Seizure-European Journal of Epilepsy最新文献_第2页

Prognostic performance of STESS and qSOFA scores in pre-hospital status epilepticus: A prospective cohort study 院前癫痫持续状态的ess和qSOFA评分的预后表现：一项前瞻性队列研究

IF 2.8 3区医学 Q2 CLINICAL NEUROLOGY

Seizure-European Journal of Epilepsy

Pub Date : 2026-03-01 Epub Date: 2026-01-29 DOI: 10.1016/j.seizure.2026.01.017

Hela Manai, Teycir Kharraz, Houyem Zouari, Saida Zelfani

Background

Status epilepticus (SE) is a life-threatening, multisystem disorder. Prognostic factors are variable, and several scores have been developed for SE, some requiring electroencephalogram results that may not be available pre-hospital. We aimed to evaluate the prognostic performance of two rapid, easily applicable pre-hospital scores: the STESS and qSOFA scores.

Methods

We conducted a prospective, observational study of SE patients managed in pre-hospital emergency care in Tunis over 35 months. We assessed the area under the receiver operating characteristic curve (AUC), sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and optimal cutoffs for both STESS and qSOFA in predicting 48-hour mortality, in-hospital mortality, and the need for mechanical ventilation.

Results

One hundred SE patients with motor-predominant seizures were included. For 48-hour mortality, AUC was 0.855 for STESS and 0.787 for qSOFA; for mechanical ventilation, AUC was 0.693 and 0.705, respectively. STESS ≥3 predicted 48-hour mortality with specificity 87.0% and sensitivity 66.7%, while qSOFA ≥3 had specificity 95.8% and sensitivity 64.3%. Exploratory analysis for in-hospital mortality (37%) showed STESS ≥3 with specificity 86% and sensitivity 68%, and qSOFA ≥3 with specificity 95% and sensitivity 64%.

Conclusions

STESS and qSOFA are simple, rapid scores suitable for pre-hospital SE management. Both exhibit good specificity but moderate sensitivity. STESS may be more informative for in-hospital outcomes, while qSOFA reflects early systemic severity. Scores should be interpreted alongside a comprehensive clinical assessment to guide triage and early management.

背景：癫痫持续状态（SE）是一种危及生命的多系统疾病。预后因素是可变的，已经为SE制定了几个评分，其中一些需要院前可能无法获得的脑电图结果。我们的目的是评估两种快速、易于应用的院前评分：ess和qSOFA评分的预后表现。方法：我们对突尼斯35个月以上院前急救管理的SE患者进行了前瞻性观察研究。我们评估了受试者工作特征曲线下面积（AUC）、敏感性、特异性、阳性预测值（PPV）、阴性预测值（NPV）以及ess和qSOFA在预测48小时死亡率、住院死亡率和机械通气需求方面的最佳截止点。结果：纳入100例以运动为主的SE患者。对于48小时死亡率，ess的AUC为0.855，qSOFA的AUC为0.787；机械通气的AUC分别为0.693和0.705。ess≥3预测48小时死亡率的特异性为87.0%，敏感性为66.7%；qSOFA≥3预测48小时死亡率的特异性为95.8%，敏感性为64.3%。对住院死亡率（37%）的探索性分析显示，ess≥3，特异性为86%，敏感性为68%；qSOFA≥3，特异性为95%，敏感性为64%。结论：ess和qSOFA是一种简便、快速的评分方法，适用于院前SE管理。两者均表现出良好的特异性，但敏感性中等。ess可能对住院结果提供更多信息，而qSOFA反映早期系统性严重程度。评分应与综合临床评估一起解释，以指导分诊和早期管理。

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引用次数: 0

Tele-neuropsychological assessment in children with self-limited epilepsy with centrotemporal spikes: a pilot study 伴有中央颞叶尖峰的自限性癫痫患儿的远端神经心理评估：一项初步研究。

