Pub Date : 2023-09-01DOI: 10.12680/balneo.2023.591
Constantin Munteanu, Mihail Hoteteu, Diana Munteanu, Gelu Onose
Primary fibroblast cultures obtained from Wistar rats were investigated with a focus on two vital physiological mechanisms: inflammatory processes and oxidative stress balance. These are believed to be affected by mud and sulfurous natural mineral waters, forming the fundamental biological basis for understanding the therapeutic effects of these substances. Existing scientific research highlights that various cell types, including fibroblasts, are recruited during inflammation. These cells respond to a wide array of intercellular and microenvironmental signals, leading to a regulated production of both pro- and anti-inflammatory mediators. Examples include cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6, as well as chemokines and enzymes like cyclooxygenase (COX)-2. Together, these play vital roles in modulating the inflammatory response.
{"title":"The effects of Mineral Waters from Slănic Moldova's Spring 1 and Spring 1 bis on Fibroblast activity: An In Vitro Study","authors":"Constantin Munteanu, Mihail Hoteteu, Diana Munteanu, Gelu Onose","doi":"10.12680/balneo.2023.591","DOIUrl":"https://doi.org/10.12680/balneo.2023.591","url":null,"abstract":"Primary fibroblast cultures obtained from Wistar rats were investigated with a focus on two vital physiological mechanisms: inflammatory processes and oxidative stress balance. These are believed to be affected by mud and sulfurous natural mineral waters, forming the fundamental biological basis for understanding the therapeutic effects of these substances. Existing scientific research highlights that various cell types, including fibroblasts, are recruited during inflammation. These cells respond to a wide array of intercellular and microenvironmental signals, leading to a regulated production of both pro- and anti-inflammatory mediators. Examples include cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6, as well as chemokines and enzymes like cyclooxygenase (COX)-2. Together, these play vital roles in modulating the inflammatory response.","PeriodicalId":496282,"journal":{"name":"Balneo and PRM Research Journal","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135588861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.12680/balneo.2023.573
Himena Adela Zippenfening, Marius Lupsa Matichescu, Maria Raluca Raduca, Elena Amaricai
In the case of Parkinson disease, the postural abnormalities accentuate as the disease advances. The loss of the gravity center is determined by the deviations from the normal posture like the changing of the head position, the anterior bending of the trunk and semi flexions of the superior and inferior members. The aim of this study is to identify the modifications of the posture and of the alignment of the body in the case of the Parkinson disease patients, following the physical exercise program. Within the study, forty patients with Parkinson disease were analyzed using Softului GaitON Posture Analysis. Following the postural analyses, the patients were integrated into a physical exercise program, for six months. The results of the study indicate significant positive changes concerning the realignment of the head posture, p=0.02, of the shoulders p=0.02, anterior superior iliac crest. Through the postural analyses system, we monitored the evolution and the efficacy of the rehabili-tation program, in its dynamic. The GaitON Posture Analysis system proved to be a good indicator for the evaluation and the monitoring of the patients with Parkinson disease. The physical exercise pro-gram, which was recommended to the patients, demonstrated to be effective and an im-portant tool for the improvement of the posture..
