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Antimicrobial consumption in a hospital environment before and after restrictive commercialization measures in Brazil 巴西采取限制性商业化措施前后医院环境中的抗菌药消耗量
Pub Date : 2024-01-31 DOI: 10.26694/repis.v9i1.3644
J. S. Malta, Cristiane Aparecida Menezes Pádua, Leandro Pinheiro Cintra, Carla Jorge Machado, Josiane Moreira da Costa, Andréia Queiroz Ribeiro
Introduction: The consumption of antimicrobials (ATB) has been described as one of the causes of Bacterial Resistance. In 2010, RDC 44 was published in Brazil, which restricts the free sale of ATB to reduce antimicrobial resistance in hospitals. Aim: to identify the consumption of ATB in a teaching hospital before and after the implementation of the restrictive measure on the commercialization of antimicrobials in Brazil. Outlining: Cross sectional study carried out in a general hospital. Analyzes were carried out in two phases, using the variables ATB consumption, expressed in defined daily dose (DDD), average use of different ATB per patient and the frequency of resistant microorganisms in the period. Results: The average use of ATB per patient was 2.56 (Standard Deviation (SD) ± 2.02) and2.40 (SD ± 1.89) in phases I and II, respectively (p=0.0007). The general variation in defined daily dose was 1.89%, however drugs with negative variation were observed. A higher frequency of resistant microorganisms isolated in phase I was observed compared to phase II (OR=1.48, CI: 1.13-1.93, respectively). Implications: A difference was identified in the consumption of ATB between the periods, with an increase in general consumption, in DDD, but a lower average number of different ATBs per patient and a lower occurrence of resistant microorganisms. 
导言:抗菌药(ATB)的使用被认为是导致细菌耐药性的原因之一。2010 年,巴西发布了 RDC 44,限制抗菌药物的自由销售,以减少医院中的抗菌药物耐药性。目的:确定巴西实施抗菌药物商业化限制措施前后一家教学医院的抗菌药物消耗量。概述:在一家综合医院开展的横断面研究。分析分两个阶段进行,使用的变量包括:以规定日剂量(DDD)表示的ATB消耗量、每位患者平均使用不同ATB的情况以及在此期间出现耐药微生物的频率。结果显示在第一和第二阶段,每位患者平均使用的 ATB 分别为 2.56(标准差(SD)±2.02)和 2.40(SD±1.89)(P=0.0007)。规定日剂量的总体变化率为 1.89%,但也观察到了负变化的药物。与第二阶段相比,第一阶段分离到的耐药微生物频率更高(OR=1.48,CI:分别为 1.13-1.93)。影响:研究发现,不同时期的ATB消耗量存在差异,DDD的总体消耗量有所增加,但每位患者平均使用不同ATB的数量较少,耐药微生物的发生率也较低。
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引用次数: 0
Does the COVID-19 pandemic have influenced the profile of primary bloodstream infections in critically ill neonates? COVID-19 大流行是否影响了重症新生儿原发性血流感染的概况?
Pub Date : 2024-01-31 DOI: 10.26694/repis.v9i1.4353
Helio de Souza Junior, Zilka dos Santos de Freitas Ribeiro, Jeane Kelly Silva de Carvalho, Priscila Stephanny Penha da Silva, Thatiane Ferreira da Conceição, Paula Regina de Souza Hermann
Introduction: Primary Bloodstream Infection (PBSI) associated with Central Venous Catheters (CVC) is the primary site of healthcare-associated infections in Neonatal Intensive Care Units (NICUs). Aim: To assess the occurrence of PBSI associated with Peripherally Inserted Central Catheters (PICC) in neonates, before and during the COVID-19 pandemic. Outlining: We conducted a retrospective cohort analysis in the NICU of a teaching hospital in the Federal District, Brazil. The sample included 169 neonates who used PICCs from 2018 to 2021. Results: There were 16 primary bloodstream infections, with 50% occurring in the pre pandemic period and 50% during the pandemic. Additionally, 267 blood cultures were performed, of which 17.23% were positive, including 61.7% gram-positive microorganisms and 36.17% gram-negative. The primary microorganisms identified were Klebsiella spp. and coagulase-negative Staphylococcus, with one microorganism exhibiting oxacillin resistance. Implications: We emphasize the importance of monitoring and maintaining continuous surveillance of PBSI associated with CVC, especially during events like the COVID-19 pandemic. Stringent infection control measures should be implemented to minimize the risk of infection and improve care in neonatal intensive care units.