IF 2.8 3区医学 Q2 CLINICAL NEUROLOGY

Seizure-European Journal of Epilepsy

Pub Date : 2026-03-01 Epub Date: 2026-02-04 DOI: 10.1016/j.seizure.2026.02.004

Viola Margheri , Simona Pellacani , Edoardo Fino , Martina Calì , Sara Senese , Costanza Ruffini , Carmen Barba , Renzo Guerrini , Chiara Pecini

Introduction

Telemedicine has gained increasing prominence in healthcare services, with neuropsychological tele-assessment emerging as a promising tool for evaluating and monitoring cognitive functions remotely, even in clinical conditions with mild vulnerabilities. Despite its growing application in adults, its use in pediatric clinical contexts remains understudied. Among pediatric disorders, Self-limited epilepsy with centrotemporal spikes (SeLECTs) may feature subtle neuropsychological deficits, particularly in higher order cognitive processes such as Executive Functions (EF), and in learning skills. Early tele-neuropsychological assessment can help delineate the neuropsychological profile in this population.

Method

The feasibility of a fully remote neuropsychological assessment protocol in children with SeLECTs was examined. Forty-seven children (aged 6–13) were recruited, of whom 43 underwent the assessment. Two online sessions via Google Meet and web-based platforms (TeleFE battery), to assess children’s cognitive and executive functioning were conducted. Clinicians evaluated the children's engagement and parents completed remote questionnaires addressing academic performances, EF-related behaviors, and feasibility of the procedure.

Results

The protocol demonstrated high feasibility and acceptability, with participants’ strong compliance and no major technical issues. Descriptive analyses highlighted the presence of vulnerabilities in executive functioning and school achievement in children with SeLECTs.

Discussion

These findings support the clinical relevance of remote neuropsychological assessment in pediatric epilepsy, offering a scalable and accessible tool to enhance care.

远程医疗在医疗保健服务中日益突出，神经心理学远程评估成为远程评估和监测认知功能的一种有前途的工具，即使在具有轻微脆弱性的临床条件下也是如此。尽管它在成人中的应用越来越多，但它在儿科临床环境中的应用仍未得到充分研究。在儿童疾病中，自限性癫痫伴中央颞叶尖峰（SeLECTs）可能具有微妙的神经心理缺陷，特别是在执行功能（EF）等高阶认知过程和学习技能方面。早期远程神经心理学评估可以帮助描述这一人群的神经心理学特征。方法：探讨全远程神经心理评估方案在儿童select中的可行性。招募了47名儿童（6-13岁），其中43名接受了评估。通过谷歌Meet和基于网络的平台（TeleFE battery）进行了两次在线会议，以评估儿童的认知和执行功能。临床医生评估了儿童的参与程度，家长完成了关于学习成绩、ef相关行为和手术可行性的远程问卷调查。结果：方案具有较高的可行性和可接受性，参与者依从性强，无重大技术问题。描述性分析强调了select儿童在执行功能和学习成绩方面存在的脆弱性。讨论：这些发现支持儿童癫痫远程神经心理学评估的临床相关性，提供了一个可扩展和可获得的工具来加强护理。

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引用次数: 0

Neonatal-onset epileptic encephalopathy with lissencephaly associated with a SCN3A variant: The first case in Korea and literature review 新生儿癫痫性脑病伴无脑畸形与SCN3A变异相关：韩国首例病例和文献综述

IF 2.8 3区医学 Q2 CLINICAL NEUROLOGY

Seizure-European Journal of Epilepsy

Pub Date : 2026-03-01 Epub Date: 2026-01-18 DOI: 10.1016/j.seizure.2026.01.008

Hyun A Lee , Seong Wan Kim , Seoheui Choi , Jang Hoon Lee , Moon Sung Park , Rita Yu , Yoong-A Suh

Purpose

Pathogenic variants inSCN3A, encoding the voltage-gated sodium channel Naᵥ1.3, have been implicated in early infantile epileptic encephalopathy (EIEE) and cortical malformations. We report the first Korean case of SCN3A-related EIEE and discuss its contribution to the expanding phenotypic spectrum.

Methods

Clinical features, electroencephalography (EEG), brain magnetic resonance imaging (MRI), treatment response, and outcomes were analyzed. A literature review of previously reported SCN3A cases was performed for phenotypic comparison.