{"title":"Postural Analysis in Patients with Parkinson's Disease and the Importance of Physical Exercise for Postural Correction","authors":"Himena Adela Zippenfening, Marius Lupsa Matichescu, Maria Raluca Raduca, Elena Amaricai","doi":"10.12680/balneo.2023.573","DOIUrl":"https://doi.org/10.12680/balneo.2023.573","url":null,"abstract":"In the case of Parkinson disease, the postural abnormalities accentuate as the disease advances. The loss of the gravity center is determined by the deviations from the normal posture like the changing of the head position, the anterior bending of the trunk and semi flexions of the superior and inferior members. The aim of this study is to identify the modifications of the posture and of the alignment of the body in the case of the Parkinson disease patients, following the physical exercise program. Within the study, forty patients with Parkinson disease were analyzed using Softului GaitON Posture Analysis. Following the postural analyses, the patients were integrated into a physical exercise program, for six months. The results of the study indicate significant positive changes concerning the realignment of the head posture, p=0.02, of the shoulders p=0.02, anterior superior iliac crest. Through the postural analyses system, we monitored the evolution and the efficacy of the rehabili-tation program, in its dynamic. The GaitON Posture Analysis system proved to be a good indicator for the evaluation and the monitoring of the patients with Parkinson disease. The physical exercise pro-gram, which was recommended to the patients, demonstrated to be effective and an im-portant tool for the improvement of the posture..","PeriodicalId":496282,"journal":{"name":"Balneo and PRM Research Journal","volume":"78 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135348801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.12680/balneo.2023.580
Carmen Oprea, Elena Valentina Ionescu, Raluca Matei, Costin Octavian Sorici, Claudia Salceanu, Victor Jeflea, Loredana Pazara, Adelina Elena Ungureanu, Lucian Petcu, Elena-Roxana Tucmeanu, Mădălina Gabriela Iliescu
The scope of the present study was to evaluate the results obtained from implementing the integrated programme of sustainable entrepreneurship specific to balneal tourism in the preand post-pandemic period at the Balneal and Rehabilitation Sanatorium of Techirghiol (SBRT), with the identification of current trends and preferences of the population regarding healthcare services in the Techirghiol area. Methods: The retrospective longitudinal study, conducted from 2018 to 2022, used data gathered in SBRT services on a number of patients grouped by condition, the quality of therapeutic water accessed by patients and of waste water discharged into the lake, books and documents specific to the proposed topic. Results: Starting with the pandemic year 2020, patients are also referred to SBRT for treatment of post covid after-effects (restrictive/obstructive respiratory diseases). Water waste discharged into Lake Techirghiol in 2020 exceeds the legal limits for the arithmetic mean values of nitrogen ammonia, returning to normal in 2021 (2.88 mg/l), reaching 0.24mg/l in 2022. Considering the 2020 pandemic year as the reference year, the number of tourists in 2020 decreased by 58% compared to 2018 and by 37% compared to 2019, with an increase of 42% and 43% in 2021 and 2022 respectively. Conclusions: The number of patients accessing natural factor therapies in the time period analysed has seen a steady postpandemic increase. The sustainable development of spa tourism in the Techirghiol area requires an integrative approach that ensures environmental protection.
{"title":"Sustainability of balneal tourism in pre- and post-pandemic period","authors":"Carmen Oprea, Elena Valentina Ionescu, Raluca Matei, Costin Octavian Sorici, Claudia Salceanu, Victor Jeflea, Loredana Pazara, Adelina Elena Ungureanu, Lucian Petcu, Elena-Roxana Tucmeanu, Mădălina Gabriela Iliescu","doi":"10.12680/balneo.2023.580","DOIUrl":"https://doi.org/10.12680/balneo.2023.580","url":null,"abstract":"The scope of the present study was to evaluate the results obtained from implementing the integrated programme of sustainable entrepreneurship specific to balneal tourism in the preand post-pandemic period at the Balneal and Rehabilitation Sanatorium of Techirghiol (SBRT), with the identification of current trends and preferences of the population regarding healthcare services in the Techirghiol area. Methods: The retrospective longitudinal study, conducted from 2018 to 2022, used data gathered in SBRT services on a number of patients grouped by condition, the quality of therapeutic water accessed by patients and of waste water discharged into the lake, books and documents specific to the proposed topic. Results: Starting with the pandemic year 2020, patients are also referred to SBRT for treatment of post covid after-effects (restrictive/obstructive respiratory diseases). Water waste discharged into Lake Techirghiol in 2020 exceeds the legal limits for the arithmetic mean values of nitrogen ammonia, returning to normal in 2021 (2.88 mg/l), reaching 0.24mg/l in 2022. Considering the 2020 pandemic year as the reference year, the number of tourists in 2020 decreased by 58% compared to 2018 and by 37% compared to 2019, with an increase of 42% and 43% in 2021 and 2022 respectively. Conclusions: The number of patients accessing natural factor therapies in the time period analysed has seen a steady postpandemic increase. The sustainable development of spa tourism in the Techirghiol area requires an integrative approach that ensures environmental protection.","PeriodicalId":496282,"journal":{"name":"Balneo and PRM Research Journal","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134993664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.12680/balneo.2023.594
