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Review of Current Policy Strategies to Reduce US Cancer Drug Costs. 降低美国癌症药物成本的现行政策策略综述。
IF 45.3 Pub Date : 2020-02-01 Epub Date: 2019-12-05 DOI: 10.1200/JCO.19.01628
Angela K Green, Jennifer A Ohn, Peter B Bach
Recent breakthroughs in cancer drugs have led to practice-changing paradigms in cancer care and new treatment options, yet patients, insurers, and policymakers struggle with determining how to afford them. Although cancer is currently among the fastest growing therapeutic areas for drug sales and the primary focus for industry research and development, rising cancer drug costs are unsustainable for the US health care system. Furthermore, financial toxicity compromises access to recommended therapies, reduces quality of life, and potentially shortens survival among patients with cancer. Averaging 12% to 15% growth each year, US health care spending on cancer drugs is projected to grow to $100 billion by 2022. In 2017, the chimeric antigen receptor (CAR) T-cell therapies, tisagenlecleucel (Kymriah; Novartis, Basel, Switzerland), and axicabtagene ciloleucel (Yescarta; Kite Pharma, Santa Monica, CA) broke the price record with one-time price tags of $475,000 and $373,000, respectively, far exceeding the estimated $150,000 average cost of cancer care and treatment.
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引用次数: 13
Analytical mathematical feedback guidance scheme for low-thrust orbital plane change maneuvers 低推力轨道变平面机动的解析数学反馈制导方案
Pub Date : 2013-12-01 DOI: 10.1016/j.mcm.2013.06.014
I. Shafieenejad , A.B. Novinzade , R. Shisheie

This paper which is based on neighboring optimal control investigates the application of an analytical feedback guidance scheme for the problems of low-thrust orbital transfer. Neighboring optimal control is one of the methods that has been proposed for the closed-loop optimal guidance. This method focuses on expanding the cost function to second order and examining the robustness of the system by the feedback law gains. At first, the open-loop analytical guidance policy is considered as the optimal thrust steering program that will transfer the vehicle from the inclined low earth orbits to the high earth orbits. Secondly, proper feedback optimal guidance laws are analytically obtained to maintain the trajectories around their optimum with assessed disturbances. The proposed guidance scheme is distinguished for two desired performance indices as minimum-time and minimum-effort. Finally performance indices are compared and the best policy is obtained regarding the robustness of the two performance indices against disturbances.

本文以邻域最优控制为基础,研究了一种解析反馈制导方案在低推力轨道转移问题中的应用。邻域最优控制是目前提出的闭环最优制导方法之一。该方法侧重于将成本函数扩展到二阶,并通过反馈律增益来检验系统的鲁棒性。首先,将开环解析制导策略视为将飞行器从倾斜的低地球轨道转移到高地球轨道的最优推力转向方案。其次,分析得到适当的反馈最优制导律,使弹道在评估干扰的情况下保持在最优轨迹附近;所提出的导引方案以最小的时间和最小的努力这两个期望的性能指标来区分。最后对性能指标进行了比较,得到了两种性能指标对扰动鲁棒性的最佳策略。
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引用次数: 4
A multiresolution and smooth fictitious domain method for one-dimensional elliptical and Stefan problems 一维椭圆和Stefan问题的多分辨率光滑虚域方法
Pub Date : 2013-12-01 DOI: 10.1016/j.mcm.2013.06.013
Ping Yin , Jacques Liandrat , Wanqiang Shen , Zhe Chen

We present a wavelet based multiresolution method coupled with smooth fictitious domain and wavelet–vaguelette method to solve the one-dimensional elliptic problem equipped with Dirichlet boundary condition. Its advantages over the classical fictitious domain method are analyzed by interior error estimate and numerical examples. The efficiency of our method is pointed out by considering a Stefan problem with exact solution in one dimension.

提出了一种基于小波的多分辨方法,结合光滑虚域和小波-小模糊方法求解具有Dirichlet边界条件的一维椭圆问题。通过内部误差估计和数值算例分析了该方法相对于经典虚域方法的优越性。通过考虑一维精确解的Stefan问题,指出了该方法的有效性。
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引用次数: 1
WITHDRAWN: A study on the influences of R&D investment on IT for the machine and material industry and the electronics industry 撤回:机械材料工业和电子工业研发投入对IT的影响研究
Pub Date : 2013-12-01 DOI: 10.1016/j.mcm.2012.06.008
Seung-Ryung Oh, Kun Woo Kim

This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy.

应作者和/或编辑的要求,本文已被撤回。对于由此造成的任何不便,出版商深表歉意。完整的爱思唯尔文章撤回政策可在http://www.elsevier.com/locate/withdrawalpolicy找到。
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引用次数: 0
Valedictory Editorial 告别编辑
Pub Date : 2013-12-01 DOI: 10.1016/j.mcm.2013.09.001
Philip Broadbridge
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引用次数: 0
WITHDRAWN: A robust control strategy for a direct drive valve based on a voice coil motor 基于音圈电机的直接驱动阀的鲁棒控制策略
Pub Date : 2013-12-01 DOI: 10.1016/j.mcm.2011.10.032
Baifen Liu , Ying Gao

This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy.

