Korean Journal of Pathology最新文献

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Papillary cystadenoma of the fallopian tube not associated with von hippel-lindau disease: a case report. 输卵管乳头状囊腺瘤与希佩尔-林道病无关:1例报告。

Korean Journal of Pathology

Pub Date : 2014-10-01 Epub Date: 2014-10-27 DOI: 10.4132/KoreanJPathol.2014.48.5.382

Jae Yeon Seok, Myunghee Kang, Jungsuk An, Hyunchul Kim, Kwang-Beom Lee, Hyun Yee Cho

Papillary cystadenoma (PC) is an epithelial tumor believed to be of mesonephric origin[1] that is found rarely in the female genital tract. Since the original report by Gersell and King in 1988[2], only 14 cases have been reported in the English literature[1,3-5]. All of the reported cases occurred in the mesosalpinx or the broad ligament. Most of the tumors (12 out of 14) were associated with von Hippel-Lindau disease (VHL), similar to epididymal tumors[6]. We report a case of PC within the wall of the fallopian tube (rather than in the mesosalpinx or the broad ligament) in a patient with no clinical history of VHL. A comprehensive review of the literature with regard to differential diagnosis and immunohistochemical profile is provided.

引用次数: 2

Pulmonary hodgkin lymphoma in a patient with Crohn's disease. 克罗恩病患者肺部霍奇金淋巴瘤。

Korean Journal of Pathology

Pub Date : 2014-10-01 Epub Date: 2014-10-27 DOI: 10.4132/KoreanJPathol.2014.48.5.387

Jae-Young Park, Juhie Lee

Classical Hodgkin lymphoma (HL) accounts for approximately 4.5% of all lymphomas in Korea. It is almost always a nodebased lymphoma, and a primary extranodal manifestation of this disease is unusual. Interestingly, patients with a history of inflammatory bowel disease (IBD) who are treated with immu nosuppressants have been noted to have an increased risk of lymphoma; most cases that have been identified in this setting in volve non-Hodgkin lymphoma (NHL). There have been few reported cases of primary intestinal HL in Crohn’s disease (CD) patients, 1 and the development of extraintestinal HL in patients with CD has been reported even less frequently. 2,3 Herein, we

引用次数: 1

Solid form of epithelioid hemangioma: a case report. 实型上皮样血管瘤1例。

Korean Journal of Pathology

Pub Date : 2014-10-01 Epub Date: 2014-10-27 DOI: 10.4132/KoreanJPathol.2014.48.5.394

Jin Roh, Min Jeong Song, Mi Woo Lee, Chan-Sik Park

Epithelioid hemangioma (EH) is an uncommon benign vascular tumor, of controversial etiology that usually presents as a slowly growing nodule on the face or digit of a middle-aged woman. 1 Most lesions have a nonspecific nodular appearance with frequent secondary changes such as excoriation and bleeding. Multiplicity is also a common finding. Histopathologically, EH is characterized by a mixture of vascular proliferation and marked mixed inflammatory cell infiltration, and was first de scribed by Wells and Whimster 2 as angiolymphoid hyperplasia with eosinophilia. The proliferation of vascular structures lined with prominent endothelial cells is a distinguishing feature of EH. The epithelioid endothelial cells that protrude into the vascular lumen create a characteristic “cobble-stone” or “tombstone” appearance. A chronic inflammatory cell infiltration in cluding lymphoplasma cells and eosinophils is a consistent find ing. EH has a diverse range of microscopic features, depending on the composition and distribution of the vascular and inflam matory cellular components. EH has been described in the literature as an inflammatory angiomatous nodule or, an atypical or pseudopyogenic granuloma, 3,4 when infiltration of various inflammatory cells is predominant, and a histiocytoid hemangi oma 5 when cobble stone-like endothelial cells are conspicuous. Some cases of EH consist entirely of solid sheets of epithelioid to spindled cells without fully canalized vascular structures. The solid form of EH can be difficult to diagnose and is occa sionally misdiagnosed as a malignant vascular tumor. EH is a benign neoplasm and surgical excision is sufficient for its treat ment. Recently, we experienced a solid form of EH with no inflammatory component, which showed a dramatic change into the typical morphology on the consecutive biopsy. This is the first reported Korean case of a solid form of EH, which patholo gists should include in the differential diagnosis of epithelioid vascular lesions to avoid overdiagnosis of epithelioid vascular malignancies.