Andreea-Ancuta Talinga, Alexandra Laura Mederle, Ada-Maria Codreanu, Roxana Ramona Onofrei, Claudia Borza
The main aim of this study was to identify the changes in nerve conduction parameters in cases of lumbar radiculopathy due to lumbar spondylosis and intervertebral disc pathology with no clinical neurologic deficit and to identify the potential of nerve conduction studies in the early diagnosis of these cases. Eleven patients aged between 41 and 78 years (mean age 58 ± 13.1 years; 4 males, 36.36%) met the inclusion criteria and agreed to participate in this study. Nerve conduction studies were performed with Neuro‐MEP‐Micro (Figure 1), a digital system designed to record electrical activity of muscles and nerves at 1 or 2‐channel stimulation, and to measure and analyze their parameters. Conduction velocity was reduced in 29.41% of the examined tibial nerves, and in none of the examined peroneal nerves. The registered amplitudes, for none of the tibial or peroneal nerve, have not been lower than the reference values. Patients with reduced tibial conduction velocity had a Grade 2 nerve root involvement on MRI. Nerve conduction studies should be used to complete the physical and imagistic assessment of patients with lumbar radiculopathy, to detect functional abnormalities not only structural ones provided by the MRI.
{"title":"Nerve conduction assessments in patients with lumbar radiculopathy – an observational study","authors":"Andreea-Ancuta Talinga, Alexandra Laura Mederle, Ada-Maria Codreanu, Roxana Ramona Onofrei, Claudia Borza","doi":"10.12680/balneo.2023.594","DOIUrl":"https://doi.org/10.12680/balneo.2023.594","url":null,"abstract":"The main aim of this study was to identify the changes in nerve conduction parameters in cases of lumbar radiculopathy due to lumbar spondylosis and intervertebral disc pathology with no clinical neurologic deficit and to identify the potential of nerve conduction studies in the early diagnosis of these cases. Eleven patients aged between 41 and 78 years (mean age 58 ± 13.1 years; 4 males, 36.36%) met the inclusion criteria and agreed to participate in this study. Nerve conduction studies were performed with Neuro‐MEP‐Micro (Figure 1), a digital system designed to record electrical activity of muscles and nerves at 1 or 2‐channel stimulation, and to measure and analyze their parameters. Conduction velocity was reduced in 29.41% of the examined tibial nerves, and in none of the examined peroneal nerves. The registered amplitudes, for none of the tibial or peroneal nerve, have not been lower than the reference values. Patients with reduced tibial conduction velocity had a Grade 2 nerve root involvement on MRI. Nerve conduction studies should be used to complete the physical and imagistic assessment of patients with lumbar radiculopathy, to detect functional abnormalities not only structural ones provided by the MRI.","PeriodicalId":496282,"journal":{"name":"Balneo and PRM Research Journal","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135588858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Juvenile idiopathic arthritis (JIA) is the most common type of arthritis in children and teens. The inflammation of various joints causes pain. Early diagnosis and management of the patients, which include medication and rehabilitation therapies, can reduce the onset of complications. Despite the progress in managing this disease, there are cases which present severe complications. Material and Methods: A 13-year-old girl, diagnosed with JIA in a paediatric service in 2019, who is under treatment with Sulfasalzine since diagnosis, presented in the Paediatric Rehabilitation Centre of Băile 1 Mai with inflammatory pain in both knees, gait impairment with need of wheelchair, limited function in hands, elbows, shoulders, knees and hips which worsened in 2022, due to low compliance to the treatment and no check-up with a paediatric rheumatologist. She had 8 admissions in the Paediatric Rehabilitation Centre between October 2022 and July 2023. The examination reveals that there is a severe limitation of mobility in both hips and knees, the hands’ small joints, elbows and shoulders. Laboratory tests were conducted showing no inflammatory markers. The radiographic finds sustained the changes encountered at the clinical examination. During her admissions in the Paediatric Rehabilitation Centre, she underwent a complex rehabilitation program which consisted of kinetotherapy, hydrokinetotherapy, massage, occupational therapy and physical agents. The program was designed according to the needs and the disease activity. Pharmacological means were used for the management of pain. The results were limited and the ability of standing up and walking were not recovered. Conclusion: In conclusion, JIA is a complex disease, which needs an early diagnosis and an early management program, which comprises of pharmacological treatment, rehabilitation program. Teamwork is necessary for managing JIA cases. The lack of compliance, and inadequate medication can lead to disabling complications.
