four waves of data among 129 older adults (63-91 years old) across 6 years. <b>Results:</b> Hierarchical linear modeling demonstrated that within-person increases in purpose in life predicted reduced levels of chronic inflammation in early old age (25th percentile or 73 years, <i>coefficient</i> = -.016, <i>p < </i>.01), but not in advanced old age (75th percentile or 81 years, <i>coefficient</i> = .002, <i>p = .</i>67). Between-person differences in purpose were not related to chronic inflammation. <b>Conclusions:</b> These results suggest that greater within-person increases in purpose may protect health processes particularly in early old age but become less effective in advanced old age.</p>","PeriodicalId":47878,"journal":{"name":"International Journal of Aging & Human Development","volume":" ","pages":"182-207"},"PeriodicalIF":2.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10845832/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10111975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-01Epub Date: 2023-10-17DOI: 10.1177/00914150231208013
Carly Lawrence, Christina M Marini
The current study examined associations between marital quality, loneliness, and sleep within a nationally representative sample of older adults who participated in Wave 2 of the National Social Life, Health, and Aging Project (NSHAP). Participants (N =559) had a spouse or partner and completed a novel sleep module that included subjective (i.e., insomnia symptoms) and objective (i.e., wake after sleep onset;WASO) markers of sleep. Upon controlling for demographics and markers of mental and physical health, a distinct pattern of findings emerged for subjective versus objective markers of sleep. Regarding subjective sleep, older adults who experienced greater loneliness reported more insomnia symptoms, but only when spousal emotional support was low-moderate. Regarding objective sleep, older adults who reported more affectionate touch from their spouse experienced less WASO. Collectively, these findings identify specific aspects of marital quality that may have unique implications for partnered older adults' subjective and objective sleep quality.
{"title":"Loneliness and Marital Quality as Predictors of Older Adults' Insomnia Symptoms.","authors":"Carly Lawrence, Christina M Marini","doi":"10.1177/00914150231208013","DOIUrl":"10.1177/00914150231208013","url":null,"abstract":"<p><p>The current study examined associations between marital quality, loneliness, and sleep within a nationally representative sample of older adults who participated in Wave 2 of the National Social Life, Health, and Aging Project (NSHAP). Participants (<i>N</i> =<i> </i>559) had a spouse or partner and completed a novel sleep module that included subjective (i.e., insomnia symptoms) and objective (i.e., wake after sleep onset;WASO) markers of sleep. Upon controlling for demographics and markers of mental and physical health, a distinct pattern of findings emerged for subjective versus objective markers of sleep. Regarding subjective sleep, older adults who experienced greater loneliness reported more insomnia symptoms, but only when spousal emotional support was low-moderate. Regarding objective sleep, older adults who reported more affectionate touch from their spouse experienced less WASO. Collectively, these findings identify specific aspects of marital quality that may have unique implications for partnered older adults' subjective and objective sleep quality.</p>","PeriodicalId":47878,"journal":{"name":"International Journal of Aging & Human Development","volume":" ","pages":"243-262"},"PeriodicalIF":2.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41239893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The aim of this descriptive study was to investigate the Self-Defining Memories (SDMs) in a large sample of 181 older adults (65-90 years; mean age = 73.0 years) and to target the relationships between their different dimensions. The sampling method was nonprobabilistic, based on voluntary participation. Participants were asked to recall three SDMs. They also completed the Mini-Mental State Examination, the Hospital Anxiety and Depression Scale, and a Self-esteem Scale. Almost half of the SDMs were specific and more than a quarter were integrated. Specificity, tension, redemption, contamination sequences, and affective response varied regarding thematic content. Specificity was positively correlated to tension whereas autobiographical reasoning was positively correlated to redemption and negatively linked to emotional response and depression. This research highlighted that identity is constituted by the main types of events that make up a life: interpersonal relationships, life-threatening events, achievement, and leisure.
