Pub Date : 2024-10-31DOI: 10.1101/2023.07.25.550557
Zhi Yu, Amélie Vromman, Ngoc Quynh H Nguyen, Art Schuermans, Thiago Rentz, Shamsudheen K Vellarikkal, Md Mesbah Uddin, Abhishek Niroula, Gabriel Griffin, Michael C Honigberg, Amy E Lin, Christopher J Gibson, Daniel H Katz, Usman Tahir, Shi Fang, Sara Haidermota, Shriienidhie Ganesh, Tajmara Antoine, Joshua Weinstock, Thomas R Austin, Vasan S Ramachandran, Gina M Peloso, Whitney Hornsby, Peter Ganz, JoAnn E Manson, Bernhard Haring, Charles L Kooperberg, Alexander P Reiner, Joshua C Bis, Bruce M Psaty, Yuan-I Min, Adolfo Correa, Leslie A Lange, Wendy S Post, Jerome I Rotter, Stephen S Rich, James G Wilson, Benjamin L Ebert, Bing Yu, Christie M Ballantyne, Josef Coresh, Vijay G Sankaran, Alexander G Bick, Siddhartha Jaiswal, Robert E Gerszten, Peter Libby, Rajat M Gupta, Pradeep Natarajan
Plasma proteomic profiles associated with subclinical somatic mutations in blood cells may offer novel insights into downstream clinical consequences. Here, we explore such patterns in clonal hematopoiesis of indeterminate potential (CHIP), which is linked to several cancer and non-cancer outcomes, including coronary artery disease (CAD). Among 61,833 ancestrally diverse participants (3,881 with CHIP) from NHLBI TOPMed and UK Biobank with blood-based DNA sequencing and proteomic measurements (1,148 proteins by SomaScan in TOPMed and 2,917 proteins by Olink in UK Biobank), we identified 32 and 345 unique proteins from TOPMed and UK Biobank, respectively, associated with the most prevalent driver genes (DNMT3A, TET2, and ASXL1). These associations showed substantial heterogeneity by driver genes, sex, and race, and were enriched for immune response and inflammation pathways. Mendelian randomization in humans, coupled with ELISA in hematopoietic Tet2-/- vs wild-type mice validation, disentangled causal proteomic perturbations from TET2 CHIP. Lastly, we identified plasma proteins shared between CHIP and CAD.
{"title":"Human Plasma Proteomic Profile of Clonal Hematopoiesis.","authors":"Zhi Yu, Amélie Vromman, Ngoc Quynh H Nguyen, Art Schuermans, Thiago Rentz, Shamsudheen K Vellarikkal, Md Mesbah Uddin, Abhishek Niroula, Gabriel Griffin, Michael C Honigberg, Amy E Lin, Christopher J Gibson, Daniel H Katz, Usman Tahir, Shi Fang, Sara Haidermota, Shriienidhie Ganesh, Tajmara Antoine, Joshua Weinstock, Thomas R Austin, Vasan S Ramachandran, Gina M Peloso, Whitney Hornsby, Peter Ganz, JoAnn E Manson, Bernhard Haring, Charles L Kooperberg, Alexander P Reiner, Joshua C Bis, Bruce M Psaty, Yuan-I Min, Adolfo Correa, Leslie A Lange, Wendy S Post, Jerome I Rotter, Stephen S Rich, James G Wilson, Benjamin L Ebert, Bing Yu, Christie M Ballantyne, Josef Coresh, Vijay G Sankaran, Alexander G Bick, Siddhartha Jaiswal, Robert E Gerszten, Peter Libby, Rajat M Gupta, Pradeep Natarajan","doi":"10.1101/2023.07.25.550557","DOIUrl":"10.1101/2023.07.25.550557","url":null,"abstract":"<p><p>Plasma proteomic profiles associated with subclinical somatic mutations in blood cells may offer novel insights into downstream clinical consequences. Here, we explore such patterns in clonal hematopoiesis of indeterminate potential (CHIP), which is linked to several cancer and non-cancer outcomes, including coronary artery disease (CAD). Among 61,833 ancestrally diverse participants (3,881 with CHIP) from NHLBI TOPMed and UK Biobank with blood-based DNA sequencing and proteomic measurements (1,148 proteins by SomaScan in TOPMed and 2,917 proteins by Olink in UK Biobank), we identified 32 and 345 unique proteins from TOPMed and UK Biobank, respectively, associated with the most prevalent driver genes (<i>DNMT3A</i>, <i>TET2</i>, and <i>ASXL1</i>). These associations showed substantial heterogeneity by driver genes, sex, and race, and were enriched for immune response and inflammation pathways. Mendelian randomization in humans, coupled with ELISA in hematopoietic <i>Tet2</i>-/- vs wild-type mice validation, disentangled causal proteomic perturbations from <i>TET2</i> CHIP. Lastly, we identified plasma proteins shared between CHIP and CAD.