{"title":"Rehabilitation in Juvenile Idiopathic Arthritis with Hip Ankylosis","authors":"Bianca-Maria Pop, Gabriela Dogaru, Felicia Andronie-Cioară","doi":"10.12680/balneo.2023.584","DOIUrl":"https://doi.org/10.12680/balneo.2023.584","url":null,"abstract":"Introduction: Juvenile idiopathic arthritis (JIA) is the most common type of arthritis in children and teens. The inflammation of various joints causes pain. Early diagnosis and management of the patients, which include medication and rehabilitation therapies, can reduce the onset of complications. Despite the progress in managing this disease, there are cases which present severe complications. Material and Methods: A 13-year-old girl, diagnosed with JIA in a paediatric service in 2019, who is under treatment with Sulfasalzine since diagnosis, presented in the Paediatric Rehabilitation Centre of Băile 1 Mai with inflammatory pain in both knees, gait impairment with need of wheelchair, limited function in hands, elbows, shoulders, knees and hips which worsened in 2022, due to low compliance to the treatment and no check-up with a paediatric rheumatologist. She had 8 admissions in the Paediatric Rehabilitation Centre between October 2022 and July 2023. The examination reveals that there is a severe limitation of mobility in both hips and knees, the hands’ small joints, elbows and shoulders. Laboratory tests were conducted showing no inflammatory markers. The radiographic finds sustained the changes encountered at the clinical examination. During her admissions in the Paediatric Rehabilitation Centre, she underwent a complex rehabilitation program which consisted of kinetotherapy, hydrokinetotherapy, massage, occupational therapy and physical agents. The program was designed according to the needs and the disease activity. Pharmacological means were used for the management of pain. The results were limited and the ability of standing up and walking were not recovered. Conclusion: In conclusion, JIA is a complex disease, which needs an early diagnosis and an early management program, which comprises of pharmacological treatment, rehabilitation program. Teamwork is necessary for managing JIA cases. The lack of compliance, and inadequate medication can lead to disabling complications.","PeriodicalId":496282,"journal":{"name":"Balneo and PRM Research Journal","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135588869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.12680/balneo.2023.575
Daniel-Andrei Iordan, Ilie Onu, Daniela-Viorelia Matei, Dragos-Petrica Sardaru, Cătălina Luca, Alashqar Sohaib, Claudiu Mereuță, Andreea Maria Adam, Dana Marin, Mariana Cordun, Carmina Mușat
Background: Knee Osteoarthritis (KOA) is a frequent type of degenerative joint disease, which results in a gradual loss of function, discomfort, and stiffness. KOA can be effectively treated with oral drugs such as corticosteroids and nonsteroidal anti-inflammatory drugs (NSAIDs). NSAIDs may raise the dangers of renal, gastrointestinal, and other systemic toxicities. Compared with oral NSAIDs, topical gels are an alternative therapeutic option with fewer side effects, with less therapeutic efficacy. Studies on ultrasound (US) as a therapeutic method go back a long time in KOA. US not only relieves symptoms but may also provide potential cartilage repair effects, and regulates inflammatory responses. Widely used as a physical enhancer of drug absorption is ultrasonic phonophoresis. By making the skin more permeable to topical pharmaceuticals, it improves the absorption of drugs used topically. (2) Material and method: A monocentric study was conducted in the Center of Physical Therapy and Rehabilitation - "Dunărea de Jos" University of Galați on 20 patients, diagnosed with bilateral and unilateral moderate KOA. The experimental group (EG) included 10 patients who received 10 sessions of PT (Physical Therapy), transcutaneous electrical nerve stimulation (TENS), and Ultrasound (US) phonophoresis therapy with hydrocortisone 10mg/g. The control group (CG) included 10 patients who received 10 sessions of TENS and US with neutral gel. (3) Results: All patients were clinically assessed with The "timed up and go test" (TUG), pain scale (VAS), and WOMAC. The t-test was used to calculate the statistical differences between the means of the EG and CG. (4) Conclusion: Hydrocortisone therapy combined with PT had a beneficial effect on pain and functional mobility in patients with KOA form EG. Furthermore, significantly greater improvement was observed among the intervention group with hydrocortisone.