Results

A female neonate developed tonic seizures 7 h after birth. EEG showed multifocal epileptiform discharges with burst-suppression patterns. Brain MRI demonstrated diffuse cortical thickening consistent with the lissencephaly–pachygyria spectrum and corpus callosum dysgenesis. Despite multiple antiseizure medications, seizures remained intractable. Profound bulbar dysfunction required gastrostomy, tracheostomy, and home ventilation. Next-generation sequencing identified a heterozygous SCN3A c.2624T>C (p.Ile875Thr) variant, previously reported as pathogenic and associated with gain-of-function effects. The patient died at 6 months of age.

Conclusion

This first Korean case of SCN3A-related EIEE caused by the recurrent p.Ile875Thr variant highlights a severe neonatal phenotype characterized by early-onset refractory seizures, profound cortical malformations, and early mortality. The case broadens both the phenotypic and geographic spectrum of SCN3A-associated neurodevelopmental disorders and underscores the importance of early genetic testing in neonates with refractory seizures and cortical malformations.

目的：编码电压门控钠通道Naᵥ1.3的scn3a致病变异与早期婴儿癫痫性脑病（EIEE）和皮质畸形有关。我们报告了韩国首例scn3a相关eee病例，并讨论了其对扩大表型谱的贡献。方法：分析患者的临床特点、脑电图（EEG）、脑磁共振成像（MRI）、治疗效果及转诊结果。对先前报道的SCN3A病例进行文献回顾，进行表型比较。结果：1例女性新生儿在出生后7 h出现强直性癫痫发作。脑电图显示多灶性癫痫样放电，伴有发作抑制模式。脑MRI显示弥漫性皮质增厚，与无脑-厚回症频谱和胼胝体发育不良一致。尽管有多种抗癫痫药物，但癫痫仍然难以治疗。严重的球功能障碍需要胃造口术、气管造口术和家庭通气。新一代测序鉴定出一种杂合子SCN3A C . 2624t >C （p.i ile875thr）变异，该变异先前被报道为致病性并与功能获得效应相关。患者在6个月大时死亡。结论：这是韩国首例由p.i ile875thr复发性变异体引起的scn3a相关eee病例，突出了一种严重的新生儿表型，其特征是早发性难固性癫痫发作、深度皮质畸形和早期死亡。该病例拓宽了scn3a相关神经发育障碍的表型和地理谱，并强调了对难治性癫痫和皮质畸形的新生儿进行早期基因检测的重要性。

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引用次数: 0

Quality and safety of youtube videos on epilepsy-specific exercises: A systematic analysis using a novel evaluation tool 关于癫痫特定练习的youtube视频的质量和安全性：使用一种新的评估工具的系统分析。

IF 2.8 3区医学 Q2 CLINICAL NEUROLOGY

Seizure-European Journal of Epilepsy

Pub Date : 2026-03-01 Epub Date: 2026-02-03 DOI: 10.1016/j.seizure.2026.02.002

Yakup Gonulal , Tuba Denizci , Mehmetcan Yesilkaya , Eda Agascioglu , Serdar Aykac , Rabia Hurrem Ozdurak Singin

Objective

Exercise benefits people with epilepsy (PWE) by reducing seizure frequency, improving quality of life, and fostering social participation. YouTube, a popular platform for health information, hosts numerous exercise videos for PWE, yet their quality, reliability, and safety remain unevaluated. This study aimed to evaluate the quality, reliability, and engagement of YouTube videos on epilepsy-specific exercises using the novel Epilepsy Content Evaluation (ECE) tool, alongside DISCERN, JAMA, and Global Quality Score (GQS).

Method

A systematic search conducted on July 22, 2025, identified 45 English-language YouTube videos, which were independently evaluated by two neurologists using the ECE, DISCERN, JAMA, and GQS tools. Video characteristics, publisher sources, and engagement metrics were analyzed.