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引用次数: 4

Histologic disorderliness in the arrangement of tumor cells as an objective measure of tumor differentiation. 肿瘤细胞排列的组织学紊乱是衡量肿瘤分化的客观指标。

Korean Journal of Pathology

Pub Date : 2014-10-01 Epub Date: 2014-10-27 DOI: 10.4132/KoreanJPathol.2014.48.5.339

Sungwook Suh, Gyeongsin Park, Young Sub Lee, Yosep Chong, Youn Soo Lee, Yeong Jin Choi

Background: Inter-observer and intra-observer variation in histologic tumor grading are well documented. To determine whether histologic disorderliness in the arrangement of tumor cells may serve as an objective criterion for grading, we tested the hypothesis the degree of disorderliness is related to the degree of tumor differentiation on which tumor grading is primarily based.

Methods: Borrowing from the statistical thermodynamic definition of entropy, we defined a novel mathematical formula to compute the relative degree of histologic disorderliness of tumor cells. We then analyzed a total of 51 photomicrographs of normal colorectal mucosa and colorectal adenocarcinoma with varying degrees of differentiation using our formula.

Results: A one-way analysis of variance followed by post hoc pairwise comparisons using Bonferroni correction indicated that the mean disorderliness score was the lowest for the normal colorectal mucosa and increased with decreasing tumor differentiation.

Conclusions: Disorderliness, a pathologic feature of malignant tumors that originate from highly organized structures is useful as an objective tumor grading proxy in the field of digital pathology.

背景:观察者之间和观察者内部肿瘤组织学分级的差异有很好的文献记载。为了确定肿瘤细胞排列的组织学紊乱是否可以作为分级的客观标准，我们检验了一个假设，即肿瘤细胞排列的紊乱程度与肿瘤分化程度有关，而肿瘤分化程度是肿瘤分级的主要依据。方法:借鉴熵的统计热力学定义，定义了计算肿瘤细胞组织无序度的数学公式。然后，我们用我们的公式分析了51张不同程度分化的正常结直肠粘膜和结直肠腺癌的显微照片。结果:采用Bonferroni校正的单因素方差分析和事后两两比较表明，正常结肠黏膜的平均紊乱评分最低，并随着肿瘤分化程度的降低而升高。结论:无序性是恶性肿瘤起源于高度组织化结构的一种病理特征，在数字病理学领域可以作为客观的肿瘤分级指标。

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引用次数: 0

Cytotoxic Variant of Mycosis Fungoides with CD8+ CD56+ Phenotype: A Case Report and Review of Literature. CD8+ CD56+表型蕈样真菌细胞毒变异1例报告及文献复习。

Korean Journal of Pathology

Pub Date : 2014-10-01 Epub Date: 2014-10-27 DOI: 10.4132/KoreanJPathol.2014.48.5.390

Meeran Kim, Moon Il Park, Myung Lim, Jinman Kim

Mycosis fungoides (MF) is the most common cutaneous Tcell lymphoma. Approximately 50% of all primary cutaneous lymphomas are MF[1]. These lymphomas are comprised of epidermotropic collections of small- to medium-sized T lymphocytes with cerebriform nuclei. The neoplastic cell shows a mature CD3+, CD4+, CD45RO+, CD8– memory T-cell phenotype. However, rarely, MF with a CD4–, CD8+ cytotoxic T-cell phenotype has been reported[2-5]. The World Health Organization (WHO)-European Organization for Research and Treatment of Cancer (EORTC) classification for cutaneous lymphomas describes three types of cutaneous lymphomas that express CD56: 1) subcutaneous panniculitis-like T-cell lymphoma, 2) extranodal natural killer (NK)/T-cell lymphoma, nasal type, and 3) CD4+/CD56+ hematodermic neoplasm (blastic NKcell lymphoma)[1]. However, the report does not mention, MF with CD56 expression. Earlier in 2003, a report by the EORTC cutaneous lymphoma task force workshop described cytotoxic/natural killer cell cutaneous lymphomas and divided them into eight categories[6]. One of these categories was the CD56+, cytotoxic variant of MF. This report presents a rare CD8+, CD56+ variant of MF having the cytotoxic phenotype.