{"title":"Effect of hydrocortisone ultrasonic phonophoresis in the treatment of knee osteoarthritis","authors":"Daniel-Andrei Iordan, Ilie Onu, Daniela-Viorelia Matei, Dragos-Petrica Sardaru, Cătălina Luca, Alashqar Sohaib, Claudiu Mereuță, Andreea Maria Adam, Dana Marin, Mariana Cordun, Carmina Mușat","doi":"10.12680/balneo.2023.575","DOIUrl":"https://doi.org/10.12680/balneo.2023.575","url":null,"abstract":"Background: Knee Osteoarthritis (KOA) is a frequent type of degenerative joint disease, which results in a gradual loss of function, discomfort, and stiffness. KOA can be effectively treated with oral drugs such as corticosteroids and nonsteroidal anti-inflammatory drugs (NSAIDs). NSAIDs may raise the dangers of renal, gastrointestinal, and other systemic toxicities. Compared with oral NSAIDs, topical gels are an alternative therapeutic option with fewer side effects, with less therapeutic efficacy. Studies on ultrasound (US) as a therapeutic method go back a long time in KOA. US not only relieves symptoms but may also provide potential cartilage repair effects, and regulates inflammatory responses. Widely used as a physical enhancer of drug absorption is ultrasonic phonophoresis. By making the skin more permeable to topical pharmaceuticals, it improves the absorption of drugs used topically. (2) Material and method: A monocentric study was conducted in the Center of Physical Therapy and Rehabilitation - \"Dunărea de Jos\" University of Galați on 20 patients, diagnosed with bilateral and unilateral moderate KOA. The experimental group (EG) included 10 patients who received 10 sessions of PT (Physical Therapy), transcutaneous electrical nerve stimulation (TENS), and Ultrasound (US) phonophoresis therapy with hydrocortisone 10mg/g. The control group (CG) included 10 patients who received 10 sessions of TENS and US with neutral gel. (3) Results: All patients were clinically assessed with The \"timed up and go test\" (TUG), pain scale (VAS), and WOMAC. The t-test was used to calculate the statistical differences between the means of the EG and CG. (4) Conclusion: Hydrocortisone therapy combined with PT had a beneficial effect on pain and functional mobility in patients with KOA form EG. Furthermore, significantly greater improvement was observed among the intervention group with hydrocortisone.","PeriodicalId":496282,"journal":{"name":"Balneo and PRM Research Journal","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135348979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.12680/balneo.2023.582
Alina Mihaela Neacsu, Corina Sporea, Nicoleta Anton, Lucian Lapusneanu, Maria Cristina Andrei, Mihaela Cosman, Dumitru Ferechide
Abstract: In the last decade, it was concluded that glaucomatous optic neuropathy is part of the neurodegenerative diseases in which destructive neuronal lesions are located not only in the structure of the retina, but they are also present at the level of the central visual and nervous pathways. The purpose of this study was to evaluate the degree of involvement of the auditory system in patients with Primitive Open Angle Glaucoma (POAG), the structural changes in the optic nerve, and to establish correlation between the hearing loss and structural changes in the optic nerve. Material and methods: It is a prospective, cross-sectional study on 32 eyes of 16 subjects with POAG in a study group and 24 eyes of 12 healthy subjects in control group, with a mean age of 62 years in both groups. Both groups underwent ophthalmological, audiological and brain magnetic resonance imaging (MRI) evaluation. Results: In the Study group patients, compared to the Control group, the average levels of the left Pure-tone audiometry (PTA), the cup/disc (C/D) area in both eyes, and the C/D ratio in both eyes are increased. Conclusions: Patients with POAG show changes in audiometry test in correlation with ophthalmological parameters demonstrating that the auditory system can be affected in glaucoma.