Results

Most videos (53.3%) were rated low quality (ECE score 0–7), with only one (2.2%) achieving high quality (ECE score 12–15). The Safety and Risk Management subdomain scored lowest (median: 2, IQR: 1.25), reflecting inadequate attention to seizure triggers and supervision. Athlete-targeted videos outperformed general-population videos in quality (p < 0.05). View counts negatively correlated with ECE scores (r = –0.375 to –0.712, p < 0.05). ECE demonstrated strong convergent validity with DISCERN (Phi = 0.606, p = 0.035).

Conclusion

In conclusion, most YouTube videos on epilepsy-specific exercises lack clinical reliability and safety guidance, posing potential risks for PWE. The ECE tool effectively identifies these deficiencies, enabling clinicians to recommend ILAE-aligned videos to enhance patient safety. Curated, evidence-based digital resources could empower millions of PWE to engage in safe physical activity, reducing stigma and improving health outcomes.

目的：通过减少癫痫发作频率、改善生活质量和促进社会参与，运动对癫痫患者（PWE）有益。YouTube是一个流行的健康信息平台，为PWE提供了大量的锻炼视频，但它们的质量、可靠性和安全性仍未得到评估。本研究旨在使用新型癫痫内容评估（ECE）工具，以及DISCERN、JAMA和全球质量评分（GQS），评估YouTube视频关于癫痫特定练习的质量、可靠性和参与度。方法：系统检索于2025年7月22日进行，确定了45个英语YouTube视频，由两位神经学家使用ECE、DISCERN、JAMA和GQS工具独立评估。我们分析了视频特征、发行商来源和用户粘性指标。结果：大多数视频（53.3%）被评为低质量（ECE评分0-7），只有一个视频（2.2%）达到高质量（ECE评分12-15）。安全和风险管理子领域得分最低（中位数：2，IQR: 1.25），反映了对癫痫发作诱因和监督的关注不足。运动员目标视频的质量优于一般人群视频（p < 0.05）。视图计数与ECE评分负相关（r = -0.375 ~ -0.712, p < 0.05）。ECE与DISCERN具有较强的收敛效度（Phi = 0.606, p = 0.035）。结论：总的来说，YouTube上大多数关于癫痫运动的视频缺乏临床可靠性和安全性指导，对PWE存在潜在风险。ECE工具有效地识别了这些缺陷，使临床医生能够推荐符合ilae的视频，以提高患者的安全性。精心策划的、以证据为基础的数字资源可以使数百万PWE能够从事安全的身体活动，减少耻辱感并改善健康结果。

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引用次数: 0

Electroencephalography in the differential diagnosis of non-epileptic paroxysmal events in infants: clinical utility and other predictors 脑电图在婴儿非癫痫性发作事件鉴别诊断中的应用：临床应用和其他预测因素。

IF 2.8 3区医学 Q2 CLINICAL NEUROLOGY

Seizure-European Journal of Epilepsy

Pub Date : 2026-03-01 Epub Date: 2026-02-05 DOI: 10.1016/j.seizure.2026.02.006

Hilal Karpuzcu , Fatih Mehmet Kışlal , Didem Ardıçlı , Deniz Yılmaz (Clinical assessment)

Background

Differentiating non-epileptic paroxysmal events (NEPE) from epileptic seizures in infants is challenging, especially in the 1–24 month age group where features overlap and data are limited. Meanwhile restricting studies to the first year may lead to overlook the events that persist into the second year. This study aimed to define the clinical spectrum of NEPE, assess diagnostic yield of electroencephalography (EEG), and identify predictors of specific subtypes.

Methods

This single-center, retrospective study included infants aged 1–24 months who underwent EEG for suspected NEPE between January 2015 and March 2021. Demographic, clinical, laboratory, neuroimaging, and EEG data were analyzed per Strengthening the reporting of observational studies in epidemiology (STROBE) guidelines.

Results

Of 5614 infants assessed, 1465 underwent EEG, and 216 (mean age 11.1 ± 6.5 months; 55.1% male) met inclusion criteria. Breath holding spells (BHS) were most frequent (55.1%), followed by jitteriness (10.6%) and shuddering attacks (9.3%). Crying was the predominant trigger for BHS (97.5%, p < 0.001). EEG was abnormal in 8.8% of patients. Anemia was present in 23.4%. Independent predictors of BHS were crying (AOR 28.7), age 13–18 months (AOR 3.95), and anemia (AOR 2.65).

