Pub Date : 2009-01-01DOI: 10.5174/tutfd.2009.03515.3
Y. Canberk, B. Ahishali, F. D. Onar, E. Karabulut
Objective: Tinea pedis is the most common superficial fungal infection of the foot. Although light microscopic characteristics of tinea pedis have already been described and are well known, electron microscopic data is still lacking. In this study, we aimed to examine the ultrastructural changes in the epidermis of patients diagnosed with tinea pedis. Material and Methods: Biopsies were taken from the lesions between the toes of patients with untreated tinea pedis and from healthy volunteers with no fungal infections. The materials obtained were prepared for electron microscopy and examined by transmission electron microscope. Results: The ultrastructural examination revealed the following changes: (1) Disturbances in the form and organization of keratinocytes; (2) Irregular distribution and interlacing of tonofilament bundles in keratinocytes; (3) Disruption of desmosomes and detachment of adjoining keratinocytes; (4) Excessive widening of intercellular spaces between keratinocytes; (5) Dilatation of intercellular spaces between basal cells; (6) Degranulation of melanocytes in the stratum basale; (7) Migration of lymphocytes and polymorphonuclear leukocytes between keratinocytes in the stratum spinosum; (8) Degradation of basal lamina; (9) Pericapillary edema in the apillary dermis. Conclusion: The ultrastructural findings in tinea pedis are described and related to the clinical symptoms and histopathologic features of the disease.
{"title":"Ultrastructural Alterations In The Epidermis Of Patients With Tinea Pedis","authors":"Y. Canberk, B. Ahishali, F. D. Onar, E. Karabulut","doi":"10.5174/tutfd.2009.03515.3","DOIUrl":"https://doi.org/10.5174/tutfd.2009.03515.3","url":null,"abstract":"Objective: Tinea pedis is the most common superficial fungal infection of the foot. Although light microscopic characteristics of tinea pedis have already been described and are well known, electron microscopic data is still lacking. In this study, we aimed to examine the ultrastructural changes in the epidermis of patients diagnosed with tinea pedis. Material and Methods: Biopsies were taken from the lesions between the toes of patients with untreated tinea pedis and from healthy volunteers with no fungal infections. The materials obtained were prepared for electron microscopy and examined by transmission electron microscope. Results: The ultrastructural examination revealed the following changes: (1) Disturbances in the form and organization of keratinocytes; (2) Irregular distribution and interlacing of tonofilament bundles in keratinocytes; (3) Disruption of desmosomes and detachment of adjoining keratinocytes; (4) Excessive widening of intercellular spaces between keratinocytes; (5) Dilatation of intercellular spaces between basal cells; (6) Degranulation of melanocytes in the stratum basale; (7) Migration of lymphocytes and polymorphonuclear leukocytes between keratinocytes in the stratum spinosum; (8) Degradation of basal lamina; (9) Pericapillary edema in the apillary dermis. Conclusion: The ultrastructural findings in tinea pedis are described and related to the clinical symptoms and histopathologic features of the disease.","PeriodicalId":49429,"journal":{"name":"Trakya Universitesi Tip Fakultesi Dergisi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5174/tutfd.2009.03515.3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70784858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-01-01DOI: 10.5174/tutfd.2009.03067.4
Atim Abdulkadir, Y. Oguz, C. Tuncer, Orhan Mehmet Emin
Arginase deficiency is an autosomal recessive disorder of the urea cycle in which a defect in conversion of arginine to urea and ornithine leads to hyperammonemia. Patients with urea cycle disorders may show increased protein catabolism due to inadequate intake of energy, protein and essential amino acids; infections, fever and surgery. A 12-year-old girl with arginase deficiency, ASA II who weighed 40 kg was scheduled for bilateral adductor, quadri-ceps and gastrocnemius tenotomies. She had mental retardation, spasticity and flexion posture of thelower limbs. Metabolic homeostasis was restored with appropriate diet. Successful anesthetic management allowed the patient to be discharged 48 hours after surgery. Increased levels of arginine and ammonia during or after surgery may lead to serious complications such as hypotension, cerebral edema, convulsions, hypothermia and spasticity. Thus special attention must be given to metabolic homeostasis and nutrition of the patients with arginase deficiency in the perioperative period. Primary goals should be to minimize stress levels by effective anxiolysis, provide an adequate amount of protein-free energy with proper fluid management and to obtain an effective preemptive and postoperative analgesia. In addition to a high level of knowledge, successful anesthesia requires professional communication among nursing staff, dietitians, pediatric metabolism specialist, surgeon and anesthesiologist.