{"title":"The impact of glaucomatous disease on lifestyle and healthy aging. Association between structural visual and auditory functional changes in glaucoma","authors":"Alina Mihaela Neacsu, Corina Sporea, Nicoleta Anton, Lucian Lapusneanu, Maria Cristina Andrei, Mihaela Cosman, Dumitru Ferechide","doi":"10.12680/balneo.2023.582","DOIUrl":"https://doi.org/10.12680/balneo.2023.582","url":null,"abstract":"Abstract: In the last decade, it was concluded that glaucomatous optic neuropathy is part of the neurodegenerative diseases in which destructive neuronal lesions are located not only in the structure of the retina, but they are also present at the level of the central visual and nervous pathways. The purpose of this study was to evaluate the degree of involvement of the auditory system in patients with Primitive Open Angle Glaucoma (POAG), the structural changes in the optic nerve, and to establish correlation between the hearing loss and structural changes in the optic nerve. Material and methods: It is a prospective, cross-sectional study on 32 eyes of 16 subjects with POAG in a study group and 24 eyes of 12 healthy subjects in control group, with a mean age of 62 years in both groups. Both groups underwent ophthalmological, audiological and brain magnetic resonance imaging (MRI) evaluation. Results: In the Study group patients, compared to the Control group, the average levels of the left Pure-tone audiometry (PTA), the cup/disc (C/D) area in both eyes, and the C/D ratio in both eyes are increased. Conclusions: Patients with POAG show changes in audiometry test in correlation with ophthalmological parameters demonstrating that the auditory system can be affected in glaucoma.","PeriodicalId":496282,"journal":{"name":"Balneo and PRM Research Journal","volume":"146 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134993662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.12680/balneo.s2023.568
Florina Frîngu, Raluca Tomoaia, Bogdan Caloian, Dumitru Zdrenghea, Diana Irimie, Horatiu Comsa, Gelu Simu, Alexandra Dădrlat-Pop, Dana Pop, Gabriel Guşetu
Background: Atrial fibrillation (AF) is increasingly prevalent among the general population as well as in those exhibiting heart failure (HF), and the symptomatology progressively worsens when both conditions are met. The aim of this study was to analyse the role of inflammation and fibrosis biomarkers in patients with AF and HF. Methods: 108 subjects with heart failure were enrolled in the study. All patients were evaluated clinically, biologically and echocardiographically. Plasma values of NTproBNP, Gal-3 and sST2 were determined. Results: Out of all patients, 64.8% experienced at least one AF event. There were no differences in the mean left ventricular ejection fraction between the groups, which was 39.4 ± 11.2%. In terms of left atrium dimensions, the values in the AF group were significantly higher ( 51.19 ± 7.3 vs. 44.68 ± 7.16 mm, p<0.001). AF history was associated with a trend of decreased eGFR - 59,22±24,1 ml/min/1.73m3 vs 75,95±29,1 ml/min/1.73m3(p=0.006). There was no statistically significant difference in the level of HF biomarkers (sST2, Galectin-3 and NT-pro BNP) between individuals with or without AF. Conclusion: Patients with HF are at greater risk to develop AF. HF biomarkers (sST2, Galectin-3 and NT-pro BNP) are not influenced by the presence of AF.