Conclusions

Most infants aged 1–24 months with suspected NEPE, had normal EEG, indicating limited diagnostic yield for epileptiform abnormalities. Age, specific triggers, and anemia can guide diagnosis and help to target EEG use to selected cases, thereby supporting more judicious resource utilization and avoiding unnecessary antiseizure medication.

背景：区分婴儿非癫痫性发作事件（NEPE）和癫痫性发作是具有挑战性的，特别是在1-24个月的年龄组中，这些年龄组的特征重叠且数据有限。同时，将学习限制在第一年可能会导致忽视持续到第二年的事件。本研究旨在定义NEPE的临床谱，评估脑电图（EEG）的诊断率，并确定特定亚型的预测因子。方法：这项单中心回顾性研究纳入了2015年1月至2021年3月期间因疑似NEPE接受脑电图检查的1-24个月婴儿。根据加强流行病学观察性研究报告（STROBE）指南对人口统计学、临床、实验室、神经影像学和脑电图数据进行分析。结果：在接受评估的5614名婴儿中，1465名接受了脑电图检查，216名（平均年龄11.1±6.5个月，男性55.1%）符合纳入标准。屏气发作（BHS）最为常见（55.1%），其次是神经紧张（10.6%）和颤抖发作（9.3%）。哭泣是诱发BHS的主要因素（97.5%,p < 0.001）。8.8%的患者脑电图异常。贫血占23.4%。BHS的独立预测因子为哭泣（AOR 28.7）、年龄13-18个月（AOR 3.95）和贫血（AOR 2.65）。结论：大多数1-24月龄疑似NEPE的婴儿脑电图正常，表明对癫痫样异常的诊断率有限。年龄、特定触发因素和贫血可以指导诊断，并有助于将脑电图用于选定的病例，从而支持更明智的资源利用，避免不必要的抗癫痫药物。

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引用次数: 0

Before status epilepticus in epilepsy patients is attributed to the SARS-CoV-2 vaccination, alternative causes must be ruled out 在将癫痫患者的癫痫持续状态归因于SARS-CoV-2疫苗接种之前，必须排除其他原因

IF 2.8 3区医学 Q2 CLINICAL NEUROLOGY

Seizure-European Journal of Epilepsy

Pub Date : 2026-03-01 Epub Date: 2026-03-10 DOI: 10.1016/j.seizure.2024.10.014

Josef Finsterer

引用次数: 0

Syncope due to loss of ventricular capture during sleep misdiagnosed as epilepsy: A case report 睡眠中失去心室俘获引起的晕厥误诊为癫痫1例

IF 2.8 3区医学 Q2 CLINICAL NEUROLOGY

Seizure-European Journal of Epilepsy

Pub Date : 2026-03-01 Epub Date: 2026-02-03 DOI: 10.1016/j.seizure.2026.02.003

Pavithra Murugesan , Matthias Dullaert , Frederic Van Heuverswyn , Alfred Meurs , Stephanie Hödl

引用次数: 0

Preoperative positron emission tomography for predicting postoperative epilepsy risk: A radiomics and clinical feature-based fusion model 术前正电子发射断层扫描预测术后癫痫风险：放射组学和基于临床特征的融合模型。

IF 2.8 3区医学 Q2 CLINICAL NEUROLOGY

Seizure-European Journal of Epilepsy

Pub Date : 2026-03-01 Epub Date: 2026-01-29 DOI: 10.1016/j.seizure.2026.01.018

Di Zhang, Zi-Hao Wang, Yan Feng, Yu-Tian Wang, Shun-Yao Zhang, Wen-Ling Li

Background

Epilepsy is a common neurological disorder characterized by recurrent seizures, and predicting the risk of postoperative epilepsy is critical for patient management. The integration of radiomics and clinical factors offers a promising approach for accurate risk assessment.