{"title":"Exploring Characteristics of Self-Defining Memories in Older Adults.","authors":"Alain Fritsch, Virginie Voltzenlogel, Christine Cuervo-Lombard","doi":"10.1177/00914150231183138","DOIUrl":"10.1177/00914150231183138","url":null,"abstract":"<p><p>The aim of this descriptive study was to investigate the Self-Defining Memories (SDMs) in a large sample of 181 older adults (65-90 years; mean age = 73.0 years) and to target the relationships between their different dimensions. The sampling method was nonprobabilistic, based on voluntary participation. Participants were asked to recall three SDMs. They also completed the Mini-Mental State Examination, the Hospital Anxiety and Depression Scale, and a Self-esteem Scale. Almost half of the SDMs were specific and more than a quarter were integrated. Specificity, tension, redemption, contamination sequences, and affective response varied regarding thematic content. Specificity was positively correlated to tension whereas autobiographical reasoning was positively correlated to redemption and negatively linked to emotional response and depression. This research highlighted that identity is constituted by the main types of events that make up a life: interpersonal relationships, life-threatening events, achievement, and leisure.</p>","PeriodicalId":47878,"journal":{"name":"International Journal of Aging & Human Development","volume":" ","pages":"159-181"},"PeriodicalIF":2.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10025340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-01Epub Date: 2023-04-25DOI: 10.1177/00914150231171839
Srinivasan Chokkanathan
The current study examined the interactions between family environment, hope, and loneliness, and their subsequent influence on the subjective well-being (SWB) of 345 noninstitutionalized older adults (aged 60 years and above) in Singapore. Door-to-door surveys information was collected on family environment (cohesiveness, relationship closeness, and support), hope, loneliness, and SWB (life satisfaction, happiness, and absence of negative affect). Structural equation modelling was conducted to test competing hypotheses derived from life stress and integrated resource theories. The results revealed that family environment influenced SWB both directly and indirectly. Family environment decreased loneliness and increased SWB. Additionally, family environment influenced SWB by offering increased hope. Family environment sets the context for the SWB of older adults in Singapore. Families should therefore be targeted for interventions to reduce loneliness, increase psychological resources, and raise SWB during old age.
{"title":"Family Environment, Loneliness, Hope, and Subjective Well-Being of Asian Older Adults.","authors":"Srinivasan Chokkanathan","doi":"10.1177/00914150231171839","DOIUrl":"10.1177/00914150231171839","url":null,"abstract":"<p><p>The current study examined the interactions between family environment, hope, and loneliness, and their subsequent influence on the subjective well-being (SWB) of 345 noninstitutionalized older adults (aged 60 years and above) in Singapore. Door-to-door surveys information was collected on family environment (cohesiveness, relationship closeness, and support), hope, loneliness, and SWB (life satisfaction, happiness, and absence of negative affect). Structural equation modelling was conducted to test competing hypotheses derived from life stress and integrated resource theories. The results revealed that family environment influenced SWB both directly and indirectly. Family environment decreased loneliness and increased SWB. Additionally, family environment influenced SWB by offering increased hope. Family environment sets the context for the SWB of older adults in Singapore. Families should therefore be targeted for interventions to reduce loneliness, increase psychological resources, and raise SWB during old age.</p>","PeriodicalId":47878,"journal":{"name":"International Journal of Aging & Human Development","volume":" ","pages":"208-220"},"PeriodicalIF":2.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9431023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives:This study aimed to measure the effect of a treatment of adapted physical activity (APA) on motor symptoms and on positive psychological resources in a group of patients with PD. Methods: 37 patients with PD (Mage= 71.5; 70.3% male) completed measures of disability level, motor performance, distress, well-being, and quality of life before and after participating in a program of APA (duration: 7 months). Analysis of variance - repeated measures was performed to evaluate the effect of APA on disability, distress, and well-being. Results: After intervention, patients reported significant improvements in their motor autonomy, disability level, psychological distress, and in life appreciation. Discussion: A brief physical activity program was beneficial not only to patients' motor functioning, but also to their mental health, by reducing distress and promoting life appreciation.