{"title":"Cytotoxic Variant of Mycosis Fungoides with CD8+ CD56+ Phenotype: A Case Report and Review of Literature.","authors":"Meeran Kim, Moon Il Park, Myung Lim, Jinman Kim","doi":"10.4132/KoreanJPathol.2014.48.5.390","DOIUrl":"https://doi.org/10.4132/KoreanJPathol.2014.48.5.390","url":null,"abstract":"Mycosis fungoides (MF) is the most common cutaneous Tcell lymphoma. Approximately 50% of all primary cutaneous lymphomas are MF[1]. These lymphomas are comprised of epidermotropic collections of small- to medium-sized T lymphocytes with cerebriform nuclei. The neoplastic cell shows a mature CD3+, CD4+, CD45RO+, CD8– memory T-cell phenotype. However, rarely, MF with a CD4–, CD8+ cytotoxic T-cell phenotype has been reported[2-5]. The World Health Organization (WHO)-European Organization for Research and Treatment of Cancer (EORTC) classification for cutaneous lymphomas describes three types of cutaneous lymphomas that express CD56: 1) subcutaneous panniculitis-like T-cell lymphoma, 2) extranodal natural killer (NK)/T-cell lymphoma, nasal type, and 3) CD4+/CD56+ hematodermic neoplasm (blastic NKcell lymphoma)[1]. However, the report does not mention, MF with CD56 expression. Earlier in 2003, a report by the EORTC cutaneous lymphoma task force workshop described cytotoxic/natural killer cell cutaneous lymphomas and divided them into eight categories[6]. One of these categories was the CD56+, cytotoxic variant of MF. This report presents a rare CD8+, CD56+ variant of MF having the cytotoxic phenotype.","PeriodicalId":49936,"journal":{"name":"Korean Journal of Pathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4132/KoreanJPathol.2014.48.5.390","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32788830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Cystic Brunner's Gland Hamartoma in the Gastric Body: A Case Report. 胃体囊性布伦纳腺错构瘤1例。

Korean Journal of Pathology

Pub Date : 2014-10-01 Epub Date: 2014-10-27 DOI: 10.4132/KoreanJPathol.2014.48.5.371

Dong Hae Chung, Na Rae Kim, Hyun Yee Cho, Yoon Jae Kim

Cystic Brunner’s gland hamartoma has been described under the various names including cystic hamartoma of Brunner’s glands, cystic Brunner’s gland heterotopia, Brunner’s gland cysts, Brunner’s gland cystadenoma, Brunner’s cyst, mucocele of Brunner’s glands, and cyst of Brunner’s glands. 1-4 Here, we report a rare case where a patient presented with an incidentally found, and long-standing pedunculated submucosal mass in the stomach body, which was diagnosed as a cystic Brunner’s gland hamartoma. To the best of our knowledge, no previous occurrence of cystic Brunner’s gland hamartoma in the

引用次数: 1

A ciliated cyst with müllerian differentiation arising in the posterior mediastinum. 发生在后纵隔的有<s:1>勒氏分枝分化的纤毛囊肿。

Korean Journal of Pathology

Pub Date : 2014-10-01 Epub Date: 2014-10-27 DOI: 10.4132/KoreanJPathol.2014.48.5.401

So Jung Lee, Chung Su Hwang, Do Youn Park, Gi Young Huh, Chang Hun Lee

Primary congenital mediastinal cysts are rare, have a broad range of etiologies, and can be bronchogenic, thymic, neuroenteric, or esophageal in origin[1]. Recently, Hattori[2] described the first case of a ciliated cyst of probable Mullerian origin arising in the posterior mediastinum, a so-called Hattori’s cyst. Since that time, several additional cases have been reported[3,4]. We found a posterior mediastinal cyst with Mullerian differentiation that was consistent with previous description of Hattori’s cyst. To our knowledge, this is the first report of Hattori’s cyst arising in the posterior mediastinum in Korea.

引用次数: 10

Mdm2 and p53 Expression in Radiation-Induced Sarcomas of the Head and Neck: Comparison with De Novo Sarcomas. Mdm2和p53在放射诱导的头颈部肉瘤中的表达:与新生肉瘤的比较。

Korean Journal of Pathology

Pub Date : 2014-10-01 Epub Date: 2014-10-27 DOI: 10.4132/KoreanJPathol.2014.48.5.346

Min Jeong Song, Joon Seon Song, Jong-Lyel Roh, Seung-Ho Choi, Soon Yuhl Nam, Sang Yoon Kim, Sung Bae Kim, Sang-Wook Lee, Kyung-Ja Cho

Background: The pathogenesis of radiation-induced sarcomas (RISs) is not well known. In RIS, TP53 mutations are frequent, but little is known about Mdm2-p53 interaction, which is a recent therapeutic target of sarcomas.

Methods: We studied the immunohistochemical expression of Mdm2 and p53 of 8 RISs. The intervals between radiation therapy and diagnosis of secondary sarcomas ranged from 3 to 17 years.

