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Seminars in Radiation Oncology最新文献

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The contemporary spectrum of radiotherapy for hematologic malignancies involving the central nervous system: From focal therapy to craniospinal. 涉及中枢神经系统的血液恶性肿瘤的当代放射治疗谱:从局灶治疗到颅脊髓。
IF 2.6 3区 医学 Q3 ONCOLOGY Pub Date : 2025-01-01 DOI: 10.1016/j.semradonc.2024.11.001
Gustav Y Cederquist, Kathryn Tringale, Joachim Yahalom, Brandon S Imber

The contemporary landscape of systemic therapy options for hematologic malignancies involving the central nervous system (CNS-HM) is rapidly evolving; a key question is how radiotherapy (RT) can be optimally integrated to improve patient outcomes. Historically, use of RT to treat CNS-HM was defined by broad fields and high doses. While effective, this approach raised concerns of potential neurotoxicity which significantly decreased RT utilization. RT was replaced by high-dose, CNS-penetrant, systemic therapies that offered durable control with lower perceived neurotoxic risk. But, as the therapeutic toolbox for CNS-HM expands, so too does the complexity and diversity of potential clinical scenarios where RT should be considered. In this review, we describe both well-established and emerging opportunities for RT integration, emphasizing how dose selection and field design could balance neurotoxicity risk and disease control. We propose an anatomical framework that captures the diverse utilization of RT for CNS-HM and serves as a practical guide for RT volume and dose design.

涉及中枢神经系统(CNS-HM)的血液恶性肿瘤的全身治疗方案正在迅速发展,其中一个关键问题是如何优化整合放射治疗(RT),以改善患者的预后。从历史上看,使用 RT 治疗中枢神经系统恶性肿瘤的定义是广域和高剂量。这种方法虽然有效,但却引起了对潜在神经毒性的担忧,从而大大降低了 RT 的使用率。大剂量、中枢神经系统穿透性的系统疗法取代了 RT,这些疗法可提供持久的控制,同时降低神经毒性风险。但是,随着 CNS-HM 治疗工具箱的扩大,应考虑 RT 的潜在临床情况也变得更加复杂和多样。在这篇综述中,我们描述了成熟的和新兴的 RT 整合机会,强调了剂量选择和治疗场设计如何平衡神经毒性风险和疾病控制。我们提出了一个解剖学框架,该框架捕捉到了 RT 在中枢神经系统疾病中的不同应用,并可作为 RT 容量和剂量设计的实用指南。
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引用次数: 0
Future of Multidisciplinary Team in the Context of Adaptive Therapy 适应性疗法背景下多学科团队的未来
IF 2.6 3区 医学 Q3 ONCOLOGY Pub Date : 2024-09-11 DOI: 10.1016/j.semradonc.2024.08.006
H.A. McNair PhD , M.F. Milosevic MD , P.J. Parikh MD , U.A. van der Heide PhD

The implementation and early adoption of online adaptive radiotherapy (oART) has required the presence of clinicians, physicists and radiation therapists (RTT) at the treatment console. The impact on each of them is unique to their profession and must be considered for safe and efficient implementation. In the short term future, widespread adoption will depend on the development of innovative workflows, and rethinking of traditional roles and responsibilities may be required. For the future, technologies such as artificial intelligence promise to change the workflow significantly in terms of speed, automation and decision-making. However, overall communication within the team will persist in being one of the most important aspects.

在线自适应放射治疗(oART)的实施和早期采用需要临床医生、物理学家和放射治疗师(RTT)在治疗控制台的参与。这对他们每个人的职业都有独特的影响,必须考虑到安全和高效的实施。在短期内,广泛应用将取决于创新工作流程的发展,可能需要重新思考传统的角色和职责。未来,人工智能等技术有望在速度、自动化和决策方面极大地改变工作流程。然而,团队内部的整体沟通仍将是最重要的方面之一。
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引用次数: 0
Green Horizons in Oncology: A Blueprint for Environmentally Sustainable Radiation Therapy Facilities 肿瘤学的绿色前景:环境可持续放射治疗设施蓝图
IF 2.6 3区 医学 Q3 ONCOLOGY Pub Date : 2024-09-11 DOI: 10.1016/j.semradonc.2024.07.004
Claire C Baniel , Rachel A. Sabol , Robert Nieto , Jessica Scholey , Alon Witztum , Robert Chuter , Erqi Pollom , Seema Gandhi , Kaiyi Wang , Kavita K. Mishra , Katie E. Lichter , Catherine Park
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引用次数: 0
Pursuing New Horizons With New Collaborators: This Is the Future of Radiation Oncology 与新合作者一起追求新视野:这就是放射肿瘤学的未来
IF 2.6 3区 医学 Q3 ONCOLOGY Pub Date : 2024-09-11 DOI: 10.1016/j.semradonc.2024.08.002
David A. Jaffray , Robert P. Coppes , Helen McNair , Akila Viswanathan
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引用次数: 0
The Future of Safety and Quality in Radiation Oncology 放射肿瘤学安全与质量的未来
IF 2.6 3区 医学 Q3 ONCOLOGY Pub Date : 2024-09-11 DOI: 10.1016/j.semradonc.2024.07.008
Wesley Talcott , Elizabeth Covington , Jose Bazan , Jean L. Wright