背景:心房颤动(AF)在普通人群和心力衰竭(HF)患者中越来越普遍，当这两种情况同时出现时，其症状会逐渐恶化。本研究的目的是分析炎症和纤维化生物标志物在房颤和心衰患者中的作用。方法:108例心力衰竭患者入组研究。所有患者均接受临床、生物学和超声心动图检查。测定血浆中NTproBNP、Gal-3和sST2的值。结果:在所有患者中，64.8%至少经历过一次房颤事件。两组左室射血分数平均值(39.4±11.2%)无显著差异。在左心房尺寸方面，AF组的数值明显高于对照组(51.19±7.3 mm vs. 44.68±7.16 mm, p<0.001)。AF病史与eGFR下降趋势相关，分别为59.22±24.1 ml/min/1.73m3 vs 75.95±29.1 ml/min/1.73m3(p=0.006)。心衰生物标志物(sST2、半乳糖凝集素-3和NT-pro BNP)在房颤患者和非房颤患者之间的水平差异无统计学意义。结论:心衰患者发生房颤的风险更高，心衰生物标志物(sST2、半乳糖凝集素-3和NT-pro BNP)不受房颤存在的影响。
{"title":"Inflammation and fibrosis in patients with atrial fibrillation and heart failure: is there a need for rehabilitation?","authors":"Florina Frîngu, Raluca Tomoaia, Bogdan Caloian, Dumitru Zdrenghea, Diana Irimie, Horatiu Comsa, Gelu Simu, Alexandra Dădrlat-Pop, Dana Pop, Gabriel Guşetu","doi":"10.12680/balneo.s2023.568","DOIUrl":"https://doi.org/10.12680/balneo.s2023.568","url":null,"abstract":"Background: Atrial fibrillation (AF) is increasingly prevalent among the general population as well as in those exhibiting heart failure (HF), and the symptomatology progressively worsens when both conditions are met. The aim of this study was to analyse the role of inflammation and fibrosis biomarkers in patients with AF and HF. Methods: 108 subjects with heart failure were enrolled in the study. All patients were evaluated clinically, biologically and echocardiographically. Plasma values of NTproBNP, Gal-3 and sST2 were determined. Results: Out of all patients, 64.8% experienced at least one AF event. There were no differences in the mean left ventricular ejection fraction between the groups, which was 39.4 ± 11.2%. In terms of left atrium dimensions, the values in the AF group were significantly higher ( 51.19 ± 7.3 vs. 44.68 ± 7.16 mm, p<0.001). AF history was associated with a trend of decreased eGFR - 59,22±24,1 ml/min/1.73m3 vs 75,95±29,1 ml/min/1.73m3(p=0.006). There was no statistically significant difference in the level of HF biomarkers (sST2, Galectin-3 and NT-pro BNP) between individuals with or without AF. Conclusion: Patients with HF are at greater risk to develop AF. HF biomarkers (sST2, Galectin-3 and NT-pro BNP) are not influenced by the presence of AF.","PeriodicalId":496282,"journal":{"name":"Balneo and PRM Research Journal","volume":"78 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135348100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Postraumatic rehabilitation represent a dynamic field, with specific protocols and technics. Our prospective study targets the tibial pilon fractures admitted in our clinic, to which a new treatment protocol was applied, consisting of two surgical steps, assesing in the end the results achieved at the discharge of the patient and later follow up. The study group consist of 196 patients (198 fractures), in the period 2019-2022. The average evaluation time was of 16 months. The most frequently applied osteosynthesis principle was staged osteosynthesis which consisted of first stage fibula plate osteosynthesis and external fixator tibia pilon, followed by minimally invasive or limited approach locked plate tibia pilon fixation. (64.14%) Olerud and Molander clinical score at more than one year after the last surgical intervention highlights good results: excellent results in the amount of 37% to 15% in the first lot, good results 52% to 29%, moderate success 7% to 39% and poor 4% to 17%. Two stage surgery protocol with external fixation in emergency and minimally invasive internal fixation with locked plate performed after the dissappearance of the local edema, as the second surgical step, allows anatomically correct articular reconstruction without skin complications, with decrease of arthitic late complications.
