Pub Date : 2025-02-01Epub Date: 2025-01-24DOI: 10.12809/hkmj2412200
C H Lee, G Tan, S C W Tang, Y W Ng, M K Y Lee, J W M Chan, T M Chan
{"title":"Incorporating the cardiovascular-kidney-metabolic health framework into the local healthcare system: a position statement from the Hong Kong College of Physicians.","authors":"C H Lee, G Tan, S C W Tang, Y W Ng, M K Y Lee, J W M Chan, T M Chan","doi":"10.12809/hkmj2412200","DOIUrl":"10.12809/hkmj2412200","url":null,"abstract":"","PeriodicalId":48828,"journal":{"name":"Hong Kong Medical Journal","volume":" ","pages":"58-64"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01DOI: 10.12809/hkmj-hkmms202502
S K Chuang
{"title":"A vintage childhood vaccination card.","authors":"S K Chuang","doi":"10.12809/hkmj-hkmms202502","DOIUrl":"https://doi.org/10.12809/hkmj-hkmms202502","url":null,"abstract":"","PeriodicalId":48828,"journal":{"name":"Hong Kong Medical Journal","volume":"31 1","pages":"82-84"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143494275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C W K Hui, J N F Lam, K H Man, C C Zhong, J Huang, M C S Wong, H C Yip
{"title":"Screening for upper gastrointestinal cancer in Hong Kong.","authors":"C W K Hui, J N F Lam, K H Man, C C Zhong, J Huang, M C S Wong, H C Yip","doi":"10.12809/hkmj255172","DOIUrl":"https://doi.org/10.12809/hkmj255172","url":null,"abstract":"","PeriodicalId":48828,"journal":{"name":"Hong Kong Medical Journal","volume":"31 1","pages":"6-8"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143494286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"From the clinic to the lab and back: an interview with Professor Eric Wai-choi Tse.","authors":"N Lam, O Wong","doi":"10.12809/hkmj-hc202502","DOIUrl":"https://doi.org/10.12809/hkmj-hc202502","url":null,"abstract":"","PeriodicalId":48828,"journal":{"name":"Hong Kong Medical Journal","volume":"31 1","pages":"80-81"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143494279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01Epub Date: 2025-02-11DOI: 10.12809/hkmj2411824
A C H Fung, K K Y Wong
{"title":"First experience using a wireless oesophageal pH monitoring system in children in Hong Kong: three case reports.","authors":"A C H Fung, K K Y Wong","doi":"10.12809/hkmj2411824","DOIUrl":"10.12809/hkmj2411824","url":null,"abstract":"","PeriodicalId":48828,"journal":{"name":"Hong Kong Medical Journal","volume":" ","pages":"65-67"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143391871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L M Chen, S C H Yu, L Li, E P Hui, W Yeo, S L Chan
Introduction: This study explored liver- and tumour-specific indicators predictive of suboptimal survival outcomes following repeat transarterial chemoembolisation (TACE) in intermediate-stage hepatocellular carcinoma (HCC) patients after an initial TACE.
Methods: This study included 300 HCC patients who underwent TACE treatment. Based on whether persistent albumin-bilirubin (ALBI) grade deterioration (PABD) occurred after the initial TACE, defining as a shift in ALBI grade to a higher grade from baseline without recovery within 90 days, patients were divided into PABD and non-PABD groups. Overall survival of non-PABD and PABD groups according to subgroups stratified by baseline ALBI grade and tumour burden was compared with that of patients receiving only sorafenib or supportive care during the same period.
Results: Repeat TACE provided a survival benefit over systemic therapy or supportive care for patients in all post-TACE non-PABD or most PABD subgroups, regardless of baseline liver condition (ie, modified albumin-bilirubin [mALBI] grade and tumour burden). This benefit was absent in two subgroups among patients who developed PABD after the initial TACE, namely, (1) those with a baseline liver condition of mALBI grade 1 or 2a and tumour burden exceeding the up-to-11 criteria, and (2) those with a baseline liver condition of mALBI grade 2b, regardless of tumour burden.