{"title":"Anesthetic Management Of A Pediatric Patient With Arginase Deficiency","authors":"Atim Abdulkadir, Y. Oguz, C. Tuncer, Orhan Mehmet Emin","doi":"10.5174/tutfd.2009.03067.4","DOIUrl":"https://doi.org/10.5174/tutfd.2009.03067.4","url":null,"abstract":"Arginase deficiency is an autosomal recessive disorder of the urea cycle in which a defect in conversion of arginine to urea and ornithine leads to hyperammonemia. Patients with urea cycle disorders may show increased protein catabolism due to inadequate intake of energy, protein and essential amino acids; infections, fever and surgery. A 12-year-old girl with arginase deficiency, ASA II who weighed 40 kg was scheduled for bilateral adductor, quadri-ceps and gastrocnemius tenotomies. She had mental retardation, spasticity and flexion posture of thelower limbs. Metabolic homeostasis was restored with appropriate diet. Successful anesthetic management allowed the patient to be discharged 48 hours after surgery. Increased levels of arginine and ammonia during or after surgery may lead to serious complications such as hypotension, cerebral edema, convulsions, hypothermia and spasticity. Thus special attention must be given to metabolic homeostasis and nutrition of the patients with arginase deficiency in the perioperative period. Primary goals should be to minimize stress levels by effective anxiolysis, provide an adequate amount of protein-free energy with proper fluid management and to obtain an effective preemptive and postoperative analgesia. In addition to a high level of knowledge, successful anesthesia requires professional communication among nursing staff, dietitians, pediatric metabolism specialist, surgeon and anesthesiologist.","PeriodicalId":49429,"journal":{"name":"Trakya Universitesi Tip Fakultesi Dergisi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5174/tutfd.2009.03067.4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70784300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-01-01DOI: 10.5174/tutfd.2009.02426.1
Abdulhamit Gencer, Y. Ozdemir, I. Sucullu, A. Filiz, E. Yucel, M. Akın, M. Yıldız
Amac: Major abdominal cerrahi uygulanan olgularda preoperatif baslanan ve erken postoperatif donemde devam edilen enteral immunonutrisyon urunu ile total parenteral nutrisyonun, immun sistem ve akut inflamatuar yanit uzerine etkilerinin arastirilmasi amaclandi. Gerec ve Yontem: Mide ve kolorektal kanser tanili 60 hasta iki gruba randomize edildi. Birinci gruba enteral immunonutrisyon, ikinci gruba Total Parenteral Nutrisyon uygulandi. Nutrisyonel degerlendirme icin albumin, prealbumin, retinol baglayici protein (RBP) ve transferin duzeylerine, immunolojik degerlendirme icin IL-2, IL-6, CRP ve T-Lenfosit degerlerine bakildi. Ayrica, postoperatif komplikasyon oranlari ile yogun bakim unitesinde (YBU) ve hastanede yatis sureleri karsilastirildi. Bulgular: Her iki grupta postoperatif 1. gunde nutrisyonel degerlerde anlamli azalma goruldu (pl0.05). Prealbumin ve RBP degerlerinde Grup I'de postoperatif 5. gun anlamli bir artma gozlendi (pl0.05). IL-6 ve CRP degerlerinde iki grupta postoperatif anlamli bir artis saptandi (pl0.01). Postoperatif 1. ve 5. gunde IL-2 miktarinda Grup I'de anlamli yukselme (pl0.05), T-Lenfosit yuzdesinde Grup II'de anlamli azalma saptandi (pl0.05). YBU ve hastanede yatis sureleri acisindan karsilastirma yapildiginda Grup II'de anlamli bir artis goruldu (pl0.05). Postoperatif enfeksiyon orani Grup I'de Grup II'ye kiyasla anlamli miktarda az bulundu (pl0.05). Sonuc: Major abdominal cerrahi sonrasi erken enteral immunonutrisyonun akut inflamatuar reaksiyon siddetini azalttigi, hucresel immun destegi artirdigi, postoperatif enfeksiyon insidansini azalttigi, yogun bakimda ve hastanede yatis suresini azalttigi gozlendi.
{"title":"The Effects Of Enteral Immunonutrient Products And Total Parenteral Nutrition In Patients Who Underwent Major Abdominal Surgery","authors":"Abdulhamit Gencer, Y. Ozdemir, I. Sucullu, A. Filiz, E. Yucel, M. Akın, M. Yıldız","doi":"10.5174/tutfd.2009.02426.1","DOIUrl":"https://doi.org/10.5174/tutfd.2009.02426.1","url":null,"abstract":"Amac: Major abdominal cerrahi uygulanan olgularda preoperatif baslanan ve erken postoperatif donemde devam edilen enteral immunonutrisyon urunu ile total parenteral nutrisyonun, immun sistem ve akut inflamatuar yanit uzerine etkilerinin arastirilmasi amaclandi. Gerec ve Yontem: Mide ve kolorektal kanser tanili 60 hasta iki gruba randomize edildi. Birinci gruba enteral immunonutrisyon, ikinci gruba Total Parenteral Nutrisyon uygulandi. Nutrisyonel degerlendirme icin albumin, prealbumin, retinol baglayici protein (RBP) ve transferin duzeylerine, immunolojik degerlendirme icin IL-2, IL-6, CRP ve T-Lenfosit degerlerine bakildi. Ayrica, postoperatif komplikasyon oranlari ile yogun bakim unitesinde (YBU) ve hastanede yatis sureleri karsilastirildi. Bulgular: Her iki grupta postoperatif 1. gunde nutrisyonel degerlerde anlamli azalma goruldu (pl0.05). Prealbumin ve RBP degerlerinde Grup I'de postoperatif 5. gun anlamli bir artma gozlendi (pl0.05). IL-6 ve CRP degerlerinde iki grupta postoperatif anlamli bir artis saptandi (pl0.01). Postoperatif 1. ve 5. gunde IL-2 miktarinda Grup I'de anlamli yukselme (pl0.05), T-Lenfosit yuzdesinde Grup II'de anlamli azalma saptandi (pl0.05). YBU ve hastanede yatis sureleri acisindan karsilastirma yapildiginda Grup II'de anlamli bir artis goruldu (pl0.05). Postoperatif enfeksiyon orani Grup I'de Grup II'ye kiyasla anlamli miktarda az bulundu (pl0.05). Sonuc: Major abdominal cerrahi sonrasi erken enteral immunonutrisyonun akut inflamatuar reaksiyon siddetini azalttigi, hucresel immun destegi artirdigi, postoperatif enfeksiyon insidansini azalttigi, yogun bakimda ve hastanede yatis suresini azalttigi gozlendi.","PeriodicalId":49429,"journal":{"name":"Trakya Universitesi Tip Fakultesi Dergisi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5174/tutfd.2009.02426.1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70783370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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