{"title":"Adapted Physical Activity Can Increase Life Appreciation in Patients with Parkinson's Disease.","authors":"Francesca Vescovelli, Giulia Cesetti, Daniele Sarti, Chiara Ruini","doi":"10.1177/00914150231183129","DOIUrl":"10.1177/00914150231183129","url":null,"abstract":"<p><p><b>Objectives:</b>This study aimed to measure the effect of a treatment of adapted physical activity (APA) on motor symptoms and on positive psychological resources in a group of patients with PD. <b>Methods:</b> 37 patients with PD (M<i><sub>age</sub></i>= 71.5; 70.3% male) completed measures of disability level, motor performance, distress, well-being, and quality of life before and after participating in a program of APA (duration: 7 months). Analysis of variance - repeated measures was performed to evaluate the effect of APA on disability, distress, and well-being. <b>Results:</b> After intervention, patients reported significant improvements in their motor autonomy, disability level, psychological distress, and in life appreciation. <b>Discussion:</b> A brief physical activity program was beneficial not only to patients' motor functioning, but also to their mental health, by reducing distress and promoting life appreciation.</p>","PeriodicalId":47878,"journal":{"name":"International Journal of Aging & Human Development","volume":" ","pages":"221-242"},"PeriodicalIF":2.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9780926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-27DOI: 10.1177/00914150241235086
Hanwei Wu, Yitao Lu, Zhiguang Fan, Lehua Zhang
Objectives: The purpose of this study was to translate and validate the adolescents' ageism toward older adults scale (AGES) in the Chinese cultural context and examine its psychometric properties among Chinese adolescents. Methods: The study consists of two phases with two separate samples. In phase one (sample 1: n = 407), exploratory factor analysis (EFA) is conducted to determine the factor structure of the C-AGES. In phase two (sample 2: n = 379), confirmatory factor analysis (CFA) is performed to confirm the factor structure and assess the model fit of the C-AGES. Results: EFA reveals a two-factor structure consisting of 17 items for the C-AGES. CFA in sample 2 confirms the factor structure and demonstrates good model fit. The C-AGES also exhibits high criterion validity, internal consistency, and cross-gender invariance. Discussion: The results suggest that the C-AGES is a valid measurement tool for assessing agism among Chinese adolescents.
{"title":"The Chinese Adaptation and Validation of the Adolescents' Ageism Toward Older Adults Scale.","authors":"Hanwei Wu, Yitao Lu, Zhiguang Fan, Lehua Zhang","doi":"10.1177/00914150241235086","DOIUrl":"https://doi.org/10.1177/00914150241235086","url":null,"abstract":"<p><p><b>Objectives:</b> The purpose of this study was to translate and validate the adolescents' ageism toward older adults scale (AGES) in the Chinese cultural context and examine its psychometric properties among Chinese adolescents. <b>Methods:</b> The study consists of two phases with two separate samples. In phase one (sample 1: n = 407), exploratory factor analysis (EFA) is conducted to determine the factor structure of the C-AGES. In phase two (sample 2: n = 379), confirmatory factor analysis (CFA) is performed to confirm the factor structure and assess the model fit of the C-AGES. <b>Results:</b> EFA reveals a two-factor structure consisting of 17 items for the C-AGES. CFA in sample 2 confirms the factor structure and demonstrates good model fit. The C-AGES also exhibits high criterion validity, internal consistency, and cross-gender invariance. <b>Discussion:</b> The results suggest that the C-AGES is a valid measurement tool for assessing agism among Chinese adolescents.</p>","PeriodicalId":47878,"journal":{"name":"International Journal of Aging & Human Development","volume":" ","pages":"914150241235086"},"PeriodicalIF":2.0,"publicationDate":"2024-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139984211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-21DOI: 10.1177/00914150241231195
Anne E Barrett, Hope Mimbs, Cherish Michael, Jessica Noblitt
Relatively little is known about how social relationships affect later life planning. Our study focuses on an underexamined aspect of social relationships, frequency of contact - not only with family members but also with friends. Using data from a survey of Floridians aged 50 and older conducted between December 2020 and April 2021 (n = 3,832), we examine the association between frequency of contact and five planning types: finances, health care, living arrangements, driving retirement, and end-of-life. We found that more frequent contact was associated with greater likelihood of planning, and this result was largely consistent across types of relationships and types of planning. Our findings suggest that contact with family members and friends may encourage more planning, which could reduce the stress that can accompany later life transitions. Our study offers further evidence of social relationships' centrality to later life well-being and points to the many benefits of enhancing them.