Conclusion: Repeat TACE is not recommended for patients with persistent liver function deterioration after the initial TACE, particularly those exhibiting suboptimal baseline liver function or excessive tumour burden. Understanding the liver condition and tumour burden in HCC patients may assist clinicians in planning optimal treatment strategies, leading to better prognosis.
{"title":"Liver- and tumour-specific indicators predicting suboptimal survival following repeat transarterial chemoembolisation in patients with hepatocellular carcinoma.","authors":"L M Chen, S C H Yu, L Li, E P Hui, W Yeo, S L Chan","doi":"10.12809/hkmj2311208","DOIUrl":"https://doi.org/10.12809/hkmj2311208","url":null,"abstract":"<p><strong>Introduction: </strong>This study explored liver- and tumour-specific indicators predictive of suboptimal survival outcomes following repeat transarterial chemoembolisation (TACE) in intermediate-stage hepatocellular carcinoma (HCC) patients after an initial TACE.</p><p><strong>Methods: </strong>This study included 300 HCC patients who underwent TACE treatment. Based on whether persistent albumin-bilirubin (ALBI) grade deterioration (PABD) occurred after the initial TACE, defining as a shift in ALBI grade to a higher grade from baseline without recovery within 90 days, patients were divided into PABD and non-PABD groups. Overall survival of non-PABD and PABD groups according to subgroups stratified by baseline ALBI grade and tumour burden was compared with that of patients receiving only sorafenib or supportive care during the same period.</p><p><strong>Results: </strong>Repeat TACE provided a survival benefit over systemic therapy or supportive care for patients in all post-TACE non-PABD or most PABD subgroups, regardless of baseline liver condition (ie, modified albumin-bilirubin [mALBI] grade and tumour burden). This benefit was absent in two subgroups among patients who developed PABD after the initial TACE, namely, (1) those with a baseline liver condition of mALBI grade 1 or 2a and tumour burden exceeding the up-to-11 criteria, and (2) those with a baseline liver condition of mALBI grade 2b, regardless of tumour burden.</p><p><strong>Conclusion: </strong>Repeat TACE is not recommended for patients with persistent liver function deterioration after the initial TACE, particularly those exhibiting suboptimal baseline liver function or excessive tumour burden. Understanding the liver condition and tumour burden in HCC patients may assist clinicians in planning optimal treatment strategies, leading to better prognosis.</p>","PeriodicalId":48828,"journal":{"name":"Hong Kong Medical Journal","volume":"31 1","pages":"32-40"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143494282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01Epub Date: 2025-02-06DOI: 10.12809/hkmj2311337
O L Chan, Y S Lee, C H Ho, C C Lee, C C Cheung
{"title":"Duplication of the portal vein and the implications for procedural planning.","authors":"O L Chan, Y S Lee, C H Ho, C C Lee, C C Cheung","doi":"10.12809/hkmj2311337","DOIUrl":"10.12809/hkmj2311337","url":null,"abstract":"","PeriodicalId":48828,"journal":{"name":"Hong Kong Medical Journal","volume":" ","pages":"72.e1-73.e3"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143256978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01Epub Date: 2025-02-17DOI: 10.12809/hkmj2411483
L T Leung, S K L Ho, W C Yiu, S S W Cheng, I F M Lo, H M Luk
{"title":"Novel <i>LMX1B</i> variants in nail-patella syndrome.","authors":"L T Leung, S K L Ho, W C Yiu, S S W Cheng, I F M Lo, H M Luk","doi":"10.12809/hkmj2411483","DOIUrl":"10.12809/hkmj2411483","url":null,"abstract":"","PeriodicalId":48828,"journal":{"name":"Hong Kong Medical Journal","volume":" ","pages":"75-77"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143434172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01Epub Date: 2025-02-17DOI: 10.12809/hkmj2310721
K L Hon, E W Y Cheung, A M Li, G P G Fung, D S Y Lam, M S H Lee, R S Y Lee, M P Leung, D K K Ng