Methods

In this study, preoperative positron emission tomography (PET) imaging and clinical data of 197 epilepsy patients were analyzed. The imaging features were extracted from three-dimensional regions of interest (ROIs). Key radiomics features were selected using the SelectKBest and the Least Absolute Shrinkage and Selection Operator (LASSO), while key clinical features were identified through univariate and multivariate analyses. Three models—radiomics, clinical, and fusion (fusing radiomics and clinical features)—were constructed using the Support Vector Machine (SVM) and Multilayer Perceptron (MLP) algorithms. The models were evaluated based on sensitivity, specificity, and area under the curve (AUC). A nomogram based on the best-performing model was developed and assessed for predictive accuracy using calibration and decision curve analysis (DCA) to estimate the risk of postoperative epilepsy following neurosurgery.

Results

A total of 11 key radiomics features were identified, with prior brain damage (PBD) as the key clinical feature. The MLP fusion model demonstrated the highest predictive performance, with an AUC of 0.85 in the validation set. The nomogram showed good predictive accuracy and superior clinical utility.

Conclusion

The integration of radiomics and clinical features provides a more accurate and clinically useful tool for predicting postoperative epilepsy risk. The fusion model demonstrates significant potential in guiding clinical decision-making and personalized treatment for epilepsy patients.

背景：癫痫是一种常见的以反复发作为特征的神经系统疾病，预测术后癫痫的风险对患者管理至关重要。放射组学和临床因素的结合为准确的风险评估提供了一种有前途的方法。方法：对197例癫痫患者的术前正电子发射断层扫描（PET）及临床资料进行分析。从三维感兴趣区域（roi）提取成像特征。使用SelectKBest和Least Absolute shrink and Selection Operator （LASSO）选择关键的放射组学特征，而通过单变量和多变量分析确定关键的临床特征。使用支持向量机（SVM）和多层感知器（MLP）算法构建三个模型-放射组学，临床和融合（融合放射组学和临床特征）。根据敏感性、特异性和曲线下面积（AUC）对模型进行评估。采用校准和决策曲线分析（校准和决策曲线分析，DCA）来评估神经外科术后癫痫风险，并基于最佳表现模型开发了一种nomogram预测图。结果：共确定了11个关键放射组学特征，其中先前脑损伤（PBD）是关键的临床特征。MLP融合模型表现出最高的预测性能，在验证集中的AUC为0.85。图显示了良好的预测准确性和优越的临床应用。结论：放射组学与临床特征的结合为预测术后癫痫风险提供了更为准确和实用的工具。该融合模型在指导癫痫患者的临床决策和个性化治疗方面具有重要的潜力。

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引用次数: 0

Evolution of disparities in pediatric epilepsy surgery use over two decades 二十年来小儿癫痫手术应用差异的演变

IF 2.8 3区医学 Q2 CLINICAL NEUROLOGY

Seizure-European Journal of Epilepsy

Pub Date : 2026-03-01 Epub Date: 2026-01-30 DOI: 10.1016/j.seizure.2026.01.020

Alex S. Aguirre , Ellen C. Broekhuizen , Daan A. Pijs , Iván Sánchez Fernández

Objective

To describe how disparities in the use of epilepsy surgery have evolved between 2004 and 2024 among children with drug-resistant epilepsy.

Methods

Retrospective descriptive study using the Pediatric Health Information System database. Outcomes were use of epilepsy surgery and time from first diagnosis of drug-resistant epilepsy to epilepsy surgery, main predictors were type of insurance, race, and ethnicity.