{"title":"Late functional and radiological outcomes in recovery of patients with staged osteosynthesis for the tibial pilon fractures","authors":"Bogdan Obada, Vlad-Alexandru Georgeanu, Ion-Andrei Popescu, Madalina-Gabriela Iliescu, Liliana-Elena Stanciu, Bogdan Marian Caraban Caraban","doi":"10.12680/balneo.2023.593","DOIUrl":"https://doi.org/10.12680/balneo.2023.593","url":null,"abstract":"Postraumatic rehabilitation represent a dynamic field, with specific protocols and technics. Our prospective study targets the tibial pilon fractures admitted in our clinic, to which a new treatment protocol was applied, consisting of two surgical steps, assesing in the end the results achieved at the discharge of the patient and later follow up. The study group consist of 196 patients (198 fractures), in the period 2019-2022. The average evaluation time was of 16 months. The most frequently applied osteosynthesis principle was staged osteosynthesis which consisted of first stage fibula plate osteosynthesis and external fixator tibia pilon, followed by minimally invasive or limited approach locked plate tibia pilon fixation. (64.14%) Olerud and Molander clinical score at more than one year after the last surgical intervention highlights good results: excellent results in the amount of 37% to 15% in the first lot, good results 52% to 29%, moderate success 7% to 39% and poor 4% to 17%. Two stage surgery protocol with external fixation in emergency and minimally invasive internal fixation with locked plate performed after the dissappearance of the local edema, as the second surgical step, allows anatomically correct articular reconstruction without skin complications, with decrease of arthitic late complications.","PeriodicalId":496282,"journal":{"name":"Balneo and PRM Research Journal","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135588857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.12680/balneo.2023.567
Monica Musunoiu Novetschi, Elena Mereuta, Tarek Nazer, Daniel Ganea, Claudiu Mereuta
A mathematical model is presented to determine the spatial displacement of an endeffector attached to the human upper limb kinematic chain. The proposed method in-volves the successive application of the homogenous rotation matrices associated with each element movement to determine the general transfer matrix or the so-called homoge-neous transformations matrix. This method is proven to be an error free method for esti-mating the position and orientation of an end-effector attached to a kinematic chain. The methodology presented in this paper combines a well know mathematical technique used in engineering (in the development of space robots) and the anatomical features of the human upper limb to estimate not only the end-effector 3D position but also the limb pos-es during a particular displacement.
{"title":"Human upper limb positional analysis using homogenous transformation matrix","authors":"Monica Musunoiu Novetschi, Elena Mereuta, Tarek Nazer, Daniel Ganea, Claudiu Mereuta","doi":"10.12680/balneo.2023.567","DOIUrl":"https://doi.org/10.12680/balneo.2023.567","url":null,"abstract":"A mathematical model is presented to determine the spatial displacement of an endeffector attached to the human upper limb kinematic chain. The proposed method in-volves the successive application of the homogenous rotation matrices associated with each element movement to determine the general transfer matrix or the so-called homoge-neous transformations matrix. This method is proven to be an error free method for esti-mating the position and orientation of an end-effector attached to a kinematic chain. The methodology presented in this paper combines a well know mathematical technique used in engineering (in the development of space robots) and the anatomical features of the human upper limb to estimate not only the end-effector 3D position but also the limb pos-es during a particular displacement.","PeriodicalId":496282,"journal":{"name":"Balneo and PRM Research Journal","volume":"311 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135349561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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