</p>","PeriodicalId":49376,"journal":{"name":"Visual Computer","volume":"31 1","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11565774/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73564233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"计算机科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-01Epub Date: 2023-08-30DOI: 10.1097/DCR.0000000000002923
Ryan A Schmelter, Marc A Gorvet, Zachary Grossmann, Clinton Crowder, Shankar R Raman
{"title":"Robotic Low Anterior Resection After Transanal Minimally Invasive Surgery and Chemoradiation Therapy for T1N1a Rectal Cancer.","authors":"Ryan A Schmelter, Marc A Gorvet, Zachary Grossmann, Clinton Crowder, Shankar R Raman","doi":"10.1097/DCR.0000000000002923","DOIUrl":"10.1097/DCR.0000000000002923","url":null,"abstract":"","PeriodicalId":49376,"journal":{"name":"Visual Computer","volume":"30 1","pages":"e2"},"PeriodicalIF":3.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73556381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"计算机科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-05DOI: 10.1007/s00371-023-03063-x
Weizhao Ma, Mengxiao Yin, Guiqing Li, Feng Yang, Kan Chang
{"title":"PCMG:3D point cloud human motion generation based on self-attention and transformer","authors":"Weizhao Ma, Mengxiao Yin, Guiqing Li, Feng Yang, Kan Chang","doi":"10.1007/s00371-023-03063-x","DOIUrl":"https://doi.org/10.1007/s00371-023-03063-x","url":null,"abstract":"","PeriodicalId":49376,"journal":{"name":"Visual Computer","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2023-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47924221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"计算机科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-02DOI: 10.1007/s00371-023-03062-y
Boban P. Bondzulic, B. Pavlović, Nenad Stojanović, Vladimir Petrović, Dimitrije Bujaković
{"title":"A simple and reliable approach to providing a visually lossless image compression","authors":"Boban P. Bondzulic, B. Pavlović, Nenad Stojanović, Vladimir Petrović, Dimitrije Bujaković","doi":"10.1007/s00371-023-03062-y","DOIUrl":"https://doi.org/10.1007/s00371-023-03062-y","url":null,"abstract":"","PeriodicalId":49376,"journal":{"name":"Visual Computer","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2023-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47545706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"计算机科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-31DOI: 10.1007/s00371-023-03065-9
Jiongli Gao, Jun Wu, Xuemei Zhao, Gang Xu
{"title":"Integrating TPS, cylindrical projection, and plumb-line constraint for natural stitching of multiple images","authors":"Jiongli Gao, Jun Wu, Xuemei Zhao, Gang Xu","doi":"10.1007/s00371-023-03065-9","DOIUrl":"https://doi.org/10.1007/s00371-023-03065-9","url":null,"abstract":"","PeriodicalId":49376,"journal":{"name":"Visual Computer","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47502185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"计算机科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-31DOI: 10.1007/s00371-023-03050-2
Sudipta Meikap, Biswapati Jana, T. Lu
{"title":"Context pixel-based reversible data hiding scheme using pixel value ordering","authors":"Sudipta Meikap, Biswapati Jana, T. Lu","doi":"10.1007/s00371-023-03050-2","DOIUrl":"https://doi.org/10.1007/s00371-023-03050-2","url":null,"abstract":"","PeriodicalId":49376,"journal":{"name":"Visual Computer","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47160280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"计算机科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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