Results

We studied 50,953 patients with drug-resistant epilepsy (median (p₂₅-p₇₅) age: 8.0 (3.5–13.4) years, 54% males), of whom 7220 (14.2%) patients had at least one epilepsy surgery. The number of epilepsy surgeries per 100 person-years increased from 4.0 in 2004–2006 to 15.8 in 2022–2024. On multivariable analysis, the odds ratio (OR) of receiving epilepsy surgery for patients with private versus public insurance increased from OR: 1.50 (1.25–1.80) in 2004–2006 to OR: 1.75 (1.50–2.04) in 2022–2024; increased for White patients versus Black patients from OR: 1.35 (1.03–1.76) in 2004–2006 to OR: 2.39 (1.86–3.08) in 2022–2024; and increased for Not Hispanic/Latino patients versus Hispanic/Latino patients from OR: 1.08 (0.85–1.38) in 2007–2009 (first years with the “Not Hispanic/Latino” category) to OR: 1.23 (1.01–1.51) in 2022–2024. On multivariable Cox regression analysis, the hazard ratio (HR) of receiving epilepsy surgery for patients with private insurance versus public insurance increased from HR: 1.55 (1.32–1.82) in 2004–2006 to HR: 1.92 (1.65–2.24) in 2022–2024; increased for White patients versus Black patients from HR: 1.46 (1.14–1.86) in 2004–2006 to HR: 2.67 (2.05–3.48) in 2022–2024; and increased for Not Hispanic/Latino patients versus Hispanic/Latino patients from HR: 1.20 (0.96–1.51) in 2007–2009 to HR: 1.30 (1.06–1.60) in 2022–2024.

Conclusion

Despite increasing use of epilepsy surgery in pediatric patients with drug-resistant epilepsy between 2004 and 2024, disparities by type of insurance, race, and ethnicity are widening.

目的描述2004年至2024年间耐药癫痫患儿癫痫手术应用差异的演变。方法采用儿童健康信息系统数据库进行回顾性描述性研究。结果为癫痫手术的使用和首次诊断为耐药癫痫到癫痫手术的时间，主要预测因素为保险类型、种族和民族。结果我们研究了50,953例耐药癫痫患者（中位年龄（p25-p75）： 8.0（3.5-13.4）岁，男性占54%），其中7220例（14.2%）患者至少接受过一次癫痫手术。每百人年癫痫手术数从2004-2006年的4.0例增加到2022-2024年的15.8例。多变量分析显示，私企与公保患者接受癫痫手术的比值比（OR）由2004-2006年的OR: 1.50（1.25-1.80）上升至2022-2024年的OR: 1.75 (1.50 - 2.04)；白人患者与黑人患者的OR从2004-2006年的1.35（1.03-1.76）增加到2022-2024年的2.39 (1.86-3.08)；非西班牙裔/拉丁裔患者与西班牙裔/拉丁裔患者的OR值从2007-2009年（“非西班牙裔/拉丁裔”类别的第一年）的1.08（0.85-1.38）增加到2022-2024年的1.23（1.01-1.51）。多变量Cox回归分析显示，私保与公保患者接受癫痫手术的风险比（HR）由2004-2006年的1.55（1.32-1.82）上升至2022-2024年的1.92 (1.65-2.24)；白人患者相对于黑人患者的风险比从2004-2006年的1.46（1.14-1.86）增加到2022-2024年的2.67 (2.05-3.48)；非西班牙裔/拉丁裔患者相对于西班牙裔/拉丁裔患者的HR从2007-2009年的1.20（0.96-1.51）增加到2022-2024年的1.30（1.06-1.60）。结论：尽管2004年至2024年间，儿童耐药癫痫患者癫痫手术的使用有所增加，但不同保险类型、种族和民族的差异正在扩大。

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引用次数: 0

Corrigendum to “Optimal cutoff score for diagnosing generalized anxiety disorder with the Generalized Anxiety Disorder 7-item scale in people living with epilepsy: A systematic review with diagnostic test accuracy meta-analysis” [Seizure: European Journal of Epilepsy 134 (2026) 229237] “癫痫患者用广泛性焦虑障碍7项量表诊断广泛性焦虑障碍的最佳临界值：诊断测试准确性荟萃分析的系统评价”的更正[癫痫：欧洲癫痫杂志134 (2026)229237]

IF 2.8 3区医学 Q2 CLINICAL NEUROLOGY

Seizure-European Journal of Epilepsy

Pub Date : 2026-03-01 Epub Date: 2026-02-04 DOI: 10.1016/j.seizure.2026.01.007

Minjung Kim , Rock Bum Kim , Tae-Won Yang , Young-Soo Kim , Do-Hyung Kim , Oh-Young Kwon

引用次数: 0