The increasing complexity of radiation therapy treatment presents new potentials for error and suboptimal care. High-performing programs thus not only require adherence to, but also ongoing improvement of, key safety and quality practices. In this article, we review these practices including standardization, risk analysis, peer review, and maintenance of strong safety culture, while also describing recent innovations and promising future directions. We specifically highlight the growing role of artificial intelligence in radiation oncology, both as a tool to deliver safe, high-quality care and as a potential new source of safety challenges.

放射治疗的复杂性与日俱增,为错误和次优治疗提供了新的可能性。因此,高绩效项目不仅需要坚持,还需要不断改进关键的安全和质量实践。在这篇文章中,我们回顾了这些实践,包括标准化、风险分析、同行评审和维护强大的安全文化,同时还介绍了最近的创新和未来的发展方向。我们特别强调了人工智能在放射肿瘤学中日益重要的作用,它既是提供安全、高质量护理的工具,也是潜在的安全挑战新来源。
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引用次数: 0
ROCR: Modernizing Radiation Oncology Payment to Embrace Innovation and Better Care ROCR:实现放射肿瘤学支付现代化,拥抱创新和更好的护理
IF 2.6 3区 医学 Q3 ONCOLOGY Pub Date : 2024-09-11 DOI: 10.1016/j.semradonc.2024.07.002
Catheryn M. Yashar , Anne Hubbard , Casey Chollet-Lipscomb

Data demonstrates that hypofractionation is increasingly utilized based on evidence-based guidelines. The outdated Medicare fee-for-service approach penalizes radiation oncology (RO) practices from adopting hypofractionation, even as many patients benefit. To address the flawed fee-for-service payment system, which rewards volume over value, ASTRO introduced the Radiation Oncology Case Rate (ROCR) Value-Based Payment Program. ROCR shifts payment for RO services from fee-for-service to payment per patient or per episode. To address disparities, ROCR provides an evidence-based approach through the Health Equity Achievement in Radiation Therapy (HEART) initiative, providing transportation assistance payment for the underserved. Additionally, ROCR allows practices sufficient capital to maintain existing equipment and invest in new technology. This increases patient access to technological advancements allowing for more efficient, targeted, and personalized care with improved patient outcomes at a lower overall cost.

数据显示,根据循证指南,越来越多的人采用了低剂量治疗。过时的联邦医疗保险(Medicare)收费服务方式惩罚了放射肿瘤学(RO)实践,使其无法采用低分量疗法,尽管许多患者从中受益。为了解决收费服务支付系统的弊端(该系统奖励的是数量而非价值),ASTRO 推出了放射肿瘤病例率(ROCR)价值支付计划。ROCR 将放射肿瘤服务的付费方式从按服务收费转变为按患者或按疗程付费。为解决差异问题,ROCR 通过 "放射治疗中的健康平等成就"(HEART)计划提供了一种循证方法,为服务不足者提供交通补助。此外,ROCR 还允许医疗机构有足够的资金来维护现有设备和投资新技术。这增加了患者获得先进技术的机会,从而以更低的总成本获得更高效、更有针对性和更个性化的治疗,并改善患者的治疗效果。
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引用次数: 0
Future of Team-based Basic and Translational Science in Radiation Oncology 放射肿瘤学团队基础与转化科学的未来
IF 2.6 3区 医学 Q3 ONCOLOGY Pub Date : 2024-09-11 DOI: 10.1016/j.semradonc.2024.07.007
R.P. Coppes PhD , L.V. van Dijk PhD

To further optimize radiotherapy, a more personalized treatment towards individual patient's risk profiles, dissecting both patient-specific tumor and normal tissue response to multimodality treatments is needed. Novel developments in radiobiology, using in vitro patient-specific complex tissue resembling 3D models and multiomics approaches at a spatial single-cell level, may provide unprecedented insight into the radiation responses of tumors and normal tissue. Here, we describe the necessary team effort, including all disciplines in radiation oncology, to integrate such data into clinical prediction models and link the relatively "big data" from the clinical practice, allowing accurate patient stratification for personalized treatment approaches.