Hong Kong has a high burden of hospitalisations associated with respiratory syncytial virus (RSV) infection in young children. Most international guidelines concerning RSV prophylaxis are based on studies conducted in temperate climates and may not fully apply to subtropical locations such as Hong Kong. In July 2022, a group of nine experts in neonatology, paediatric intensive care, paediatric respiratory medicine, and paediatric cardiology in Hong Kong convened to formulate recommendations for RSV prophylaxis. The recommendations were based on literature review and expert discussion. Each expert reviewed evidence specific to a particular area and formulated consensus statements. The expert panel reached a consensus on 11 statements, which addressed the epidemiology of RSV infection in Hong Kong, the goals and outcomes of RSV prophylaxis in preterm infants and infants with congenital heart disease or bronchopulmonary dysplasia, safety, and cost. Because there is no clear seasonality pattern for RSV infection in Hong Kong, panel members emphasised using gestational age, rather than season, to guide prophylaxis recommendations. The experts agreed that RSV prophylaxis should be considered for 5 to 6 months after hospital discharge among preterm infants born at <29 weeks gestational age; it should also be considered for children aged <1 year with haemodynamically significant congenital heart disease or bronchopulmonary dysplasia.
{"title":"Practice recommendations for respiratory syncytial virus prophylaxis among children in Hong Kong.","authors":"K L Hon, E W Y Cheung, A M Li, G P G Fung, D S Y Lam, M S H Lee, R S Y Lee, M P Leung, D K K Ng","doi":"10.12809/hkmj2310721","DOIUrl":"10.12809/hkmj2310721","url":null,"abstract":"<p><p>Hong Kong has a high burden of hospitalisations associated with respiratory syncytial virus (RSV) infection in young children. Most international guidelines concerning RSV prophylaxis are based on studies conducted in temperate climates and may not fully apply to subtropical locations such as Hong Kong. In July 2022, a group of nine experts in neonatology, paediatric intensive care, paediatric respiratory medicine, and paediatric cardiology in Hong Kong convened to formulate recommendations for RSV prophylaxis. The recommendations were based on literature review and expert discussion. Each expert reviewed evidence specific to a particular area and formulated consensus statements. The expert panel reached a consensus on 11 statements, which addressed the epidemiology of RSV infection in Hong Kong, the goals and outcomes of RSV prophylaxis in preterm infants and infants with congenital heart disease or bronchopulmonary dysplasia, safety, and cost. Because there is no clear seasonality pattern for RSV infection in Hong Kong, panel members emphasised using gestational age, rather than season, to guide prophylaxis recommendations. The experts agreed that RSV prophylaxis should be considered for 5 to 6 months after hospital discharge among preterm infants born at <29 weeks gestational age; it should also be considered for children aged <1 year with haemodynamically significant congenital heart disease or bronchopulmonary dysplasia.</p>","PeriodicalId":48828,"journal":{"name":"Hong Kong Medical Journal","volume":" ","pages":"48-57"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143434181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-01Epub Date: 2025-02-10DOI: 10.12809/hkmj2411904
V Y T Chan, W T Tse, M C Chan, K K Y Wong, W C Leung, T Y Leung
{"title":"Pneumothorax associated with a displaced thoracoamniotic Somatex shunt in an infant with congenital pulmonary airway malformation: a case report.","authors":"V Y T Chan, W T Tse, M C Chan, K K Y Wong, W C Leung, T Y Leung","doi":"10.12809/hkmj2411904","DOIUrl":"10.12809/hkmj2411904","url":null,"abstract":"","PeriodicalId":48828,"journal":{"name":"Hong Kong Medical Journal","volume":" ","pages":"68-71"},"PeriodicalIF":3.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143383904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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