导言:与中心静脉导管 (CVC) 相关的原发性血流感染 (PBSI) 是新生儿重症监护病房 (NICU) 中医疗相关感染的主要部位。目的:评估 COVID-19 大流行之前和期间新生儿外周置入中心导管 (PICC) 相关 PBSI 的发生情况。概述:我们在巴西联邦区一家教学医院的新生儿重症监护室进行了一项回顾性队列分析。样本包括 2018 年至 2021 年期间使用 PICC 的 169 名新生儿。分析结果共有16例原发性血流感染,其中50%发生在大流行前,50%发生在大流行期间。此外,共进行了 267 次血培养,其中 17.23% 为阳性,包括 61.7% 的革兰氏阳性微生物和 36.17% 的革兰氏阴性微生物。鉴定出的主要微生物是克雷伯氏菌属和凝固酶阴性葡萄球菌,其中一种微生物对奥沙西林产生耐药性。影响:我们强调监测和持续监控与 CVC 相关的 PBSI 的重要性,尤其是在 COVID-19 大流行期间。应实施严格的感染控制措施,将感染风险降至最低,并改善新生儿重症监护病房的护理工作。
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引用次数: 0
TECNOLOGIAS EM SAÚDE E PREVENÇÃO DE INCAPACIDADES FÍSICAS POR HANSENÍASE: REVISÃO INTEGRATIVA 麻风病造成的身体残疾的卫生技术和预防:综合综述
Pub Date : 2023-10-26 DOI: 10.26694/repis.v9i1.4763
Stephany Costa Novo Candido, Priscilla Dantas Almeida
Introduction: Leprosy is of significant public health concern as it is an infectious and chronic disease with the potential to cause physical disabilities. Aim: To identify health technologies in scientific literature for preventing physical disabilities caused by leprosy. Outlining: This is an integrative literature review, based on the research question: "What health technologies are applied to prevent physical disabilities caused by leprosy?" formulated using the PICo strategy, where "P" stands for Population (leprosy), "I" for phenomenon of Interest (technologies), and "Co" for Context of the study (prevention of physical disabilities). Results: Eleven articles published between 2001 and 2020 in Brazil were included. More than seventy technologies were identified for use in disability prevention. The primary types of health technologies for preventing physical disabilities include strategies and materials such as lectures, home visits, and establishing a strong relationship between healthcare professionals and patients. Implications: It was identified that in the context of preventing physical disabilities caused by leprosy, assistive technology (assessment of physical disabilities, wound care, and immobilization, among others); educational technology (such as guidance on hygiene and proper medication use); and managerial technology (clinical meetings, for example) play crucial roles.