为了进一步优化放射治疗,需要根据患者的个体风险特征进行更加个性化的治疗,剖析患者特异性肿瘤和正常组织对多模式治疗的反应。放射生物学的新发展,利用体外患者特异性复杂组织类似三维模型和空间单细胞水平的多组学方法,可以为肿瘤和正常组织的辐射反应提供前所未有的洞察力。在此,我们将介绍包括放射肿瘤学所有学科在内的必要团队工作,以便将这些数据整合到临床预测模型中,并将临床实践中的相对 "大数据 "联系起来,从而为个性化治疗方法提供准确的患者分层。
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引用次数: 0
Prioritizing Patient-Centered Care in a World of Increasingly Advanced Technologies and Disconnected Care 在技术日益先进、医疗服务日益脱节的世界里,优先考虑以患者为中心的医疗服务
IF 2.6 3区 医学 Q3 ONCOLOGY Pub Date : 2024-09-11 DOI: 10.1016/j.semradonc.2024.07.001
Sarah Marion , Lauren Ghazal , Toni Roth , Kelly Shanahan , Bridgette Thom , Fumiko Chino

With more treatment options in oncology lead to better outcomes and more favorable side effect profiles, patients are living longer—with higher quality of life—than ever, with a growing survivor population. As the needs of patients and providers evolve, and technology advances, cancer care is subject to change. This review explores the myriad of changes in the current oncology landscape with a focus on the patient perspective and patient-centered care.

随着肿瘤治疗方法越来越多,疗效越来越好,副作用越来越小,患者的寿命越来越长,生活质量越来越高,幸存者人数也在不断增加。随着患者和医疗服务提供者需求的变化以及技术的进步,癌症护理也在不断变化。本综述以患者视角和以患者为中心的护理为重点,探讨了当前肿瘤学领域的众多变化。
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引用次数: 0
Future of Telemedicine in Radiation Oncology 放射肿瘤学远程医疗的未来
IF 2.6 3区 医学 Q3 ONCOLOGY Pub Date : 2024-09-11 DOI: 10.1016/j.semradonc.2024.07.010
Sean M. McBride MD, MPH , Helen K. Hughes MD, MPH , Shannon M. MacDonald MD

Telemedicine allows providers and patients to communicate without being in the same room through video platforms or telephone. Like the increased use of telework for businesses, telemedicine exploded during the pandemic. While many workplaces and clinics have returned to some level of in-person interactions, the convenience and comfort have given telemedicine staying power. Patients can be seen from the comfort of their homes; family members can join from the same or a different location. Driving, obtaining childcare, or taking time off from work is unnecessary. Pediatric patients’ parents can pull them into the conversation at appropriate times and avoid the awkwardness of having them leave for portions of the discussion. Because virtual visits are more efficient for everyone, they can often be scheduled sooner than an in-person visit. While not every visit can be done without the patient physically with the provider, many can. This is particularly true for cancer patients, who often have several visits with multiple providers. For immunocompromised patients, there is an added benefit of avoiding exposure from travel and a hospital visit. Oncology and radiation oncology practices have widely adopted telemedicine. While legal and logistical barriers exist in some areas of the world, these are sure to be resolved to make this medicine feasible for all in the modern era.

远程医疗允许医疗服务提供者和患者通过视频平台或电话进行交流,而无需在同一病房。与企业越来越多地使用远程办公一样,远程医疗在大流行病期间也出现了爆炸式增长。虽然许多工作场所和诊所已经恢复了某种程度的面对面交流,但远程医疗的便利性和舒适性使其保持了强劲的发展势头。病人可以在舒适的家中就诊,家人也可以在同一地点或不同地点就诊。开车、托儿或请假都没有必要。儿科患者的父母可以在适当的时候把他们拉进谈话中,避免了让他们在部分讨论中离开的尴尬。由于虚拟就诊对每个人来说都更有效率,因此往往可以比面对面就诊更快地安排时间。虽然不是每次就诊都能在患者不与医疗服务提供者面对面的情况下进行,但很多情况下是可以的。对于癌症患者来说尤其如此,因为他们通常需要与多个医疗服务提供者进行多次就诊。对于免疫力低下的患者来说,还有一个额外的好处,就是避免了旅行和医院就诊带来的风险。肿瘤学和放射肿瘤学实践已广泛采用远程医疗。虽然世界上某些地区还存在法律和后勤障碍,但这些问题一定会得到解决,使这一医学在现代对所有人都可行。
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引用次数: 0
The History and Future of Multidisciplinary Cancer Care 多学科癌症治疗的历史与未来
IF 2.6 3区 医学 Q3 ONCOLOGY Pub Date : 2024-09-11 DOI: 10.1016/j.semradonc.2024.07.006
Anna W. LaVigne MD , Victoria L. Doss MD , Donna Berizzi DNP , Fabian M. Johnston MD, MHS , Ana P. Kiess MD, PhD , Kedar S. Kirtane MD , Drew Moghanaki MD, MPH , Michael Roumeliotis PhD , George Q. Yang MD , Akila N. Viswanathan MD, MPH
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引用次数: 0
期刊
Seminars in Radiation Oncology
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