Smita D. Madagundi, Prasanna Vasantrao Habbu, Vaishali Todkar, Venkatrao Kulkarni
Medicinal plants have long been recognized as valuable sources of therapeutic compounds, and the discovery of plant-associated endophytes has expanded this potential significantly. Endophytes such as bacteria and fungi that inhabit plant tissues without causing disease have emerged as powerful contributors to natural product research and drug discovery. These microorganisms are capable of producing structurally diverse metabolites such as alkaloids, terpenoids, phenolics, peptides, and other secondary metabolites that exhibit antimicrobial, anticancer, antioxidant, anti-inflammatory, antidiabetic, neuroprotective, and immunomodulatory effects. A major breakthrough in this field was the discovery of a taxol-producing endophytic fungus from Taxus brevifolia, which demonstrated that endophytes could generate pharmaceutically relevant compounds previously believed to be exclusive to host plants. Recent advancements in biotechnology and pharmaceutical sciences have further accelerated endophyte research. Techniques such as genome mining, metabolic engineering, metagenomics, and synthetic biology have enabled the identification and activation of previously silent biosynthetic pathways. Additionally, bioprocess engineering and fermentation optimization offer scalable and sustainable production routes for rare or high-value metabolites, reducing dependency on threatened medicinal plant species. Artificial intelligence and omics based platforms are also transforming screening, dereplication, and lead optimization processes. Despite these advancements, challenges remain, including variability in isolation protocols, regulatory gaps, difficulties in metabolite replication outside the host, and the need for rigorous pharmacological and clinical validation. Nevertheless, the integration of modern analytical tools, sustainable bioprospecting strategies, and interdisciplinary research continues to position plant-associated endophytes as a promising and innovative frontier in the development of future natural therapeutics.
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XIX International Scientific and Practical Conference «World science priorities» November 20-21, 2025 Vienna. Austria
第十九届国际科学与实践会议«世界科学优先事项»，2025年11月20日至21日，维也纳。奥地利
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Pub Date : 2023-11-28DOI: 10.51473/rcmos.v1i11.183
Geisse Martins
{"title":"ALTAS HABILIDADES DENTRO DO ESPECTRO DO TRANSTORNO AUTISTA: UM RELATO DE EXPERIÊNCIA","authors":"Geisse Martins","doi":"10.51473/rcmos.v1i11.183","DOIUrl":"https://doi.org/10.51473/rcmos.v1i11.183","url":null,"abstract":"","PeriodicalId":485424,"journal":{"name":"Zenodo (CERN European Organization for Nuclear Research)","volume":"1 5","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136228012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Remote Sensing Assessment of Farmer-Managed Land Restoration in Seven African Countries using Dense NDVI Time Series Forecasting","authors":"Kleinsmann, Jasper, Ahmad, Muhammad, Kooistra, Lammert, Vägen, Tor-Gunnar","doi":"10.5281/zenodo.8181836","DOIUrl":"https://doi.org/10.5281/zenodo.8181836","url":null,"abstract":"","PeriodicalId":485424,"journal":{"name":"Zenodo (CERN European Organization for Nuclear Research)","volume":"11 28","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136226798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ebraheem Farag, F. X. Timmes, Morgan T. Chidester, Samalka Anandagoda, Dieter Hartmann
{"title":"Stellar Neutrino Emission Across The Mass-Metallicity Plane","authors":"Ebraheem Farag, F. X. Timmes, Morgan T. Chidester, Samalka Anandagoda, Dieter Hartmann","doi":"10.5281/zenodo.8327401","DOIUrl":"https://doi.org/10.5281/zenodo.8327401","url":null,"abstract":"","PeriodicalId":485424,"journal":{"name":"Zenodo (CERN European Organization for Nuclear Research)","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136229715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The compromised microbial topography between nasopharyngeal and oropharyngeal microbiota associate with pediatric pneumonia","authors":"Fengxiang Wei","doi":"10.5281/zenodo.7820825","DOIUrl":"https://doi.org/10.5281/zenodo.7820825","url":null,"abstract":"","PeriodicalId":485424,"journal":{"name":"Zenodo (CERN European Organization for Nuclear Research)","volume":"105 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136352848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ahmad Haziq Mohd Rahmat, Mastura Omar, Shalida Rosnan, Mohd Khairul Azahari Abdul Rani, Bakri Daud, Ellyana Mohd Muslim Tan, Mohd Jamil Muhamad, Ezrin Mustafa Bakri
{"title":"The Innovation of a Packaging for Songkok With QR Code and Augmented Reality Technology","authors":"Ahmad Haziq Mohd Rahmat, Mastura Omar, Shalida Rosnan, Mohd Khairul Azahari Abdul Rani, Bakri Daud, Ellyana Mohd Muslim Tan, Mohd Jamil Muhamad, Ezrin Mustafa Bakri","doi":"10.5281/zenodo.8115388","DOIUrl":"https://doi.org/10.5281/zenodo.8115388","url":null,"abstract":"","PeriodicalId":485424,"journal":{"name":"Zenodo (CERN European Organization for Nuclear Research)","volume":"31 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135723950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Khairul Hisyam Baharuddin, Nazatul Syima Mohd Nasir, Alexander Stark
{"title":"Enhancing Academic Essay Writing through the Effective Use of Checklist","authors":"Khairul Hisyam Baharuddin, Nazatul Syima Mohd Nasir, Alexander Stark","doi":"10.5281/zenodo.8115398","DOIUrl":"https://doi.org/10.5281/zenodo.8115398","url":null,"abstract":"","PeriodicalId":485424,"journal":{"name":"Zenodo (CERN European Organization for Nuclear Research)","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135723952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Wan Razazila Wan Abdullah, Enny Nurdin Sutan Maruhun, Norzarina Noordin, Sunarti Halid, Naimah Ahmad Yahya, Ahmad Saiful Azlin Puteh Salin
{"title":"Optimizing Financial Decisions with My e-Credit Banking Apps Version 3 (Mecba) v3","authors":"Wan Razazila Wan Abdullah, Enny Nurdin Sutan Maruhun, Norzarina Noordin, Sunarti Halid, Naimah Ahmad Yahya, Ahmad Saiful Azlin Puteh Salin","doi":"10.5281/zenodo.8115372","DOIUrl":"https://doi.org/10.5281/zenodo.8115372","url":null,"abstract":"","PeriodicalId":485424,"journal":{"name":"Zenodo (CERN European Organization for Nuclear Research)","volume":"31 2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135723951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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