{"title":"How Do Social Relationships Affect Later Life Planning?","authors":"Anne E Barrett, Hope Mimbs, Cherish Michael, Jessica Noblitt","doi":"10.1177/00914150241231195","DOIUrl":"https://doi.org/10.1177/00914150241231195","url":null,"abstract":"<p><p>Relatively little is known about how social relationships affect later life planning. Our study focuses on an underexamined aspect of social relationships, frequency of contact - not only with family members but also with friends. Using data from a survey of Floridians aged 50 and older conducted between December 2020 and April 2021 (n = 3,832), we examine the association between frequency of contact and five planning types: finances, health care, living arrangements, driving retirement, and end-of-life. We found that more frequent contact was associated with greater likelihood of planning, and this result was largely consistent across types of relationships and types of planning. Our findings suggest that contact with family members and friends may encourage more planning, which could reduce the stress that can accompany later life transitions. Our study offers further evidence of social relationships' centrality to later life well-being and points to the many benefits of enhancing them.</p>","PeriodicalId":47878,"journal":{"name":"International Journal of Aging & Human Development","volume":" ","pages":"914150241231195"},"PeriodicalIF":2.0,"publicationDate":"2024-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139913765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-12DOI: 10.1177/00914150241231192
David W Sosnowski, Emily J Smail, Brion S Maher, Ann Zenobia Moore, Pei-Lun Kuo, Mark N Wu, Dominique V Low, Katie L Stone, Eleanor M Simonsick, Luigi Ferrucci, Adam P Spira
We sought to explore whether genetic risk for, and self-reported, short sleep are associated with biological aging and whether age and sex moderate these associations. Participants were a subset of individuals from the Baltimore Longitudinal Study of Aging who had complete data on self-reported sleep (n = 567) or genotype (n = 367). Outcomes included: Intrinsic Horvath age, Hannum age, PhenoAge, GrimAge, and DNAm-based estimates of plasminogen activator inhibitor-1 (PAI-1) and granulocyte count. Results demonstrated that polygenic risk for short sleep was positively associated with granulocyte count; compared to those reporting <6 hr sleep, those reporting >7 hr demonstrated faster PhenoAge and GrimAge acceleration and higher estimated PAI-1. Polygenic risk for short sleep and self-reported sleep duration interacted with age and sex in their associations with some of the outcomes. Findings highlight that polygenic risk for short sleep and self-reported long sleep is associated with variation in the epigenetic landscape and subsequently aging.
我们试图探讨睡眠时间短的遗传风险和自我报告的睡眠时间短是否与生物衰老有关,以及年龄和性别是否会缓和这些关联。参与者是巴尔的摩老龄化纵向研究(Baltimore Longitudinal Study of Aging)中的一部分人,他们拥有完整的自我报告睡眠数据(567 人)或基因型数据(367 人)。结果包括内在 Horvath 年龄、Hannum 年龄、PhenoAge、GrimAge 以及基于 DNAm 的纤溶酶原激活物抑制剂-1(PAI-1)和粒细胞计数估计值。结果表明,短时睡眠的多基因风险与粒细胞计数呈正相关;与报告 7 小时睡眠的人相比,PhenoAge 和 GrimAge 加速更快,估计的 PAI-1 值更高。睡眠时间短的多基因风险和自我报告的睡眠时间与年龄和性别在某些结果上存在相互作用。研究结果突出表明,睡眠时间短的多基因风险和自我报告的睡眠时间长与表观遗传景观的变化以及随后的衰老有关。
{"title":"Sleep Duration Polygenic Risk and Phenotype: Associations with Biomarkers of Accelerated Aging in the Baltimore Longitudinal Study of Aging.","authors":"David W Sosnowski, Emily J Smail, Brion S Maher, Ann Zenobia Moore, Pei-Lun Kuo, Mark N Wu, Dominique V Low, Katie L Stone, Eleanor M Simonsick, Luigi Ferrucci, Adam P Spira","doi":"10.1177/00914150241231192","DOIUrl":"10.1177/00914150241231192","url":null,"abstract":"<p><p>We sought to explore whether genetic risk for, and self-reported, short sleep are associated with biological aging and whether age and sex moderate these associations. Participants were a subset of individuals from the Baltimore Longitudinal Study of Aging who had complete data on self-reported sleep (<i>n</i> = 567) or genotype (<i>n</i> = 367). Outcomes included: Intrinsic Horvath age, Hannum age, PhenoAge, GrimAge, and DNAm-based estimates of plasminogen activator inhibitor-1 (PAI-1) and granulocyte count. Results demonstrated that polygenic risk for short sleep was positively associated with granulocyte count; compared to those reporting <6 hr sleep, those reporting >7 hr demonstrated faster PhenoAge and GrimAge acceleration and higher estimated PAI-1. Polygenic risk for short sleep and self-reported sleep duration interacted with age and sex in their associations with some of the outcomes. Findings highlight that polygenic risk for short sleep and self-reported long sleep is associated with variation in the epigenetic landscape and subsequently aging.</p>","PeriodicalId":47878,"journal":{"name":"International Journal of Aging & Human Development","volume":" ","pages":"914150241231192"},"PeriodicalIF":1.2,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11317550/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139724539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}