简介:麻风病是一种有可能导致身体残疾的传染性和慢性疾病,是一项重大的公共卫生问题。目的:从科学文献中找出预防麻风病所致身体残疾的卫生技术。概述:这是一篇综合文献综述,基于研究问题:“哪些卫生技术应用于预防由麻风病引起的身体残疾?”使用PICo策略制定,其中“P”代表人口(麻风病),“I”代表感兴趣的现象(技术),“Co”代表研究背景(预防身体残疾)。结果:纳入了2001 - 2020年在巴西发表的11篇文章。确定了70多种用于预防残疾的技术。预防身体残疾的主要卫生技术类型包括战略和材料,如讲座、家访以及在保健专业人员和患者之间建立牢固的关系。结论:在预防由麻风病引起的身体残疾方面,辅助技术(身体残疾评估、伤口护理和固定等);教育技术(如卫生和正确用药指导);管理技术(例如临床会议)起着至关重要的作用。
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引用次数: 0
Users' perception of hesitancy and delay in vaccination in Primary Health Care 用户对初级卫生保健中疫苗接种的犹豫和延迟的看法
Pub Date : 2023-10-26 DOI: 10.26694/repis.v9i1.3010
David Gomes Araújo Júnior, Bruna Fontenele de Meneses, Jevanildo Paulino Aguiar, Antônia Larissa de Miranda Cardoso, Joaciara Nogueira de Sales, Jordânia Marques de Oliveira Freire
Introduction: Vaccination is an extremely important and necessary act from the beginning of a human being's life. Aim: Unveil users' perception of the reasons for hesitancy and delay in vaccination. Outlining: This is an exploratory-descriptive study with a qualitative approach, through the application of a semi-structured interview with users (51) of the Basic Health Units (UBS) in the city of Tianguá – CE, data collection was carried out between November and December 2021, the interviews were transcribed, Bardin's content analysis technique (2016) was used to organize data and the results were presented with the help of the Iramuteq™ software. Results: four thematic categories were identified: 1 – Fear and dread of the adverse effects is a factor in the vaccine refusal, 2 – Challenges in ensuring user accessibility to vaccines, 3 – Users' distrust about the benefits of vaccines and 4 – Lack of information and understanding about the effects of non-adherence to vaccination. It was then found that hesitancy and/or refusal to get vaccinated is motivated by multifactorial aspects, which can influence users' decisions individually or jointly. Implications: Health professionals play a key role in promoting vaccination, being a preferred source of information indicated by users.
疫苗接种是一项极其重要和必要的行为,从一个人的生命开始。目的:揭示用户对疫苗接种犹豫不决和延迟的原因的看法。概述:这是一项采用定性方法的探索性描述性研究,通过应用对天anguae - CE市基本卫生单位(UBS)用户(51)的半结构化访谈,在2021年11月至12月期间进行数据收集,对访谈进行转录,使用Bardin的内容分析技术(2016)组织数据,并在Iramuteq™软件的帮助下呈现结果。结果:确定了四个主题类别:1 -对不良影响的恐惧和恐惧是拒绝接种疫苗的一个因素;2 -确保用户获得疫苗方面的挑战;3 -用户对疫苗益处的不信任;4 -对不坚持接种疫苗的影响缺乏信息和了解。然后发现,犹豫和/或拒绝接种疫苗是由多因素因素引起的,这些因素可以单独或共同影响用户的决定。含义:卫生专业人员在促进疫苗接种方面发挥关键作用,是用户表示的首选信息来源。
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引用次数: 0
Educational technologies for children about parasitic diseases: an integrative review 儿童寄生虫病教育技术综述
Pub Date : 2023-10-18 DOI: 10.26694/repis.v9i1.4289
Jaira dos Santos Silva, Daniela Reis Joaquim de Freitas
Introduction: Parasitic diseases have been causing serious public health problems around the world, especially in developing countries, with children being considered a more vulnerable group. This study aimed to identify educational technologies developed for or aimed at children about parasitic diseases in the scientific literature. Outlining: This is an integrative review, carried out in the following databases: MEDLINE, via PubMed; Embase; Web of Science; SCOPUS (Elsevier); LILACS and CINAHL. The population, interest, context strategy was used, combined with controlled and uncontrolled descriptors and the Boolean operators AND and OR. The analysis of the studies occurred in a descriptive way. Two categories emerged: digital educational technologies developed for or aimed at children about parasitic diseases and non-digital educational technologies developed for or aimed at children about parasitic diseases. Results: Eleven studies were included. Digital technologies were identified, such as cartoons, videos, and PowerPoint presentations, as well as non digital technologies, such as comic books, leaflets, board games and printed booklets. Educational technologies developed in school environments and/or in the community were found. The parasitic diseases covered were intestinal ones, the visceral leishmaniasis, malaria, Chagas disease, lymphatic filariasis and schistosomiasis mansoni. Implications: Digital and non-digital educational technologies have proven to be motivational, attractive, and complementary technological resources that contribute to children's active learning.
