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Pediatric Discovery: Opportunities and challenges in pediatric medicine 儿科发现:儿科医学的机遇与挑战
Pub Date : 2023-05-30 DOI: 10.1002/pdi3.4
Qiu Li, Yaolong Chen, Tong‐Chuan He
We are excited about launching the new open access journal, Pediatric Discovery, which aims to promote and advance the health and well-being of infants, children, and adolescents by disseminating cutting-edge discoveries and knowledge about all aspects of pediatric medicine. This new journal will serve as an essential platform for illuminating basic, translational, and clinical discoveries that impact pediatric health and development. Pediatrics, a clinical medicine specialty, focuses on the medical care and health management of infants, children, and adolescents from birth up to the age of 18.1 However, the American Academy of Pediatrics recommended people seek pediatric care through the age of 21 in the 1960s and eliminated the upper age limit for pediatric care in 2017,2 based on the rationale that the transition to adult care should be specific to patient needs, not an arbitrary number. The term pediatrics was first introduced in English in 1859 by a German physician, Dr. Abraham Jacobi (1830–1919), who became the first dedicated pediatrician in the world and is known as the father of American pediatrics. Nonetheless, child-specific medical problems, such as childhood epilepsy, rashes, premature births, and meningitis, were described in the Hippocratic Corpus in the fifth century B.C., as well as by Greek philosophers and physicians Celsus, Soranus of Ephesus, Aretaeus, Galen, and Oribasius from the first to fourth centuries A.D.3 Some of the early publications specifically focusing on children's medical concerns appeared between the 1790s and the 1920s. Pediatrics has now emerged as a major branch of medical science and encompasses a broad spectrum of physical, mental, and social health care, ranging from preventive health care to the diagnosis and treatment of acute and chronic diseases. The field has been evolving at an unprecedented pace due to the advances in our understanding of human diseases at the genome, cell and organ levels. The overall goals of pediatric medicine are to reduce the rates of infant and child deaths, control the spread of infectious diseases, promote healthy lifestyles for a long disease-free life, and to help improve the lives of children and adolescents with chronic conditions. Pediatric practitioners are also involved in the prevention, early diagnosis, and management of developmental delays and disorders, behavioral problems, functional disabilities, social stresses, and mental disorders, including depression and anxiety disorders. Pediatrics is different from adult medicine in many ways because a child is different physiologically from an adult. As a result, congenital defects, genetic variance, and development-related disorders are of great concern to pediatricians. Children are not simply miniature adults. A child's immature and developing physiology must be taken into account when considering symptoms, prescribing medications, and diagnosing illnesses. In particular, pediatric physiology greatly impacts the