Results: Mdm2 expression was more common in de novo sarcomas than RISs (75% vs 37.5%), and p53 expression was more common in RISs than in de novo cases (75% vs 37.5%). While half of the RISs were Mdm2(-)/p53(+), none of de novo cases showed such combination; while half of de novo sarcomas were Mdm2(+)/p53(-), which are a candidate group of Mdm2 inhibitors, only 1 RIS showed such a combination. Variable immunoprofiles observed in both groups did not correlate with tumor types, except that all of 2 myxofibrosarcomas were Mdm2(+)/p53(+).

Conclusions: In conclusion, we speculated that both radiation-induced and de novo sarcomagenesis are not due to a unique genetic mechanism. Mdm2-expression without p53 overexpression in 1 case of RIS decreases the future possibility of applying Mdm2 inhibitors on a subset of these difficult tumors.

背景:辐射诱导肉瘤(RISs)的发病机制尚不清楚。在RIS中，TP53突变是常见的，但对Mdm2-p53相互作用知之甚少，这是最近肉瘤的治疗靶点。方法:采用免疫组化方法研究8个RISs细胞Mdm2和p53的表达。从放射治疗到继发性肉瘤的诊断时间间隔为3至17年。结果:Mdm2在新生肉瘤中比RISs更常见(75%比37.5%)，p53在RISs中比新生肉瘤更常见(75%比37.5%)。虽然一半的RISs是Mdm2(-)/p53(+)，但新生病例没有出现这种组合;而一半的新生肉瘤是Mdm2(+)/p53(-)，这是Mdm2抑制剂的候选组，只有1个RIS显示出这种组合。除了2例黏液纤维肉瘤均为Mdm2(+)/p53(+)外，两组观察到的可变免疫图谱与肿瘤类型无关。结论:总之，我们推测辐射诱导的和新生的肉瘤形成都不是由于一个独特的遗传机制。在1例RIS患者中，Mdm2的表达没有p53过表达，降低了在这些难治性肿瘤中应用Mdm2抑制剂的可能性。

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引用次数: 3

Detection of human papillomavirus type 39 in a seborrheic inclusion cyst of the buttock. 人乳头瘤病毒39型在臀部脂溢性包涵囊肿中的检测。

Korean Journal of Pathology

Pub Date : 2014-10-01 Epub Date: 2014-10-27 DOI: 10.4132/KoreanJPathol.2014.48.5.398

Dae Hyun Song, Sang-Guk Lee, Dong Chul Kim, Jeong Hee Lee, Gyung Hyuck Ko, Jong Sil Lee

A seborrheic inclusion cyst (SIC) is a lesion, which has been described as a combination of seborrheic keratosis and an epidermoid cyst (EC). To the best of our knowledge, only eight cases of SIC have been reported thus far in the English literature[1-3]. Microscopically, SICs exhibit features that are suggestive of viral infection[4]. Therefore, an association between SICs and human papillomavirus (HPV) has been suspected, but it has only been demonstrated in one previous report by Terada,[1] which identified an HPV-positive SIC through immunohistochemical staining for HPV antigens. However, no SIC study has ever used HPV genotyping. Herein, we report the first case of SIC associated with HPV type 39, which we identified using the HPV DNA chip.

引用次数: 0

The limitations of endoscopic ultrasound-guided fine needle aspiration cytology in the diagnosis of pancreatic serous cystadenoma: a brief case report. 内镜超声引导下细针穿刺细胞学诊断胰腺浆液性囊腺瘤的局限性:1例简短报告。

Korean Journal of Pathology

Pub Date : 2014-10-01 Epub Date: 2014-10-27 DOI: 10.4132/KoreanJPathol.2014.48.5.405

Heae Surng Park, Sun Och Yoon, Beom Jin Lim, Joo Hee Kim, Soon Won Hong

Endoscopic ultrasound (EUS) fine needle aspiration (FNA) biopsy is commonly used in the diagnosis of pancreatic tumors. Although adenocarcinoma is the most commonly diagnosed primary pancreatic neoplasm, other neoplasms can also arise in this organ. For accurate diagnosis, pathologists must be familiar with the cytomorphology associated with all types of pancreatic tumors. Serous cystadenoma (SCA) is a rare, benign neoplasm that originates in the centro-acinar epithelium of the pancreas. Excluding any symptomatic or diagnostic uncertainty, patients presenting with SCA need no further management. Here, we report a case of pancreatic SCA that was suspected to be adenocarcinoma in preoperative test using EUS-guided FNA.

引用次数: 2

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