导言:寄生虫病在世界各地造成严重的公共卫生问题,特别是在发展中国家,儿童被认为是一个较为脆弱的群体。本研究旨在确定科学文献中为儿童开发或针对儿童的寄生虫病教育技术。概述:这是一项综合综述,在以下数据库中进行:MEDLINE,通过PubMed;Embase;Web of Science;斯高帕斯(爱思唯尔);紫丁香和丁香。使用了人口、兴趣、上下文策略,并结合了受控和非受控描述符以及布尔操作符and和OR。对研究的分析是以描述性的方式进行的。出现了两类:为儿童开发或以儿童为目标的关于寄生虫病的数字教育技术和为儿童开发或以儿童为目标的关于寄生虫病的非数字教育技术。结果:纳入11项研究。数字技术,如漫画、视频和ppt演示,以及非数字技术,如漫画书、传单、棋盘游戏和印刷小册子。发现在学校环境和/或社区发展的教育技术。所涵盖的寄生虫病包括肠道寄生虫病、内脏利什曼病、疟疾、恰加斯病、淋巴丝虫病和曼氏血吸虫病。启示:数字和非数字教育技术已被证明是激励、有吸引力和互补的技术资源,有助于儿童的主动学习。
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引用次数: 0
Factors associated with colonization by carbapenem-resistant enterobacteria in oncological patients: a case-control study 肿瘤患者中碳青霉烯耐药肠杆菌定植相关因素:一项病例对照研究
Pub Date : 2023-09-16 DOI: 10.26694/repis.v9i1.3760
Marina Araújo da Cruz Moraes, Teresa Cristina Teixeira Sukiennik, Cícero Armídio Gomes Dias
Introduction: Colonization and infections caused by Carbapenemase Producing Enterobacteria (CPE) are a global problem, being associated with an increase in hospitalization time, costs for health services, and morbidity and mortality rates. Oncologic patients represent a group of special interest and there are few studies involving CPE colonization among these patients. Aim: to investigate factors associated with colonization in cancer patients. Outlining: Case-control study developed in a tertiary reference hospital in cancer treatment in Porto Alegre, Brazil, from January to December 2017. The population consisted of patients diagnosed with cancer in clinical or surgical hospitalization. Results: The univariate analysis showed that variables associated with colonization by CPE were age, male sex, tumors with bone type of surgical hospitalization, number of intra-hospital transfers since hospitalization, hospitalization time >30 days, ICU hospitalization in the last 30 days, ICU time more than 15 days, surgical procedure in the last 30 days, use of antibiotics in the last 30 days, presence of tumor wound, and KPC infection. After multivariate analysis, male sex, external hospital as origin, hospital stay longer than 30 days, antibiotic use in the last 30 days, and presence of tumor wound, remained associated with EPC colonization. Use of aminoglycosides, and linezolide were associated with CPE colonization. Implications: We identified variables associated with CPE colonization in oncologic patients. Our results may indicate actions to prevent CPE colonization and consequent development of infections.
由产碳青霉烯酶肠杆菌(CPE)引起的定植和感染是一个全球性问题,与住院时间、卫生服务费用以及发病率和死亡率的增加有关。肿瘤患者是一个特别关注的群体,在这些患者中涉及CPE定植的研究很少。目的:探讨肿瘤患者体内定植的相关因素。概述:2017年1月至12月在巴西阿雷格里港的一家三级参考医院开展的癌症治疗病例对照研究。该人群包括在临床或手术住院期间被诊断为癌症的患者。结果:单因素分析显示,与CPE定植相关的变量为年龄、男性、手术住院的肿瘤骨类型、住院后院内转院次数、住院时间30天、最近30天ICU住院、ICU时间超过15天、最近30天手术方式、最近30天抗生素使用情况、有无肿瘤创面、KPC感染。多因素分析表明,男性、外部医院、住院时间超过30天、最近30天内使用抗生素以及是否存在肿瘤伤口与EPC定植有关。氨基糖苷类和利奈唑胺的使用与CPE定植有关。意义:我们确定了与肿瘤患者CPE定植相关的变量。我们的结果可能表明可以采取措施防止CPE定植和随后的感染发展。
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Revista Prevenção de Infecção e Saúde
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