我们很高兴推出新的开放获取期刊《儿科发现》,它旨在通过传播儿科医学各方面的前沿发现和知识,促进和促进婴儿、儿童和青少年的健康和福祉。这本新杂志将作为一个重要的平台,阐明影响儿童健康和发展的基础、转化和临床发现。儿科是一门临床医学专业,专注于婴儿、儿童和青少年从出生到18.1岁的医疗保健和健康管理。然而,美国儿科学会(American Academy of Pediatrics)在20世纪60年代建议人们在21岁之前寻求儿科护理,并在2017年取消了儿科护理的年龄上限2,理由是向成人护理的过渡应该针对患者的需求,而不是一个任意的数字。1859年,德国医生亚伯拉罕·雅可比(Abraham Jacobi, 1830-1919)首次将儿科一词引入英语,他是世界上第一位专门从事儿科医生的医生,被称为“美国儿科之父”。然而,儿童特有的医学问题,如儿童癫痫、皮疹、早产和脑膜炎,在公元前5世纪的希波克拉底语料库中,以及公元1至4世纪的希腊哲学家和医生塞尔苏斯、以弗所的索拉努斯、阿雷泰乌斯、盖伦和奥里巴修斯都有描述一些专门关注儿童医疗问题的早期出版物出现在18世纪90年代到20世纪20年代之间。儿科学现在已经成为医学的一个主要分支,涵盖了广泛的身体、精神和社会卫生保健,从预防保健到急性和慢性疾病的诊断和治疗。由于我们在基因组、细胞和器官水平上对人类疾病的理解取得了进步,该领域正以前所未有的速度发展。儿科医学的总体目标是降低婴儿和儿童死亡率,控制传染病的传播,促进健康的生活方式,以实现无病的长期生活,并帮助改善患有慢性病的儿童和青少年的生活。儿科医生还参与发育迟缓和障碍、行为问题、功能障碍、社会压力和精神障碍(包括抑郁症和焦虑症)的预防、早期诊断和管理。儿科学在很多方面不同于成人医学,因为儿童在生理上不同于成人。因此,先天性缺陷、遗传变异和发育相关疾病是儿科医生非常关注的问题。儿童不仅仅是缩小版的成年人。在考虑症状、开药和诊断疾病时,必须考虑到儿童不成熟和发育中的生理机能。特别是,儿童生理对发育中的儿童药物的药代动力学特性(吸收、分布、代谢和消除)有很大影响。某些法律问题使儿科保健的提供进一步复杂化,因为儿童是未成年人,在大多数司法管辖区,他们不能自己做决定。因此,与监护、隐私、法律责任和知情同意有关的问题需要在每一个儿科手术中加以考虑,尽管最近的研究表明,儿童和青少年能够在12岁或13.4岁时做出自己的健康决定。在过去的几十年里,生物医学研究的进展大大改善了婴儿、儿童和青少年的生活和健康。事实上,Cheng等人通过对儿科专业人员的开放式调查,确定了过去40年来儿科研究取得的七大成就:通过挽救生命的免疫接种预防传染病,通过“重返睡眠”运动减少婴儿猝死,找到治疗急性淋巴细胞白血病的方法,通过表面活性剂治疗改善早产儿的呼吸功能,防止艾滋病毒母婴传播,延长患有镰状细胞性贫血和囊性纤维化的儿童的预期寿命,以及通过汽车座椅和安全带挽救生命。 5此外,该小组还预测了未来儿科医学的七项重大成就,其中包括更有效的儿科免疫接种,以预防新出现的和持续的疾病,有希望的免疫疗法治疗儿科癌症,新的基因组发现,以预测、预防和治疗儿科疾病,广泛的终身数据,以确定成人健康和疾病的胎儿和儿童起源,以便进行早期干预。5 .更好地了解社会环境对生物学和健康的影响,以改善个人和人口的健康;提高质量,以在全世界建立安全和有效的保健系统;执行和传播儿科研究,以在全球范围内减少贫穷虽然很难预测任何科学发现,因为这些发现通常是由意想不到的方向的开创性见解驱动的,但毫无疑问,我们正处于一个创新技术的非凡时代。我们相信,我们正处于令人兴奋的发现和倡议的边缘,以改善儿童和他们将成为的成年人的生活。事实上,生物医学科学的新知识正在不断扩大研究的视野。基因组学、蛋白质组学、转录组学、药物基因组学、表观遗传学、代谢组学、纳米系统和生物信息学等领域的创新技术和跨学科方法使我们能够比以往任何时候都更有效地克服许多科学挑战,从而更快地将观察结果从实验室转化为临床,反之亦然。因此,必须将基础、转化和临床儿科医学各方面的新发现和新进展迅速传播给参与儿科护理的专业人员。《儿科发现》将作为一个及时和有价值的平台,发布和宣传可能从根本上影响儿童和青少年健康的重要和最新的发现。在这个科学丰富的时代,大量信息和技术的可用性,我们的期刊定位于努力与儿科社区进行更有效的沟通和教育,了解医学上取得的重要科学里程碑的实际意义,特别是儿科医学。该杂志的最终目标是成为基础、转化和临床研究人员和专业人员的声音,以交流他们的创新观察,这可能导致未来的干预和预防儿科疾病。通过与John Wiley & Sons, Inc.的合作,我们将为《儿科发现》建立一个中央编辑部,接收来自世界各地的所有手稿,从而使提交和审查过程无缝化。无纸化审查过程将有助于减少周转时间,而不会损害审查过程的质量或公平性。我们将鼓励来自儿科医学各学科的儿科科学家和专业人员向《儿科发现》提交他们最好和/或最有前途的工作,以提高该杂志的地位。我们相信,随着儿科科学的发展,这些努力将为进步奠定基础,并将确保我们的期刊处于儿科研究的前沿。儿科发现的一个关键方面是它对循证的承诺,因为我们认识到这在改善患者预后和整体护理质量方面发挥的关键作用。该杂志将鼓励提交系统评论和临床实践指南,通过综合现有的最佳研究和专家共识,为循证实践提供坚实的基础。此外,儿科发现将努力为高质量指南的制定做出贡献,并在制定指南时促进严格方法的使用,确保儿科患者获得最高标准的护理。虽然由中国国家儿童健康与疾病临床研究中心和重庆医科大学儿童医院监管,但儿科发现服务于全球所有儿科学科的学术和专业社区。我们努力满足儿科社区的期望,并依靠他们的帮助和支持来克服挑战,最终将《儿科发现》建立为儿科医学领域的领先期刊。最后但并非最不重要的是,作为创始主编,我们很荣幸并感谢对我们的信任和代表儿科发现的机会。数据共享不适用于本文,因为在当前研究中没有生成或分析数据集。
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引用次数: 1
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Pediatric Discovery
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