应作者和/或编辑的要求,本文已被撤回。对于由此造成的任何不便,出版商深表歉意。完整的爱思唯尔文章撤回政策可在http://www.elsevier.com/locate/withdrawalpolicy找到。
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引用次数: 1
WITHDRAWN: Risk analysis and damage assessment of financial institutions in cyber attacks between nations 撤回:金融机构在国家间网络攻击中的风险分析和损害评估
Pub Date : 2013-12-01 DOI: 10.1016/j.mcm.2012.06.007
Won Hyung Park

This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy.

应作者和/或编辑的要求,本文已被撤回。对于由此造成的任何不便,出版商深表歉意。完整的爱思唯尔文章撤回政策可在http://www.elsevier.com/locate/withdrawalpolicy找到。
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引用次数: 2
A fuzzy logic based decision support system for evaluation of suppliers in supply chain management practices 供应链管理实践中基于模糊逻辑的供应商评价决策支持系统
Pub Date : 2013-12-01 DOI: 10.1016/j.mcm.2013.07.003
Darshan Kumar , Jagdev Singh , Om Pal Singh , Seema

Supply chain management is an increasingly important organizational concern, and proper evaluation of suppliers constitutes one essential element of supply chain success. Continuous evaluation of a particular supplier becomes more important considering the fact that in most industries the cost of raw materials and component parts constitutes the main cost of a product, such that in some cases it can account for up to 70%. However, there is little research that has helped the organizations in continuous evaluation of their suppliers. We propose a new model, based on fuzzy logic to handle the various attributes, associated with supplier evaluation problems. Four multi-input single output (MISO) mamdani fuzzy inference systems have been proposed for supplier evaluation. The proposed model has also been illustrated through a case study.

供应链管理是一个越来越重要的组织问题,对供应商的适当评估构成了供应链成功的一个基本要素。考虑到在大多数行业中原材料和零部件的成本构成了产品的主要成本,因此在某些情况下它可以占到70%,对特定供应商的持续评估变得更加重要。然而,很少有研究可以帮助组织对其供应商进行持续评估。本文提出了一种基于模糊逻辑的新模型来处理与供应商评价问题相关的各种属性。提出了四种多输入单输出(MISO) mamdani模糊推理系统用于供应商评价。本文还通过一个案例对所提出的模型进行了说明。
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引用次数: 0
Airline network design and adjustment in response to fluctuation in jet fuel prices 航空公司网络设计及调整以因应航油价格波动
Pub Date : 2013-12-01 DOI: 10.1016/j.mcm.2013.04.005
Chaug-Ing Hsu, Wei-Yin Eie

This study develops a series of models to determine aircraft types and flight frequencies on individual routes, and evaluate the reliability of proposed network planning during fluctuations in jet fuel prices. The reliability of individual routes is evaluated as to whether revenues from flights with initially proposed flight frequencies and aircraft types can accommodate variations in jet fuel expenditures. We define reliability as the probability that the proposed flight frequencies will operate in at least a break-even condition under future fuel price fluctuations. A case study is provided using an international airline in Taiwan to evaluate its network reliability in response to jet fuel price fluctuations in 2008. The results indicate that not only do routes with low load factors show low reliability, but long distance routes with high load factors also show low reliability during periods with high fuel prices. The results of the study provide effective ways to enhance commercial airline network designs in response to the uncertainty of jet fuel prices.

本研究开发了一系列模型,以确定飞机类型和个别航线的飞行频率,并评估在航空燃料价格波动期间提出的网络规划的可靠性。对个别航线的可靠性进行评估,看最初提议的航班频率和飞机类型的收入能否适应喷气燃料支出的变化。我们将可靠性定义为在未来燃料价格波动的情况下,所提议的航班频率至少在盈亏平衡的情况下运行的概率。本文以台湾一家国际航空公司为例,评估其网络可靠性以应对2008年航空燃料价格波动。结果表明,在高油价时期,不仅低客座率航线的可靠性较低,高客座率长途航线的可靠性也较低。研究结果为提高商业航线网络设计水平以应对航空燃油价格的不确定性提供了有效途径。
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引用次数: 9
Numerical solution of a nonlinear singular Volterra integral system by the Newton product integration method 用牛顿积积分法求解非线性奇异Volterra积分系统
Pub Date : 2013-12-01 DOI: 10.1016/j.mcm.2013.06.016
B. Babayar-Razlighi , B. Soltanalizadeh

In this paper, we consider a nonlinear system of Volterra integral equations, and apply Newton’s method to linearize it. We solve each step of Newton’s system by the product integration technique. Also, we provide the sufficient conditions for convergence of the numerical method. Finally, we give a test problem to illustrate the applicability and accuracy of the presented method.

本文考虑一类非线性Volterra积分方程组,并应用牛顿法对其进行线性化。我们用积积分法求解牛顿系统的每一步。并给出了数值方法收敛的充分条件。最后,给出了一个测试问题来说明该方法的适用性和准确性。
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引用次数: 12
期刊
Mathematical and Computer Modelling
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